Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.

Background: Sleep disorders have a significant impact on physical health, mental health, and daily functioning, exacerbated by the accelerating pace of life and rising work-related stress in contemporary society. The incidence of sleep disorders continues to rise annually, becoming a significant global public health issue. The white blood cell-to-HDL-cholesterol ratio (WHR), lymphocyte-to-HDL-cholesterol ratio (LHR), monocyte-to-HDL-cholesterol ratio (MHR), neutrophil-to-HDL-cholesterol ratio (NHR), and platelet-to-HDL-cholesterol ratio (PHR) are emerging, convenient, and cost-effective biomarkers that reflect systemic inflammation and immunometabolic status.

The Experiment Effect of Voice Therapy Techniques on the Voice of the Elderly Choir Members.

Objective: To explore the experiment effect of voice therapy techniques on the voice of choirs in the aging period.

Methods: Two senior choirs in Xi'an City were randomly divided into an experimental group (n = 43, male 14, female 29) and a control group (n = 37, male 8, female 29). The control group conducted choral training according to regular choral rehearsal, while the experimental group was designed voice therapy techniques based on the regular choral rehearsal method.

Exploring the link between Training Transfer Climate and Work Engagement among Clinical Nurse Specialists in China: the mediating role of Craftsmanship Spirit.

Background: Clinical nursing specialists are essential in emergency care, chronic disease management, and telehealth.Their work engagement is increasingly tied to training quality, particularly through the professional values embodied in the Craftsmanship Spirit. This study aims to explore the mediating role of Craftsmanship Spirit in the relationship between Training Transfer Climate and Work Engagement among Clinical Nurse Specialists in China.

Dynamic monitoring of antibody titers in people living with HIV during Omicron epidemic: comparison between unvaccinated and vaccinated individuals.

Background: The 2019 Coronavirus disease (COVID-19) pandemic has affected hundreds of millions globally, resulting in millions of deaths. People living with HIV (PLWH) typically exhibit significantly lower antibody titers after vaccination compared to healthy individuals, and are particularly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their compromised immune system. Given the continuous emergence of SARS-CoV-2 variants, monitoring immune responses in this high-risk population is crucial.

Investigating the efficacy of dipotassium glycyrrhizin emollients in adult atopic dermatitis: A focused randomized parallel-controlled clinical study.

Background & Objective: Atopic dermatitis (AD), a chronic inflammatory skin condition, is primarily characterized by persistent itching and significant sleep disruption. Dipotassium glycyrrhizin, known for its anti-inflammatory properties, has shown potential in AD treatment. This study aims to evaluate the effectiveness of emollients containing dipotassium glycyrrhiza extract and the impact of varying application methods on improving the clinical severity of atopic dermatitis in adults during remission periods.

Piezo1 participates in sevoflurane-induced developmental neurotoxicity via neuroinflammation and synaptic damage in the hippocampus.

Background: Multiple exposures to sevoflurane in developmental neonatal mice lead to neurocognitive deficits. The present study investigates the role and mechanisms of Piezo1 in sevoflurane-induced developmental neurotoxicity.

Methods: Neonatal mice received sevoflurane on postnatal days (P) 6, 7, and 8.

Design, Synthesis and Radioprotective Activity Evaluation of Novel N-Phenyl-2H-chromene-3-carboxamides Derived from Ex-RAD.

Exposures to ionizing radiation can cause serious damages to human body, and the development of radiation countermeasures is urgently needed. In this paper, a series of N-phenyl-2H-chromene-3-carboxamides were designed and synthesized as potential radiation countermeasures. Their radioprotective activities were evaluated in vitro and in vivo, and compound B5 was identified as the most effective molecule among the target compounds.

Target-oriented synthesis of yellow fluorescent nitrogen-doped carbon dots for intelligent and real-time visual detection of malachite green in fish.

As a triphenylmethane dye, malachite green (MG) is strictly regulated in aquaculture by numerous countries due to its persistence and acute toxicity, posing significant risks to human health. This has driven the demand for rapid and sensitive detection methods for MG. Herein, we present a lateral flow test strips (LFTS)-based sensing platform utilizing yellow fluorescent nitrogen-doped carbon dots (N-CDs) for real-time visual detection of MG.

Integrated physiological, metabolomic, and transcriptomic responses of maize (Zea mays) and soybean (Glycine max) to nanoplastic-induced stress.

The widespread use and degradation of agricultural plastics lead to the accumulation of nanoplastics (NPs) and soil contamination, posing growing risks to agroecosystems. This study investigated the differential physiological and molecular responses of maize (Zea mays) and soybean (Glycine max) to polyethylene nanoparticles (PE-NPs) and polypropylene nanoparticles (PP-NPs), each within the size range of 20-50 nm, at concentrations of 50 and 500 mg/kg of soil. Over a 45-day exposure period, at 500 mg/kg concentration, both NPs types significantly suppressed plant height and fresh biomass in both maize and soybean, with PP-NPs demonstrating greater toxicity in soybean than in maize.

Cryoprotective mechanism of enzymatically interesterified rapeseed oil-based plastic fats on frozen dough: interaction with water, gluten and starch.

Enzymatically interesterified rapeseed oil-based plastic fats (EIPF) are effective in mitigating frozen storage-induced quality deterioration of frozen dough. However, the cryoprotective mechanism is little explored. This study investigated the influence of EIPF addition on steamed bread quality, fermentation dynamic, water redistribution behavior, and structure evolution of gluten-starch matrices.

Comparative efficacy of glioma treatment strategies: an umbrella review of meta-analyses.

Objective: To assess the quality of evidence, identify potential biases, and verify the validity of existing studies on glioma treatment outcomes.

Methods: We extracted and analyzed data from systematic reviews and meta-analyses assessing therapies in glioma patients. Our search included PubMed, Embase, Web of Science, and the Cochrane Database up to July 2024.

Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021.

Objectives: Tuberculosis (TB) poses a significant threat to global public health, particularly, among elderly individuals. This study aimed to provide a comprehensive analysis of the patterns and temporal trends in the global disease burden of HIV-negative TB among adults aged ≥60 years from 1990 to 2021.

Methods: Data on incidence, deaths, and disability-adjusted life-years of TB, drug-susceptible TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) were obtained from the Global Burden of Disease 2021.

Beyond Folate: The Emerging Role of Maternal Vitamin B12 in Neural Tube Development.

Folic acid (FA) supplementation can effectively reduce the occurrence of neural tube defects (NTDs). Vitamin B12 is involved in folate metabolism; however, studies have not reached a definitive conclusion on the association between vitamin B12 and NTDs independent of folate levels. A systematic review and meta-analysis were performed to summarize existing research and investigate the effect of vitamin B12 on NTDs.

Innovative strategies for post-stroke depression: integrating traditional Chinese medicine with neurobiological insights, including the gut-brain axis.

Post-stroke depression (PSD) is a debilitating condition affecting more than one-third of stroke survivors, leading to significant impairments in mood, cognitive function, and overall quality of life. While conventional treatments like selective serotonin reuptake inhibitors (SSRIs) are commonly used, their efficacy is often limited, and they are associated with adverse side effects. Emerging research underscores the critical roles of neuroinflammation, neurotransmitter imbalances, and disruptions in the gut-brain axis in the development and progression of PSD, suggesting that targeting these pathways could lead to more effective therapeutic outcomes.

Specific dual-mode fluorometric and colorimetric detection of nitrite based on oxidase-like activity of carbon dots/iron alkoxide composite.

Trace detection of nitrite in food has gained increasing attention due to its connection with biological and environmental processes. Herein, a dual-mode fluorometric/colorimetric sensor is established for nitrite detection by combining the oxidase-like activity of iron alkoxide (IA) with the bimodal excitation properties of nitrogen-doped carbon dots (N-CDs). IA oxidizes the colorless 3,3',5,5'-tetramethylbenzidine into blue-colored 3,3',5,5'-tetramethylbenzidine oxide.

Associations between the triglyceride-glucose index and its combined indices with sleep disorders and the mediating role of depressive symptoms: Results from two nationally representative population studies.

Background: The triglyceride-glucose (TyG) index and its combined indices serve as markers of insulin resistance, but their associations with sleep disorders remain unclear. This study examines the links between the TyG index, its combined indices, and sleep disorders while assessing the mediating role of depressive symptoms.

Methods: Using data from NHANES (n = 17,538, USA) and CHARLS (n = 7758, China), we conducted cross-sectional and longitudinal analyses.

Psychometric properties of the questionnaire for assessing the childbirth experience in a Chinese sample of postpartum women.

Background: The objective of this paper was to test the psychometric properties of the questionnaire for assessing the childbirth experience (QACE) among Chinese postpartum women.

Methods: Research instruments included the demographic characteristics form, the QACE, the Edinburgh Postnatal Depression Scale (EPDS), and the Generalized Anxiety Disorder-7 (GAD-7). The item analysis, confirmatory factor analysis (CFA), known-groups discriminant validity, divergent validity, and internal consistency reliability were assessed for the psychometric properties of QACE.

A putative elicitor CcHE1 from Cytospora chrysosperma enhances plant resistance to phytopathogenic fungi.

Background: Plant pathogens secrete a large number of effectors to host cells during the infection processes, which will manipulate plant immunity and promote fungal infection. Contrarily, some of the effectors can be recognized by the host plants, and then activate the immunity reactions. Therefore, unveiling the critical roles of effectors during the pathogen-plant interactions will benefit disease control.

Synthesis and Anti-hypoxic Activity Research of Daidzein Derivatives.

To search for safe and efficient anti-hypoxia active molecules, 27 derivatives were synthesized by introducing aminoalkyl groups at daidzein's position-7 and position-8. The structures of these derivatives were confirmed by H-NMR, C-NMR, and mass spectrometry. The anti-hypoxia activity was evaluated in vitro using a cell hypoxia model established with the AnaeroPack-anaero.

Global incidence and mortality of pancreatitis in women of childbearing age from 1990 to 2021.

To analyze the global burden of pancreatitis in women of childbearing age (WCBA) at the global, regional and national levels from 1990 to 2021. Data for pancreatitis incidence and deaths in females aged 15 to 49 years were downloaded from the Global Burden of Disease 2021 database. Estimated annual percentage changes (EAPCs) were calculated to describe the temporal trends.

The joint effect of triglyceride-glucose related indices and depression on cardio-renal-metabolic multimorbidity among middle-aged and older Chinese adults.

Background: The triglyceride-glucose (TyG) related indices, indicators for insulin resistance, and depression are both established predictors of cardiovascular diseases. However, the single and combined effect of TyG related indices and depression on cardio-renal-metabolic multimorbidity (CRMM) risk remain uncertain.

Methods: This study included 7848 respondents aged 45 years and older, derived from the China Health and Retirement Longitudinal Study (CHARLS) 2011, 2020.

Triggering cascade detection of rutin and Al via 3D ratiometric fluorescent probe through lateral flow assay installation based on dual-emission carbon dots.

The persistent existence of flavonoid medications and hazardous ion residues continue to be a concern. Herein, a novel 3D cascade nitrogen-doped carbon dots (N-CDs) based sensing platform for specific detection of rutin and Al has been developed, utilizing 3,3-diaminobenzidine and catechol as precursors through solvothermal way. The N-CDs exhibit a blue emission peak at 410 nm and a green emission peak at 518 nm.

Two-Year Surveillance of Dengue, Zika, and Chikungunya Viruses Among Chinese Blood Donors - Guangxi and Yunnan PLADs, China, 2022-2023.

What Is Already Known About This Topic?: The transmission of emerging and re-emerging arboviruses represent a critical challenge to blood transfusion safety worldwide.

What Is Added By This Report?: This study established a comprehensive quality assurance system for Dengue virus (DENV), Zika virus (ZIKV), and Chikungunya virus (CHIKV) nucleic acid testing (NAT) blood screening. The system included external quality assessment (EQA) implementation across all participating central blood stations and performance evaluation of six domestic blood screening reagents.

Factors associated with exposure to tuberculosis education among internal migrants with diabetes in China: a multilevel regression analysis of cross-sectional data from the 2017 China Migrants Dynamic Survey.

Objective: Individuals with diabetes are at high risk for tuberculosis (TB) infection. This study aimed to identify the barriers to access to TB education among internal migrants with diabetes in China.

Design: Cross-sectional study.

Dysregulated glutathione metabolism impairs natural killer cell function in patients with acute leukemia.

Natural killer (NK) cell function is markedly impaired in patients with acute leukemia, weakening their anti-tumor immune response. However, the mechanisms underlying NK cell dysfunction are not fully understood. Here, we reveal that NK cells from patients with acute leukemia (AL-NK) exhibit significantly reduced intracellular glutathione (GSH) levels, accompanied by disrupted redox homeostasis and increased levels of mitochondrial reactive oxygen species.