Integrated transcriptomic and proteomic analysis reveals that the anti-endometriosis effects of Pingchong Jiangni recipe may involve pathways and genes/proteins related to inflammation, autophagy, mitochondrial function, and angiogenesis in ectopic endometrial stromal cells.

Ethnopharmacological Relevance: Pingchong Jiangni recipe (PJR) is a Chinese herbal formula that has been used clinically for decades in the treatment of endometriosis, with effects such as shrinking the lesions and reducing the recurrence rate. However, the mechanisms underlying the inhibition of ectopic endometrium by PJR remain unclear.

Aim Of The Study: This study aimed to explore the potential mechanism through which PJR ameliorates endometriosis by acting on ectopic endometrial stromal cells (EESCs).

Intertransverse process block: A narrative review.

The intertransverse process block (ITPB) is a general term for a class of novel thoracic paraspinal nerve block techniques proposed in recent years, which can be divided into the mid-point transverse process to pleura block, multiple-injection costotransverse block, costotransverse foramen block and the subtransverse process interligamentary plane block. The four types of ITPB all target the retro-superior costotransverse ligament space, but slightly differ in terms of needle entry approach and needle tip target. ITPB is easy to locate, quick to perform, and provides reliable analgesic effects.

Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia.

Acute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exhaustion in AML patients could provide critical insights for developing novel strategies to optimize NK cell-based immunotherapies.

KIF4A Facilitates Oxaliplatin Resistance and Stemness in Colon Cancer by Boosting Glucose Metabolism.

Introduction: Colon cancer (CC) is a malignant tumor commonly found in the intestines with high incidence and mortality rates. Oxaliplatin (OXA) is a platinum-based chemotherapy drug widely used to treat CC. However, frequent drug resistance in patients results in suboptimal treatment outcomes.

Phase-Mixed Nickel Sulfide Nanoarrays for Electrochemical Water Oxidation at Low Overpotential.

Transition metal sulfide materials have demonstrated exceptional electrocatalytic activities for the hydrogen evolution reaction (HER); however, their efficacy for the oxygen evolution reaction (OER) remains limited, particularly in alkaline environments. This study introduces a novel nanoarray structure composed of phase-mixed nickel sulfides, specifically rhombohedral NiS and NiS, directly grown on nickel foam (denoted as bi-NiS/NF) through a straightforward hydrothermal method. The optimized bi-NiS/NF catalyst achieves an impressive overpotential of only 43 mV to reach a current density of 10 mA cm in 1 m KOH electrolyte.

Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China.

Background: Chemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.

Methods: A case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free controls.

Changes of T cell subsets across treatments associated with prognosis in newly diagnosed follicular lymphoma.

Follicular lymphoma (FL) is an immune-responsive tumor with spontaneous remission. T cells play a pivotal role in the anti-lymphoma immune response. However, the dynamics of T cells during treatment, their impact on FL clinical outcomes, and the risk factors contributing to T-cell cytopenia remain largely unexplored.

Defect-Engineered Coordination Compound Nanoparticles Based on Prussian Blue Analogues for Surface-Enhanced Raman Spectroscopy.

Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for label-free chemical analysis. The emergence of nonmetallic materials as SERS substrates, offering chemical signal enhancements, presents an exciting direction for achieving reproducible and biocompatible SERS, a challenge with traditional metallic substrates. Despite the potential, the realm of nonmetallic SERS substrates, particularly nanoparticles, remains largely untapped.

Meta-analysis of the curative effect of sacral nerve magnetic stimulation on neurogenic bladder after spinal cord injury.

Background: The curative effect of sacral nerve magnetic stimulation on the neurogenic bladder (NB) after spinal cord injury (SCI) is unclear. This study made a meta-analysis of the curative effect of sacral nerve magnetic stimulation on the NB after SCI and put forward a theoretical basis for the clinical treatment of this disease.

Methods: The databases of PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, WanFang Data, VIP, and CBM were searched by computer, and the randomized controlled trials of sacral nerve magnetic stimulation in the treatment of NB after SCI were collected.

Zishen Qingre Lishi Huayu Recipe May Ameliorate the Symptoms of PCOS Model Rats via Alleviating Systemic and Ovarian Inflammation.

Background: Zishen Qingre Lishi Huayu recipe (ZQLHR) has shown significant therapeutic effects in treating sex hormone levels and follicular developmental disorders in patients with polycystic ovary syndrome (PCOS). However, little is known about the potential mechanisms of its treatment.

Methods: Dehydroepiandrosterone and a high-fat diet induced the PCOS model rat.

Revealing the impact of autophagy-related genes in rheumatoid arthritis: Insights from bioinformatics.

Background: Rheumatoid arthritis is a systemic inflammatory autoimmune disease that severely impacts physical and mental health. Autophagy is a cellular process involving the degradation of cellular components in lysosomes. However, from a bioinformatics perspective, autophagy-related genes have not been comprehensively elucidated in rheumatoid arthritis.

Zishen Qingre Lishi Huayu recipe promotes proliferation and inhibits apoptosis of GCs of PCOS via KLF4-C/EBPβ pathway.

Ethnopharmacological Relevance: Zishen Qingre Lishi Huayu recipe (ZQLHR) is a herbal recipe created on the basis on the theory of traditional Chinese medicine and clinical practice, and is mainly used in the treatment of polycystic ovary syndrome (PCOS). However, the underlying mechanism for this fact has not been clearly elucidated.

Aim Of The Study: To verify whether ZQLHR regulates granulosa cells (GCs) proliferation and apoptosis through the Krüppel-like factor 4 (KLF4) - CCATT enhancer-binding proteinβ (C/EBPβ) pathway, and to provide in vitro molecular mechanism supporting for the effects of ZQLHR to enhance follicular development and treat patients with PCOS.

Treatment of bilateral developmental dysplasia of the hip joint with an improved technique: A case report.

Background: Developmental dysplasia of the hip (DDH) is a common osteoarticular deformity in pediatric orthopedics. A patient with bilateral DDH was diagnosed and treated using our improved technique "(powerful overturning acetabuloplasty)" combined with femoral rotational shortening osteotomy.

Case Summary: A 4-year-old girl who was diagnosed with bilateral DDH could not stand normally, and sought surgical treatment to solve the problem of double hip extension and standing.

Lactate acid promotes PD-1 Tregs accumulation in the bone marrow with high tumor burden of Acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) displayed poor response to programmed death-1 (PD-1) blockade therapy. Regulatory T cells (Tregs) was one of major immunosuppressive components in Tumor microenvironment and plays a vital role in the resistance of immunotherapy. Coinhibitory receptors regulate function of regulatory Tregs and are associated with resistance of PD-1 blockade.

Decade Milestone Advancement of Defect-Engineered g-CN for Solar Catalytic Applications.

Over the past decade, graphitic carbon nitride (g-CN) has emerged as a universal photocatalyst toward various sustainable carbo-neutral technologies. Despite solar applications discrepancy, g-CN is still confronted with a general fatal issue of insufficient supply of thermodynamically active photocarriers due to its inferior solar harvesting ability and sluggish charge transfer dynamics. Fortunately, this could be significantly alleviated by the "all-in-one" defect engineering strategy, which enables a simultaneous amelioration of both textural uniqueness and intrinsic electronic band structures.

Hematological and biochemical markers influencing breast cancer risk and mortality: Prospective cohort study in the UK Biobank by multi-state models.

Background: Breast cancer is the most common cancer and the leading cause of cancer-related death among women. However, evidence concerning hematological and biochemical markers influencing the natural history of breast cancer from in situ breast cancer to mortality is limited.

Methods: In the UK Biobank cohort, 260,079 women were enrolled during 2006-2010 and were followed up until 2019 to test the 59 hematological and biochemical markers associated with breast cancer risk and mortality.

Identifying Crucial Biomarkers in Osteoporosis and Ulcerative Colitis Through Bioinformatics Analysis of Co-expressed Genes.

Osteoporosis (OP) and ulcerative colitis (UC), prevalent immune diseases, exert a substantial socioeconomic impact globally. This study identifies biomarkers for these diseases, paving the way for in-depth research. Initially, the Gene Expression Omnibus (GEO) database was employed to analyze datasets GSE35958 and GSE87466.

Regulated synthesis of an Au NB-DT@Ag bimetallic core-molecule-shell nanostructure for reliable SERS detection.

In recent research, anisotropic plasmonic core-shell nanomaterials have gained a lot of attention in surface-enhanced Raman scattering (SERS) due to their brilliant uniformity and optical properties. Herein, a bimetallic core-molecule-shell (CMS) composite nanorod SERS substrate nanomaterial (Au NB-DT@Ag NRs) was designed and synthesized under precise regulation. The inner core is gold nanobipyramids (Au NBs), which possess superior plasmonic properties.

Expanded clinical-grade NK cells exhibit stronger effects than primary NK cells against HCMV infection.

Cytomegalovirus (CMV) reactivation remains a common complication and leads to high mortality in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early natural killer (NK) cell reconstitution may protect against the development of human CMV (HCMV) infection post-HSCT. Our previous data showed that ex vivo mbIL21/4-1BBL-expanded NK cells exhibited high cytotoxicity against leukemia cells.

High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma.

Transformed follicular lymphoma (t-FL) is an aggressive malignancy that is refractory and rapidly progressing with poor prognosis. There is currently no effective treatment. High-throughput screening (HTS) platforms are used to profile the sensitivity or toxicity of hundreds of drug molecules, and this approach is applied to identify potential effective treatments for t-FL.

Genetic and lifestyle factors for breast cancer risk assessment in Southeast China.

Background: Despite the rising incidence and mortality of breast cancer among women in China, there are currently few predictive models for breast cancer in the Chinese population and with low accuracy. This study aimed to identify major genetic and life-style risk factors in a Chinese population for potential application in risk assessment models.

Methods: A case-control study in southeast China was conducted including 1321 breast cancer patients and 2045 controls during 2013-2016, in which the data were randomly divided into a training set and a test set on a 7:3 scale.

Precise Defect Engineering on Graphitic Carbon Nitrides for Boosted Solar H Production.

Defect engineering has been regarded as an "all-in-one strategy" to alleviate the insufficient solar utilization in g-CN. However, without appropriate modification, the defect benefits will be partly offset due to the formation of deep localized defect states and deteriorated surface states, lowering the photocarrier separation efficiency. To this end, the defective g-CN is designed with both S dopants and N vacancies via a dual-solvent-assisted synthetic approach.

The temporal trend of women's cancer in Changle, China and a migrant epidemiological study.

Background: Although the etiology of women's cancer has been extensively studied in the last few decades, there is still little evidence comparing the temporal pattern of these cancers among different populations.

Methods: Cancer incidence and mortality data from 1988 to 2015 were extracted from the Changle Cancer Register in China, and cancer incidence data for Los Angeles were extracted from Cancer Incidence in Five Continents plus database. A Joinpoint regression model was used to analyze the temporal trends of incidence and mortality for breast, cervical, corpus uteri and ovarian cancers.

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia.

Introduction: Despite accumulated evidence in T-cell exhaustion in acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade in AML failed to achieve satisfying efficacy. Characteristics of exhausted T cells in AML remained to be explored.

Methods: Phenotypic analysis of T cells in bone marrow (BM) using flow cytometry combining senescent and exhausted markers was performed in de novo AML patients and healthy donors as well as AML patients with complete remission (CR).