4D-MRI at 0.55T for internal target volume delineation in liver radiation therapy planning.

Background: Low-field MRI provides superior soft-tissue contrast compared to CT while costing significantly less than high-field MRI, which makes it a more accessible option for MRI-guided radiation therapy planning. Four-dimensional MRI (4D-MRI) is a technique that has been increasingly adopted clinically for internal target volume (ITV) delineation in free-breathing liver radiotherapy planning, and it requires high spatial resolution and accurate respiratory phase differentiation to enable precise dose planning. The feasibility of 4D-MRI at low-field strength, specifically at 0.

Global, regional, and national burden of multiple myeloma, 1990 to 2021 and predictions to 2035: an analysis of the Global Burden of Disease Study 2021.

Background And Objective: Multiple myeloma (MM) is the second most common haematologic malignancy. This study aimed to assess the global burden of multiple myeloma across 204 countries and territories from 1990 to 2021.

Methods: The data for this study were obtained from the Global Burden of Disease (GBD) 2021 dataset, which provides comprehensive information on the global and regional burden of 369 diseases, injuries, and 88 risk factors across 204 countries and territories from 1990 to 2021.

Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1.

Cholangiocarcinoma (CCA) is a highly heterogeneous primary malignant tumor of the biliary tract. Intrahepatic and extrahepatic cholangiocytes originate from different sources, resulting in significant clinical, epidemiological, molecular, and genetic heterogeneity. Globally, the incidence and mortality rates of CCA are generally increasing, highlighting the need for more foundational research to support advances in clinical diagnosis and treatment.

Serum β-klotho is a potential biomarker for diagnosing alcoholic liver disease and differentiating from nonalcoholic fatty liver disease.

Background: Alcoholic liver disease (ALD), with the control of infectious liver disease and the improvement in living standards, is emerging as a significant liver disease posing a threat to public health. Besides, ALD often overlaps or coexists with nonalcoholic fatty liver disease (NAFLD), however, due to the lack of specific non-invasive biomarkers and the fact that drinkers' self-reported alcohol consumption is often concealed, the identification of ALD and NAFLD is sometimes not easy. This study aims to explore a new specific serum biomarker to more easily diagnose ALD and differentiate it from NAFLD.

Global, regional, and national epidemiology of otitis media in children from 1990 to 2021.

Background: Otitis media(OM) is a prevalent ear condition, particularly among children, with a significant impact on quality of life. This study aimed to elucidate the global prevalence and disability-adjusted life years (DALYs) associated with OM in the 0-14 age group from 1990-2021, using data from the 2021 Global Burden of Disease (GBD) study.

Methods: Our study conducted a comprehensive analysis of OM data from the GBD 2021 report, examining the prevalence and DALYs related to OM across 204 countries and territories over a 32-year period.

Metabolic network remodeling through PxJHE modulates temperature adaptation in a cosmopolitan insect.

Understanding the molecular mechanisms underlying temperature adaptation in agricultural pests is crucial for predicting their evolutionary responses to climate change. Here, we investigate the role of juvenile hormone esterase gene PxJHE in temperature adaptation of Plutella xylostella, a globally distributed pest. Spatial-temporal expression patterns demonstrates significantly reduced PxJHE transcript levels in hot-evolved (HS), and cold-evolved (CS) strains across all tested temperatures compared to ancestral strain (AS).

Effectiveness of different medication management measures in older patients with chronic diseases and Polypharmacy: A systematic review and network meta-analysis.

Purpose: Currently there is still no network meta-analysis of the effectiveness of different medication management measures for older adults with chronic diseases and polypharmacy. Therefore, a network meta-analysis was conducted to assess the impact of different management measures on older patients with chronic diseases and polypharmacy.

Methods: Multiple databases, including PubMed, Web of Science, Embase, Cochrane Library, and CINAHL, were searched from inception to February 28, 2024.

Three-dimensional lower limb kinematics and kinetics in femoroacetabular impingement syndrome (FAIS) patients with and without borderline developmental dysplasia of the hip (BDDH) during level walking.

Purpose: The impact of femoroacetabular impingement syndrome (FAIS) on gait has been reported; however, no studies have documented the effects of Borderline Developmental Dysplasia of the Hip (BDDH) combined with FAIS on gait. This study aimed to evaluate the kinematic and kinetic abnormalities of the lower extremities in patients with combined FAIS and BDDH during level walking.

Methods: A total of 42 participants were included, consisting of 14 patients with FAIS + BDDH, 14 with isolated FAIS and 14 healthy controls.

MEMS-Based Portable Reflection Confocal Microscope for In Vivo Skin Imaging.

This study aims to develop a portable reflective confocal microscope (PCRM) based on MEMS micro-mirrors for in vivo skin imaging. The design of PCRM is intended to overcome the limitations of traditional invasive biopsies and bulky desktop microscopes, enabling handheld operation and access to hard-to-reach skin areas. This research innovatively integrates MEMS technology into the PCM through precise mechanical design, using an 830 nm laser and a commercial Olympus objective lens, achieving a lateral resolution of 1.

Teclistamab Dosing in Responders: Modeling and Simulation Results from the MajesTEC-1 Study in Relapsed/Refractory Multiple Myeloma.

Background: Based on the phase I/II MajesTEC-1 study, the B-cell maturation antigen (BCMA) and cluster of differentiation (CD)3 bispecific antibody, teclistamab, is approved for relapsed/refractory multiple myeloma (RRMM) at a dose of 1.5 mg/kg weekly (QW), with the option to switch to 1.5 mg/kg every other week (Q2W) in patients maintaining complete response (CR) or better for ≥ 6 months on the QW schedule.

Multidimensional health status and its impact on health care consumption behavior among elderly people with chronic diseases: evidence from CHARLS in China.

Purpose: This study aims to provide a comprehensive understanding of the multidimensional health status of elderly individuals with chronic diseases in China and examine its impact on their healthcare consumption behavior.

Methods: A chi-square test was conducted to assess the variations in healthcare consumption behavior across different multidimensional health categories. Additionally, a logistic regression model was employed to identify the key determinants influencing healthcare consumption among elderly individuals with chronic diseases from a multidimensional health perspective.

Ultrafast Ratiometric Fluorescent Probe and Deep Learning-Assisted On-Site Detection Platform for BAs and Meat Freshness Based on Molecular Engineering.

As metabolic byproducts and representative indicators of food spoilage, the monitoring and detection for biogenic amines (BAs) are crucial but challenging for food quality assessment. Here, a strategy is proposed by combining fluorescent probe molecular engineering with a portable detection platform integrating a smartphone and a deep convolutional neural network (DCNN). Four ratiometric fluorescent probes with tunable intramolecular charge transfer (ICT) properties are designed by introducing different electron-withdrawing substituents (-F, -OCH, -Py, and -CN) to the carbazole.

A zinc finger protein shapes the temperature adaptability of a cosmopolitan pest.

Global climate change is characterized by increased extreme temperatures affecting insects at all trophic levels. Zinc finger proteins (ZFPs) are key regulators of gene expression and cell differentiation in eukaryotes, essential for stress resistance in both animals and plants. Using CRISPR/Cas9 for gene deletion, this study predicted and examined the structure of ZFP320 in the diamondback moth () and investigated its function in temperature stress response through a comprehensive age-stage, two-sex life table analysis.

Poly(glycerol succinate) hydrogel promotes spinal cord repair by regulating bio-energetic activity in severe injury.

Traumatic spinal cord injury (SCI) is a major clinical challenge, imposing a significant burden on both patients and healthcare systems. The complexity of SCI stems from its multifactorial pathogenesis, incorporating a variety of regulating factors. Despite the exploration of mechanisms of SCI pathophysiology and the development of biomedical therapies, current clinical interventions are still limited to surgical interventions and rehabilitative care.

Establishment and characterization of CHC-X1: the third human combined hepatocellular-cholangiocarcinoma cell line.

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) represents an uncommon variant of primary liver cancer. In recent years, its incidence rate has increased. Thus, it is essential to perform comprehensive investigations into cHCC-CCA to develop suitable treatment strategies.

Multi-contrast 4DMR via MR multitasking: Early clinical experience and implication for liver stereotactic body radiation therapy.

Background: Liver tumors have low contrast on 4DCT. A novel Multitasking (MT)MR imaging technique has been implemented on the MR simulator, providing both T1 and T2-weighted 4DMR images in a single 8-min free-breathing scan for better tumor delineation and motion evaluation. This study reports our early clinical experience of MTMR regarding tumor visibility, motion characteristics, and resultant dosimetry compared to post-contrast 4DCT for liver SBRT.

Quantitative evaluation of policy texts of hospital workplace violence prevention and control in China: based on the PMC-Index model.

Background: Workplace violence is one of the major public health problems in the world. In China, the problem of hospital workplace violence has been improved, but it remains significant. In order to prevent and punish such adverse events, China has introduced a series of policies and measures, however, there is still a lack of evaluative research on the effectiveness of these policies.

Charge transfer and photophysical properties of DSSCs based on different π-conjugated bridges: DFT and TD-DFT study.

Dye-sensitized solar cells (DSSCs) are photovoltaic devices that directly convert solar radiation into current, in which the dye sensitizer serves as a critical structure that plays a significant role in determining the performance and conversion efficiency of DSSCs devices. In this paper, a series of D-A-π-A type dyes are designed, in which 2,2'-bithiophene, 1,1'-biphenyl as well as C=C and azo groups are used as π-conjugated bridges to transport electrons, respectively. The ground and excited state properties of several molecules were analyzed by density functional theory (DFT) and time-dependent density functional theory (TD-DFT).

Development of a colloidal gold immunochromatographic assay utilizing dual-antibody sandwich method for detecting .

A colloidal gold immunochromatographic assay (ICA) based on a dual-antibody sandwich method was developed for the rapid and convenient detection of () antigens in the early stages of infection. Monoclonal antibodies designed as 5B3 targeting the conserved region of 56 kDa outer membrane protein in various strains of were generated through cell fusion and screening techniques and combined with previously prepared polyclonal antibodies as detection antibodies to establish the ICA. Colloidal gold and polyclonal antibody-colloidal gold complexes were synthesized under optimized conditions.

Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis.

Background: Coronary atherosclerotic heart disease (coronary heart disease; CHD) is the leading cause of death in women worldwide, and the number of patients and deaths is increasing each year. Approximately 3.8 million women die from CHD every year globally.

Establishment and characterization of a new intestinal-type ampullary carcinoma cell line, DPC-X3.

Ampullary carcinoma (AC) of the intestinal type represents a distinct variant within the broader category of ampullary neoplasms. The scarcity of pertinent cellular models has constrained investigations centered on this particular malignancy. This research effectively generated a cell line (CL) of intestinal-type AC (DPC-X3).

Ratiometric fluorescence probes for visible detection and accurate identification of MPEA vapor.

Methamphetamine (MA), as one kind of overflowed synthetic illicit drugs, has posed severe threats to health and social security. However, the on-site and visible fluorescence detection to MA remains limited. Herein, through covalently coupling diphenylacridine (DPA) and dimethylacridine (DMA) with pyridine, two ratiometric fluorescence probes (PyDPA and PyDMA) are constructed, which present rapid response, bathochromic-shifts over 100 nm and visible fluorescence color changes from blue to cyan upon the exposure to methylphenethylamine (MPEA, a simulant of MA).

Investigating the environmental dynamics of emerging pollutants in response to global climate change: Insights from bibliometrics-based visualization analysis.

The environmental dynamics of emerging pollutants were profoundly influenced by global climate change, attracting widespread attention to this complex interaction. However, single studies or reviews were insufficient to grasp, clarify, and predict the evolutionary characteristics and coupling patterns of emerging pollutants under global climate change. Here, 2389 research articles collected from the Web of Science Core Collection database for the period 2000-2023 were analyzed using systematic bibliometric visual analysis software.

DFT-Guided Design of Dual Dopants in Anatase TiO for Boosted Sodium Storage.

Anatase titanium dioxide (TiO) has drawn great attention as an anode material in sodium ion batteries (SIBs), but it suffers from the sluggish diffusion kinetics of Na within TiO and inferior electronic conductivity. Herein, under the guidance of density functional theory (DFT), we propose a nitrogen and selenium dual-doped TiO system as an advanced SIB anode. Both DFT and experimental investigations reveal the cooperative effect of dopants in boosting the electrochemical performance of TiO, finding the optimal content ratio (N/Se at 1:3) for overall improved SIB performances.