Sewage surveillance revealed the emergence and prevalence of human rhinovirus and human parainfluenza virus in China based on their fecal shedding rates.

Human parainfluenza virus (HPIV) and human rhinovirus (HRV) significantly contribute to acute respiratory tract infections (ARIs), especially in children. Wastewater surveillance (WWS) is a valuable tool for monitoring these viruses, but limited understanding of their fecal shedding patterns restricts the broader application of WWS. This study aimed to investigate fecal shedding dynamics of HPIV and HRV for developing a mass-balance model to predict infection prevalence, and conduct wastewater sequencing to explore genetic diversity.

[Digital design and manufacturing method of double constrained split guide for orthodontic miniscrew implantation].

This study explored a novel digital design and fabrication method for a double constrained split orthodontic miniscrew guide to improve the accuracy and safety of clinical miniscrew implantation and reduce related complications. A patient requiring miniscrew implantation was selected, and data were acquired using cone beam computed tomography (CBCT) and intraoral optical scanning. For the construction of a double constrained split guide including a screw-hole guide and an insertion rod guide, different types of software such as Mimics 24.

Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With or Without Metabolic Syndrome.

Aims: The impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation is still inconclusive. Besides, their efficacy on AF recurrence stratified by metabolic syndrome (MetS) status remains unknown.

Methods: Patients with AF undergoing initial catheter ablation between January 2017 and December 2023 from the China-AF Registry were included.

Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China.

Background: Influenza vaccination is widely recommended to prevent death and serious illness in vulnerable people, including those with heart failure. However, the randomised evidence to support this practice is limited and few people are vaccinated in many parts of the world. We aimed to determine whether influenza vaccination can improve the outcome of patients after an episode of acute heart failure requiring admission to hospital in China.

Statistical Analysis Plan for a Randomized Controlled Trial of Intensive Blood Pressure Control on Cardiovascular risk Reduction in Patients with Atrial Fibrillation.

Introduction: Elevated blood pressure (BP) is a key modifiable risk factor for cardiovascular (CV) complications in patients with atrial fibrillation (AF). While current guidelines recommend modest BP targets, the optimal target in AF patients remains uncertain. The Cardiovascular Risk Reduction in Atrial Fibrillation Trial (CRAFT) is a multicenter, prospective, randomized, open-label, blinded-endpoint trial that evaluates whether intensive home systolic BP control (<120 mmHg) is superior to standard BP control (<135 mmHg) in reducing major CV events.

Sharp recanalization of superior vena cava occlusion with stent migration in a hemodialysis patient: Rescue strategy for life-threatening hemothorax.

Superior vena cava (SVC) occlusion in hemodialysis patients presents significant therapeutic challenges, particularly when complicated by stent migration. Sharp recanalization may serve as a salvage intervention for refractory cases though high-risk. Here, we present a 72-year-old male with stent migration-induced recurrent SVC syndrome.

Direct stent puncture-assisted recanalization for occluded central venous stent graft.

Central venous occlusive disease (CVOD) is a common complication in hemodialysis patients, often necessitating endovascular interventions such as angioplasty and stenting. However, stent occlusion remains a significant challenge, with conventional recanalization techniques frequently failing. This case report describes the successful application of a direct stent puncture (DSP)-assisted bidirectional approach to revascularize a refractory occlusion of a central venous stent graft in a 70-year-old hemodialysis patient.

Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients with renal impairment or on continuous renal replacement therapy.

Purpose: This study aimed to characterize the pharmacokinetics (PK) of meropenem in patients with renal impairment or on continuous renal replacement therapy (CRRT), investigate the factors contributing to PK variability, and evaluate the performance of different dosing regimens to optimize the pharmacokinetics/pharmacodynamics PK/PD) targets.

Methods: This study enrolled patients with severe infections and renal impairment who received meropenem treatment at the Second Affiliated Hospital of Soochow University. Participants were grouped according to whether CRRT was used.

Exploring Biological Evidence of Radioprotective Effects and Critical Oxygen Thresholds in (Diptera: Tephritidae).

Irradiation combined with Modified Atmosphere (MA) Packaging (MAP) is increasingly applied to disinfest fresh harvested produce while maintaining quality. However, anoxia and hypoxic conditions created by MA can reduce the effectiveness of ionizing radiation by inducing radioprotective effects in insects. This study investigated the relationship between oxygen levels and radiation efficacy in late third-instar larvae of .

Clinicopathological Features and Pathogenesis of Thymoma Complicated with Alopecia Areata: A Multicenter, Matched Case Analysis.

Background: Thymoma is a malignant tumor originating from the thymic epithelium and can be associated with over 100 paraneoplastic syndromes (PNSs). Due to the low incidence of thymoma and the relative rarity of alopecia areata (AA) as an associated autoimmune disease, patients with thymoma combined with AA are relatively uncommon in clinical practice. As a result, the clinicopathological features and pathogenesis of such patients have been rarely investigated.

Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial.

Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial).

Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence.

It remains unclear why vaccines targeting prominent microbial virulence factors often fail in clinical trials. Because microbial virulence depends on interaction with the host immune system, we investigated how changes in host immune function alter vaccine efficacy. Using a vaccine against alpha toxin (Hla), which targets host metalloprotease ADAM10 on myeloid cells, we show that Hla virulence is reduced in aged mice due to diminished ADAM10 activity and impaired myeloid cell function.

Population prevalence and correlates of prolonged and shortened QTc intervals in a nationwide survey of adults in China: a report from Chinese arrhythmia epidemiology cross-sectional study.

Objective: QT interval irregularities correlate with severe arrhythmias and sudden cardiac death. However, epidemiological data on QT intervals in Chinese adults are lacking. This study aimed to elucidate the distribution of the QT interval (QTc) patterns in Chinese adults and the risk factors associated with a prolonged QTc interval and shortened QTc interval.

Impact of sodium-glucose cotransporter 2 inhibitor on recurrence and cardiovascular outcomes after catheter ablation for atrial fibrillation in patients with chronic kidney disease.

Background: The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation in patients with chronic kidney disease (CKD) remains uncertain.

Objective: The purpose of this study was to investigate whether SGLT2i treatment is associated with a reduced risk of AF recurrence after catheter ablation in patients with CKD.

Methods: From the prospective Chinese Atrial Fibrillation Registry, we identified 628 patients with AF and CKD undergoing initial catheter ablation from January 2019 to December 2023.

Exploring the inhibitory effects of Guben Antai Decoction on oxidative stress damage and ferroptosis via the Nrf2/HO-1 pathway: A mechanistic study on improving Recurrent Spontaneous Abortion.

Ethnopharmacological Relevance: Guben Antai Decoction (GBAT) is a traditional Chinese medicine formula that significantly increases embryo implantation rates and reduces early pregnancy loss in patients with recurrent spontaneous abortion (RSA).

Aim Of The Study: This study aims to explore the influence and possible mechanism of GBAT in improving recurrent spontaneous abortion.

Materials And Methods: In vivo, normal pregnancy and RSA models were established using CBA/J female × BALB/c male and CBA/J female × DBA/2 male mouse pairings, respectively.

Catheter Ablation for Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy: Electrophysiological Characteristics and Long-Term Outcomes.

Background: Studies on catheter ablation of hypertrophic cardiomyopathy (HCM)- ventricular tachycardia (VT) are relatively limited and mainly focused on feasibility and safety, whereas the VT distribution and electrophysiological properties remain insufficiently characterized.

Objectives: The aim of this study was to detail the site-specific electrophysiological properties and ablation outcomes in HCM-VT.

Methods: A total of 32 patients with HCM-VT who underwent catheter ablation were included.

Influenza vaccination in patients with heart failure compared to usual practice: A model-based cost-effectiveness analysis.

Introduction: People with heart failure (HF) are at higher risk of experiencing severe cardiac complications including hospitalization and death, from seasonal influenza infection. In addition to preventing influenza infections, influenza vaccination's effect on preventing hospitalization and death may impact its cost-effectiveness among people with HF. Moreover, uncertainty of its cost-effectiveness has been reported as a barrier for public funding of influenza vaccination in such populations.

Impact of disease progression avoidance by catheter ablation on clinical outcomes in atrial fibrillation: Insights from the CABANA trial.

Background: Delaying disease progression by catheter ablation has been recognized in patients with paroxysmal atrial fibrillation (AF); however, its direct association with clinical outcome improvement remains unclear.

Objective: This study aimed to evaluate the effect of catheter ablation on reducing AF progression and associations with outcomes.

Methods: The Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial compared the efficacy of catheter ablation with drug therapy in 2204 patients with AF.

Sex differences in health status trajectories among Chinese angina patients: a post-hoc analysis of the GREAT multicenter prospective cohort.

Background: Sex differences in health status trajectories among Chinese patients with angina pectoris (AP) remain underexplored in real-world settings.

Methods: This post-hoc analysis utilized data from the GREAT registry, a multicenter, prospective cohort study that enrolled 1,556 consecutive patients with AP from nine hospitals in China between September 2021 and May 2022. Patients were stratified by sex, and their health status was assessed using the Seattle Angina Questionnaire (SAQ) at baseline, 3, 6, 9, and 12 months.

A deep learning-based computer-aided diagnosis system for detecting atypical endometrial hyperplasia and endometrial cancer through hysteroscopy.

Timely diagnosis of endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is crucial, yet traditional hysteroscopy faces accuracy challenges. This study introduces ECCADx, a deep learning-based computer-aided diagnosis system utilizing contrastive learning for hysteroscopic identification of AEH and EC. This is the system to integrate contrastive learning for this specific differentiation.

A Biomimetic Hierarchical Porous Microneedle for Transdermal Ovarian Cancer Detection.

Precision in early-stage ovarian cancer detection is crucial for improving survival rates, yet often involves invasive or resource-intensive procedures. It is here engineered a portable transdermal biosensor comprising antibody-functionalized hierarchical porous microneedles (hp-MNs) that enables on -needle quantitatively detect human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) via fluorescence immunoassay. Fabricated through a novel phase separation micro-molding technique, the biomimetic microneedles feature a coral-like hierarchical inter-connective porous structure with noteworthy liquid absorption capacity and high antibody-binding density, enabling reliable in vivo biomarkers enrichment and detection with nanomolar sensitivity to differentiate disease from benign biofluids.

Intensive Blood Pressure Control in Patients With Diabetes and Previous Stroke: A Post-Hoc Analysis of ACCORD-BP Trial.

Intensive systolic blood pressure (SBP) control reduces cardiovascular outcomes in hypertensive patients, but its effects in those with diabetes and prior stroke need further evidence. Among 4733 patients with elevated SBP enrolled in the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) trial, this post-hoc analysis focused on 307 patients with type 2 diabetes and prior stroke to evaluate intensive versus standard SBP control. The primary outcome was major adverse cardiovascular events (MACE), a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke.

Development and validation of risk stratification and shared decision-making tool for catheter ablation for atrial fibrillation in patients with heart failure: a multicentre cohort study.

Background: The coexistence of atrial fibrillation (AF) and heart failure (HF) presents a significant challenge in risk evaluation and treatment decision-making. This study aimed to develop a shared decision-making tool that aids in risk stratification and guides radiofrequency catheter ablation (RFCA) decisions for patients with AF and HF.

Methods: In this multicentre cohort study, we derived a shared decision-making tool by applying unsupervised clustering and supervised learning models to data from the China-AF registry, collected from 31 hospitals between August 1, 2011, and December 31, 2022.

Walking as a viable alternative to moderate-to-vigorous physical activity for improving cardiovascular outcomes in coronary artery disease patients.

Background: Home-based cardiac rehabilitation is recommended for coronary artery disease (CAD) patients, while exercise is the most important component. There is lack of evidence on whether walking alone can improve cardiovascular prognosis in CAD patients, particularly those unable to tolerate moderate-to-vigorous physical activity (MVPA).

Methods: Participants with diagnosed CAD from the UK Biobank with baseline PA assessment were included.