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http://dx.doi.org/10.1038/s41591-025-03836-y | DOI Listing |
Anal Chem
September 2025
College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha 410083, China.
While deep learning-enhanced Raman spectroscopy enables rapid sample analysis, model portability among spectrometers remains hindered by systematic interdevice variations. In this study, a Low-Rank Adaptation-based Calibration Transfer method (LoRA-CT) is proposed to perform parameter-efficient fine-tuning of deep learning models across spectrometers. By decomposing weight updates into low-rank matrices, LoRA-CT achieves superior calibration transfer with minimal samples, reducing trainable parameters by 600× compared to full parameter fine-tuning.
View Article and Find Full Text PDFMikrochim Acta
September 2025
Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, 110016, Liaoning, People's Republic of China.
A novel dual-mode sensing system integrating a magnetic core-shell CuFeO/Cu/MnO nanozyme with a stimuli-responsive agarose-deep eutectic solvent hydrogel (DES-Aga) is reported. The nanozyme exhibits exceptional oxidase-like activity, characterized by a low Michaelis constant (K = 0.14 mM) and high catalytic efficiency (V = 1.
View Article and Find Full Text PDFFEMS Microbiol Rev
September 2025
CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
African Swine Fever (ASF), caused by the highly contagious African swine fever virus (ASFV), poses a significant threat to domestic and wild pigs worldwide. Despite its limited host range and lack of zoonotic potential, ASF has severe socio-economic and environmental consequences. Current control strategies primarily rely on early detection and culling of infected animals, but these measures are insufficient given the rapid spread of the disease.
View Article and Find Full Text PDFmBio
September 2025
Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) ESKAPE pathogens pose a significant global health threat due to their ability to evade antibiotics through intrinsic and acquired mechanisms. These bacteria, including , , , , , and species, evade antibiotics through intrinsic and adaptive mechanisms. Common strategies include capsule formation, biofilm, β-lactamase production, and efflux activity.
View Article and Find Full Text PDFFront Plant Sci
August 2025
College of Engineering, Qinghai Institute of Technology, Xining, China.
The plateau pika () is a keystone species on the Qinghai-Tibet Plateau, and its population density-typically inferred from burrow counts-requires rapid, low-cost monitoring. We propose YOLO-Pika, a lightweight detector built on YOLOv8n that integrates (1) a Fusion_Block into the backbone, leveraging high-dimensional mapping and fine-grained gating to enhance feature representation with negligible computational overhead, and (2) an MS_Fusion_FPN composed of multiple MSEI modules for multi-scale frequency-domain fusion and edge enhancement. On a plateau pika burrow dataset, YOLO-Pika increases mAP50 by 3.
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