SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice.

Panicle architecture is largely determined by meristem activity. This previous study shows that DNA binding with one finger (Dof) transcription factor Short Panicle 3 (SP3) regulates panicle architecture. However, the molecular mechanisms of SP3 controlling panicle architecture remain largely unknown.

A network analysis study of anxiety, depression and loneliness among middle-aged and elderly people in Xining area.

Background: Low oxygen levels, low atmospheric pressure, and intense sunlight characterize high-altitude regions. These environmental factors can disrupt the body's biochemical mechanisms and neural functions, which may increase the risk of mental health issues in affected individuals. Depression, anxiety, and loneliness are common mental health conditions.

Ribosomal Incorporation of Fluorosulfonyloxy--Phenylalanine into Macrocyclic Peptides for De Novo Target-Specific Covalent Binders.

Macrocyclic peptides are emerging as a promising molecular framework in covalent drug development due to their high specificity, affinity, and low toxicity, addressing challenges such as off-target effects and nonspecific binding associated with traditional covalent binders. Although mRNA display technology has advanced the discovery of covalent peptide binders, it has primarily focused on cysteine residues, thereby limiting the diversity of targetable proteins. In this study, we ribosomally incorporated 4-fluorosulfonyloxy-l-phenylalanine (FSY) into macrocyclic peptides, enabling the construction of a diverse covalent macrocyclic peptide library for de novo screening against human α-thrombin and fibroblast activation protein.

Molecular Classification Guides Fertility-Sparing Treatment for Endometrial Cancer and Atypical Hyperplasia Patients.

Objectives: The objective of this study was to investigate the significance of molecular classification in guiding treatment decisions for patients with endometrial cancer (EC) or atypical hyperplasia (AH) undergoing fertility-sparing treatment (FST), particularly for those with non-NSMP subtypes.

Methods: We conducted a retrospective cohort study involving EC/AH patients undergoing FST and molecular classification using next-generation sequencing at Peking University People's Hospital between June 2020 and September 2023.

Results: A total of 118 EC/AH patients were included, including 92 cases with NSMP, 11 with MMRd, 11 with mut, and 4 with p53abn.

Salting-induced lipid hydrolysis and oxidation in dried squid fillets: A mechanistic link to formaldehyde formation, color browning, and flavor alteration.

Salt-dried squid fillets (SDSF) is a popular seafood product. In this study, the effect of different NaCl concentrations (0 %, 1 %, 5 % and 10 %) on the color, formaldehyde (FA) and volatile compounds (VOCs) of SDSF was investigated by determining the acid value (AV), thiobarbituric acid reactive substances (TBARS) value, lipid-related enzyme activities and lipidomics. These findings showed that the AV and TBARS value initially increased and subsequently decreased with increasing NaCl concentrations.

Zero-Dimensional Plastic Phase Transition Iron-Based Compounds with High and Switchable SHG Responses.

Organic-inorganic hybrid materials have garnered significant interest due to their unique combination of phase transition characteristics, substantial entropy changes, simple preparation methods, and structural flexibility, making them promising candidates for applications in sensor technologies and data storage systems. In the present research, two plastic organic-inorganic hybrid phase transition materials: [CHNF]FeCl () and [CHNF]FeBr () were successfully synthesized by the H/F substitution strategy. Significant step-like dielectric changes were observed during the reversible phase transitions of (401 K) and (406 K).

Preparation, identification and application of lipid-Maillard reaction products during the drying process of squid fillets.

Squid fillets are susceptible to lipid oxidation and Maillard reaction during the drying process. In this study, a novel additive agent lipid-Maillard reaction products (L-MRPs) was optimized by response surface methodology, then the main antioxidant components of L-MRPs were identified. Finally, L-MRPs was applied to the drying process of squid fillets (LMSF) by comparing with the control group.

Association of Life's Essential 8 Scores with Carotid Artery Plaque in Chinese Adults: A Prospective Cohort Study.

Aim: The American Heart Association (AHA) proposed Life's Essential 8 score (LE8) in 2022 as a new metric for cardiovascular health (CVH). This study investigated the association between the LE8 score and the development of carotid artery plaque.

Methods: Data were drawn from the Asymptomatic Polyvascular Abnormalities Community (APAC) cohort study.

Low temperature, high salinity depuration enhances Pacific oyster (Crassostrea gigas) lipid nutrition during anhydrous living-preservation: Lipidomic insights based on RPLC-Q-TOF-MS/MS.

Using UHPLC-HRMS-based lipidomics, this study investigated lipid nutrition in Pacific oysters (C. gigas) under two depuration conditions-normal temperature and salinity (N group) and low temperature with high salinity (S group)-during a five-day anhydrous living-preservation period. Quantitative analysis of 927 lipid molecular species across 13 classes revealed that oysters in the S group retained higher levels of glycerolipids, phospholipids, and functional fatty acids (DHA, EPA, and AA) after preservation.

The new insight into the impact of hemocyanin on quality deterioration of Pacific white shrimp during refrigerated storage.

This study explored the role of hemocyanin (Hc) in shrimp quality deterioration during storage. Pacific white shrimp (Litopenaeus vannamei) subjected to bloodletting and stored at 4 °C showed 22.97 % and 21.

2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-CN-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride.

In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-CN/SO system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant-product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the SO into SO and enhancing the cathodic ECL emission of g-CN.

Effects of mitochondrial lipidome alterations on quality deterioration of Larimichthys crocea postmortem storage: New insight from the perspective of mediating mitochondria-dependent apoptosis.

Apoptosis occurs in the myocyte of fish postmortem storage. Based on the important role of mitochondrial lipid molecules in regulating apoptosis, the study aims to investigate the potential impact of mitochondrial lipids on apoptosis and quality deterioration of large yellow croaker. A total of 1079 lipid molecule species in 13 classes were identified in mitochondria.

Insight into the mechanism of Maillard reaction and lipids mutually contribute to the flavor release of squid fillets during the drying process.

Dried squid fillet is a popular seafood product with a unique flavor. However, its flavor release mechanism is unclear. In this study, volatile compounds (VOCs) were dynamically monitored in thawed squid (TS), salted squid (SS) and dried squid for 6 h (D6) and 24 h (D24).

Electrodeposition, microstructure and characterization of high-strength, low-roughness copper foils with polyethylene glycol additives.

Electroplating additives play a key role in enhancing the physical and chemical performances of electrodeposited copper foils. Currently, a lot of research on polyethylene glycol (PEG) additives has been reported on the metallisation interconnections for printed circuit boards (PCBs); however, research on its applications for electrodeposited copper foils is rarely documented. Herein, high-quality copper foils with high tensile strength (433.

Lipid-involved browning mechanism during the drying process of squid.

The present study evaluated lipid-involved browning mechanism during the drying process of squid. Initially, different lipid-Maillard reaction (MR) models were conducted based on the composition of squid (lipids, reducing sugars and amino acids). The degree of MR as well as α-dicarbonyl compounds (α-DCs) and lipid oxidation-mediated browning products (pyrroles and lipofuscin-like pigments) were detected.

OsIAA23 Promotes Heading by Directly Downregulating Ghd7 in rice.

Ghd7 is a central regulator to multiple growth and development processes in rice. While it is not clear how Ghd7 is regulated by upstream factors. To identify its upstream regulator, the truncated Ghd7 promoter fragments were used to screen cis elements binding to rice total nuclear proteins.

Tert-butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death.

Trabecular meshwork (TM) tissue has a crucial role in regulating aqueous humor circulation in the eye, thus maintaining normal intraocular pressure (IOP). TM dysfunction causes IOP elevation, which leads to glaucoma. To investigate biological changes in TM tissue in patients with glaucoma, we analyzed the mRNA expression microarray dataset, GSE27276.

CTR-FAPI PET Enables Precision Management of Medullary Thyroid Carcinoma.

Medullary thyroid carcinoma (MTC) can only be cured through the excision of all metastatic lesions, but current clinical practice fails to localize the disease in 29% to 60% of patients. Previously, we developed a fibroblast activation protein inhibitor (FAPI)-based covalent targeted radioligand (CTR) for improved detection sensitivity and accuracy. In this first-in-class clinical trial, we head-to-head compared [68Ga]Ga-CTR-FAPI PET-CT and [18F]fluorodeoxyglucose ([18F]FDG) PET-CT in 50 patients with MTC.

Longitudinal In Vivo Imaging of Retinal Cells with Tailored Adeno-Associated Virus Serotypes via Confocal Scanning Laser Ophthalmoscopy.

The dynamic nature of retinal cellular processes necessitates advancements in gene delivery and live monitoring techniques to enhance the understanding and treatment of ocular diseases. This study introduces an optimized adeno-associated virus (AAV) approach, utilizing specific serotypes and promoters to achieve optimal transfection efficiency in targeted retinal cells, including retinal ganglion cells (RGCs) and Müller glia. Leveraging the precision of confocal scanning laser ophthalmoscopy (CSLO), this work presents a non-invasive method for in vivo imaging that captures the longitudinal expression of AAV-mediated green fluorescent protein (GFP).

A comparative lipid profile of four fish species: From muscle to industrial by-products based on RPLC-Q-TOF-MS/MS.

Fish are crucial for the fishing industry and essential nutrient provision, including lipids. This study employed a high-throughput lipidomic approach to evaluate and contrast the lipid profiles of three marine fish species (P. crocea, S.

Comprehensive Lipidomic Analysis of Three Edible Microalgae Species Based on RPLC-Q-TOF-MS/MS.

Microalgae, integral to marine ecosystems for their rich nutrient content, notably lipids and proteins, were investigated by using reversed-phase liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (RPLC-Q-TOF-MS/MS). This study focused on lipid composition in three commonly used microalgae species (, , and ) for functional food applications. The analysis unveiled more than 700 lipid molecular species, including glycolipids (GLs), phospholipids (PLs), sphingolipids (SLs), glycerolipids, and betaine lipids (BLs).

Effect of cytochrome c release on the mitochondrial-dependent apoptosis and quality deterioration of black rockfish (Sebastes schlegelii) postmortem storage.

Apoptosis was associated with decreased sensory quality attributes of fish during postmortem storage. Based on cytochrome c (cyt-c) release plays a crucial role in apoptosis, the study aims to investigate the factors regulating cyt-c release and whether cyt-c acts as an endogenous pro-oxidant to trigger lipid oxidation. Within 12 h postmortem, dramatic changes in the intramuscular environment (glycogen from 1.