NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210.

Chronic hypoperfusion-induced neuronal damage is the pathological basis of vascular dementia (VD). Hypoxia enhances the paracrine effects of neural stem cells (NSCs) by promoting neuroprotection and synaptic plasticity, which may be mediated by extracellular vehicles (EVs) secretion. In this study, we aimed to investigate the therapeutic effects and underlying mechanisms of hypoxic NSC-derived EVs (hypoxic NSC-EVs) in VD.

Reliability and validity of the Chinese version of the Family Resilience Inventory.

Introduction: Family resilience plays a crucial role in helping patients with chronic diseases manage their conditions and maintain overall well-being. The Family Resilience Inventory (FRI) assesses resilience across generations with a focus on protective and promotive factors. However, the FRI has not been translated into Chinese or validated for use among families managing chronic diseases.

Promoting Mn Spin-State Transitions from t to e through Ni Doping in Antiperovskite CuNMn for Highly Efficient Ammonia Synthesis.

The electrochemical nitrogen reduction reaction (e-NRR) offers a sustainable approach to ammonia synthesis under ambient conditions, with the potential to replace the energy-intensive Haber-Bosch process. Despite significant progress in this promising field, the low NH yield rate and limited Faradaic efficiency (FE) remain formidable challenges. Here, we introduce antiperovskite CuNiNMn, where partial substitution of Cu by Ni in CuNMn is developed as an effective and robust e-NRR electrocatalyst.

Enhancing Interfacial Polarization through Electron Accumulation in Carbon Nanotube-Encapsulated α-FeO for Highly Efficient Microwave Absorption.

Interface polarization (one of the slow polarizations) is considered the primary mechanism driving microwave absorption (MA), but limitations in material composition and microstructure design often lead to weak interfacial polarization relaxation. In this work, we developed an interesting heterostructure consisting of carbon nanotube-encapsulated α-FeO nanocolumns (CNTs@α-FeO). The curvature effects of CNTs induce a built-in electric field between CNTs and α-FeO nanocolumns, facilitating effective interface polarization.

Clinical Characteristics of SARS-COV-2 Omicron Variant in Acute Myeloid Leukemia and Acute Lymphocytic Leukemia Patients: A Multi-Center Retrospective Study.

Background: The death rate of hematological malignancies is high, and the death rate of patients with COVID-19 infection is further increased. Although there have been expert consensus and relevant guidelines to introduce the recommendations of the guidelines for patients with hematological malignancies complicated with COVID-19 infection, there is limited understanding of the clinical characteristics of Chinese patients with acute leukemia complicated with COVID-19 infection.

Aims: This study aimed to analyze the clinical manifestations, mortality, and determinants of viral shedding duration in Chinese AL patients infected with COVID-19.

Diagnostic challenges in emergency stroke: a case series.

Background: Acute ischemic stroke (AIS) is a disease associated with high rates of death and disability. The most effective treatment for AIS is intravenous thrombolysis (IVT) and mechanical thrombectomy (MT). In the acute phase of AIS, the accuracy of diagnosis is crucial for deciding on IVT and MT, but can be complicated by the presence of a large number of stroke mimics (SMs) and stroke chameleons (SCs).

Double-crosslinked polyvinyl alcohol/starch bioplastic with superior water-resistance and flame retardancy.

The high water solubility and flammability of polyvinyl alcohol (PVA) limits its further widespread use in areas such as bioplastic and green packaging. In this study, double-crosslinked polyvinyl alcohol/starch bioplastics (named PDA) were fabricated using PVA, dialdehyde starch (DAS), and phytic acid (PA), resulting in a material with superior water resistance, flame retardancy, and excellent degradability. PA not only plays the role of catalyst for the chemical crosslinking but also as the physical crosslinker to form the intermolecular hydrogen bonds with PVA and DAS.

The Relationship Between Moral Sensitivity, Missed Nursing Care and Moral Distress Among New Nurses: A Cross-Sectional Study.

Unlabelled: Moral sensitivity, missed nursing care and moral distress among healthcare professionals have received considerable attention in recent years. These factors represent important healthcare challenges for new nurses (graduation to 2 years of work experience). However, studies on the relationships among these variables in the context of new nurses in China remain lacking.

Microvesicles from quiescent and TGF-β1 stimulated hepatic stellate cells: Divergent impact on hepatic vascular injury.

Background: This study evaluated the effect of microvesicles(MVs) from quiescent and TGF-β1 stimulated hepatic stellate cells (HSC-MVs, TGF-β1HSC-MVs) on H2O2-induced human umbilical vein endothelial cells (HUVECs) injury and CCl4-induced rat hepatic vascular injury.

Methods: HUVECs were exposed to hydrogen peroxide (H2O2) to establish a model for vascular endothelial cell injury. HSC-MVs or TGF-β1HSC-MVs were co-cultured with H2O2-treated HUVECs, respectively.

Atomic Valence Reversal-Induced Polarization Resonance Spurs Highly Efficient Electromagnetic Wave Absorption in α-FeO@Carbon Microtubes.

Variegation and complexity of polarization relaxation loss in many heterostructured materials provide available mechanisms to seek a strong electromagnetic wave (EMW) absorption performance. Here we construct a unique heterostructured compound that bonds α-FeO nanosheets of the (110) plane on carbon microtubes (CMTs). Through effective alignment between the Fermi energy level of CMTs and the conduction band position of α-FeO nanosheets at the interface, we attain substantial polarization relaxation loss via novel atomic valence reversal between Fe(III) ↔ Fe(III) induced with periodic electron injection from conductive CMTs under EMW irradiation to give α-FeO nanosheets.

Surface CN bonds mediate photocatalytic CO reduction into efficient CH production in TiO-decorated g-CN nanosheets.

Graphitic carbon nitride (g-CN, CN) has garnered considerable attention in the field of photocatalysis due to its favorable band gap and high specific surface area. However, its primary practical limitation lies in the strong radiative recombination of lone pair (LP) electronic states, leading to limited efficiency in separating photogenerated carriers and subsequently diminishing photocatalytic performance. In this study, we devised and synthesized a heterojunction photocatalytic system comprising TiO nanosheets supported on modified g-CN (MCN), designated as MCN/TiO.

Dynamic nonlinear CO2 emission effects of urbanization routes in the eight most populous countries.

A dynamic STIRPAT model used in the current study is based on panel data from the eight most populous countries from 1975 to 2020, revealing the nonlinear effects of urbanization routes (percentage of total urbanization, percentage of small cities and percentage of large cities) on carbon dioxide (CO2) emissions. Using "Dynamic Display Unrelated Regression (DSUR)" and "Fully Modified Ordinary Least Squares (FMOLS)" regressions, the outcomes reflect that percentage of total urbanization and percentage of small cities have an incremental influence on carbon dioxide emissions. However, square percentage of small cities and square percentage of total urbanization have significant adverse effects on carbon dioxide (CO2) emissions.

Preparation of degradable chemically cross-linked polylactic acid films and its application on disposable straws.

The semi-rigidity of the polylactic acid (PLA) molecular chain makes it brittle, poor impact resistance and barrier properties, which severely limits its practical applications. In this paper, a bio-based reactive plasticizer epoxy soybean oil (ESO) was used to improve the mechanical and barrier properties of maleic anhydride grafted polylactic acid (MAPLA) by the chemical reaction between the epoxy and anhydride group. Firstly, the optimum curing conditions were 93.

A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study.

Background: The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori (H. pylori) infection, as compared with conventional outpatient education (OE).

Magnetoelectricity-Mediated Tunable Absorption and Release of Peroxide Dianions.

Peroxide dianion (O) has strong oxidizing activity and ease of proton abstraction and is extremely unstable. Direct and controllable adsorption and release of O has large application implication and is a large challenge so far. Here, we use a unique metal (Ni)-organic (diphenylalanine, DPA) framework (MOF), Ni(DPA), as adsorbents for absorption and release of O.

High-density electron transfer in Ni-metal-organic framework@FeNi-layered double hydroxide for efficient electrocatalytic oxygen evolution.

The electrochemical oxygen evolution reaction is a bottleneck reaction in hydrolysis and electrolysis because the four-step electron transfer leads to slow reaction kinetics and large overpotentials. This situation can be improved by fast charge transfer by optimizing the interfacial electronic structure and enhancing polarization. Herein, a unique metal (Ni) organic (diphenylalanine, DPA) framework Ni(DPA) (Ni-MOF) with tunable polarization is designed to bond with FeNi-LDH (layered double hydroxides) nanoflakes.

Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model.

Background/aims: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and ischemic tissue repair by transferring their contained miRs to target cells.

Ten-Day Vonoprazan-Amoxicillin Dual Therapy as a First-Line Treatment of Helicobacter pylori Infection Compared With Bismuth-Containing Quadruple Therapy.

Introduction: No study has investigated the efficacy and safety of vonoprazan-amoxicillin dual therapy compared with bismuth quadruple therapy (B-quadruple). This study aimed to evaluate the efficacy and safety of 10-day vonoprazan-amoxicillin dual therapy as a first-line treatment of Helicobacter pylori infection compared with B-quadruple and to explore the optimal dosage of amoxicillin in the dual therapy.

Methods: A total of 375 treatment-naive, H.

Influence of sigmoid plate and dura mater on vascular wall displacement, vibroacoustic/hydroacoustic sources characteristics, and frequency-loudness assessments of venous pulsatile tinnitus: A coupled-computational fluid dynamics study combining transcanal recording investigation.

Investigations of pulsatile tinnitus (PT) caused by sigmoid sinus wall anomalies (SSWAs) using computational fluid dynamics (CFD) have recently increased in prevalence. However, accurate modeling of anatomical structures regarding sigmoid plate dehiscence and acoustic sources of PT remains lacking. This study incorporates coupled CFD techniques, micro-computed tomography, and scanning electron microscope to reveal the vibroacoustic and hydroacoustic sources and displacement characteristics of the transverse-sigmoid sinus system.

Surface Electron Localization in Cu-MOF-Bonded Double-Heterojunction CuO Induces Highly Efficient Photocatalytic CO Reduction.

Truncated octahedron CuO (TOC) has attracted more attention for its suitable band gap and high carrier separation efficiency due to introduction of the facet heterojunction, but its practical drawback is still the instability caused by the irreversible disproportionation reaction (CuO → Cu + CuO). Here, we design and fabricate the TOC/Cu-MOF (MOF: metal-organic framework) double-heterojunction structures with different Cu-MOF loadings. The introduced heterojunction between TOC and Cu-MOF not only produces a stable interface Cu bonding structure with the electronic states localized within the average collisional diameter of electrons 1.

Combination of EPC-EXs and NPC-EXs with miR-126 and miR-210 overexpression produces better therapeutic effects on ischemic stroke by protecting neurons through the Nox2/ROS and BDNF/TrkB pathways.

Backgrounds/aims: Neural progenitor cells (NPCs) and endothelial progenitor cell (EPCs) exhibit synergistical effects on protecting endothelial cell functions. MiR-126 and miR-210 can protect cell activities by regulating brain-derived neurotrophic factor (BDNF) and reactive oxygen species (ROS) production. Exosomes (EXs) mediate the beneficial effects of stem cells via delivering microRNAs (miRs).

Asymmetric Exchange Interaction Induces Highly Efficient Alkaline Hydrogen Evolution in RhFe Bimetallene.

An RhFe bimetallene with Fe atoms doped into Rh host for efficient hydrogen evolution reaction (HER), is constructed. When two doped Fe atoms occupy neighboring asymmetric spatial positions, their asymmetric exchange interaction drives electron hopping between the d orbital of a Fe atom and the d orbital of its neighboring Fe atom to push the d band center closer to the Fermi level as a result of electronic state reconstruction. The designed bimetallene with thickness of 0.

How Duty-Free Policy Influences Travel Intention: Mediating Role of Perceived Value and Moderating Roles of COVID-19 Severity and Counterfactual Thinking.

Counterfactual thinking is presumed to play a preparatory function in promoting people's behavioural intentions. This study specifically addresses the impacts of COVID-19 severity, tourists' counterfactual thinking about the pandemic, and tourists' perceived duty-free consumption value on the effect of a duty-free policy on travel intentions. Four hundred and ten participants took part in this study, which involved a 2 (duty-free policy: absent vs.

Evidence of air-conduction transmission pathway and strategized transtemporal operative techniques for venous pulsatile tinnitus: Combining water occlusion test and operative sensing applications.

Objectives: (1) To establish evidence of the transmission pathway of venous pulsatile tinnitus (PT) associated with sigmoid sinus wall anomalies (SSWAs) and (2) quantify the efficacy of transtemporal surgery.

Methods: This retrospective study included 33 surgical cases of PT associated with SSWAs and 15 controls with venous PT without SSWAs. Quantitative water occlusion test (q-WOT) and imaging data were acquired for preoperative evaluation prior to strategized transtemporal osteovascular reconstruction surgery.

Antitumor CD8 T cell responses in glioma patients are effectively suppressed by T follicular regulatory cells.

Regulatory T (Treg) cells are thought to contribute to tumor pathogenesis by suppressing tumor immunosurveillance and antitumor immunity. T follicular regulatory (Tfr) cells are a recently characterized Treg subset that expresses both the Treg transcription factor (TF) Foxp3 and the T follicular helper (Tfh) TF Bcl-6. The role of Tfr cells in glioma patients remains unclear.