The formation mechanism of "sports fandom circle" in the digital media era: An analysis from the perspective of fan emotional dynamic development.

The rise of the "sports fandom circle" has become a significant phenomenon in the digital media era, reshaping the emotional and social dynamics of sports fan communities. This study employs grounded theory methodology to analyze web-scraped data from 40 selected accounts on major Chinese social media platforms [Weibo, Xiaohongshu, and Bilibili] over a two-year period. These accounts were identified based on their focus on celebrity athletes [e.

Concurrent Surgical Management of Achalasia and Obesity: an MBSAQIP Analysis.

Background: The safety of concurrent Heller myotomy (HM) and metabolic bariatric surgery (MBS) remains underexplored, with existing literature limited to case reports. This study evaluated 30-day postoperative outcomes of concurrent HM-MBS versus MBS alone.

Methods: A retrospective analysis of the 2020-2023 MBSAQIP database was conducted.

Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study.

Optimizing both on-target and off-target potencies is essential for developing effective and selective small-molecule therapeutics. Free energy calculations offer rapid potency predictions, usually within hours and with experimental accuracy and thus enables efficient identification of promising compounds for synthesis, accelerating early-stage drug discovery campaigns. While free energy predictions are routinely applied to individual proteins, here, we present a free energy framework for efficiently achieving kinome-wide selectivity that led to the discovery of selective Wee1 kinase inhibitors.

The Role of Physical Activity in Minimizing Recurrence of Weight Gain Following Metabolic and Bariatric Surgery: Current Evidence and Suggestions for Advancing Future Research.

Purpose Of Review: Patients who undergo metabolic and bariatric surgery (MBS) are advised to increase physical activity (PA) to help minimize weight recurrence. This report reviews current evidence for this recommendation and offers suggestions for advancing future research.

Recent Findings: Most observational studies suggest a link between higher PA and lower weight recurrence, yet they often rely on cross-sectional designs, making it difficult to determine the direction of this relationship.

How testosterone administration affects learning to avoid harm in healthy men: A double-blind, placebo-controlled study.

Preventing harm to others is a foundational principle of human morality that relies on distinct learning processes when avoiding harm to others versus oneself. Using a behavioral neuroendocrinology perspective, we investigated the effects of a single dose of testosterone administration on harm-avoidance learning. 120 healthy men randomly received either testosterone or placebo.

Effectiveness and safety of oral nutrition in older patients with moderate dysphagia: a real-world cohort study in geriatric inpatients.

Background: Dysphagia and malnutrition increase with age and are correlated with adverse clinical outcomes. Researchers have not fully studied the safety and effectiveness between oral nutrition pathway and tube feeding in dysphagic and malnourished elderly individuals.

Methods: Elderly individuals > 65 years old with nutrition risk admitted to the department of geriatrics from 58 third-grade hospitals between September 2020 and December 2022 were recruited.

Association between albumin and short-term outcomes of unplanned early readmission emergency department patients: A retrospective cohort study.

Objective: This study was a post hoc analysis of data from a retrospective cohort population. The purpose of this study was to analyze the predictive value of albumin for the short-term survival of patients with unplanned early readmission to the emergency department (ED).

Methods: A total of 6,249 emergency patients were enrolled in this study, including 5,368 patients (85.

Computerised Tomographic Analysis of Differences in Scaphoid Trabecular Density in the Intact Bone.

Percutaneous screw placement can treat nondisplaced or scaphoid waist fractures. Screws positioned in areas of highest trabecular density improve fracture stability and bone healing. This study aims to compare the density of six segments of the intact scaphoid bone to facilitate optimal screw positioning.

Associations between the effectiveness of sleeve gastrectomy and the composition and function of gut microbiome in obese rats.

Background: With the increasing prevalence of obesity and related metabolic diseases, this study focused on the comprehensive effects of sleeve gastrectomy (SG) on obese rats, revealing the association between obesity and metabolic disorders, and the potential of SG in improving metabolism.

Methods: A high-fat diet (HFD) was used to induce obesity in rats and then randomly divided into HFD-induced obese, sham, and SG groups. Body weight and fasting blood glucose (FBG) were regularly monitored.

An exercise prescription algorithm for clinicians to use with their patients with cardiovascular disease risk factors.

Background: Half of US adults have ≥1 cardiovascular disease (CVD) risk factors. Exercise is the first-line lifestyle therapy to prevent and treat CVD. We developed the Prioritize Personalize Prescribe Exercise algorithm (P3-EX), an evidence-based tool that clinicians can use to prescribe exercise for patients with CVD risk factors.

Post-operative pancreatitis following ERCP and EST in elderly patients with choledocholithiasis.

Objective: Herein, we identified risk factors (RFs) for post-operative pancreatitis among elderly sufferers of choledocholithiasis undergoing endoscopic retrograde cholangiopancreatography (ERCP) along with endoscopic sphincterotomy (EST), and to develop a predictive model for pancreatitis occurrence.

Methods: We retrospectively collected clinical data of elderly patients (≥ 65 years old) with choledocholithiasis undergoing ERCP+EST at Affiliated Liupanshui Hospital of Zunyi Medical University from January 2017 to April 2024. Participants were stratified into pancreatitis and non-pancreatitis cohorts according to their post-operative outcomes.

Investigation of Energy Metabolism Alterations in Diabetic Muscles Using CEST MRI at 5 T.

Diabetes mellitus (DM) causes skeletal muscle damage. Energy metabolism alterations in diabetic muscles remain to be elucidated. Chemical exchange saturation transfer (CEST) MRI is increasingly adopted in imaging muscle energy metabolism.

Autophagy-associated ncRNAs in lung cancer: From drug resistance to therapeutic targets.

Lung cancer (LC) serves as the major cause of cancer-related deaths globally, predominated by high rates of drug resistance which accelerates the progression of the disease. Non-coding RNAs (ncRNAs), a category of RNA molecules that do not encode proteins, have emerged as crucial regulators of gene expression and cellular functions. Autophagy, an intracellular degradation and recycling process, is vital for sustaining cellular homeostasis and managing stress responses.

Transcranial Magnetic Stimulation for Reducing Food Reinforcement in Patients Pursuing Metabolic Bariatric Surgery: A Within-Participants Sham-Controlled Pilot Trial.

Individuals who undergo metabolic bariatric surgery (MBS) and have high preoccupation with and drive to consume palatable foods are at risk of overeating and suboptimal outcomes after MBS. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, shows promise for altering cognitive aspects of food reward. Yet, no study has examined rTMS effects on behavioral aspects of food reward in the context of MBS.

Pivotal role of AhR protein in the therapeutic efficacy of HuangKui capsule against calcium oxalate-induced kidney damage: An integrated study of network pharmacology and experimental verification.

Kidney stone are a frequently-occurring disease that may lead to severe renal impairment and eventual renal malfunction. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor and transcription factor that belongs to the family of basic helix-loop-helix transcription factors, which plays an important role in the pathogenesis of kidney stones. The HuangKui Capsule (HKC) is a Traditional Chinese Medicine used for managing chronic glomerulonephritis.

Maternal exposure to lamotrigine and the risk of orofacial clefts in offspring: A systematic review and meta-analysis.

Lamotrigine is used to treat epilepsy, migraine, and psychiatric disorders during pregnancy. However, concerns remain regarding whether lamotrigine exposure increases the risk of orofacial clefts (OFCs) in offspring. A systematic literature search was conducted to identify relevant studies published from inception to February 2025.

Puerarin Improves Cancer-Induced Bone Pain by Recovering Mitochondrial Dysfunction in the Spinal Cord.

Cancer metastases induce bone pain and central sensitization in the spinal cord. Mitochondrial dysfunction is associated with pian signal transmission and involved in cancer-induced bone pain. Pueratin (Pue) is a natural isoflavone compound that works as a potential natural neuroprotective agent.

Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma.

Background: The majority of patients with melanoma develop immune-related adverse events (irAEs), and over half do not respond to anti-PD-1 (Programmed cell death protein 1) checkpoint inhibitor (CPI) immunotherapy. Accurate predictive biomarkers for both response to therapy and development of irAEs are currently lacking in clinical practice. Here, we conduct deep immunophenotyping of circulating regulatory and class-switched B cell and antibody immune states in patients with advanced stage III/IV melanoma prior to and longitudinally during CPI.

Structural basis of Fanconi anemia pathway activation by FANCM.

FANCM is crucial in genome maintenance, functioning in the Fanconi anemia (FA) pathway, alternative lengthening of telomeres (ALT), and replication fork protection. FANCM recognizes branched DNA structures and promotes their remodeling through ATP-dependent branch migration. The protein has emerged as a promising therapeutic target due to synthetic lethal interactions with BRCA1, SMARCAL1, and RAD52, and in ALT-positive cancers.

FE-DIC-Based Motion and Intensity Correction for Enhanced CEST-MRI Registration.

Physiological and external motion cause inter-frame misalignment in chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI), thereby compromising quantitative accuracy. In CEST-MRI, saturation effects induce intensity variations, resulting in motion-intensity coupling that makes registration particularly challenging. To address this issue, we extend the finite element digital image correlation (FE-DIC) framework by introducing an alternating correction strategy that iteratively refines both motion and intensity estimation.

The Research Trend of Non-surgical Rhinoplasty: A Bibliometric and Visualized Analysis.

Background: Rhinoplasty is one of the most common aesthetic surgeries, with non-surgical rhinoplasty (NSR) gaining popularity due to its affordability and minimal risks. The aim of this study is to use bibliometric analysis to identify prominent research areas and emerging trends within this field.

Methods: Research articles on NSR were gathered from the Web of Science Core Collection database.

Engineering for the Production of 5-Aminolevulinic Acid under Microaerobic Conditions Guided by a Genome-Scale Metabolic Network.

5-Aminolevulinic acid (5-ALA) has been widely used in modern agriculture and therapy as a biostimulant, feed nutrient, and photodynamic drug. Although metabolic engineering strategies have been employed to increase the yield of 5-ALA in , the production of 5-ALA under microaerobic conditions has not been studied. In this paper, we developed, for the first time, overproducing-5-ALA strains under microaerobic conditions, guided by a genome-scale metabolic network model.

[The Influence of COVID-19 Infection on the Mobilization and Collection of Autologous Peripheral Blood Stem Cells in Patients with Multiple Myeloma].

Objective: To analyze the effect of COVID-19 infection on the mobilization and collection of autologous peripheral blood stem cells in patients with multiple myeloma.

Methods: The general baseline data, treatment factors before mobilization collection, collection status, and treatment overview after collection of autologous peripheral blood stem cells at Beijing Chaoyang Hospital affiliated with Capital Medical University from January 1, 2020 to July 15, 2023 were analyzed.

Results: 269 patients underwent mobilization and collection of autologous peripheral blood stem cells.

A CVAE-based generative model for generalized B inhomogeneity corrected chemical exchange saturation transfer MRI at 5 T.

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful tool to image endogenous or exogenous macromolecules. CEST contrast highly depends on radiofrequency irradiation B level. Spatial inhomogeneity of B field would bias CEST measurement.

Impact of the Timing of Protective Stoma Reversal on Survival in Rectal Cancer Patients Undergoing Postoperative Adjuvant Chemotherapy: A Retrospective Single Center Study.

Background: Postoperative adjuvant chemotherapy used in patients with stage II/III rectal cancer, is usually administered for 3 to 6 months. However, the optimal timing of protective stoma reversal remains controversial. This study aimed to investigate the effect of stoma closure before or after adjuvant chemotherapy on survival and stoma-related complications.