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Background: Half of US adults have ≥1 cardiovascular disease (CVD) risk factors. Exercise is the first-line lifestyle therapy to prevent and treat CVD. We developed the Prioritize Personalize Prescribe Exercise algorithm (P3-EX), an evidence-based tool that clinicians can use to prescribe exercise for patients with CVD risk factors.
Purpose: To conduct a feasibility survey study of user satisfaction and usability of P3-EX as an exercise prescription (ExRx) tool among healthcare providers.
Methods: Healthcare providers enter information on the patient's medical history and CVD risk factors into P3-EX. Prioritize Personalize Prescribe Exercise algorithm then scores and prioritizes CVD risk factors and produces an ExRx for the prioritized CVD risk factor. We recruited physicians ( = 39), nurses ( = 63), and allied health professionals ( = 231) who recommend exercise to patients through professional society meetings, presentations, newsletters, and investigators' networks. Participants completed a timed case study of a patient with CVD risk factors using P3-EX on a templated website. They then completed an adapted version of the Mobile Application Rating Scale, with responses ranging from 5 (completely agree) to 1 (completely disagree) to evaluate the ease of use, system information arrangement, and usefulness of P3-EX. Descriptive statistics determined the % response, time spent using P3-EX, and ExRx produced.
Results: Of the 844 recruited participants, 309 completed the feasibility survey study (healthcare provider N = 143, people with other professional affiliates N = 166). Of these, 86.9% agreed using P3-EX will make their patients healthier; 86.6% agreed feedback is immediate and understandable; 81.4% agreed P3-EX is intuitive, producing high-quality, evidenced-based, individualized ExRx; 83.5% are generally satisfied with P3-EX; 81.3% would recommend P3-EX to colleagues; and 79.2% agreed ExRx produced by P3-EX is safe. However, 34.4% agreed fault tolerance could be improved. Most participants (88.8%) produced an ExRx for the same prioritized CVD risk factor. The average time spent using P3-EX was 4.6 min.
Conclusion: We found healthcare providers are satisfied with P3-EX and agreed that it is a usable ExRx tool for patients with CVD risk factors. Our results are promising because healthcare providers lack the time, knowledge, confidence, and guidance to recommend exercise to patients. Prioritize Personalize Prescribe Exercise algorithm appears to be a potential solution to this problem.
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http://dx.doi.org/10.1177/20552076251360884 | DOI Listing |
Curr Atheroscler Rep
September 2025
Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Health, Houston Methodist Hospital, Houston, TX, USA.
Purpose Of Review: This review aims to characterize the known cardiovascular (CV) manifestations associated with inflammatory bowel disease (IBD) and the underlying mechanisms driving these associations.
Recent Findings: Gut dysbiosis, a hallmark of patients with IBD, can result in both local and systemic inflammation, thereby potentially increasing the risk of cardiovascular disease (CVD) in the IBD population. Micronutrient deficiencies, anemia, and sarcopenia independently increase the risk of CVD and are frequent comorbidities of patients with IBD.
Biomed Environ Sci
August 2025
Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital Heart Center, Zhengzhou 451464, Henan, China.
Hypertrophic cardiomyopathy (HCM) is a major contributor to cardiovascular diseases (CVD), the leading cause of death globally. HCM can precipitate heart failure (HF) by causing the cardiac tissue to weaken and stretch, thereby impairing its pumping efficiency. Moreover, HCM increases the risk of atrial fibrillation, which in turn elevates the likelihood of thrombus formation and stroke.
View Article and Find Full Text PDFBiomed Environ Sci
August 2025
National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.
Cardiovascular diseases (CVD) and their risk factors are exerting an increasingly significant impact on public health, and the incidence rate of CVD continues to rise. This article provides an interpretation of essentials from the newly published Annual Report on Cardiovascular Health and Diseases in China (2024), aiming to offer scientific evidence for CVD prevention, treatment, and the formulation of relevant policies.
View Article and Find Full Text PDFKardiologiia
September 2025
Research Institute of Therapy and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk.
Aim To identify non-pharmacological factors associated with ineffective blood pressure (BP) control among individuals with arterial hypertension (AH) in a Siberian urban population sample.Material and methods A considerable proportion of individuals with AH does not achieve BP goals. BP control is influenced by a number of non-drug determinants, including non-modifiable and multiple modifiable factors.
View Article and Find Full Text PDFProtein Cell
August 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53,026 UK Biobank participants over a 14-year follow-up. Association analyses identified 3,089 significant associations involving 892 unique protein analytes across 13 CVD outcomes.
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