Deciphering the genetic regulation of flowering time in rapeseed for early-maturation breeding.

Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptability of rapeseed (Brassica napus L.). Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic conditions and facilitate the cultivation of subsequent crops on the same land, thereby enhancing overall agricultural efficiency.

Discontinuation of Glacial Meltwater Input Reshapes the Diversity and Stability of Eukaryotic Planktonic Microbial Communities in Glacial Lakes.

Glacial lakes play a vital role as indicators of global climate change and regional environmental responses. Eukaryotic planktonic microorganisms, pivotal in driving biogeochemical cycling of nutrients within these ecosystems, are crucial for preserving stability and ecological function of glacial lake environments. Nevertheless, the spatial and temporal dynamics, along with the mechanisms responsible for sustaining eukaryotic planktonic microbial communities in glacial lakes, especially during the glacier retreat and lake formation, are still largely uncharted.

Elucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking.

Objective: Polychlorinated dibenzo-p-dioxins (PCDDs) present a significant long-term threat to human health attributable to their toxicological properties, chemical stability and propensity for bioaccumulation. This study seeks to explore the correlation between PCDDs exposure and prostate cancer (PCa) through comprehensive analysis.

Methods: The multi-dimensional analysis was conducted based on various online databases.

Systematic assessment of landfill mining potential in Zhejiang Province, China: Resource recovery and economic potential.

Landfilling has been the predominant municipal solid waste disposal method in recent decades. Recently, landfill mining has gained attention due to increasing raw material costs and environmental concerns. However, most research has focused on individual or limited specific cases, with insufficient studies on landfill mining potential at the regional or national level.

Targeting the akt/mtor signaling pathway by maprotiline leads to tumor suppression in T-cell lymphoma.

T-cell lymphoma (TCL) is a prevalent malignancy characterized by the aberrant proliferation of T cells. The molecular mechanism underlying TCL remains poorly understood, and effective therapeutic strategies are still limited. Maprotiline, a highly selective norepinephrine reuptake blocker, is primarily used in the treatment of various types of depression.

Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study.

Background: Sarcopenia, characterized by progressive muscle loss and functional decline in aging, poses significant health challenges. Sex steroids, such as estradiol and testosterone, have potential therapeutic roles in mitigating muscle degeneration. This study explores the molecular mechanisms and targets of sex steroids in the treatment of sarcopenia using network pharmacology, enrichment analysis, machine learning, molecular docking, and molecular dynamics simulations.

Advancing Traditional Chinese Medicine Research through Network Pharmacology: Strategies for Target Identification, Mechanism Elucidation and Innovative Therapeutic Applications.

Traditional Chinese medicine (TCM) is characterized by its multi-component, multi-target, and multi-pathway properties, which make it an ideal candidate for network pharmacology applications. This approach provides a comprehensive framework for understanding the therapeutic effects of TCM in managing complex diseases. This review highlights recent advancements in network pharmacology as applied to TCM, and focuses on key achievements such as the identification of core bioactive components, target prediction, and the elucidation of mechanisms of action.

Gamma-Band Binaural Beats Neuromodulation Enhances P300 Classification in an Auditory Brain-Computer Interface Paradigm.

While established neuromodulation techniques like transcranial magnetic stimulation and transcranial direct current stimulation have shown potential for enhancing brain-computer interface (BCI) performance, their clinical adoption faces challenges including high implementation costs, technical complexity, and safety concerns. This study investigated binaural beats (BB), a non-invasive auditory neuromodulation method characterized by operational simplicity and minimal adverse effects, as a practical alternative for optimizing auditory P300-BCI. Employing a crossover experimental design, thirty healthy participants underwent gamma-band (40 Hz) and alpha-band (10 Hz) BB stimulation in separate sessions.

Is integrative therapy of traditional Chinese medicine and progesterone capsule more effective than monotherapies in oligomenorrhea and hypomenorrhea? Evidence based on a multi-center randomized controlled trial and metabolomic profile.

Background And Objectives: Oligomenorrhea and hypomenorrhea were common conditions in outpatient visit which affected child-bearing aged women, and the conventional progesterone treatment has been related to several side effect and contradiction, and this study aimed to evaluate the effectiveness and safety of traditional Chinese medicine (TCM), progesterone capsules, and their combination in treating oligomenorrhea and hypomenorrhea both clinical and metabolomic approach.

Methods: A prospective, randomized, multi-center trial has been conducted, and a total of 239 oligomenorrhea and hypomenorrhea were randomly assigned to receive TCM, progesterone capsules (PG), or the combined Chinese and Western medicine (COM) and treated from 3 months, respectively. Scores were recorded at 1 and 3 month of treatment, while the seral samples for sex hormone and safety parameters were taken before and after management, with adverse events recorded.

An Integrated Grid Interface of Electrode for Sodium-Ion Battery.

Sodium-ion batteries (SIBs) attract the research interest of many scientists due to their cost-effectiveness, the abundance of natural sodium resources, and the great potential to replace metal lithium batteries. However, they also encounter substantial issues including sluggish ion kinetics, substantial volume changes, and interfacial instability during cycling. In this study, a GDY/SnO/GDY heterostructured anode is fabricated using a grid encapsulation strategy, where SnO nanoparticles are dispersed within a framework of graphdiyne (GDY) nanowalls.

Synthesis of an Sp-Carbon-Rich Carbonaceous Material Exhibiting Distinctive Anode Performance.

Among carbon allotropes, carbyne, composed solely of sp-hybridized carbon atoms, has garnered significant interest due to its potential unique physical and chemical properties. Nevertheless, the synthesis of carbyne or its analogs remains a persistent challenge, hindering further exploration in this area. Herein, a straightforward synthesis method is proposed to prepare TMS-capped sp-carbon hybridized carbonaceous material (TMS-C).

Hierarchical Hydrogen Bond-Metal Coordination for High-Strength, High-Dissipation Elastomers over a Broad Temperature Range.

Developing high-performance elastomers that simultaneously exhibit high strength, excellent elasticity, broad temperature-range damping, and multifunctionality remains a significant challenge in materials science. In this study, a supramolecular polyurethane elastomer (PUTAZn) is successfully synthesized by constructing a hierarchical hydrogen-bonding network via tartaric acid (TA) chain extension and incorporating dynamic zinc ion coordination crosslinking. The hierarchical hydrogen bonds display an ordered, temperature-dependent dissociation behavior and maintain a dynamic balance between dissociation and reformation, leading to a broad damping peak in the Damping factor (tan δ) profile.

Cadmium toxicity in plants: from transport to tolerance mechanisms.

Cadmium (Cd), a non-essential heavy metal, induces severe phytotoxicity through oxidative stress and cellular homeostasis disruption. Chronic Cd exposure inhibits plant growth via leaf chlorosis, stunted stem elongation, and impaired root architecture, while disrupting physiological functions through chlorophyll degradation, membrane peroxidation, and antioxidant system collapse. This review systematically investigates plant adaptive responses to Cd stress.

Aberrant glycosylation in pulmonary fibrosis: Mechanisms, biomarkers, and treatment opportunities.

Fibrosis is characterized by excessive accumulation of scar tissue extending beyond the physiological healing process, ultimately leading to tissue damage and organ dysfunction. In many industrialized countries, fibrosis is a leading cause of mortality, contributing to approximately 45 % of deaths. Despite considerable advances in elucidating its underlying molecular and cellular mechanisms, current therapeutic strategies remain largely limited to palliative care.

Life cycle environmental and economic assessment of co-combustion strategies for raw and landfilled municipal solid waste.

Co-combustion of landfilled municipal solid waste (LMSW) in raw municipal solid waste (RMSW) incinerators addressed regional incineration overcapacity and waste scarcity. However, the economic-environmental trade-offs at high co-combustion ratios remained unclear. This study integrated life cycle assessment (LCA) and life cycle costing (LCC) to quantify the impacts of LMSW co-combustion at varying ratios: 0 %, 15 %, 25 %, 35 %, and 45 %.

Ecotoxicological hazards of sea star-derived asterosaponins: mechanistic insights into embryotoxicity and cardiotoxicity in marine medaka.

Outbreaks of the sea star in northern China Sea, supported by its robust chemical and physical defenses, have disrupted marine ecological balance and caused substantial economic losses to aquaculture. To investigate the compounds responsible for its chemical defense, three asterosaponins (SP1-SP3) and their shared aglycone (AG) were isolated and identified. The embryotoxicity of these compounds was evaluated using marine medaka embryos (Oryzias melastigma), with 96 h-LC values determined as 76.

Polyurethane Elastomer with Unprecedented Thermostability, Long-Cycle Antifatigue, and Ultrafast Self-Healing Capability.

Elastomers play important roles in major equipment, mega facilities, and other advanced applications. However, in practical applications, it is often subjected to extreme environmental conditions, such as repeated cyclic mechanical loading, high temperatures, external impacts, etc. Designing an elastomer with high strength/toughness and resistant to fatigue is particularly challenging.

Oxidative stress mediates the association between brominated flame retardants and hyperlipidemia in US adults.

Brominated flame retardants (BFRs) are classified as persistent organic pollutants (POPs), and studies suggest that exposure to POPs may contribute to the development of metabolic diseases. However, the specific link between single and mixed BFRs and hyperlipidemia remains unclear, as does the potential mediating role of oxidative stress in this relationship. We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2016, encompassing 6800 participants, to investigate the association between BFRs and hyperlipidemia.

A Redox-Active Manganese Nanocluster Reverses Depression-Impaired Bone Regeneration via Targeting Cellular Senescence, Lymphangiogenesis, and the Muscle-Bone Metabolic Axis.

Depression, a prevalent chronic psychological disorder in aging populations, is increasingly recognized for its deleterious impact on bone regeneration; yet its pathological mechanisms and targeted therapies remain underexplored. Here, a rationally engineered tetranuclear manganese nanocluster (Mn), supported by a heptadentate chelating ligand (TPDP), as a multifunctional nanozyme platform to combat depression-induced skeletal dysfunction, is introduced. Utilizing a murine chronic restraint stress model combined with tibial drill-hole injury, it is demonstrated that depression impairs bone healing through a complex interplay of cellular senescence, inflammatory dysregulation, compromised lymphatic vessel proliferation, and disruption of the muscle-bone metabolic axis.

SERS and Raman: deciphering interfacial phenomena and processes.

Raman spectroscopy and surface enhanced Raman spectroscopy (SERS) are techniques for obtaining fingerprint-like vibrational spectral information from specific substrate surfaces. Attributed to its high sensitivity towards molecular electron density distributions, Raman or SERS employed during chemical reactions can assist in analyzing detailed chemical conversion processes. However, multiple influencing factors impede the development of SERS substrates and in-depth data analysis.

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics.

Background: Tryptophan (Trp) metabolism plays a vital role in tumor development and outcomes. However, Trp in esophageal squamous cell carcinoma (ESCC) remains poorly understood. We aimed to explore the role and mechanism of Trp metabolism in ESCC.

Clinical manifestations and immune correlations in anti-centromere antibody-positive and anti-SSA/Ro antibody-positive primary Sjögren's syndrome: A retrospective analysis.

Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by dry eyes and mouth, often with systemic involvement. This study aimed to investigate the clinical manifestations and laboratory features in pSS patients, particularly focusing on those with anti-centromere antibodies (ACA) and anti-SSA/Ro antibodies. We conducted a retrospective analysis of 152 patients diagnosed with pSS at Ningbo Medical Center Lihuili Hospital from 2018 to 2023, using the 2016 ACR/EULAR criteria.

High-dose romosozumab promoted bone regeneration of critical-size ulnar defect filled with demineralized bone matrix in nonhuman primates.

Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates.

Methods: In cynomolgus monkeys (N = 22, male, 10-12 years old), a full-cortex bone defect (0.

Comparison of the therapeutic effects of three internal fixation methods for transverse fractures of the patella.

Background: This study aimed to evaluate the treatment effects of three internal fixation methods, including tension band with K-wires, tension band with cannulated screws and tension band with ring-pins on transverse fractures of the patella.

Methods: Patellar fracture patients treated in Shanghai Yangpu District Shidong Hospital from March 2016 to January 2023 were divided into three groups based on the internal fixation method: the ring-pins group (tension band with ring-pins), the K-wires group (tension band with K-wires), and the cannulated screws group (tension band with cannulated screws). Surgery duration, hemoglobin decrease, excellent rate of knee joint function evaluation at postoperative 3 months and 12 months, VAS scores before surgery and at 3 and 12 months after surgery, postoperative complication rate, and removal rate of internal fixation were compared among the three groups of patients.

Distribution characteristics and formation mechanisms of PCDD/Fs during pyrolysis and gasification of municipal solid waste.

Pyrolysis gasification (PG) technology is a promising waste disposal technology, which is more efficient and cleaner compared with incineration technology. However, few work has studied the generation characteristics of polychlorinated dibenzo-p-dioxin and furans (PCDD/Fs) and the influencing factors in the PG process. This study investigates the effects of air ratio (AR) and gasification temperature on the generation and distribution of PCDD/Fs during the PG process of municipal solid waste (MSW).