Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report.

Background: Thrombotic microangiopathy (TMA) is an acute syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multi-organ dysfunction due to the microcirculation of platelet thrombi. Cancer-associated TMA is a rare and fatal complication, which often occurs during cancer remission. It is frequently misdiagnosed because of limited clinical awareness.

A new dipeptide from entomogenous fungus Y9.

A new dipeptide compound, namely N-[(Phenylmethoxy) carbonyl]-L-m-tyrosyl-L-proline methyl ester (), along with six identified nature products were separated from the entomogenous fungus Y9. 1D and 2D NMR spectroscopic data, MS spectroscopic data as well as HRESIMS data were used to elucidate the chemical structures of these compounds. For the new dipeptide , electronic circular dichroism (ECD) data and specific rotation were used to confirm its absolute configuration.

Clonal parental effects on competitive interactions between two duckweeds.

Introduction: Parental environments can influence offspring fitness via clonal (asexual) propagation, and such clonal parental effects may vary among plant species and depend on offspring environments as well. Consequently, clonal parental effects may alter competitive interactions between plant species, and such impacts may vary with offspring environments.

Methods: We conducted a two-phase experiment with two clonal floating duckweeds, and .

Beyond Pairwise Interactions: How Other Species Regulate Competition Between Two Plants?

A plant species in a community often grows with some other plant species. While many studies have assessed interspecific interactions between two target plant species, few have considered the impacts of the other plant species (e.g.

Oral cryotherapy by Kangfuxin for prophylaxis of oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation.

Oral mucositis is a common complication in patients undergoing autologous hematopoietic stem cell transplantation (auto-HSCT), and currently, there is no universally effective treatment. This study aims to evaluate the preventive and delaying effects of oral cryotherapy using Kangfuxin (KFX) on oral mucositis in auto-HSCT patients. A total of 86 patients, treated between January 2020 and August 2023, were randomly assigned into 2 groups: the control group (40 cases) received cryotherapy using frozen physiological saline ice cubes, and the experimental group (46 cases) received KFX ice cubes.

Covalent Organic Frameworks-Delivered Reuterin Drives Trained Immunity in Tumor-Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism.

The gut microbiota is increasingly recognized as a promising therapeutic target in cancer treatment. However, the specific mechanisms by which gut bacteria and their metabolites exert therapeutic effects in melanoma remain poorly understood. In this study, it is unexpectedly demonstrated that prophylactic supplementation with Limosilactobacillus reuteri exhibits significant tumor-suppressive properties, primarily mediated by its secreted metabolite, reuterin.

Correlation of non-esterified fatty acids with acute coronary syndrome risk in young Chinese adults.

Objective: Circulating non-esterified fatty acids (NEFAs) are linked to endothelial dysfunction and coronary artery disease (CAD) mainly in older adults. This study examines the association between NEFAs and acute coronary syndrome (ACS) risk in young Chinese individuals.

Method: Of the 1264 young ACS patients and 1072 age-matched controls aged 55 years or younger assessed, 1108 ACS patients and 979 controls were found eligible.

Trained immunity driven by Enterococcus faecalis ribosomal protein S11 enhances antigen presentation and boosts influenza vaccine efficacy via nanoparticle delivery.

The limited availability of adjuvants poses a significant challenge in modern vaccine development, as they play a crucial role in enhancing vaccine efficacy. Trained immunity, driven by metabolic and epigenetic reprogramming of innate immune cells, offers a novel platform for adjuvant discovery. However, current studies predominantly focus on classical inducers such as β-glucan and BCG, limiting the exploration of key genes underlying trained immune responses.

M28 family peptidase derived from initiates trained immunity to prevent MRSA via the complosome-phosphatidylcholine axis.

Methicillin-resistant (MRSA) represents a major global health threat due to its resistance to conventional antibiotics. The commensal microbiota maintains a symbiotic relationship with the host, playing essential roles in metabolism, energy regulation, immune modulation, and pathogen control. Mammals harbor a wide range of commensal bacteria capable of producing unique metabolites with potential therapeutic properties.

Hydride Transfer-Enabled Dearomative Spirocyclization of Isoxazoles with -Alkyl -Oxybenzaldehydes.

The TfOH-catalyzed dearomative [5 + 1] annulations were developed for the construction of chromane-fused spiroisoxazolines from readily available 5-amino-isoxazoles and -alkyl -oxybenzaldehydes. The "two-birds-with-one-stone" strategy featuring dearomatization of 5-amino-isoxazoles and α-C(sp)-H bond functionalization of oxygen was disclosed via a cascade condensation/[1,5]-hydride transfer/dearomative spirocyclization process. In addition, the unprecedented direct dearomative spirocyclization of isoxazoles was achieved, which introduced a new family member of dearomative spirocyclization for dearomatization chemistry.

Rational design of phospholipase D to enhance thermostability and catalytic activity for efficient biocatalytic phosphatidylserine synthesis.

Phospholipase D (PLD) is an essential enzyme for the enzymatic synthesis of phosphatidylserine (PS), but its widespread application is limited by its low stability and activity. Herein, a highly active and thermostable multi-mutant PLD was obtained through a comprehensive strategy based on various computer-aided mutant design and systematic clustering analysis, extending its half-life from 3.7 to 89.

Prevalence of infection in Chinese military personnel: A cross-sectional, multicenter-based study.

Background: () infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia, gastritis, and peptic ulcer, which are common diseases in military personnel. Current guidelines in China state all patients with evidence of active infection with are offered treatment. However, the prevalence of infection and its regional distribution in the military population remain unclear, which hinders effective prevention and treatment strategies.

Regulatory significance of terminator: A systematic approach for dissecting terminator-mediated enhancement of upstream mRNA stability.

The primary function of terminators is to terminate transcription in gene expression. Although some studies have suggested that terminators also contribute positively to upstream gene expression, the extent and underlying mechanism of this effect remain largely unexplored. Here, the correlation between terminating strength and upstream mRNA stability was investigated by constructing a terminator mutation library through randomizing 5 nucleotides, assisted by FlowSeq technology, terminator variants were categorized based on the downstream fluorescence intensity, followed by high-throughput sequencing.

The efficient green bio-manufacturing of Vitamin K: design, production and applications.

Vitamin K, also known as methylnaphthoquinone, is a crucial fat-soluble nutrient necessary for the human body. The biological production of Vitamin K has received widespread attention due to its environmental friendliness and maneuverability in recent years. This review provides insights into the modular metabolic pathways of Vitamin K, lays the foundation for microbial metabolic flow balancing, cofactor engineering and dynamic regulation, and realizes the production of Vitamin K by synthesizing artificial cells from scratch.

[Effect of different initial processing treatments on commercial characters and chemical components of Fritillaria taipaiensis].

To investigate the effects of different initial processing methods on the quality of Fritillaria taipaiensis, this study explored the effects of anti-browning treatment, drying methods, and drying temperatures on the commercial characters, chromaticity values, and alkaloid and nucleoside components of Fritillariae Taipaiensis Bulbus. The results were comprehensively evaluated through correlation analysis(CA), principal component analysis(PCA), and hierarchical clustering analysis(HCA). Compared with those of the direct drying group(WD60), the chromaticity values(ΔE*) of the groups with scraped outer skin( FHB1) and mixed lime powder treatments(FHB2) were significantly reduced, indicating the inhibition of the browning process.

The novel TERF2::PDGFRB fusion gene enhances tumorigenesis via PDGFRB/STAT5 signalling pathways and sensitivity to TKI in ph-like ALL.

Patients with Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like ALL) often face a grim prognosis, with PDGFRB gene fusions being commonly detected in this subgroup. Our study has unveiled a newfound fusion gene, TERF2::PDGFRB, and we have found that patients carrying this fusion gene exhibit sensitivity to dasatinib. Ba/F3 cells harbouring the TERF2::PDGFRB fusion display IL-3-independent cell proliferation through activation of the p-PDGFRB and p-STAT5 signalling pathways.

Changes in Cytokine Levels in Patients with Severe Fever with Thrombocytopenia Syndrome Virus.

Purpose: To characterize the cytokine profile of patients with severe fever with thrombocytopenia syndrome (SFTS) in relation to disease severity.

Patients And Methods: 60 laboratory-confirmed SFTS patients and 12 healthy individuals from multi-centers in Shandong Province of China were included, and all patients were divided into fatal patients (9) and recovered patients (51) due to their final outcomes. Multiplex-microbead immunoassays were conducted to estimate levels of 27 cytokines in the sera of patients and controls.

[Yigong Powder regulates CXCL12/CXCR4 signaling to reduce glutamate release and prevent cognitive decline in mouse model of aging].

This study aims to explore the effect of preventive administration of Yigong Powder on the learning and memory abilities of the mouse model of aging induced by D-galactose and decipher the underlying mechanism, so as to provide a basis for the application of Yigong Powder in the prevention and treatment of cognitive decline. Forty KM mice were randomized into control, model, donepezil(1.5 mg·kg~(-1)), and high-dose(7.

A new sesquiterpene from endophytic fungus sp. B-89.

A new sesquiterpene, named (1, 4a, 7 , 8 , 8a) Decahydro-1,4a-dimethyl-7-(1-methylethyl)-1,8-naphthalenediol (), and six known compounds (-) were obtained from sp. B-89, an endophytic fungus isolated from collected at Xishuangbanna, Yunnan. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data, and the structure of was further determined by X-ray diffraction analysis.