Asymmetric Stress Engineering of Dense Dislocations in Brittle Superconductors for Strong Vortex Pinning.

Large lossless currents in high-temperature superconductors (HTS) critically rely on dense defects with suitable size and dimensionality to pin vortices, with dislocations being particularly effective due to their 1D geometry to interact extensively with vortex lines. However, in non-metallic compounds such as HTS with rigid lattices, conventional deformation methods typically lead to catastrophic fracture rather than dislocation-mediated plasticity, making it a persistent challenge to introduce dislocations at high density. Here, an asymmetric stress field strategy is proposed using extrusion to directly nucleate a high density of dislocations in HTS by activating shear-driven lattice slip and twisting under superimposed hydrostatic compression.

Genome-wide identification of the TIFY gene family in Helianthus annuus and expression analysis in response to drought and salt stresses.

Given the increasing recognition of frequent drought problems associated with global warming, sunflower (Helianthus annuus L.) has been widely studied as a model plant tolerant to drought and salt stresses. However, there is a lack of information on the systematic identification of the sunflower HaTIFY gene family.

Insights into the halogen-induced p-band center regulation promising high-performance lithium-sulfur batteries.

Sn-based halide perovskites are expected to solve the problems of the shuttle effect and sluggish redox kinetics of lithium polysulfides (LiPSs) in lithium-sulfur batteries (LSBs) due to their high conductivity and electrocatalytic activity, but their intrinsic catalytic mechanism for LiPSs remains to be explored. Herein, halide perovskites with varying halide anions, CsSnX (X = Cl, Br, I), are purposefully designed to unveil the halogen-induced regulatory mechanism. Theoretical calculations demonstrate that increasing the halogen atomic number induces the shift of the p-band center closer to the Fermi level, which results in the localized charge distribution around halide anions and rapid charge separation/transfer at Sn sites, enhancing the adsorptive and catalytic activity and redox kinetics of LiPSs.

Opioids With or Without Low-Dose Naloxone During the Perioperative Period: A Systematic Review With Meta-Analysis.

The aim of this systematic review and meta-analysis from randomized controlled trials is to assess opioids with or without low-dose naloxone during the perioperative period at pain intensity and opioids-related adverse events. We searched of Medline, Embase, International Clinical Trials Registry Platform, and the Cochrane Library up to May 31, 2023. We included randomized controlled trials (RCTs) of low-dose naloxone combined with opioids in adults reporting pain intensity or opioid-related adverse event during the perioperative period.

Genome-wide identification and expression analysis of ZF-HD family in sunflower (Helianthus annuus L.) under drought and salt stresses.

Background: Sunflower (Helianthus annuus L.) is widely cultured in globally tropical and subtropical regions, with better resistance to various abiotic stresses as a model crop. Despite the fact that zinc finger-homeodomain (ZF-HD) genes play an important role in responding to plant growth, development and stress resistance across the multiple species, the evolutionary history and abiotic function of the ZF-HD gene family in sunflower remain largely unexplored.

Human umbilical cord mesenchymal stem cells improve the ovarian function through oxidative stress-mediated PERK/eIF-2α/ATF4/CHOP signaling in premature ovarian insufficiency mice.

Background: Premature ovarian insufficiency (POI) is a refractory disease that severely affects female fertility. The PERK/eIF-2α/ATF4/CHOP pathway is one of the classical pathways involved in the unfolded protein response to endoplasmic reticulum stress by regulating protein synthesis and promoting apoptosis. This study aimed to investigate the functional role and mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in the POI animal model through the PERK/eIF-2α/ATF4/CHOP pathway.

Role of NF-κB p65/TNF-α in Cell Apoptosis in the Fetal Membranes of Pregnant Women with Preterm Premature Rupture of Membranes.

Objective: This study aimed to investigate the roles of nuclear factor-kappa B p65 (NF-[Formula: see text]B p65) and tumor necrosis factor- (TNF-) in cell apoptosis occurring in the fetal membranes of pregnant women who experience preterm premature rupture of membranes (PPROM).

Methods: This was a case-control study involving 57 pregnant women who delivered in the obstetric department of Affiliated Loudi Hospital, Hengyang Medical School, University of South China, from June 2021 to June 2022. Samples of fetal membrane tissue were collected from pregnant women with PPROM (n=27) and pregnant women who had normal deliveries (control group; n=30).

Evaluation of Safety and Efficacy of Amniotic Mesenchymal Stem Cells for POI in Animals.

The efficacy of human amniotic mesenchymal stem cell (hAMSC) ovarian injection in improving ovarian function in primary ovarian insufficiency (POI) patients has been shown in some reports. However, the safety and efficacy of hAMSC vein injection remains unclear. In this study, we evaluated the safety and efficacy of hAMSC intravenous injection in cynomolgus macaques and SD rats and provided evidence for clinical trials.

Changes in Gene Expression of Whiteflies, MED Feeding on Tomato Plants Infected by One of the Criniviruses, Tomato Chlorosis Virus through Transcriptome Analysis.

Tomato chlorosis virus (ToCV), transmitted by the whitefly, (Gennadius; Hemiptera: Aleyrodidae) has been continuously emerging on tomato plants and causing a significant economic loss throughout China. In the current study, RNA-Seq analysis was used to explore the gene expression profiles of Mediterranean (MED) that fed on both ToCV-infected and -uninfected tomato plants for 6, 12, 24, and 48 hours, respectively. The results revealed that dynamic changes occurred in the gene expressions of whiteflies at different time intervals after they acquired the virus.

The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology.

We investigated the influence of DNA fragmentation index (DFI) on fertilization (IVF), embryo transfer (ET), and intracytoplasmic sperm injection (ICSI). We analyzed the semen parameters of 61 cycles in infertile couples undergoing IVF-ET and ICSI and determined DFI by sperm chromatin dispersion testing. Based on DFI, the patients were differentiated into a control group (DFI < 25%, = 35) and a test group (DFI ≥ 25%, = 26).

Interactions of Tomato Chlorosis Virus p27 Protein with Tomato Catalase Are Involved in Viral Infection.

Tomato chlorosis virus (ToCV) severely threatens tomato production worldwide. P27 is known to be involved in virion assembly, but its other roles in ToCV infection are unclear. In this study, we found that removal of p27 reduced systemic infection, while ectopic expression of p27 promoted systemic infection of potato virus X in .

Tomato chlorosis virus p22 interacts with NbBAG5 to inhibit autophagy and regulate virus infection.

Tomato chlorosis virus (ToCV) is a member of the genus Crinivirus in the family Closteroviridae. It has a wide host range and wide distribution, causing serious harm to the vegetable industry. The autophagy pathway plays an important role in plant resistance to virus infection.

Potential risk of plant viruses entering disease cycle in surface water in protected vegetable growing areas of Eastern China.

With the expansion of protected vegetable growing areas (PVGAs), viral plant diseases have become more prevalent, causing severe economic losses to the vegetable production industry in China. At present, researches on plant viruses mainly focus on plants, but there is only a few reports on the species of viruses in surface water from PVGAs. The surface water samples in PVGAs are representative to a certain extent, which has an important reference value for studying the characteristics of plant viruses in surface water.

Gut microbiota: Linking nutrition and perinatal depression.

Perinatal depression is a mood disorder that is reported in women during pregnancy (prenatal) and after childbirth (postnatal). The onset of perinatal depression is associated with changes in reproductive hormones, stress hormones and neurosteroids. These chemical compounds can be modulated by the gut microbiota, which may affect maternal mental health during the perinatal period the gut-brain-axis.

Angelica Sinensis Polysaccharide Suppresses the Aging of Hematopoietic Stem Cells Through Sirt1/FoxO1 Signaling.

Background: This study investigated the anti-aging effects of Angelica sinensis polysaccharide (ASP) on mouse hematopoietic stem cells (HSCs) and related mechanisms.

Methods: Seventy-two C57BL/6J mice were randomly divided into the following three groups (n = 24 per group): control group; aging group, in which mice were irradiated with X-ray uniformly to establish the aging model of HSCs; and ASP group, in which mice were given 200 mg/kg ASP during irradiation. HSCs were collected by immunomagnetic beads, transmission electron microscopy was used to examine the morphological changes in HSCs, SA-β-Gal staining was used to detect the aging cells, immunofluorescence staining was used to detect the reactive oxygen species (ROS), and western blotting was used to evaluate the expression levels of sirtuin 1 (Sirt1) and forkhead box O1 (FoxO1).

Reverse transcription recombinase polymerase amplification assay for rapid detection of the cucurbit chlorotic yellows virus.

The cucurbit chlorotic yellows virus (CCYV) causes severe economic losses in cucurbit plants. Although it has been widely known in various countries for several years, CCYV is rarely recognized due to the lack of rapid and effective detection methods in the early stage of the disease. Recombinase polymerase amplification (RPA) is a new, efficient, and simple technology for nucleic acid detection.

[Lentivirus-mediated silencing of P75 neurotrophin receptor combined with nerve growth factor overexpression and transfection of bone marrow mesenchymal stem cells combined with demineralized bone matrix for heterotopic osteogenesis].

Objective: To investigate the effects of silencing P75 neurotrophin receptor (P75NTR) and nerve growth factor (NGF) overexpression on the proliferative activity and ectopic osteogenesis ability of bone marrow mesenchymal stem cells (BMSCs) combined with demineralized bone matrix for heterotopic osteogenesis.

Methods: BMSCs of Sprague Dawley (SD) rats were cultured and passaged by adherent isolation method. The third generation BMSCs were transfected with lentivirus mediated P75NTR gene silencing (group B), NGF overexpression gene (group C), P75NTR silencing and NGF overexpression double genes (group D), respectively, and untransfected cells as control (group A).

The Role of Diet, Eating Behavior, and Nutrition Intervention in Seasonal Affective Disorder: A Systematic Review.

Seasonal affective disorder (SAD) is a biological and mood disorder with a seasonal pattern. Dietary intervention and nutritional status have been reported to affect SAD severity. The objective of this study was to systematically review the evidence of associations between SAD and diet, eating behavior, and nutrition intervention.

-Butanol Extract of Suppresses Inflammatory Responses in Lipopolysaccharide-Stimulated Macrophages and Complete Freund's Adjuvant- (CFA-) Induced Arthritis Rats via Inhibition of MAPK Signaling Pathway.

is a traditional herbal medicine that has been used for centuries to treat rheumatism. Previous studies have confirmed that ethanol extracts of have anti-inflammatory and antioxidant activities, and the -butanol fraction exerts a higher inhibitory effect. However, the in vivo anti-inflammatory effects of have not been evaluated.

Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma.

Background: FBXO11, a member of the F-box protein family, regulates the cell-cycle by promoting the degradation of Bcl-6 and p53. This protein has been implicated in the progression of several cancers, including renal cell carcinoma (RCC). The aim of this study was to determine the prognostic role of FBXO11 in the clinical outcome of RCC patients.

Impacts of General and Spinal Anaesthesia on Short-Term Cognitive Function and Mental Status in Elderly Patients Undergoing Orthopaedic Surgery.

Objective: To investigate the impacts of general and spinal anesthesia on short-term cognitive function and mental status in elderly patients undergoing orthopaedic surgery.

Study Design: An experimental study.

Place And Duration Of Study: Department of Anesthetics, the Central People's Hospital of Tengzhou City, Shandong Province, China, from December 2016 to December 2017.

Immunomodulatory drugs and the risk of serious infection in multiple myeloma: systematic review and meta-analysis of randomized and observational studies.

The effect of immunomodulatory drugs (IMiDs) on serious infection remains uncertain. We therefore conducted a systematic review and meta-analysis to assess the possible impact of IMiDs on serious infection in patients with multiple myeloma (MM). We searched randomized controlled trials (RCTs) and observational studies from databases that addressed the effect of IMiDs on serious infection in patients with MM.

Association between vascular endothelial growth factor polymorphism and recurrent pregnancy loss: A systematic review and meta-analysis.

Purpose: Some studies have reported that vascular endothelial growth factor (VEGF) genetic polymorphisms are associated with recurrent pregnancy loss (RPL), but the results are controversial. This study is aimed to quantify the strength of this association.

Methods: A systematic review of the published literature from Medline, Springer, and China National Knowledge Infra structure (CNKI) databases was conducted and investigations of VEGF genetic polymorphisms in RPL were selected.

Large transport J(c) in Cu-sheathed Sr(0.6)K(0.4)Fe2As2 superconducting tape conductors.

Copper sheath is the first choice for manufacturing high-T(c) superconducting wires and tapes because of its high electrical and thermal conductivities, low-cost and good mechanical properties. However, Cu can easily react with superconducting cores, such as BSCCO, MgB2 and pnictides, and therefore drastically decrease the transport J(c). Here, we report the fabrication of Cu-sheathed Sr(1-x)K(x)Fe2As2 tapes with superior J(c) performance using a simple hot pressing method that is capable of eliminating the lengthy high-temperature sintering.