Biomechanical influence of residual lateral wall thickness and resin reinforcement on the performance of endocrowns in premolars.

Background: Restoring endodontically treated premolars (ETPMs) with mesio-occluso-distal (MOD) cavities poses clinical challenges due to reduced coronal thickness and heightened fracture risk. Despite advances in adhesive dentistry, the biomechanical effects of residual lateral wall (RLW) thickness and composite resin reinforcement on the performance of ceramic endocrowns in ETPMs remain underdefined. This study aims to evaluate how RLW thickness and resin reinforcement influence fracture resistance, stress distribution, and failure modes in ETPMs restored with ceramic endocrowns.

MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14.

Critical limb ischemia (CLI) is a refractory peripheral artery disease characterized by tissue ischemia, presenting significant therapeutic challenges. Current surgical revascularization treatments are limited by indications, complications, and other constraints, making the identification of novel therapeutic strategies an important objective for CLI management. In this study, we designed and synthesized a novel short peptide, named MY-1, and developed a GelMA/MY-1 hydrogel sustained-release system for local application in a mouse hindlimb ischemia model.

Nanotherapies based on bacterial metabolism: Mechanisms, design and application.

Bacterial metabolism provides the essential materials and energy for growth and reproduction. Through complex transformations and electron transfer, bacteria convert external nutrients into useable forms and achieve pathogenicity in the human body. In recent years, with the global spread of antibiotic resistance, traditional antibiotic treatments have become increasingly ineffective and may even exacerbate the imbalance of the human microbiota.

Bacillus amyloliquefaciens HN11 enhances cowpea growth and systemic resistance to Spodoptera litura via JA/SA pathways and growth-mediated tolerance.

Background: Plant growth and development benefit from the contribution of plant growth-promoting rhizobacteria (PGPR), which have a positive effect on plants by breaking down organic matter and synthesizing growth hormones. In addition, PGPR can stimulate plants to produce secondary metabolites, thereby enhancing its defense against pathogens and pests. To study the effects of Bacillus amyloliquefaciens 8421 (HN11) on the promotion and induction of defense against pests in cowpea, the effects and mechanisms were determined on the basis of phenotypic traits and changes in the levels of defense enzymes and phytohormones in cowpea after application of HN11.

Comparable immune escape capacity between KP.2 and other SARS-CoV-2 variants in the central Chinese population after the first COVID-19 booster.

The neutralisation ability of homologous and heterologous booster vaccinations against the KP.2 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. Therefore, we aimed to evaluate the neutralisation of the Omicron variants by comparing serum samples from Chinese individuals who received heterologous boosters (from different manufacturers) with those who received homologous boosters (from the same manufacturer) against SARS-CoV-2.

Biomimetic Microstructured Scaffold with Release of Re-Modified Teriparatide for Osteoporotic Tendon-to-Bone Regeneration via Balancing Bone Homeostasis.

Osteoporotic tendon-to-bone interface healing is challenging, with a high surgical repair failure rate of up to 68%. Conventional tissue engineering approaches have primarily focused on promoting interface healing by stimulating regeneration in either the tendon or bone. However, these methods often fall short of achieving optimal therapeutic outcomes due to their neglect of balancing bone homeostasis and remodeling the microstructure at the osteoporotic tendon-to-bone interface.

Herbivore-induced maize volatiles: dual functions in repelling fall armyworm and attracting natural enemies.

Background: Since its invasion of China, the fall armyworm (FAW, Spodoptera frugiperda) has rapidly become a major threat to maize production, raising significant concerns about national food security. This study investigates the effects of herbivore-induced plant volatiles (HIPVs), released by maize in response to FAW larval infestation, on the oviposition behavior of female FAW.

Results: Larval feeding behavior induces the release of specific volatiles that deter female oviposition through olfactory repulsion and oviposition inhibition.

Nanotherapies Based on ROS Regulation in Oral Diseases.

Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine.

Characteristics of humoral responses to the first coronavirus disease booster vaccine and breakthrough infection in central China: a multicentre, prospective, longitudinal cohort study.

Introduction: The long-term immunogenicity, adverse effects, influencing factors, and protection from booster vaccines remain unclear. Specifically, little is known regarding the humoral immunity and breakthrough infections associated with COVID-19 booster immunization. Therefore, we evaluated the immunogenicity, reactogenicity, influencing factors, and protective effects of the first coronavirus disease booster vaccine 23 months before and after implementation of dynamic zero epidemic control measures among healthcare staff.

Chinese dentists' restorative preferences and choices for endodontically treated teeth: a representative survey.

Background: The optimal restoration protocol for endodontically treated teeth (ETT) remains a subject of debate. This survey aims to assess the current level of awareness, knowledge, and prevailing opinions among dental practitioners in China regarding the application of endocrown versus the post/core/crown ensemble for post-endodontic restoration strategies.

Methods: A validated questionnaire, encompassing three sections, was distributed electronically to dentists practicing in China.

Prehabilitation Interventions for Cardiac Surgery to Prevent Postoperative Pulmonary Complications: Systematic Review and Meta-Analysis.

Background: Postoperative pulmonary complications (PPCs) are associated with a higher risk of morbidity and mortality in patients undergoing cardiac surgery. We aimed to investigate the effect of preoperative interventions on PPCs and length of intensive care unit and hospital stay in patients undergoing cardiac surgery.

Methods: A systematic review and meta-analysis was conducted on randomized or quasi-randomized trials by searching PubMed, Medline, ISI Web of Science, Science Direct, Physiotherapy Evidence Database (PEDro), and the Cochrane Library for all available years until December 2023.

Lactonization of Diols Over Highly Efficient Metal-Based Catalysts.

Lactones has gained increasing attention in recent years due to wide application in polymer and pharmaceutical industries. Traditional synthetic methods of lactones often involve harsh operating temperature, use of strong alkalis and toxic oxidants. Therefore, lactonization of diols under milder conditions have been viewed as the most promising route for future commercialization.

Optimizing restorative procedure and material selection for pulpotomized primary molars: Mechanical characterization by 3D finite element analysis.

Purpose: This study aimed to assess the stress distribution in pulpotomized primary molars with different types of restorative materials using 3D-finite element analysis (FEA), and provide valuable insights into the selection and application of restorative materials, with the ultimate goal of reducing the risk of pulpotomy failure and protecting residual dental tissue.

Methods: Four 3D models of pulpotomized primary molars with different restorative materials according to the material and its elastic modulus were analysed: resin composite, stainless steel crowns (SSCs), prefabricated zirconia crowns and endocrowns. The food layer was also designed before vertical and bucco-lingual forces were applied to simulate physiological masticatory conditions.

Lattice-Strained Bimetallic Nanocatalysts: Fundamentals of Synthesis and Structure.

Bimetallic nanostructured catalysts have shown great promise in the areas of energy, environment and magnetics. Tunable composition and electronic configurations due to lattice strain at bimetal interfaces have motivated researchers worldwide to explore them industrial applications. However, to date, the fundamentals of the synthesis of lattice-mismatched bimetallic nanocrystals are still largely uninvestigated for most supported catalyst materials.

Accuracy and adaptation of one-piece endodontic crowns fabricated through 3D printing and milling.

Statement Of Problem: High-level evidence regarding the accuracy and adaptation of 1-piece endodontic crowns fabricated by using 3-dimensional (3D) printing technology is lacking.

Purpose: The purpose of this in vitro study was to compare the accuracy and adaptation of 1-piece endodontic crowns produced through 3D printing and computer-numerical-control milling technology and to explore the influence of trueness on 1-piece endodontic crown adaptation.

Material And Methods: One-piece endodontic crowns were prepared for a typodont right mandibular first molar, scanned with a 3Shape E3 scanner, and designed with a computer-aided design software program.

Coating of maize seeds with acephate for precision agriculture: Safety assessment in earthworms, bees, and soil microorganisms.

Acephate is commonly used as a seed treatment (ST) in precision agriculture, but its impact on pollinators, earthworms, and soil microorganisms remains unclear. This study aimed to compare the fate of acephate seed dressing (SD) and seed coating (SC) treatments and assess potential risks to bees, earthworms, and soil microorganisms. Additionally, a follow-up study on maize seeds treated with acephate in a greenhouse was conducted to evaluate the maize growth process and the dissipation dynamics of the insecticide.

The development and validation of a prediction model for imminent vertebral osteoporotic fracture in postmenopausal women.

Purpose: This study aimed to develop and validate a new model that focused on the risk of imminent vertebral fractures in women with osteoporosis.

Methods: Data from 2,048 patients were extracted from three hospitals, of which 1,720 patients passed the inclusion and exclusion screen. The patients from Nanfang Hospital (NFH) were randomized at a 2:1 ratio to create a training cohort (n = 709) and an internal validation cohort (n = 355), with the patients from the other two hospitals (n = 656) used for external validation.

Ceftazidime-Avibactam Combination Therapy versus Monotherapy for the Treatment Carbapenem-Resistant Gram-Negative Bacterial Infections: A Retrospective Observational Study.

Purpose: Since the introduction of ceftazidime-avibactam (CZA) in the Chinese market, accumulating clinical evidence has substantiated its efficacy in the treatment of infections caused by carbapenem-resistant gram-negative bacteria (CR-GNB). Nevertheless, an ongoing debate persists concerning the choice between monotherapy and combination therapy when devising clinical anti-infection protocols.

Patients And Methods: This retrospective, single-center observational study enrolled patients with CR-GNB infections who received CZA treatment between December 2019 and August 2023.

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix.

Extracellular matrix (ECM) remodeling is accompanied by the continuous synthesis and degradation of the ECM components. This dynamic process plays an important role in guiding cell adhesion, migration, proliferation, and differentiation, as well as in tissue development, body repair, and maintenance of homeostasis. Nanomaterials, due to their photoelectric and catalytic properties and special structure, have garnered much attention in biomedical fields for use in processes such as tissue engineering and disease treatment.

Effect of Oil on the Toxicity of β-Cypermethrin Emulsifiable Concentrate Formulation.

Enhancing the performance of traditional pesticide formulations by improving their leaf surface wetting capabilities is a crucial approach for maximizing the pesticide efficiency. This study develops an emulsifiable concentrate (EC) of 4.5% β-cypermethrin containing oil (BJO).

Risk Factors and Outcomes for Isolation with Polymyxin B-Resistant Enterobacterales from 2018-2022: A Case-Control Study.

Purpose: To analyze the risk factors and clinical outcomes of patients isolated with polymyxin B-resistant (PR) from various clinical specimens to prevent and control the spread of these strains.

Methods: This retrospective case-control study included 72 PR -positive cases and 144 polymyxin B-susceptible (PS) controls from 2018 to 2022. Patients with PR isolated in various clinical cultures were defined as cases.

Clinical effect of acupoint application with turmeric blistering moxibustion plaster on post-stroke hemiplegic shoulder pain.

Objectives: To observe the effects of acupoint application with turmeric blistering moxibustion plaster on pain, shoulder range of motion (ROM) and upper limb motor function in the patients with post-stroke hemiplegic shoulder pain (PSHSP).

Methods: Eighty-two patients with PSHSP were randomly divided into an observation group (41 cases, 1 case was eliminated, 4 cases dropped out) and a control group (41 cases, 2 cases were eliminated and 2 cases dropped out). The routine treatment, nursing care and rehabilitation training were performed in the control group.