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Dental caries, one of the most prevalent diseases globally, affects individuals throughout their lifetimes. Recently, researchers have increasingly focused on postbiotics for caries prevention. Postbiotics, comprising inanimate microorganisms and/or their components, confer health benefits to the host. Growing evidence suggests postbiotics' potential anticaries effects. Specifically, numerous postbiotics have demonstrated the ability to inhibit dental caries onset and progression by modulating oral flora microecology and reducing human caries susceptibility. This review elaborates on the current research regarding postbiotics' anticaries effects, highlights some studies' shortcomings, and innovatively proposes that postbiotics could potentially influence tooth development and salivary characteristics through epigenetic modifications. Furthermore, it anticipates postbiotics' future application in personalised caries treatment, given their multifaceted anticaries potential.
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http://dx.doi.org/10.3290/j.ohpd.b5740317 | DOI Listing |
HNO
September 2025
Universitätsklinik für Hals‑, Nasen- und Ohrenheilkunde, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.
The human microbiome consists of a diverse array of microorganisms that perform essential functions for health. In particular, the oral microbiome plays a crucial role in maintaining oral health by preventing the colonization of pathogenic bacteria and regulating pH balance. Dysbiosis of the oral microbiome has been linked to the development of caries, periodontal diseases and oral squamous cell carcinoma.
View Article and Find Full Text PDFNutrients
July 2025
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Nørre Allé 20, 2200 Copenhagen, Denmark.
Background/objectives: Children with an oral presence of spp. have an elevated prevalence of dental caries. As an alternative to conventional antifungal drugs, the use of biofilm-modulating strategies, such as probiotic bacteria, may be a sustainable option.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
July 2025
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Oral biofilms are intricate microbial communities that can enhance oral health, yet their equilibrium is susceptible to disruption, leading to oral infectious diseases. The most prevalent of these are dental caries, periodontitis, and peri-implant infections. The formation of pathogenic biofilms is the primary cause of these diseases, and their resistance to antimicrobial agents and immune responses poses significant treatment challenges.
View Article and Find Full Text PDFMicrob Genom
May 2025
Food, Microbiomes and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Everyday actions such as eating, tooth brushing or applying cosmetics inherently modulate our microbiome. Advances in sequencing technologies now facilitate detailed microbial profiling, driving intentional microbiome-targeted product development. Inspired by an academic-industry workshop held in January 2024, this review explores the oral, skin and gut microbiomes, focussing on the potential long-term implications of perturbations.
View Article and Find Full Text PDFFront Biosci (Elite Ed)
March 2025
CBQF-Centre for Biotechnology and Fine Chemistry-Associated Laboratory, Portuguese Catholic University, 4169-005 Porto, Portugal.
Background: Oral diseases affect over three billion peopleand are among the most commonly observed infections worldwide. Recent studies have shown that controlling the ecology of the oralome is more effective in reducing the risk of caries than the complete removal of both harmful and beneficial microorganisms. This work aimed to develop a strategy for preventing dysbiosis in the oral cavity by applying a postbiotic-based orodispersible film.
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