Mechanical Properties and σ-Phase Precipitation in FeCoCrNiMo (x = 0, 0.4, 0.5, 0.8, 1.3) High-Entropy Alloys: Insights from First-Principles Study.

High-entropy alloys (HEAs) have garnered significant global interest due to their outstanding properties. This study investigates the structural stability and mechanical properties of FeCoCrNiMo (x = 0, 0.4, 0.

Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages.

Background: Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti-PD-1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti-PD-1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to dissect the molecular mechanisms of specific immunosuppressive subpopulations to drive anti-PD-1 resistance in GBM.

Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of .

Introduction: , a half-woody plant belonging to the Asteraceae family, is valued as both a medicinal and industrial crop primarily for its phytochemical component, (-)-borneol. Nitrogen (N) is essential for regulating the growth of and the biosynthesis of (-)-borneol; however, the molecular mechanisms by which N influences these processes remain inadequately understood. This study aimed to elucidate the effects of N on growth and (-)-borneol synthesis at the molecular level.

Loop engineering of cellobiose 2-epimerase from Dictyoglomus thermophilum for efficient synthesis of lactulose.

Lactulose holds broad application due to its unique pharmaceutical and prebiotic properties. Cellobiose 2-epimerase (CE) efficiently catalyzes the production of lactulose, offering an eco-friendly biosynthetic alternative. However, its relatively low isomerization activity hampers widespread application in the manufacture of lactulose.

Predicting EV battery state of health using long short term degradation feature extraction and FEA TimeMixer.

Accurately predicting the State of Health (SOH) of new energy vehicle batteries is critical for ensuring their reliable operation and extending battery's service life. To address the issue of low SOH prediction accuracy across different prediction lengths, this paper proposes a prediction method based on long-short-term battery degradation feature extraction and FEA-TimeMixer model. First, a novel automatic SOH extraction algorithm for offline charging data is introduced to label the battery SOH degradation data.

An overview of sound source localization based condition monitoring robots.

As artificial intelligence advances and demand for cost-effective equipment maintenance in various fields increases, it is worth insightful research on utilizing robots embedded with sound source localization (SSL) technology for condition monitoring. Combining the two techniques has significant advantages, which are conducive to further classifying and tracking abnormal sources, thereby enhancing system performance at a lower cost. The paper provides an overview of current acoustic-based robotic techniques for condition monitoring, highlights the common SSL methods, and finds that localization performance heavily depends on signal quality.

O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner.

Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.

Super-Elastic and Temperature-Tolerant Hydrogel Electrodes for Supercapacitors via MXene Enhanced Ice-Templating Synthesis.

Developing flexible energy storage devices with good deformation resistance under extreme operating conditions is highly desirable yet remains very challenging. Super-elastic MXene-enhanced polyvinyl alcohol/polyaniline (AMPH) hydrogel electrodes are designed and synthesized through vertical gradient ice templating-induced polymerization. This approach allows for the unidirectional growth of polyaniline (PANI) and 2D MXene layers along the elongated arrayed ice crystals in a controlled manner.

Grain Protein Content Phenotyping in Rice via Hyperspectral Imaging Technology and a Genome-Wide Association Study.

Efficient and accurate acquisition of the rice grain protein content (GPC) is important for selecting high-quality rice varieties, and remote sensing technology is an attractive potential method for this task. However, the majority of multispectral sensors are poor predictors of GPC due to their broad spectral bands. Hyperspectral technology provides a new analytical technology for bridging the gap between phenomics and genomics.

The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice.

Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Developing high-NUE rice cultivars through balancing nitrogen uptake and the formation of productive tillers remains a long-standing challenge, yet how these two processes are coordinated in rice remains elusive. Here we identify the transcription factor OsGATA8 as a key coordinator of nitrogen uptake and tiller formation in rice.

Abscisic acid for acute respiratory distress syndrome therapy by suppressing alveolar macrophage pyroptosis via upregulating acyloxyacyl hydrolase expression.

Objective: Abscisic acid (ABA) is a phytohormone that inhibits airway inflammation in acute respiratory distress syndrome (ARDS) mouse models. However, the molecular mechanism underlying this phenomenon remains unclear.

Methods: Serum ABA level in patients and mice was measured via liquid chromatography-tandem mass spectrometry (LC-MS/MS).

A Novel Allele in the Promoter of Decreases Gene Expression and Confers Lower Apparent Amylose Contents in Rice ( L.).

is the key gene that controls amylose content (AC), and various alleles have been found in rice populations. is the major allele in and produces moderate AC (15~18%). It was recently found that editing the promoter of could produce a series of alleles that have different Wx activities.

Highly efficient reduction of bromate by vacuum UV/sulfite system.

Bromate (BrO3-), a worldwide regulated by-product after ozone disinfection, is often detected in bromide-containing water, and has a strict limit of 10 μg L in potable water. BrO3- degradation by advanced reduction processes (ARPs) has gained much attention because of efficient removal and easy integration with ultraviolet disinfection (UV at 254 nm). In the vacuum UV (VUV, 185/254 nm)/sulfite system, the elimination kinetics of BrO increased by 9-fold and 15-fold comparing with VUV alone and UV/sulfite system.

Case Report: Successful surgical management of a challenging primary cardiac angiosarcoma.

Primary cardiac tumors are exceptionally rare, with malignant tumor occurrences ranging from 0.0017% to 0.28%.

OsCIPK9 Interacts with OsSOS3 and Affects Salt-Related Transport to Improve Salt Tolerance.

Salt is harmful to crop production. Therefore, it is important to understand the mechanism of salt tolerance in rice. genes have various functions, including regulating salt tolerance and other types of stress and nitrogen use efficiency.

Advancing cardiac regeneration through 3D bioprinting: methods, applications, and future directions.

Cardiovascular diseases (CVDs) represent a paramount global mortality concern, and their prevalence is on a relentless ascent. Despite the effectiveness of contemporary medical interventions in mitigating CVD-related fatality rates and complications, their efficacy remains curtailed by an array of limitations. These include the suboptimal efficiency of direct cell injection and an inherent disequilibrium between the demand and availability of heart transplantations.

Aberrant spontaneous static and dynamic amplitude of low-frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment.

Background: Cerebral small vessel disease (CSVD) is considered an age-related degenerative neurological disorder and the most common risk factor for vascular cognitive impairment (VCI). The amplitude of fluctuation of low frequency (ALFF) can detect altered intrinsic brain activity in CSVD. This study explored the static and dynamic ALFFs in the early stage of CSVD with (CSVD-M) or without (CSVD-W) mild cognitive impairment (MCI) in these patients and how these changes contribute to cognitive deterioration.

Case report: Surgical management of a rare right coronary artery fistula with a giant pseudoaneurysm compressing the pulmonary vein in a young patient.

Congenital coronary artery fistula (CAF) represents a remarkable rarity within the realm of cardiovascular anomalies, characterized by an aberrant connection between coronary arteries and either cardiac chambers or major vessels. Clinical manifestations of CAFs often remain unspecified or may even be entirely absent, posing diagnostic challenges. Notably, patients harboring substantial CAFs may exhibit symptoms such as palpitations, chest tightness, and dyspnea.

A natural gene drive system confers reproductive isolation in rice.

Hybrid sterility restricts the utilization of superior heterosis of indica-japonica inter-subspecific hybrids. In this study, we report the identification of RHS12, a major locus controlling male gamete sterility in indica-japonica hybrid rice. We show that RHS12 consists of two genes (iORF3/DUYAO and iORF4/JIEYAO) that confer preferential transmission of the RHS12-i type male gamete into the progeny, thereby forming a natural gene drive.

Case report: Surgical valvular pulmonary reconstruction for a previous unreported rheumatic right-sided valve disease with severe pulmonary regurgitation.

Rheumatic heart disease (RHD) is a widespread illness in developing countries. RHD causes 99% of mitral stenoses in adults and 25% of aortic regurgitation. However, it only causes 10% of stenoses of the tricuspid valve, and is almost always associated with left-side valvular lesions.

CMOS-Compatible Ultralow-Loss Three-Step Silicon Edge Coupler with Substrate Substitution in the Whole Communication Band.

Edge coupler is a key component of silicon-based optoelectronic chips, which dramatically reduces the coupling loss between fibers and transmission waveguides. Here, we propose an ultralow-loss three-step silicon edge coupler based on a 130 nm CMOS process. By replacing the silicon substrate with a material with a lower refractive index than silicon oxide, the silicon leakage loss and polarization-dependent loss can be significantly improved.

Selection and Validation of 48 KASP Markers for Variety Identification and Breeding Guidance in Conventional and Hybrid Rice (Oryza sativa L.).

Background: Breeding of conventional and hybrid rice (Oryza sativa L.) have solved hunger problems and increased farmers' income in the world. Molecular markers have been widely used in marker-assisted breeding and identification of larger numbers of different bred varieties in the past decades.

Non-coding RNAs to regulate cardiomyocyte proliferation: A new trend in therapeutic cardiac regeneration.

Cardiovascular diseases remain the leading cause of death worldwide, particularly ischemic heart disease (IHD). It is also classified as incurable given the irreversible damage it causes to cardiomyocytes. Thus, myocardial tissue rejuvenation following ischemia is one of the global primary research concerns for scientists.

Ultralow-loss waveguide crossing for photonic integrated circuits by using inverted tapers.

An ultralow-loss silicon planar waveguide crossing operating in the O-band was experimentally demonstrated based on the Gaussian beam synthesis method. Elliptical parabolic inverted tapers were introduced in our design to reduce the crossing loss. According to the measurement results, the proposed device exhibits an insertion loss of 0.