Long-chain PFAS potently disrupt renal carboxylesterase activity and exacerbate nephrotoxicity: an investigation of the chain length-dependent nephrotoxicity of PFAS.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are recognized as critical environmental health hazards, however, their toxicity mechanisms in specific organ systems remain poorly characterized. This study systematically investigated the chain length-dependent nephrotoxicity of PFAS and their inhibitory effects on renal carboxylesterase (CES) activity. In vitro experiments revealed that PFAS were cytotoxic to Human Kidney-2 (HK-2) cells in a dose-dependent and chain length-dependent manner.

Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and cellular experimental validation.

Background: Periodontitis has been associated with an increased risk of pre-eclampsia, but the underlying mechanisms and causal relationship remain unclear. Oxidative stress has been implicated in both conditions, suggesting a potential mechanistic link.

Objectives: To investigate the causal relationship between periodontitis and pre-eclampsia and elucidate shared molecular pathways, with a focus on oxidative stress-related mechanisms.

Comprehensive multi-omics characterization of different cuts of Dezhou donkey meat.

This study conducted a detailed analysis of the nutritional composition of five different cuts of Dezhou donkey meat. Combining these findings with transcriptome data, the researchers identified region-specific gene expression patterns and uncovered key regulatory networks associated with meat quality traits across the various cuts. The genes and were identified as crucial for regulating amino acid metabolism in the hind legs.

Study on the Coal Underground Gasification Reaction Characteristics Based on the Controlled Retraction Injection Point Gasification Process.

Although modern coal underground gasification technology using the controlled retraction injection point (CRIP) has made significant advancements, several issues remain, such as unstable gas quality, limited process control methods, and an unclear understanding of the distribution and expansion of the gasification reaction zone. This study uses COMSOL Multiphysics software to establish a three-dimensional model of coal seam horizontal well injection underground gasification based on the CRIP process, with a focus on a single backward gasification reaction cycle. The distribution of temperature fields and the heat-affected zone of the combustion cavity during a single reaction cycle are analyzed under three parameters: gas flow rate, oxygen concentration, and gasification pressure.

The Transcriptomic Signature of Donkey Ovarian Tissue Revealed by Cross-Species Comparative Analysis at Single-Cell Resolution.

Donkeys () hold significant agricultural value in China, particularly for their hides and meat, which possess notable medicinal and dietary importance. However, their reproductive efficiency remains suboptimal compared with other livestock. Ovarian function is a key determinant of fertility, yet the molecular mechanisms underlying donkey ovarian biology remain largely unexplored.

The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway.

Background: Cervical cancer (CC), the most prevalent malignant tumor in the female reproductive system, is characterized by its high incidence and mortality rates. Chloroquine(CQ), a 4-aminoquinoline drug originally used to prevent and treat malaria, has gained recognition as an adjuvant anti-cancer agent. However, whether chloroquine exhibits anti-CC activity and its underlying mechanisms remain unclear.

Comprehensive comparison of technical performance, surgical outcomes, and oncologic prognosis between remnant gastric cancer and primary upper-third gastric cancer in the era of minimally invasive surgery: A pooled analysis of 3 prospective trials.

Background And Objective: To compare the technical performances and short- and long-term outcomes of laparoscopic total gastrectomy for remnant gastric cancer and primary upper gastric cancer.

Methods: This prospective study (FUGES-004 study) enrolled 50 remnant gastric cancer patients who underwent laparoscopic total gastrectomy at Fujian Medical University Union Hospital between June 2016 and June 2020 (ClinicalTrials.gov identifier: NCT02792881).

Rituximab in the Treatment of Subarachnoid Hemorrhage and Widespread Bleeding in Microscopic Polyangiitis : A Case Report.

Microscopic polyangiitis (MPA) is a rare autoimmune disorder characterized by small-vessel vasculitis and the presence of anti-neutrophil cytoplasmic antibody (ANCA). Typically, MPA primarily affects the respiratory system, kidneys, and skin, with infrequent involvement of the nervous system, resulting in neuropathy. However, the occurrence of subarachnoid hemorrhage (SAH) in MPA is exceedingly rare, especially when it is accompanied by hemorrhagic events in multiple organs.

Comprehensive genomic analysis of genetic diversity, body size, and origins of the Hetian Gray donkey.

Background: The Hetian Gray donkey, characterized by its large stature and gray coat color, is a relatively recently identified breed. This breed plays an important role in local agricultural practices and cultural heritage. However, with the widespread adoption of mechanization, its use as a draft animal has gradually diminished.

Zinc Sulfate Open Frameworks with Nonconventional Room-Temperature Phosphorescence for Selective Amine Vapor Detection.

Molecular-based afterglow materials have garnered significant attention due to their diverse applications. However, most studies focus on conventional luminophores, leaving nonconventional systems underexplored, particularly regarding the screening of new material subclasses and the development of applications such as sensing. Herein we report the successful preparation of two new two-dimensional ZnSO-based open-framework materials (OFMs)─(HDABCO)[Zn(μ-OH)(SO)]·HO () and (HDABCO)[Zn(SO)] ()─through self-assembly of Zn/SO with nonaromatic triethylenediamine (DABCO).

Impact of microplastics on plant biogenic volatile organic compounds emission: A preliminary study.

Plants produce biogenic volatile organic compounds (BVOCs) that are essential for interacting with the environment. As emerging pollutants, microplastics (MPs) may influence BVOCs emissions, yet their effects remain poorly underexplored. This study employed headspace solid phase microextraction coupled with gas chromatography - mass spectrum to investigate the impact of MPs on the BVOC emission profiles of lettuce (Lactuca sativa).

Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation.

Background: Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear.

Latent profile analysis of mental workload among emergency department nurses: a cross-sectional study.

Aim: Emergency department nurses experience varying degrees of mental workload due to various factors. The group with medium to high levels of mental workload requires particular attention. There is limited research on the potential profiles of mental workload among emergency department nurses.

Research Progress on Influencing Factors of Gastrointestinal Microbial Diversity in Equine.

Microbiota in the gastrointestinal tract play a crucial role in nutrient digestion, health and so forth in equines. As the research attention on gut microbes has increased, several studies have investigated the composition of the gastrointestinal microbial flora in equines. This article reviews the effects of breed, age, intestinal site, nutritional management and diseases on the gastrointestinal microbiota of horses and donkeys, thus offering references for improving the gastrointestinal microecological environment in these animals and preventing and controlling disease occurrence in them.

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas.

Worldwide, donkeys (Equus asinus) are valued for their meat and milk, and in China also for the medical value of their skin. Physiological characteristics are key to the donkey's adaptability, including their digestive, respiratory, and reproductive systems, which enable them to survive and work in a variety of environments. However, the understanding of donkey physiological characteristics at the cellular level remains poor.

Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction.

Immune cells are sensitive to the perception of mechanical stimuli in the tumor microenvironment. Changes in biophysical cues within tumor tissue can alter the force-sensing mechanisms experienced by cells. Mechanical stimuli within the extracellular matrix are transformed into biochemical signals through mechanotransduction.

Non-targeted LC-MS metabolomics reveals serum metabolites for high-altitude adaptation in Tibetan donkeys.

Tibetan donkeys inhabit the harsh environment of the Qinghai-Tibet Plateau. Research on serum metabolites related to their high-altitude adaptation is limited compared to other livestock. We used liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from healthy adult donkeys in Shigatse, Changdu, and Dezhou to evaluate the effects of high altitudes on serum metabolites.

Effect of slope position on the spatial distribution of soil preferential flow paths based on point pattern analysis.

The mechanisms of soil preferential flow occurrence and development are influenced by topographic and geomorphological factors. However, the complex distribution patterns of soil preferential flow paths on different slopes remain unclear. Therefore, taking the subtropical evergreen broad-leaved forest area of Simian Mountain as the study area, this study conducted a quantitative analysis of the spatial distribution characteristics and spatial association of soil preferential flow at different slope positions (slope shoulder (SS), mid-slope (SM) and slope foot (SF)) using field staining tracer tests and spatial point pattern analysis.

Novel scoring system for predicting stone-free rate after flexible ureteroscopy lithotripsy.

This study aims to investigate the factors affecting the stone-free rate (SFR) of flexible ureteroscopy and laser lithotripsy (fURSL) for renal stones and establish predictive models by identifying their prognostic factors. We retrospectively examined 252 patients with renal stones who were treated with fURSL between July 2020 and April 2022. We analyzed the relationship between the patient's clinical data (sex, age, and body mass index), stone status (side, size, location, stone/transverse process pixel ratio [STPR], and the CT value of stone [SCTV]), and SFR to determine the relevant factors and analyze their influence.

A fast solid-phase microextraction scheme for in vivo monitoring of bio-accumulation and bio-transformation of arbidol in living plants.

Large quantity of the antiviral drug arbidol is used for resisting virus infection like the Corona Virus Disease 2019 and influenza, resulting in unanticipated environmental pollution. Herein, to investigate the environmental risks of the unanticipated arbidol contamination, a novel in vivo sampling probe was developed based on a bromo-substituted porous organic polymer (Br-POP) and then adopted for tracking the bio-accumulation and bio-transformation of arbidol in living plants by coupling with a nano-electrospray ionization fourier-transform ion cyclotron resonance mass spectrometry (Nano-ESI-FT-ICR-MS) method. The established method showed good extraction performance towards arbidol with limit of detection (LOD) of 0.

Group empathy for pain is stronger than individual empathy for pain in the auditory modality.

Humans live in collective groups and are highly sensitive to perceived emotions of a group, including the pain of a group. However, previous research on empathy for pain mainly focused on the suffering of a single individual ("individual empathy for pain"), with limited understanding of empathy for pain to a group ("group empathy for pain"). Thus, the present study aimed to investigate the cognitive neural mechanisms of group empathy for pain in the auditory modality.

Plant Root Secretion Alleviates Carbamate-Induced Molecular Alterations of Dissolved Organic Matter.

Studying the interaction between pesticide contamination in the plant system and the dissolved organic matter (DOM) composition is important to understand the impact of pesticides and plants on the ecological function of DOM. The present study investigated the effects of DOM on the bioaccumulation and biotransformation of carbamates in plants, carbamate exposure on DOM composition, and plant root secretion on the interaction between DOM and carbamates. The concentrations of carbamates and their metabolites in living cabbage plants were continuously tracked through an in vivo analytical method.

Factors affecting the quality and nutritional value of donkey meat: a comprehensive review.

Donkey meat is characterized by a high content of proteins, essential amino acids, and unsaturated fatty acids and is low in fat, cholesterol, and calories. Thus, it is considered a high-quality source of meat. Based on the data from PubMed and Web of science within past 10 years, this review summarizes the factors affecting the quality of donkey meat and its nutritional value, including breed, genetics, gender, age, muscle type, feeding regimen, storage and processing conditions.