Study protocol: a randomized controlled clinical trial on the use of electroacupuncture for postoperative abdominal distension following laparoscopic cholecystectomy.

Background: In recent years, global cholecyst-related disorders have been increasing daily. Laparoscopic cholecystectomy (LC) is an advanced gallbladder surgical technique. However, pneumoperitoneum and various factors leading to abdominal distension and other gastrointestinal dysfunctions are common postoperative complications.

A Japanese encephalitis virus biological clone with an gene point mutation exhibits and attenuation of neurovirulence.

The Japanese encephalitis virus (JEV), a leading cause of viral encephalitis, exists as similar but non-identical biological clones whose genomic variations/mutations may determine neurovirulence. Two biological clones purified from a brain-derived, clinical isolate were tested for neurovirulence using human neuronal cells (SK-N-MC) and mouse neuronal cells (NIE-115) and on a footpad-inoculation mouse model. One clone (JEV-M) demonstrated significantly reduced infectivity in both neuronal cells and the mouse model compared to another clone (JEV-V).

Synergistic Effects of Walnut Oil and Nervonic Acid on Antioxidant Activity and Cognitive Impairment.

Cognitive impairment (CI) poses a significant public health challenge, where oxidative stress plays a crucial role in its initiation and advancement. Previous research has emphasized that walnut oil (WO) and nervonic acid (NA) are potential therapeutic foods for CI. This study aimed to investigate the synergistic effects of WO and NA on antioxidant activity and CI improvement.

A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants.

Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity.

Oxygen vacancy-rich TiO nanobelts buffed Ru clusters for green chemosynthesis of amino acid from lignocellulosic derivatives.

Amino acids are widely used in various applications, its production mainly relies on the fermentation of grain crops, and the chemosynthesis method from non-grain biomass still faces the challenge of low efficiency (<50 %). Herein, Ru clusters anchored on ultrathin TiO nanobelts (NBs) with abundant oxygen vacancies are fabricated and used to convert lignocellulose-derived α-hydroxy acids to α-amino acids. The Ru/TiO NBs achieved up to 80 % alanine yield from lignocellulose-derived lactic acid (LA).

Sensitive Detection of Exosomal Biomarkers via a Drop-Shaped Porous Microfluidic Chip for Potential Diagnosis of Alzheimer's Disease.

Alzheimer's disease (AD), a progressive and irreversible neurodegenerative disorder, underscores the critical need for developing noninvasive early diagnostic methods. In recent years, blood-exosome-based diagnostics have emerged as a promising approach, as exosomes carry disease-specific biomarkers. However, sensitive detection of AD biomarkers in serum exosomes remains technically challenging due to the low abundance of target molecules and the complexity of biological samples.

The Job Embeddedness Scale: A Test of Its Reliability and Validity in Chinese Perioperative Settings.

This study aimed to translate, validate, and implement the Job Embeddedness Scale (JES) in perioperative settings in Taiwan. Job embeddedness is an important determinant of predicting job turnover; however, no tool exists to measure among perioperative nurses in Taiwan. A cross-sectional research design was employed using self-administered questionnaires in this study.

Transition-metal-free KSO-promoted oxidative C-C triple bond cleavage and esterification leading to α-ketoesters.

A sustainable method for converting alkynes into α-ketoesters is reported through KSO-promoted oxidative C-C triple bond cleavage and esterification. This approach avoids transition metal catalysis, photocatalysts, and pure oxygen conditions, making it both efficient and more convenient.

Enhancing CO Preferential Oxidation in H-Rich Stream on Solid Solution CuO_CeO Catalyst with Abundant Oxygen Vacancies.

In this study, we propose a strategy for preparing solid solution CuO_CeO catalysts derived from Ce-based MOFs for CO preferential oxidation. The support provided by frameworks and the anchoring of amino groups prevent the agglomeration of Cu species during subsequent annealing. Therefore, highly dispersed Cu species are formed, and even some are atomically embedded in the CeO lattice.

Short- and mid-term outcomes of surgical repair of acute type A aortic dissection and concomitant coronary artery bypass grafting or extracorporeal membrane oxygenation support.

Objectives: In this study, we aimed to retrospectively analyse the risk factors for failing to wean from CPB and short- and mid-term outcomes of surgical repair of acute type A aortic dissection (TAAD) and concomitant coronary artery bypass grafting (CABG) versus extracorporeal membrane oxygenation (ECMO) support in patients.

Methods: Two hundred and three patients were enrolled and categorized into the simple TAAD group (n = 106) or the complex TAAD group (n = 97). Following propensity score matching, 68 patients in the complex TAAD group were distributed between the CABG subgroup (n = 34) and the ECMO subgroup (n = 34) for further analysis.

High-Performance GaN/BAs Heterojunctions: Dual Functionality of BAs for Enhanced Electrical and Thermal Management in Power Electronics.

Benefit from the unusually outstanding thermal and electrical transport properties, the integration of cubic boron arsenide (BAs) with other semiconductors presents a promising avenue for advanced electronic and optoelectronic devices. However, assemblage of BAs-based devices poses significant challenges due to constraints in BAs growth conditions. In this study, gallium nitride/BAs (GaN/BAs) heterojunctions are fabricated using the surface-activated bonding method, achieving high-quality interfaces.

Antipsychotic prescription pattern in ASEAN: Comparison of antipsychotic prescription formulation and type from REAP-AP4 consortium study.

BackgroundTo date, there has not been an evaluation of antipsychotic prescription practices specific to the Association of Southeast Asian Nations (ASEAN) region. This study examined antipsychotic prescription for schizophrenia patients in ASEAN countries based on Research on Asian Psychotropic Prescription (REAP) survey.MethodsThis study used data from the fourth REAP antipsychotic survey (REAP-AP4), conducted between March and May 2016 using standardized procedures.

A Professional Nurse Competence Scale (PNCS): Development and psychometric testing.

Background: Nurses face significant challenges due to the rapid changes brought about by the emergence of increasingly complex clinical practices. Although many instruments have been validated for measuring nursing competence, they lack an updated and more comprehensive perspective. We aimed to develop and conduct psychometric testing of a comprehensive scale for measuring the self-perceived competence of professional nurses in clinical settings.

The Complete Mitochondrial Genome of Red Costate Tiger Moth ( [Cramer, 1777]), and Phylogenetic Analyses of the Subfamily Arctiinae.

Background/objectives: , class Insecta, order Lepidoptera, superfamily Noctuoidea, family Erebidae, and subfamily Arctiinae, is a polytrophic agricultural pest. However, there are still many sequences missing for Arctiinae from mitochondrial whole-genome sequences.

Methods: In this study, we determined and analyzed the complete mitochondrial genome sequence of .

Head injury risk prediction for vulnerable road users based on Chinese adult male head data.

Prediction of injuries to vulnerable road users (VRUs) during the head-ground collision phase has been a long-standing challenges in accident modeling. This study aims to reveal the severity of head injury in vehicle-VRU collision (VVC) accidents and quantify the relationship between the head-ground collision (HGC) velocity and the injury levels of brain tissue with local human attributes. First, a finite element head model with Chinese human attributes was constructed and verified.

A retrospective analysis of vortioxetine utilization in children and adolescents with major depressive disorder in clinical practice.

Background: Treating depression in children and adolescents has always been a challenge in clinical pharmacotherapy. Vortioxetine, as a new type of antidepressant, is considered to have the potential for use in the treatment of depression in children and adolescents. This study aimed to evaluate the usage of vortioxetine and its efficacy and tolerability in children and adolescents with major depressive disorder in a real-world study.

A case report of mesalazine alleviating diarrhea in a patient with nasopharyngeal cancer after tislelizumab treatment.

Immunotherapy has become a significant research focus for cancer treatment in recent years because it can generate enduring immunological responses and has promising therapeutic potential. Nevertheless, excessive stimulation of the immune system may adversely affect healthy organs, which can lead to immune-related toxicities, including gastrointestinal, pulmonary, hepatic, and dermatological toxicities. Among them, gastrointestinal toxicity induced by the immune response is the most common.

Fragmented Ultrathin Carbon Buffed Copper Clusters for Selective Hydrogenation of -Heteroarenes under Ambient Pressure.

Selective hydrogenation of quinolines to 1,2,3,4-tetrahydroquinolines (py-THQ) realized by cost-effective catalysts holds great importance in the pharmaceutical and agrochemical industries but is challenging due to the high requirement of antipoisoning ability and selectivity. Herein, we propose a universal strategy for the preparation of ultrathin carbon-coated Cu nanoclusters inside the channels of MCM-41 by etching the carbonized template with oxygen-containing gas. The optimized catalyst (Cu/C@MCM-A) exhibits 100% quinoline conversion and 100% py-THQ selectivity at 80 °C and atmospheric pressure.

Chinese Version of the Career Adapt-Abilities Scale for Clinical Nurses: A Translation and Psychometric Validation Study.

The global environment is continually changing; therefore, adaptability has become a crucial skill in most careers, including nursing. Career adaptability, which is essential to nurses' career development, influences nurse retention. However, to the best of our knowledge, no suitable tool has been developed for assessing the career adaptability of clinical nurses in Taiwan.

Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.

Background: Nocardia cyriacigeorgica, an opportunistic pathogen, is increasingly implicated in human infections. This pathogen predominantly causes pulmonary infections, leading to acute, subacute, or chronic necrotizing suppurative lesions, in severe cases, may progress to disseminated infections. Effective clinical diagnosis, prevention, and treatment strategies require a thorough understanding of its biological characteristics and pathogenic mechanisms.

Constructing Dense Morphology of Sn with High Reversibility under High Areal-capacity for Anode-Free Tin Batteries.

Sn electrode possesses high reversibility, redox kinetics and corrosion resistance, as well as non-toxic and environmental compatibility, which is competitive candidate for aqueous batteries. However, due to huge size of deposition particles and "dead Sn", it is a great challenge to obtain high areal-capacity (>5 mAh cm) and high coulombic efficiency (>99 %) simultaneously. Here, we demonstrate a highly reversible Sn redox electrochemistry with high areal-capacity enabled by thiourea additive.

Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction.

Background And Purpose: The incidence of autonomic dysfunction is frequently underestimated and often overlooked in patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). This study comprehensively analyzes the clinical manifestations, laboratory and imaging findings, and treatment modalities for patients demonstrating GFAP-A involvement in the autonomic nervous system. The present article primarily elucidates the prevalence and prognosis of diverse autonomic system symptoms while examining the associated laboratory and imaging indicators.

Diagnostic accuracy of high-resolution melting curve analysis for discrimination of oncology-associated mutations: a systematic review and meta-analysis.

Objective: To investigate the diagnostic value of high-resolution melting (HRM) analysis for oncology-associated epidermal growth factor receptor ( gene mutations.

Methods: We systematically searched Embase, PubMed, and Web of Science for HRM and mutation detection studies published through September 2024. True and false positives and negatives were extracted to evaluate the diagnostic accuracy of HRM to detect mutations.

Microstructure and Bioactivity of Ca- and Mg-Modified Silicon Oxycarbide-Based Amorphous Ceramics.

Silicon oxycarbide (SiOC), Ca- and Mg-modified silicon oxycarbide (SiCaOC and SiMgOC) were synthesized via sol-gel processing with subsequent pyrolysis in an inert gas atmosphere. The physicochemical structures of the materials were characterized by XRD, SEM, FTIR, and Si MAS NMR. Biocompatibility and in vitro bioactivity were detected by MTT, cell adhesion assay, and simulated body fluid (SBF) immersion test.

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.

Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood.