Diagnostic accuracy of high-resolution melting curve analysis for discrimination of oncology-associated mutations: a systematic review and meta-analysis.

Objective: To investigate the diagnostic value of high-resolution melting (HRM) analysis for oncology-associated epidermal growth factor receptor ( gene mutations.

Methods: We systematically searched Embase, PubMed, and Web of Science for HRM and mutation detection studies published through September 2024. True and false positives and negatives were extracted to evaluate the diagnostic accuracy of HRM to detect mutations.

Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla.

Attenuation of monoamine oxidase B (MAO-B) activity may provide protection against oxidative neurodegeneration. For this reason, inhibition of MAO-B activity is used as part of the treatment of Parkinson's and Alzheimer's patients. The hook of Uncaria rhynchophylla (Miq.