Ethanol Infusion of the Vein of Marshall in Catheter Ablation of Persistent Atrial Fibrillation in Patients with Mitral Valve Replacement.

Background: The effectiveness of ethanol infusion of the vein of Marshall (EIVOM) for persistent atrial fibrillation (AF) in patients with mitral valve replacement (MVR) remains to be determined.

Objectives: This study investigated the effectiveness and safety of EIVOM in catheter ablation of persistent AF in patients with MVR.

Methods: This is a retrospective case-control study.

Predictive value of sudden cardiac death risk stratification for outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy.

Background: Prediction models for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) incorporate factors that influence outcomes of catheter ablation (CA) of atrial fibrillation (AF).

Objective: This study aimed to investigate the outcomes of CA of AF in patients with HCM stratified by SCD risk.

Methods: Of the 23,904 patients who underwent CA of AF, 417 patients with HCM were screened.

Epidemiology of the global burden of atrial fibrillation among women of child-bearing age, 1990-2021: insights from the Global Burden of Disease Study 2021.

Background: This study aimed to analyze the global, regional, and national burden of atrial fibrillation (AF) in women of childbearing age (WCBA) from 1990 to 2021, to identify trends and disparities and to project the future burden of AF in population.

Methods And Results: Data from the GBD 2021 were used to estimate the burden of AF in WCBA. Age-standardized rates (ASRs) of incidence, prevalence, disability-adjusted life years (DALYs), and mortality rate were calculated from 1990 to 2021.

Aging China's cardiac challenge: Projected growth of atrial arrhythmia cases and healthcare preparedness through 2045 - A global burden disease analysis.

Atrial fibrillation/flutter (AF/AFL) poses significant risks of heart failure and stroke. From 1990 to 2021, China's AF/AFL cases surged from 3.20 to 10.

Additive effect of atherogenic index of plasma and social determinants of health on all-cause and cardiovascular mortality in U.S. adults with diabetes and prediabetes.

Aims: Diabetes and prediabetes present significant global health challenges, especially as the population ages. However, prediabetes is often under-recognized, and reliable predictors of long-term outcomes remain scarce. This study aimed to identify the most effective metabolic health-related indicator and combine it with Social Determinants of Health (SDoH) to enhance the accuracy of predicting long-term mortality in U.

Global burden of maternal hypertensive disorders (1990-2045): trends, regional disparities, and causal links to occupational exposures.

Background: Maternal Hypertensive Disorders (MHD), encompassing gestational hypertension, chronic hypertension, preeclampsia, and eclampsia, which was a significant contributor to maternal morbidity and mortality, particularly in regions with lower socioeconomic status.

Methods: Using data from the 2021 Global Burden of Disease (GBD) study, we analyzed the burden of MHD globally. We used the slope index and concentration index to measure cross-country inequality in MHD burden, and employed a Bayesian age-period-cohort (BAPC) model to project the burden from 2022 to 2045.

Exploring the predictive value of pH in stratified mortality risk of NEC patients undergoing surgery: a retrospective study based on the PIC database.

Background: Neonatal necrotizing enterocolitis (NEC) represents a severe gastrointestinal condition characterized by a high mortality rate, with a paucity of reliable prognostic biomarkers. The presence of an acidic pH, indicative of systemic acidosis and intestinal ischemia, has potential as a predictor of adverse outcomes. However, the relationship between pH levels and inflammatory markers, as well as its applicability across surgical and non-surgical patient subgroups, remains inadequately understood.

Global, regional, and national burden of alcoholic cardiomyopathy from 1990 to 2021: an age-period-cohort analysis using the global burden of disease 2021 study.

Background: As a serious public health problem, alcoholic cardiomyopathy (ACM) has caused a heavy burden of disease.

Methods: To summarize and deeply analyze the development trend of ACM at the global, regional, and national levels in the past 30 years, this study used the age-period-cohort model to analyze the age, period, and cohort effects of the prevalence, deaths, and disability-adjusted life years (DALYs) of ACM.

Results: The results found that the overall time trend of ACM prevalence, deaths, and DALYs had been decreasing worldwide, but the opposite trend was observed in some countries and regions.

Ablation characteristics associated with steam pops in ablation index-guided radiofrequency ablation of atrial fibrillation.

Aims: Steam pops present a significant concern during radiofrequency (RF) ablation of atrial fibrillation (AF). It is crucial to analyse the incidence and ablation characteristics associated with steam pops. This study aims to investigate the occurrence and potential predictors of steam pops.

Antiarrhythmic Drug Use in the Blanking Period After Re-Ablation and Recurrence in Paroxysmal Atrial Fibrillation.

Background: The effectiveness of continuous anti-arrhythmic drugs (AAD) therapy during the 3-month blanking period following repeat catheter ablation to prevent atrial fibrillation (AF) recurrence remains unclear. To evaluate the impact of continuous AAD therapy during the blanking period on AF recurrence in patients with paroxysmal atrial fibrillation (PAF) undergoing repeat ablation.

Methods: Patients with PAF who underwent repeat ablation from the China-AF Registry (2011-2022) were included in this study and categorized into two groups based on AAD use during the 3-month blanking period.

Iatrogenic aortic dissection during catheter ablation for ventricular arrhythmia.

Background: Attempted catheter manipulation through the retrograde aortic approach carries a risk of aortic dissection (AD) during catheter ablation.

Objective: This study aimed to determine the incidence, management, and outcomes of iatrogenic AD associated with ablation of ventricular arrhythmia (VA).

Methods: All patients who sustained iatrogenic AD during retrograde aortic VA ablation at 6 centers between January 1, 2011, and September 30, 2023, were prospectively identified.

Development and validation of a novel metabolic health-related nomogram to improve predictive performance of cardiovascular disease risk in patients with prediabetes.

Objective: The prevalence of prediabetes among adults in the U.S. is three times higher than that of diabetes, highlighting a greater disease burden.

Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calvé-Perthes disease.

Background: Legg-Calvé-Perthes disease (LCPD) commonly occurs among adolescents, threatening their health. However, the potential mechanism underlying LCPD remains unclear. miR-214-3p is shown as a critical role in LCPD development with unspecified upstream regulators.

Noninvasive platelet membrane-coated FeO nanoparticles identify vulnerable atherosclerotic plaques.

Vulnerable atherosclerotic plaques serve as the primary pathological basis for fatal cardiovascular and cerebrovascular diseases. The precise identification and treatment of these vulnerable plaques hold paramount clinical importance in mitigating the incidence of myocardial infarction and stroke. Nevertheless, the identification of vulnerable plaques within the diffuse atherosclerotic plaques dispersed throughout the systemic circulation continues to pose a substantial challenge in clinical practice.

Use of three-dimensional electroanatomic mapping for epicardial access: needle tracking, electrographic characteristics, and clinical application.

Aims: Pericardiocentesis is usually completed under fluoroscopy. The electroanatomic mapping (EAM) system allows visualizing puncture needle tip (NT) while displaying the electrogram recorded from NT, making it possible to obtain epicardial access (EA) independent of fluoroscopy. This study was designed to establish and validate a technique by which EA is obtained under guidance of three-dimensional (3D) EAM combined with NT electrogram.

Catheter ablation of atrial fibrillation in patients with left bundle branch block.

Background: Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation.

Construction and validation of a novel NAD metabolism-related risk model for prognostic prediction in osteosarcoma.

Currently, the prognosis of osteosarcoma (OS) remains discouraging, especially in elderly/metastatic OS patients. By impairing the antitumor effect of immune cells, tumor immune microenvironment (TIME) provides an environment conducive to tumor proliferation, which highly requires accelerated nicotinamide adenine dinucleotide (NAD) metabolism for energy. Recently, many genes involved in the sustained production of NAD in malignant tumors have been verified to be possible prognostic indicators and therapeutic targets.

Outcome of cancer patients after atrial fibrillation ablation: Insights from the China-AF registry.

Background: Cancer has become significant comorbidity in patients with atrial fibrillation (AF). However, little is known about the efficacy and safety of AF ablation, the first-line rhythm control strategy, in patients with cancer. This study aims to evaluate the incidence and risk of AF recurrence and safety endpoints in patients with cancer compared to the non-cancer group after ablation.

Targeting proteostasis network in osteoporosis: Pathological mechanisms and therapeutic implications.

As the most common bone disease, osteoporosis (OP) increases bone fragility and makes patients more vulnerable to the threat of osteoporotic fractures. With the ageing population in today's society, OP has become a huge and growing public health problem. Unfortunately, the clear pathogenesis of OP is still under exploration, and effective interventions are still scarce.

Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson's disease: a cross-sectional study.

Introduction: As the population ages, the incidence of osteoporosis among patients suffering from Parkinson's disease (PD) will surge continually, and the ensuing disability from falls is becoming a serious social burden. Due to its antioxidant properties, much literature has indicated the possible ability of serum uric acid (UA) to prevent ageing-related diseases caused by oxidative stress, including osteoporosis and PD. Therefore, this study was for exploring the connection of serum UA levels with bone mineral density (BMD) and the osteoporosis presence in Chinese PD patients.

Exosomes from chondrocytes overexpressing miR-214-3p facilitate M2 macrophage polarization and angiogenesis to relieve Legg Calvé-Perthes disease.

Objective: Legg-Calvé-Perthes disease (LCPD) is a partial or total necrosis of femoral head bone caused by blood supply disorder and its etiology is not clear. Studies have revealed that microRNA-214-3p (miR-214-3p) plays a vital role in LCPD, however, its exact mechanism is still unclear. In this study, we investigated the potential role of chondrocytes-derived exosomes carrying miR-214-3p (exos-miR-214-3p) in the pathogenesis of LCPD.

Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease.

Background: Legg-Calvé-Perthes disease (LCPD) is still a refractory disease in children's orthopedics. With the introduction of the concept of "osteoimmunology", the immune-inflammatory mechanisms between bone and immune system have become a research focus of LCPD. However, few studies have reported on the pathological role of inflammation-related receptors such as toll-like receptors (TLRs) as well as immune cells such as macrophages in LCPD.

Indirect bilirubin impairs invasion of osteosarcoma cells inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS.

Background: Osteosarcoma is most prevalently found primary malignant bone tumors, with primary metastatic patients accounting for approximately 25% of all osteosarcoma patients, yet their 5-year OS remains below 30%. Bilirubin plays a key role in oxidative stress-associated events, including malignancies, making the regulation of its serum levels a potential anti-tumor strategy. Herein, we investigated the association of osteosarcoma prognosis with serum levels of TBIL, IBIL and DBIL, and further explored the mechanisms by which bilirubin affects tumor invasion and migration.

Visualization and mapping of the right phrenic nerve by intracardiac echocardiography during atrial fibrillation ablation.

Objective: This study aimed to evaluate the feasibility of real-time visualization and mapping of the right phrenic nerve (RPN) by using intracardiac echocardiography (ICE) during atrial fibrillation (AF) ablation.

Background: RPN injury is a complication associated with the ablation of AF. Multiple approaches are currently being used to prevent and detect RPN injuries.