Bacteria-driven bio-electroactive sterilization.

Developing responsive antibacterial materials is crucial in addressing antibiotic overuse. While many materials respond to indirect external stimuli like pH, light, and enzymes, bacterial self-metabolism remains an underutilized activation mechanism for precision sterilization. Here, we present a self-sustaining bioreactor consisting of bacteria-reduced graphene oxide-copper biohybrids (BrGO-Cu), wherein living bacteria activate graphene oxide-copper ions (GO-Cu) for self-termination through metabolic redirection.

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain.

Discogenic pain, caused by intervertebral disc degeneration (IVDD), is a prevalent and challenging condition to treat effectively. Macrophage infiltration with neural ectopic in-growth resulting from structural disturbances within the intervertebral disc (IVD) is a major cause of discogenic pain. This work systematically reveals how nanoparticles can synergistically regulate the immune microenvironment and mitochondrial communication to attenuate discogenic pain.

Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis.

Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential of gallic acid (GA)-derived PGA-Cu nanoparticles, enhanced with functional octapeptide (Cys-Lys-His-Gly-d-Arg-d-Tyr-Lys-Phe, SS08) to build the mitochondria-targeted nanoparticles (PGA-Cu@SS08), and embedded within a hydrogel matrix to form a nanocomposite hydrogel, is explored.

Synergistic polyphenol-amino acid nanoparticles: a new strategy for reactive oxygen species management.

Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability and low bioavailability. To address these challenges, we developed polyphenol-amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability and bioavailability. These nanoparticles demonstrate significantly improved ROS scavenging efficiency and promote cell proliferation .

Enhancing antibacterial properties by regulating valence configurations of copper: a focus on Cu-carboxyl chelates.

Optimizing the antibacterial effectiveness of copper ions while reducing environmental and cellular toxicity is essential for public health. A copper chelate, named PAI-Cu, is skillfully created using a specially designed carboxyl copolymer (a combination of acrylic and itaconic acids) with copper ions. PAI-Cu demonstrates a broad-spectrum antibacterial capability both and , without causing obvious cytotoxic effects.

Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis.

Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it is important to block the harmful feedback caused by reactive oxygen species (ROS) produced during joint wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn (PGA-Mn) nanoparticles, oxidized sodium alginate, and gelatin.

Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu).

Harnessing gradient gelatin nanocomposite hydrogels: a progressive approach to tackling antibacterial biofilms.

Infectious wounds pose significant challenges due to their susceptibility to bacterial infections, hindering tissue repair. This study introduces gradient gelatin nanocomposite hydrogels for wound healing and antibacterial biofilm management. These hydrogels, synthesized UV light polymerization, incorporate copper-doped polydopamine nanoparticles (PDA-Cu) and GelMA (gelatin methacrylate).

Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases.

Laparoendoscopic single-site surgery (LESS) has become a novel minimally invasive approach applied as an option to perform hysterectomy. The aim of the study was to evaluate the influence of LESS hysterectomy on the sexual function in women with benign gynecologic indications. From October 2016 to May 2021, a total of 486 premenopausal, sexually active women were eligible.

Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain. The strategy of using functional materials to deliver nucleic acids provides a powerful tool for ameliorating IVDD. However, the immunogenicity of nucleic acid vectors and the poor mechanical properties of functional materials greatly limit their effects.

The potential therapeutic impacts of trehalose on cardiovascular diseases as the environmental-influenced disorders: An overview of contemporary findings.

Cardiovascular diseases (CVDs) as environmental-influenced disorders, are a major concern and the leading cause of death worldwide. A range of therapeutic approaches has been proposed, including conventional and novel methods. Natural compounds offer a promising alternative for CVD treatment due to their ability to regulate molecular pathways with minimal adverse effects.

Copper functionalized poly (acrylic acid-co-itaconic acid) nanohydrogel: Its antibacterial properties on oral pathogens and biocompatibility.

Although extensive efforts have been made to explore effective antibiotics, the development of antibiotics lags far behind the emergence of drug-resistant bacteria. Antimicrobial materials as an alternative strategy provide effective functions in aiding in relieving the dose of antibiotics. Herein, we report a novel antibacterial agent with high antibacterial effectivity and low toxicity, which is simply composed of a trace amount of Cu ion and nanoscale biocompatible polymer poly (acrylic acid-co-itaconic acid) (PAI-Cu).

Gold nanoparticles with helical surface structure transformed from chiral molecules for SERS-active substrates preparation.

Surface-enhanced Raman scattering (SERS) technique has enlarged the application of Raman spectroscopy, and the most crucial problem is the exploration of SERS-active materials. In the paper, a SERS substrate made of helical gold nanoparticles by the directed synthesis of L-glutathione (L-GSH) was proposed. Because of the large surface specific area and the uneven conduction electrons distribution for sharp tips resulted from the complex concave surface and the symmetry breaking structure, The nanostructure has shown an impressive average enhancement factor (EF) of 2.

Asymmetric barrier membranes based on polysaccharide micro-nanocomposite hydrogel: Synthesis, characterization, and their antibacterial and osteogenic activities.

Guided tissue regeneration (GTR) strategies enable periodontal tissue regeneration, generally by providing barrier membranes. However, currently available membranes have limited osteoconductive and antibacterial potential. To address these challenges, we fabricated a new asymmetric barrier membrane.

Differential Impacts on Bacterial Composition and Abundance in Rhizosphere Compartments between Al-Tolerant and Al-Sensitive Soybean Genotypes in Acidic Soil.

In this study, two soybean genotypes . aluminum-tolerant Baxi 10 (BX10) and aluminum-sensitive Bendi 2 (BD2) were used as plant materials and the acidic red soil was used as growth medium. The soil layers from the inside to the outside of the root are: rhizospheric soil after washing (WRH), rhizospheric soil after brushing (BRH) and rhizospheric soil at two sides (SRH), respectively.

Sequence isomerism-dependent self-assembly of glycopeptide mimetics with switchable antibiofilm properties.

In biological systems, diverse amino acid sequences and functional decorations endow proteins with specific functions. Functionally modified oligopeptides are attractive building blocks to assemble stimuli-responsive biomimetic superstructures for mimicking soft structures in nature and biomaterial applications. In this work, we selectively synthesized the structurally simplest isomeric tripeptides (, Ala-Gly-Gly-OH, Gly-Ala-Gly-OH and Gly-Gly-Ala-OH) to demonstrate how the subtlest change in sequence isomerism influences the self-assembly of glycopeptides.

Switchable modulation of bacterial growth and biofilm formation based on supramolecular tripeptide amphiphiles.

Design and fabrication of smart supramolecular peptide systems is an effective strategy to develop antibacterial agents that can be selectively activated/inactivated by external stimuli for combating bacterial resistance. In this work, we selectively synthesized isomeric tripeptides (i.e.

Reversible modulation of plasmonic chiral signals of achiral gold nanorods using a chiral supramolecular template.

We report here the fabrication of a multiple stimuli-responsive chiral plasmonic system based on the reversible self-assembly of phenylboronic acid-capped gold nanorods (PBA-Au NRs) guided by a supramolecular glycopeptide mimetic template. The plasmonic chiral signals of PBA-Au NRs can be reversibly switched on and off by temperature, light, pH and glucose concentration variations.

HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1.

In this study, we confirmed that HOXC13 might be a potential oncogene in lung adenocarcinoma through an analysis of The Cancer Genome Atlas (TCGA) datasets. Further analysis revealed that the expression of HOXC13 was significantly higher in lung adenocarcinoma tissues than in adjacent normal tissues; importantly, its expression correlated with poor clinical characteristics and worse prognosis. experiments showed that HOXC13 expression generally increased in lung adenocarcinoma cell lines.

Anisotropic particles from a one-pot double emulsion induced by partial wetting and their triggered release.

A family of anisotropic particles is synthesized via a facile, scalable, and versatile method based on a conventional double emulsion, which is very well suited for practical production and applications. Partial wetting theory is well established as a powerful instrument to elucidate the controlled phase separation within the double emulsion. This theory is employed to assist the manipulation of the phase separation process for the formation of well-defined nonspherical particles as well as their triggered release.

A photo-annealing approach for building functional polymer layers on paper.

A straightforward photo-annealing approach was developed for building functional polymer layers on paper. Conducting polyaniline with the ability for photothermal conversion can be readily annealed by near-infrared light. The annealed polymers become both insulating and hydrophobic.

Controllable and facile fabrication of gold nanostructures for selective metal-assisted etching of silicon.

A method with the combination of organic-vapor-assisted polymer swelling and nanotransfer printing (nTP) is used to manufacture desirable patterns consisting of gold nano-clusters on silicon wafers for Au-assisted etching of silicon. This method remarkably benefits to the size control and regional selection of the deposited Au. By tuning the thickness of the Au films deposited on the polydimethylsiloxane (PDMS) stamps, along with the swelling of PDMS stamps in acetone atmosphere, the Au films are cracked into diverse nanostructures.