Application of metal-organic framework-based reactive oxygen species therapy in cancer.

Reactive oxygen species (ROS) hold significant therapeutic potential in cancer treatment, with metal-organic framework (MOF)-based nanocarriers showing considerable promise for ROS-mediated therapies. This review systematically explores the advantages of MOFs in cancer treatment, focusing on their synthesis, structure, and biological applications. It further focuses on the efficacy of MOFs in ROS therapy, emphasizing their role in modulating the tumor microenvironment through Fenton/Fenton-like reactions and enzyme-like activity.

CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer.

The five-year survival rate of patients with colorectal cancer (CRC) liver metastasis is less than 30 %, and chemotherapy resistance and metastatic microenvironment remodeling are the current treatment bottlenecks. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) form a "CRCs-CAFs crosstalk" with colorectal cancer cells (CRCs) by secreting dense extracellular matrix (ECM), free fatty acids (FFA), and pro-metastatic factors, driving a vicious cycle of drug resistance and metastasis. During liver metastasis, hepatic stellate cells (HSCs)-derived CAFs (HSC-CAFs) promote tumor metastasis by remodeling the pre-metastatic microenvironment.

MIL-100(Fe)-based Co-delivery platform as cascade synergistic chemotherapy and immunotherapy agents for colorectal cancer via the cGAS-STING pathway.

Colorectal cancer (CRC) remains a major global health burden as the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. While combination chemotherapy and immune agonists hold potential to overcome tumor heterogeneity through multi-pathway modulation, their therapeutic efficacy remains limited by off-target drug distribution and immunosuppressive tumor microenvironment (TME). To address this, we developed a tumor-targeted chemo-immunotherapy platform by encapsulating irinotecan (CPT-11) and resiquimod (R848) in hyaluronic acid (HA) coated MIL-100(Fe) metal-organic frameworks (CRMH NPs), enabling CD44-mediated delivery and synergistic anti-tumor responses.

Soft multistable magnetic-responsive metamaterials.

The wireless actuation of magnetic soft architectures can enable complex functionalities important in biomedicine and soft robotics. However, transforming and maintaining a device's desired geometry without a sustained energy input remains challenging, especially where environmental stresses can be unpredictable. Here, we create a soft multistable magnetic-responsive metamaterial with programmable energy barriers enabled by a bistable geometry made entirely from soft material.

Toll-like receptors in B cells and obesity.

Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, primarily by detecting pathogen-associated molecular patterns (PAMPs) and orchestrating immune responses. Although TLR-driven activation of dendritic cells (DCs) and subsequent T cell differentiation are well characterized, the function of TLRs in B cells remains underexplored. In the context of obesity, excessive adipose tissue accumulation triggers chronic inflammation driven in part by activation of TLR signaling.

Active Organic Salts Enabling Non-Intrusive Electrolyte Presodiation Strategy.

Na-ion batteries show great promise, but their practical utilization is hindered by irreversible Na-ion loss during cell formation, resulting in initial coulombic efficiencies typically below 80%. Conventional presodiation methods, which involve solid additives in the cathode, can compromise electrode integrity and leave deteriorated residues, especially with high Na ion compensation (20%). An electrolyte presodiation approach is introduced that utilizes sodium thiocyanate (NaSCN) as an electrolyte additive, discovered through cheminformatics and machine learning.

Harmonically Induced Shape Morphing of Bistable Buckled Beam with Static Bias.

We investigate the effect of a constant static bias force on the dynamically induced shape morphing of a pre-buckled bistable beam, focusing on the beam's ability to change its vibration to be near different stable states under harmonic excitation. Our study explores four categories of oscillatory motions: switching, reverting, vacillating, and intra-well in the parameter space. We aim to achieve transitions between stable states of the pre-buckled bistable beam with minimal excitation amplitude.

Compensating K Ions Through an Organic Salt in Electrolytes for Practical K-Ion Batteries.

K-ion batteries face significant challenges due to a severe shortage of active K ions, with cathode materials typically containing less than 70% K ions and first-cycle irreversible reactions consuming up to 20% more. Conventional K-ion compensation methods fail to supply sufficient K ions without compromising cell integrity. To address this, we introduce potassium sulfocyanate (KSCN) as an electrolyte additive capable of delivering up to 100% active K ions.

Development and validation of the ethnic trust scale in China.

Background: Considerable research has shown that ethnic trust reflects the existence of friendly relations among all ethnic groups and ethnic individuals, and can help in resolving ethnic conflicts and contradictions, promoting exchanges among various ethnic groups, which is highly relevant to social stability.

Methods: This research, including three studies, aimed to explore the conceptual structure of ethnic trust in China, and develop and validate a measurement of the ethnic trust scale. In the first study, we used free association and in-depth interview methodology, applied cluster analysis, multidimensional scaling analysis, and grounded theory to construct the theoretical framework of Chinese people's ethnic trust concept.

Asymmetric electron occupation of transition metals for the oxygen evolution reaction a ligand-metal synergistic strategy.

The performance of two-dimensional transition-metal (oxy)hydroxides (TMOOHs) for the electrocatalytic oxygen evolution reaction (OER), as well as their large-scale practical applications, are severely limited by the sluggish kinetics of the four-electron OER process. Herein, using a symmetry-breaking strategy, we simulated a complex catalyst composed of a single Co atom and a 1,10-phenanthroline (phen) ligand on CoOOH through density functional theory studies, which exhibits excellent OER performance. The active site Co undergoes a valence oscillation between +2, +3 and even high valence +4 oxidation states during the catalytic process, resulting from the distorted coordination effect after the ligand modification.

Bimetal Metaphosphate/Molybdenum Oxide Heterostructure Nanowires for Boosting Overall Freshwater/Seawater Splitting at High Current Densities.

Exploring excellent non-noble bifunctional electrocatalysts for freshwater/seawater splitting at high current densities has attracted extensive interest owing to strong anodic oxidation and severe chloride corrosion challenges. Herein, hierarchical bimetal Ni-Co metaphosphate/molybdenum oxide heterostructure nanowires (NiCoMoPO) are rationally designed and fabricated to efficiently boost oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in alkaline freshwater/seawater, where the favorable electronic structure from heterostructures, signified by X-ray absorption spectra, endows NiCoMoPO with the enhanced intrinsic activity, while its hierarchical nanowire structure and heterostructures provide abundant active sites. Additionally, the PO improves the chloride-corrosion resistance and efficiently facilitates the OER kinetics verified by theoretical and experimental studies.

A NIR-II absorbing conjugated polymer based on tetra-fused isoindigo with ultrahigh photothermal conversion efficiency for cancer therapy.

A conjugated polymer, P4TTD-DPP, based on tetra-fused isoindigo--diketopyrrolopyrrole, has been synthesized as a photothermal therapeutic nanotransducer within the near-infrared-II (NIR-II) window. P4TTD-DPP exhibits a notable mass extinction coefficient of 62.8 L g cm at 1064 nm.

Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10 Breg cells and protect against T1D.

Introduction: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β cells. Toll-like receptor 9 (TLR9) plays a role in autoimmune diseases, and B cell-specific TLR9 deficiency delays T1D development. Gut microbiota are implicated in T1D, although the relationship is complex.

[Response of radial growth of to climate change in Mount Qomolangma, Tibet, China].

Global warming would significantly impact tree growth in the Tibetan Plateau. However, the specific effects of climate change on the radial growth of in Mount Qomolangma are still uncertain. To investigate the responses of radial growth of to climate change, we analyzed tree-ring samples in Mount Qomolangma.

Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis.

Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell-specific Tlr9-deficient (Tlr9/Cd19Cre, KO) B6 mice and model obesity using a high-fat diet.

Shimmering emerging adulthood: in search of the invariant IDEA model for collectivistic countries.

Emerging adulthood is the youth trajectory characterized by self-focus, identity exploration, feeling between adolescence and adulthood, instability, and experimentation. This trajectory was first identified in industrialized individualistic countries with gender equality and technological progress. To measure transition to adulthood, the Inventory of the Dimensions of Emerging Adulthood () was created.

Aqueous Electroreduction of Nitric Oxide to Ammonia at Low Concentration via Vacancy Engineered FeOCl.

Electroreduction of nitric oxide (NO) to NH (NORR) has gained extensive attention for the sake of low carbon emission and air pollutant treatment. Unfortunately, NORR is greatly hindered by its sluggish kinetics, especially under low concentrations of NO. Herein, we developed a chlorine (Cl) vacancy strategy to overcome this limitation over FeOCl nanosheets (FeOCl-V ).

Characterizing Mechanical Properties of Layered Engineered Wood Using Guided Waves and Genetic Algorithm.

This study develops a framework for determining the material parameters of layered engineered wood in a nondestructive manner. The motivation lies in enhancing nondestructive evaluation (NDE) and quality assurance (QA) for engineered wood or mass timber, promising construction materials for sustainable and resilient civil structures. The study employs static compression tests, guided wave measurements, and a genetic algorithm (GA) to solve the inverse problem of determining the mechanical properties of a laminated veneer lumber (LVL) bar.

Drawing Dispersion Curves: Band Structure Customization via Nonlocal Phononic Crystals.

Dispersion relations govern wave behaviors, and tailoring them is a grand challenge in wave manipulation. We demonstrate the inverse design of phononic dispersion using nonlocal interactions on one-dimensional spring-mass chains. For both single-band and double-band cases, we can achieve any valid dispersion curves with analytical precision.

Fractal patterns in the parameter space of a bistable Duffing oscillator.

We study the dissipative bistable Duffing oscillator with equal energy wells and observe fractal patterns in the parameter space of driving frequency, forcing amplitude, and damping ratio. Our numerical investigation reveals the Hausdorff fractal dimension of the boundaries that separate the oscillator's intrawell and interwell behaviors. Furthermore, we categorize the interwell behaviors as three steady-state types: switching, reverting, and vacillating.

Thienoisoindigo-Based Conjugated Polymers Synthesized by Direct Arylation Polycondensation.

A series of thienoisoindigo (TIG)-based conjugated polymers (CPs) with high molecular weights are synthesized by direct arylation polycondensation (DArP) by using TIG derivatives as CBr monomer and multi-halogenated thiophene derivatives, i.e., (E)-1,2-bis(3,4-difluorothien-2-yl)ethene (4FTVT), (E)-1,2-bis(3,4-dichlorothien-2-yl)ethene (4ClTVT), 3,3',4,4'-tetrafluoro-2,2'-bithiophene (4FBT), and 3,3',4,4'-tetrachloro-2,2'-bithiophene (4ClBT), as CH monomers.

MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335-5p signaling pathway.

Background: The decreased osteogenic differentiation ability of mesenchymal stem cells (MSCs) is one of the important reasons for SOP. Inhibition of Wnt signaling in MSCs is closely related to SOP. Microtubule actin crosslinking factor 1 (MACF1) is an important regulator in Wnt/β-catenin signal transduction.

Erratum: Origin of amplitude synchronization in coupled nonidentical oscillators [Phys. Rev. E 101, 022210 (2020)].

This corrects the article DOI: 10.1103/PhysRevE.101.

Construction of stable MoS/CeO heterostructures for the electrocatalytic hydrogen evolution reaction.

The unique structures of polynuclear MoS clusters make it possible to maximize the number of their active sites and for them to be good candidates for HER catalysts. An appropriate support is highly necessary not only to avoid the desorption of MoS clusters in a working environment, but also to improve their HER activity. Our work here shows that the CeO support could provide strong support for interaction with various MoS clusters and the formed MoS/CeO hetero-structures also have modest Δ for the HER.