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A conjugated polymer, P4TTD-DPP, based on tetra-fused isoindigo--diketopyrrolopyrrole, has been synthesized as a photothermal therapeutic nanotransducer within the near-infrared-II (NIR-II) window. P4TTD-DPP exhibits a notable mass extinction coefficient of 62.8 L g cm at 1064 nm. Additionally, P4TTD-DPP nanoparticles demonstrate remarkable photothermal conversion efficiency of 91.5% at 1064 nm and exhibit excellent anticancer efficacy under photothermal conditions.
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http://dx.doi.org/10.1039/d4cc02546f | DOI Listing |
Int J Biol Macromol
September 2025
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, 400019, India. Electronic address:
Polysaccharide copolymers Conjuates have surfaced as a versatile foundation in the development of advanced smart drug delivery systems, owing to their inherent biocompatibility, biodegradability, and capacity for chemical modification. This review brings into focus the recent advances in co-polymeric drug delivery systems based on naturally occurring polysaccharides like chitosan, alginate, dextran, hyaluronic acid, pullulan, guar gum, xanthan gum, agarose, gellan gum, and starch. Their structural malleability and functionalization capabilities are emphasized to engineer therapeutic payload stability, bioavailability, and controlled release.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Chemistry and Biochemistry, School of Materials Science and Engineering, Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Molecular spin systems that can be chemically tuned, coherently controlled, and readily integrated within devices remain central to the realization of emerging quantum technologies. Organic high-spin materials are prime candidates owing to their similarity in electronic structure to leading solid-state defect-based systems, light element composition, and the potential for entanglement and qubit operations mediated through spin-spin exchange. However, the inherent instability of these species precludes their rational design, development, and application.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Key Laboratory of Hebei Province for Molecular Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300401, P.R. China.
Polythiophene-based nanoparticles (PTNPs), a prominent class of conjugated polymer nanoparticles (CPNs) with remarkable optical and electronic properties, have gained significant attention in applications such as electronics and bioimaging. However, current methods in generating PTNPs have run into obstacles including low variety of morphologies, poor reproducibility, and low preparation efficiency, restricting their further application. In this study, we report a facile and efficient fabrication strategy based on template synthesis method.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Department of Pharmaceutical Analysis, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra 400056, India. Electronic address:
Gum Arabic (GA), a naturally occurring polysaccharide, has emerged as a promising biomaterial for drug delivery systems (DDS) due to its high water solubility, emulsifying capacity, biocompatibility, and biodegradability. Its structural richness in arabinogalactan facilitates strong interactions with biomolecules, enabling the development of various drug formulations including hydrogels, nanoparticles, liposomes, and emulsions. GA-based DDS have demonstrated significant potential in enhancing the solubility of poorly water-soluble drugs, protecting bioactive compounds from degradation, and enabling sustained and controlled drug release.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Cellulose nanocrystals (CNCs) have garnered attention for their renewable and reactive nature, yet CNC allomorph II (CNC-II) remains underexplored compared to the extensively studied CNC-I. This study bridges this gap by introducing a two-step carboxylamine condensation strategy to conjugate poly(ethylene glycol) (PEG) onto CNC-II via ethylenediamine, leveraging the high topochemical reactivity of CNC-II. Utilizing bicarboxylate-capped PEG as a probe, quartz crystal microbalance with energy dissipation (QCM-D) assays revealed a significant reactivity increase of 16.
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