A clinical study of shoulder arthroscopic rotator cuff repair on the psychological function of patients after operation.

Background: Recently, psychological function in patients who underwent rotator cuff repair has been emphasized. However, the relationship of psychological function and clinical outcomes after rotator cuff repair is still poorly understood. This study aims to investigate the impact of arthroscopic rotator cuff repair on psychological status.

Improving the Fenton-like catalytic performance of MnO-FeO/biochar using reducing agents: A comparative study.

In this work, a Fenton-like system with MnO-FeO/biochar composite (FeMn/biochar) and reducing agents (RAs) was constructed for pollutant degradation, aiming to enhance Fenton-like performance from both degradation efficacy and operational cost aspects. Batch experiments revealed that five well-characterized RAs (sodium borohydride (SBH), sodium thiosulfate (STS), ascorbic acid (AA), hydroxylamine (HA) and oxalic acid (OA)) could impact performance of FeMn/biochar-HO system through multiple mechanisms, including variation of solution pH, competition for HO, electrostatic attraction and acceleration of metal redox cycle. Significantly, only OA and HA obviously enhanced the catalytic capacity of Fenton-like process and HA increased ciprofloxacin degradation efficiency from 38.

Spatial Optimization of Residential Care Facility Configuration Based on the Integration of Modified Immune Algorithm and GIS: A Case Study of Jing'an District in Shanghai, China.

As the population is aging rapidly, the irrationality of residential care facility (RCF) configuration has impacted the efficiency and quality of the aged care services so significantly that the optimization of RCF configuration is urgently required. A multi-objective spatial optimization model for the RCF configuration is developed by considering the demands of three stakeholders, including the government, the elderly, and the investor. A modified immune algorithm (MIA) is implemented to find the optimal solutions, and the geographic information system (GIS) is used to extract information on spatial relationships and visually display optimization results.

Vacuum Ultraviolet Photodissociation Branching Ratios of CO, CO, and CO from 100500 to 102320 cm.

The C ion photofragment spectra and photodissociation branching ratios into the two energetically available channels, C(D) + O(P) and C(P) + O(P), have been obtained for the three CO isotopologues, CO, CO, and CO, in the vacuum ultraviolet range 100500-102320 cm. The two vibronic states of Σ symmetry, F(3dσ) Σ(υ' = 1) and J(4sσ) Σ(υ' = 0), predominantly dissociate into the lowest channel C(P) + O(P) through interactions with the repulsive D'Σ state. All three vibronic states of Π symmetry, E'Π(υ' = 1, 2) and G(3dπ) Π(υ' = 0), dissociate into both of the channels above.

Upregulated β-arrestin1 predicts poor prognosis and promotes metastasis via AKT/ERK signaling pathway in gastric cancer.

Background: β-Arrestins have been found to regulate cell proliferation, invasion and migration; transmit anti-apoptotic survival signals; and affect other characteristics of tumours. However, their role in gastric cancer (GC) is not clear. We investigated the role and mechanism of β-arrestins in the regulation of GC.

RNA-seq reveals the diverse effects of substrate stiffness on epidermal ovarian cancer cells.

Background: Increasing evidence has confirmed that ovarian cancer is a mechanically responsive tumor both and . However, an understanding of the complete molecular mechanism involved in the response to substrate stiffness is lacking, as the associated transcriptome-wide effects have not been mapped. This limited understanding has restricted the identification of potential mechanically responsive targets in ovarian cancer.

CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis.

A number of circular RNAs (circRNAs) have been implicated in rheumatoid arthritis (RA) pathogenesis; however, little is known about their function and hidden molecular mechanism in immune and inflammation regulation. We investigated the role and the underlying mechanism of circRNA_09505 in RA in this study. Real-time PCR and fluorescence in situ hybridization (FISH) are adopted to estimate the quantitative expression and localization of circRNA_09505 in macrophages.

Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives.

Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between -haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties.

Mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles: Potential roles in rheumatic diseases.

Background: Mesenchymal stem cells (MSCs) have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties. Recently, mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they produce. Extracellular vesicles (EVs) derived from MSCs have been identified as a promising cell-free therapy due to low immunogenicity.

Progress and challenges of metal-organic frameworks-based materials for SR-AOPs applications in water treatment.

As environmental problems become more and more severe, sulfate radical (SO) based advanced oxidation processes (SR-AOPs) are widely recognized for their high removal efficiency of recalcitrant organic pollutants in water. Metal-organic frameworks (MOFs) have attracted wide attention in SR-AOPs due to their outstanding properties (e.g.

Determining and mapping the spatial mismatch between soil and rice cadmium (Cd) pollution based on a decision tree model.

Environmental complexity leads to differences in the spatial distribution of heavy metal pollution in soil and rice. Such spatial differences will seriously affect the safety of planted rice and can impact regional management and control. How to scientifically reveal these spatial differences is an urgent problem.

Biophysical signal transduction in cancer cells: Understanding its role in cancer pathogenesis and treatment.

Signaling between cells can promote both the development and progression of cancer. It has been found that chemical and physical signals, together with extracellular factors, can influence cancer progression. In this review, we focus on the physical microenvironment of cancer cells and examine the action of mechanical, electromagnetic, thermal, and acoustic signals on cancer cells, which may provide new directions for cancer research and treatment.

Degradation of sulfamethazine by biochar-supported bimetallic oxide/persulfate system in natural water: Performance and reaction mechanism.

The rapid development of aquaculture results in the increased concentrations and kinds of antibiotics in water environment, and the sharply growing antibiotic contamination has caused increasing concerns. Herein, an innovative sulfamethazine (SMT) removal approach was developed by activation of persulfate (PS) using biochar-based materials prepared by co-precipitation and pyrolysis: Fe-Mg oxide/biochar (FeMgO/BC). Experiments on the activation of PS by FeMgO/BC under different factors were carried out.

In-situ self-assembly construction of hollow tubular g-CN isotype heterojunction for enhanced visible-light photocatalysis: Experiments and theories.

A highly reactive hollow tubular g-CN isotype heterojunction (SCN-CN) was designed to enhance visible light absorption and manipulate the directed transfer of electrons and holes. The results of UV-vis DRS, XPS valence band and DFT theoretical calculations indicated S doping increases the visible-light absorption capacity and changed the ba nd gap structure of g-CN (CN), resulting in the transfer of electrons from the CN to the SCN and holes from the SCN to the CN under visible light. In addition, the tubular structure of the SCN-CN facilitated the transfer of electrons in the longitudinal direction, which reduced charge carrier recombination.

Reinvestigation of the Rydberg WΠ(ν = 1) level of CO, CO, and CO through rotationally dependent photodissociation branching ratio measurements.

A recent high resolution photoabsorption study revealed that the Rydberg WΠ(ν = 1) level of carbon monoxide (CO) is perturbed by the valence E″Π(ν = 0) level, and the predissociation linewidth shows drastic variation at the crossing point due to the interference effect [Heays et al., J. Chem.

Metagenomic analysis of the lung microbiome in pulmonary tuberculosis - a pilot study.

The lung microbiome plays an important role in the pathophysiological processes associated with pulmonary tuberculosis (PTB). However, only a few studies using 16S rDNA amplicon sequencing have been reported, and the interactions between (MTB) and the lung microbiome remain poorly understood. Patients with respiratory symptoms and imaging abnormalities compatible with tuberculosis (TB) were enrolled.

Boosting Transport Kinetics of Cobalt Sulfides Yolk-Shell Spheres by Anion Doping for Advanced Lithium and Sodium Storage.

Cobalt sulfides have been popularly used in energy storage because of their high theoretical capacity and abundant redox reactions. However, poor reaction kinetics, rapid capacity decay, and severe polarization owing to volume changes during electrochemical reaction are still huge challenges for cobalt sulfides in practical applications. Herein, cobalt sulfide yolk-shell spheres were synthesized by phosphorus doping (P-CoS) to stabilize the structure of cobalt sulfides and improve their electronic/ion conductivity.

miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.

Objective: To seek the clinical significance and regulatory mechanism of miR-135a and Rho-associated protein kinase 1 (ROCK1) in non-small cell lung cancer (NSCLC).

Methods: NSCLC cells were purchased, and miR-135a-mimics, miR-135a-inhibitor, miR-NC, si-ROCK1 and Sh-ROCK1 were transfected into NSCLC cells HCC827 and NCI-H524. qRT-PCR and Western blot were used to detect the expression of miR-135a, ROCK1, Bax, Caspase3, Bcl-2, N-cadherin, vimentin and E-cadherin.

Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel.

Although endothelial progenitor cells (EPCs) are considered to be an essential source of vascular endothelial repair, their bidirectional differentiation determines that they play a double-edged role in the restoration of endothelial injury. In this research, we investigated the effect of Kir2.1 ion channel on the transdifferentiation of endothelial progenitor cells (EPCs) under the oscillating shear stress (OSS) and the molecular mechanisms underlying the pathological vascular remodeling.

Crosslinked Hyaluronic Acid Gels for the Prevention of Intrauterine Adhesions after a Hysteroscopic Myomectomy in Women with Submucosal Myomas: A Prospective, Randomized, Controlled Trial.

Intrauterine adhesion (IUA), fibrosis, and scarring resulting from damage to the endometrium is a rare but serious clinical disease, contributing to a significant impairment of reproductive function. Uterine instrumentation, especially that of a hysteroscopic myomectomy, has become the main cause of IUA. Therefore, a prospective randomized controlled study to assess the effectiveness and short-term safety of the use of hyaluronic acid gels in the prevention of IUA after a hysteroscopic myomectomy and an evaluation of the characteristics of IUA observed at follow-up are presented here.

Insights into catalytic removal and separation of attached metals from natural-aged microplastics by magnetic biochar activating oxidation process.

Natural-aged microplastics with changed surface properties accumulate, redistribute and spread in all water fields as carriers of hazardous substances. The combined hazard of co-contamination of microplastics and hazardous substances expands the ecological risks, which urgently needs to design treatment schemes for pollutant removal from microplastics. In this paper, a facile and applicable magnetic biochar with porosity and graphitization (PGMB) was prepared for realizing the goal of metal removal from the microplastics.

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins.

Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs consist of embryo-derived (EMRMs) and bone marrow-derived RMs (BMRMs), but the fate, dynamics, replenishment, functions and metabolic states of these two RM populations remain unclear. Here we investigate and characterize RMs at different ages by conditionally labeling and ablating RMs populations in several transgenic lines.

Oscillatory shear stress induces the transition of EPCs into mesenchymal cells through ROS/PKCζ/p53 pathway.

Aims: Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the mechanism involved.

Distinct lung microbial community states in patients with pulmonary tuberculosis.

An improved understanding of the lung microbiome may lead to better strategies to diagnose, treat, and prevent pulmonary tuberculosis (PTB). However, the characteristics of the lung microbiomes of patients with TB remain largely undefined. In this study, 163 bronchoalveolar lavage (BAL) samples were collected from 163 sputum-negative suspected PTB patients.