From Spiropyran to a Circadian-Responsive Photochromic Supramolecular System for Sustainable Crop Protection: Enhanced Photostability, Biofilm Disintegration, and Foliar Adhesion.

Biofilms establish protective sanctuaries that shield resident bacteria, facilitating resistance. Despite extensive efforts, current chemicals for biofilm eradication remain insufficient, with the reliance on single-structure antimicrobials further exacerbating resistance. Photoisomerizable spiropyran derivatives reversibly transition between conformational states, alternately exerting antimicrobial activity against pathogens and potentially mitigating resistance.

Identification of candidate genes for grain size in barley through combined GWAS and transcriptome analysis.

Barley (Hordeum vulgare L.) is an important cereal crop with diverse uses, including animal feed, beer brewing, and food production. Grain size plays a crucial role in determining grain weight and quality, which is one of the key breeding objectives in response to market and industry demands.

Clinical features and novel pathogenic variants of patients with Behçet's disease like trisomy 8.

Purpose: Chromosomal abnormalities, such as Trisomy 8 (T8), and genetic mutations may contribute to the unique clinical phenotype of Behçet's Disease (BD). This study aims to characterize the clinical and genetic features of patients presenting with BD-like symptoms associated with T8 (T8-BD).

Methods: We analyzed a cohort of 8 patients with T8-BD and associated genetic variants, including 1 newly identified case from our center and 7 previously reported in the literature.

Exploring experiences of healthcare and clinical challenges for Deaf people: for better healthcare equity! A mixed-methods study protocol.

Introduction: China is home to the world's largest deaf population, yet there remains a dearth of knowledge regarding the healthcare experiences and challenges encountered by this community, as well as the factors influencing their healthcare encounters. This protocol will outline a mixed-methods study aimed at gaining comprehensive insights into the healthcare experiences and challenges faced by the Deaf population in China.

Methods And Analysis: This study will adopt a mixed research design strategy in relation to the cultural context of the Deaf population.

Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis.

Objective: Curcumin extracted from the rhizome of Curcuma longa has anti-inflammatory, antioxidant and antitumour properties. In previous studies, curcumin has been reported to have therapeutic effects on systemic lupus erythematosus (SLE), in which the upregulation of double-negative T (DNT) cells was detected. Therefore, the purpose of this study is to explore the role of curcumin in the remission of SLE by regulating DNT cell homeostasis.

Assembling Hexahedral Supramolecular Nano-Aggregates on Rice Wax Layer Matrices to Promote the Leaf Deposition and Bioavailability of Bactericides for Plant Protections.

Naturally hydrophobic wax layer microstructures in plants seriously hinder the leaf adhesion and deposition of pesticide droplets, thereby causing low pesticide bioavailability and inevitable environmental pollution. Inspired by the supramolecular self-assembly strategy, two anisotropic supramolecular building units (BiTA18@β-CD and BiTA18@γ-CD) are invented based on the host-guest complexation between a benzimidazole-modified bactericidal molecule (BiTA18) and β-/γ-cyclodextrin (β-CD/γ-CD), which self-assemble into nano-sized hexagonal cuboids on the rice microcrystalline matrix. This consequence markedly enhances the retention of bactericidal ingredients on target plants.

In Situ Reducible Ionic Frameworks for Dual-Site and Photothermal Catalysis.

Ionic frameworks (IFs), characterized by ionic bonds and periodic framework structures, find extensive applications in several fields. However, the inherent high bond energy of ionic bonds often leads to the formation of close-packed structures rather than open frameworks. Consequently, the selection of suitable building units is pivotal for the successful synthesis of IFs.

Silicon-coated carbon quantum dots composite nanomaterials mediate pest resistance activation in tobacco (Nicotiana tabacum).

Background: Plant resistance inducers based on nanomaterials (NMs) are a cutting-edge and promising field of interdisciplinary research, focused on developing environmentally and ecologically friendly alternatives for protecting crops. Studies have shown that NMs composed of silicon (SiO) and carbon quantum dots (CDs) can help plants better withstand various environmental and pest-related stresses.

Results: We synthesized and characterized SiO-coated CDs (SiO@CDs) NMs that were found to be absorbed by tobacco leaves.

Artificial intelligence-assisted diagnosis of early allograft dysfunction based on ultrasound image and data.

Early allograft dysfunction (EAD) significantly affects liver transplantation prognosis. This study evaluated the effectiveness of artificial intelligence (AI)-assisted methods in accurately diagnosing EAD and identifying its causes. The primary metric for assessing the accuracy was the area under the receiver operating characteristic curve (AUC).

Heterogeneity of peripheral immune cell landscape in systemic lupus erythematosus patients after belimumab treatment.

Objectives: The diversity and heterogeneity of circulating immune cells have been extensively investigated in systemic lupus erythematosus (SLE). However, little is known about the influence of belimumab, an anti-BAFF (B cell-activating factor) monoclonal antibody, on the heterogeneity of peripheral immune cell landscape in SLE patients. In this study, we aimed to investigate the altering effect of belimumab on autoimmunity in SLE.

Rhodamine/Cucurbit[8]uril Co-assembled supramolecular aggregates realize the precise and enhancive bioimaging of plant active signals.

Fluorescent molecular probes are commonly used to detect active substances. However, in variable living microenvironmental systems, most of conventional aromatic fluorescent probes often suffer from aggregation-caused quenching (ACQ) due to π-π stacking, which severely limit their selective recognition and bioimaging functions. To tackle this challenge, we devise an structurally novel small-molecule-adamantane-modified Rhodamine probe (RAA) and employ a predictable cucurbit[8]uril (Q[8])-involved host-guest supramolecular strategy to optimize molecular aggregation behaviors at the molecular level, thereby creating supramolecular aggregates (RAA@Q[8]) as an innovative fluorescent probe.

From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control.

Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves, resulting in poor efficacy, further impaired by biofilms and Type III Secretion Systems (T3SS). Herein, this study presents a supramolecular strategy to fabricate BtP27@β-CD, a sunflower-like material engineered through host-guest recognition between de novo designed molecule BtP27 and β-cyclodextrin. BtP27@β-CD manifests enhanced foliar affinity and in vivo efficiency, demonstrating superior protective (62.

A supramolecular bactericidal material for preventing and treating plant-associated biofilms.

Treating bacterial biofilms on plants poses challenges due to biofilm induced resistance and poor agent adhesion on plant leaves. Here, we report on a host-guest self-assembled material which is biocompatible, has a lamellar supramolecular structure for leaf retention and prevents and treats bacterial biofilms. Phosphate/isopropanolamine-modified ferrocene forms a host-guest complex with β-CD which assembles into a lamella structure.

Integrated metabolomic and transcriptomic strategies to reveal adaptive mechanisms in barley plant during germination stage under waterlogging stress.

Barley (Hordeum vulgare L.) is an important cereal crop used in animal feed, beer brewing, and food production. Waterlogging stress is one of the prominent abiotic stresses that has a significant impact on the yield and quality of barley.

Fabrication of Multifunctional Three-Component Supramolecular Nano-Biscuits via Two Macrocycles-Involved Self-Assembly for Rice, Citrus and Kiwifruit Protections.

Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three-component supramolecular nano-biscuits (NI6R@CB[7]@β-CD) are successfully engineered via ordered self-assembly between two macrocycles [cucurbit[7]uril (CB[7]), β-cyclodextrin (β-CD)] and (R)-2-naphthol-based bis-imidazolium bromide salt (NI6R).

From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker.

Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites.

Exploring the nexus between financial inclusion, governance, and carbon emissions in SAARC countries.

This study examines the impact of financial inclusion (FI) and institutional quality (INSQ) on carbon dioxide (CO) emissions in South Asian Association for Regional Cooperation (SAARC) economies, using data from 2004 to 2022. The hypotheses were tested using a generalized method of moments (GMM) approach. Beside, a robust moment method quantile regression (MM-QR) static model and Granger causality tests were employed to validate the results.

Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases.

Recent outbreaks of alarming bacterial diseases have significantly impacted global agricultural productivity. Conventional bactericides exhibit certain limitations in efficiently impeding biofilm formation and annihilating biofilm-dispersed pathogens, and often expose to high off-target movement during foliar spraying. Here, we produce an innovative helical dendrimer-like supramolecular material (PhA28@β-CD) assembled by a bioactive small-molecule 2-chlorophenylisopropanolamine (PhA28) and β-cyclodextrin (β-CD) through host-guest recognition principle.

β-Cyclodextrin-optimized supramolecular nanovesicles enhance the droplet/foliage interface interactions and inhibition of succinate dehydrogenase (SDH) for efficient treatment of fungal diseases.

Background: Plant fungal diseases present a major challenge to global agricultural production. Despite extensive efforts to develop fungicides, particularly succinate dehydrogenase inhibitors (SDHIs), their effectiveness is often limited by poor retention of fungicide droplets on hydrophobic leaves. The off-target losses and unintended release cause fungal resistance and severe environmental pollution.

Effectiveness of topical corticosteroids on the prevention of acute radiation dermatitis in patients with breast cancer: An updated systematic review and meta-analysis.

Objectives: To evaluate the effect of topical corticosteroids (TCS) in preventing acute radiation dermatitis in patients with breast cancer.

Methods: An updated systematic review and meta-analysis were conducted following the preferred reporting items for systematic reviews and meta-analyses. Randomized controlled trials (RCTs) in six English databases (PubMed, Web of Science, Scopus, CINAHL, Cochrane Library, Embase), three Chinese databases (Sinomed, China National Knowledge Infrastructure, Cqvip), and two clinical trial registration platforms (CHICTR, Clinicaltrials.

Removal of intracellular and extracellular antibiotic resistance genes and virulence factor genes using electricity-intensified constructed wetlands.

Constructed wetland (CW) is considered a promising technology for the removal of emerging contaminants. However, its removal performance for antibiotic resistance genes (ARGs) is not efficient and influence of virulence factor genes (VFGs) have not been elucidated. Here, removal of intracellular and extracellular ARGs as well as VFGs by electricity-intensified CWs was comprehensively evaluated.

Diclofenac sodium nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the spinal cord of SNI rats.

Neuropathic pain is chronic pain caused by a lesion or disease of the somatosensory nervous system. Neuropathic pain, with a high incidence and complex pathogenesis, is one of the most significant areas of clinical medicine and basic research. Currently, prescribed treatments are still unsatisfactory or have limited effectiveness.