Reduced Peak Myocardial Work Efficiency With Coronary Flow Velocity Reserve Predicts Significant Coronary Artery Stenosis in Chronic Coronary Syndrome.

Background: Identification of significant coronary artery stenosis (CAS) in patients with chronic coronary syndromes (CCS) is crucial for clinical management. Myocardial work (MW) is a new noninvasive method reflecting myocardial metabolism and has been applied in myocardial ischemia. We aimed to explore the value of global MW during vasodilator stress echocardiography in detecting significant CAS.

Succinate Dehydrogenase A-Deficient Renal Cell Carcinoma with Predominantly Papillary Structures: A Case Report and Review of the Literature.

Succinate dehydrogenase ()-deficient renal cell carcinoma (RCC) is a rare molecularly defined renal tumor characterized by defects in the subunit types , , , and , with most of these genetic alterations involving the subunit, whereas the , and gene mutations are less frequent. The classic pathological features of -deficient RCC include a nest-like arrangement of tumor cells containing abundant eosinophilic cytoplasm, intracytoplasmic translucent or pale inclusion bodies, and inconspicuous nucleoli. Immunohistochemistry studies have revealed SDH protein deletion with mutations in the gene in this condition.

Reserve of global constructive work for early diagnosis of myocardial ischemia and risk stratification in chronic coronary syndrome.

Background: In chronic coronary syndrome (CCS), assessing myocardial ischemia is difficult due to its variable severity. Myocardial mechanical parameters are helpful in ischemia detection. This study investigates the use of non-invasive myocardial work (MW) for ischemia detection and risk assessment in CCS patients.

Natural medicines target tumor vascular microenvironment to inhibit tumor.

The abnormally active tumor vasculature provides a good blood supply for the rapid proliferation of tumors. The tumor microenvironment of tumor cells is associated with the secretion of a lot of angiogenic factors to promote the formation of blood vessels. However, the blood vessels are often irregular and immature.

25HC Depleted PMs-Accessible Cholesterol to Restrict SFTSV Entry and Infectious-EVs Mediated Infection.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel tick-borne phlebitis virus of Bunyaviridae, newly named as Banda virus, characterized by high fever, thrombocytopenia, and leukopenia with high case fatality. Currently, no specific antiviral drugs are available to treat patients. Here, we report a natural lipid metabolite 25-Hydroxycholesterol (25HC) that inhibited SFTSV entry by activating the activity of acetyl-CoA-cholesterol acyltransferase (ACAT), a lipid metabolism enzyme, affecting the accessible cholesterol translocation between the cytoplasm and plasma membranes (PMs).

Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7.

Small extracellular vesicles (sEVs) are membrane-bound nanoparticles released by cells for intercellular or inter-tissue communication and play key roles in multiple cardiovascular disorders. However, the mechanisms underlying sEV-mediated myocardial fibrosis in hypertrophic cardiomyopathy (HCM) are not well understood. In this study, it is discovered that the levels of miR-15a-5p and miR-96-5p in circulating sEVs (miR-15a-5p/96-5p) are elevated in HCM patients with myocardial fibrosis.

Development of reactive oxygen species-sensitive polyethylene glycol-modified voriconazole-loaded nanomicelles for treating fungal keratitis.

In fungal keratitis (FK), excessive reactive oxygen species (ROS) accumulation at the inflammation site primarily promotes hyphal transformation in Candida albicans (CA). Therefore, ROS scavenging is beneficial for suppressing CA hyphal formation and FK-associated inflammation. This study aimed to synthesize an ROS-sensitive micellar material (SPS) and use it to encapsulate voriconazole, resulting in the formation of an ROS-responsive drug-loaded nanomicelle (SPSV).

Core-shell Zn/P-doped calcium silicate bioceramics with spatiotemporally regulated degradation and high-efficient oesteogensis for emergent bone trauma repair.

Ca-silicate (CSi) bioceramics have garnered significant interest in bone tissue engineering but their multifunction and biodegradation are suboptimal for some emergent bone trauma conditions. Foreign ion doping and core-shell architectural design offer promising strategies to optimize osteogenic efficacy while precisely regulating degradation kinetics and biologically functional ion release. Herein we developed the core-shell porous bioceramics via coaxial nozzle system, featuring a P-doping wollastonite (CSi-P) core and Zn-doping wollastonite (CSi-Zn)/β-tricalcium phosphate (β-TCP) shells.

Metagenomic insights into the microbial communities and functional traits of hot springs in Guizhou Province, China.

Introduction: Hot springs were previously believed to be uninhabitable due to their hostile nature. However, recent studies have determined that hot springs not only have a rich microbiota but are also involved in various biogeochemical processes and possess unique characteristics that can be utilized for several biotechnological applications. This study aimed to determine the bacterial taxonomic diversity and functional profiles of 11 hot springs in the Guizhou Province, China.

Clinical characteristics of 27 children with febrile infection-related epilepsy syndrome in a single center.

To investigate the clinical characteristics of febrile infection-related epilepsy syndrome (FIRES). We used trajectory analysis and logistic regression analysis to investigate the clinical characteristics and prognostic risk factors respectively. Twenty-seven patients (16 males) were included.

Experimental identification of the high-lying 4Δ state of C in the vacuum ultraviolet region.

Spectroscopic study of C, an important homonuclear diatomic molecule, has attracted considerable attention over the past 200 years owing to its significant applications in both the comprehension of chemical bond theory and astronomical observation. Despite substantial achievements in experimental and theoretical identifications of the low-lying electronic transitions of C in the UV, visible and infrared regions, originating either from its ground singlet Σ+g or triplet Π state, further spectroscopic investigation in the vacuum ultraviolet (VUV) region is essential, particularly for identifying its high-lying excited states in the energy region from its dissociation to ionization threshold. In this study, we reported the identification of a new high-lying excited state of C originating from the Π state through the 1VUV + 1'UV resonance-enhanced multiphoton ionization scheme.

A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.

The hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) gene has been reported to regulate the spontaneous depolarization of sinoatrial node cells. A novel HCN4 mutation (c.2036 G>A) may lead to sick sinus syndrome.

How does psychological capital affect construction workers' proactive safety behavior? The roles of autonomous safety motivation and perceived organizational support.

BackgroundThe proactive safety behavior of construction workers serves to prevent safety accidents. There is a lack of research on the effects of positive psychology on construction workers' proactive safety behaviors.ObjectiveThis study aims to investigate the influence of construction workers' psychological capital on proactive safety behaviors, as well as the mediating effect of autonomous safety motivation and the moderating role of perceived organizational support therein.

Optimization of microwave-assisted extraction for Herba Patriniae polysaccharide and its impact on physicochemical properties, antioxidant and hypoglycemic capacities: Primary structure-activity relationship.

This study optimized microwave-assisted extraction (MAE) of Herba Patriniae polysaccharide (HPP) and systematically compared its yield, properties and bioactivities with hot water extraction (HWE) and ultrasonic-assisted cellulase extraction (UACE). MAE (43.92 min, 437.

Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma.

Background: Ammonia metabolism plays a crucial role in cancer progression and immune modulation. However, the prognostic relevance and immunological effects of ammonia-induced cell death (ACD) in HNSC remain insufficiently studied. ACD is a newly characterized form of regulated cell death caused by pathological ammonia accumulation, leading to mitochondrial dysfunction, oxidative stress, and DNA damage.

The role of Piezo1 in cardiovascular diseases: from molecular mechanisms to targeted therapeutic potential.

Piezo1 is a mechanosensitive cation channel protein that responds to mechanical stimuli such as fluid shear stress, stretch force, and extracellular matrix stiffness. It converts mechanical signals into biochemical signals, thereby regulating cellular biological behaviours including inflammation, oxidative stress, mitochondrial homeostasis, and angiogenesis. Growing evidence indicates that multiple cellular biological behaviours modulated by Piezo1 play a critical role in the physiological and pathological processes of cardiovascular diseases (CVDs).

CD49a NK cells promote esophageal cancer development by inducing MDCSs infiltration via GM-CSF.

Background: Although extensive evidence indicates that tissue-resident natural killer (trNK) cells are closely related to the development and clinical outcomes of various tumours, their roles in esophageal cancer remain obscure.

Methods: Tumour tissues collected from 54 esophageal squamous cell carcinoma (ESCC) patients during surgery and human ESCC tissue arrays including samples from 258 patients were subjected to analyse the phenotype and functions of immune cells.

Results: We observed a population of CD49a NK cells with a CD103CD69 resident phenotype predominantly within the CD56 NK cell subset in the intratumoral tissue of ESCC patients.

State-Of-The-Art Structural Regulation Methods and Quantum Chemistry for Carbon-Based Single-Atom Catalysts in Advanced Oxidation Process: Critical Perspectives into Molecular Level.

Advanced oxidation processes (AOPs) by carbon-based single-atom catalysts (SACs) are recognized as an attractive scientific frontier for water treatment, with the outstanding benefits of ultra-effective and anti-interference capability. However, most of the research has paid more attention to the performance of SACs, while the in-depth understanding of catalytic regulation by molecular interaction is relatively deficient. This critical review delves into deciphering the catalytic mechanism through a micro-level, which makes it more convenient to interpret apparent catalytic phenomena.

An Organic-Inorganic-Integrated Solid Electrolyte Interphase with High-Resilience and Anti-Corrosion for Sustainable Zinc Metal Anode.

Aqueous zinc metal batteries (AZMBs) are highly regarded for their exceptional safety, low cost, environmental compatibility, and potential as a sustainable alternative to lithium-ion batteries. However, Zn dendrite growth and hydrogen evolution on anode side result in limited lifespan and safety issues. Herein, an organic-inorganic-integrated solid electrolyte interphase (SEI) was in situ formed by adding 4-(trifluoromethyl)-1H-imidazole (TFMI) as an electrolyte additive.

Global prevalence and risk factors of varicose veins among health care workers: a systematic review and meta-analysis.

Aims: To explore the global prevalence of varicose veins among healthcare workers and their associated risk factors.

Background: Varicose veins are a common occupational disease among healthcare staff. To enhance the occupational health of this population, it is necessary to understand their prevalence and risk factors.

SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). SFTSV infection carries a high mortality rate and has emerged to be a public health concern. SFTSV infection could induce many classical cell death pathways.

P-type Cathode Material Design Guided by Material Descriptors for High-Energy Density Sodium Batteries.

P-type organic electrode materials (OEMs) face considerable challenges in constructing high-energy density sodium metal batteries (SMBs) due to their low capacity. To preserve their voltage advantage, developing effective structural design strategies is essential. However, the lack of material descriptors hampers the efficiency of material design and screening.

Effect of impurities in FePO raw materials on the performance of LiFePO cathode materials.

Here, the effects of Mg, Mn, and SO impurities in FePO raw materials on the properties of LFP were studied by converting impurities into doping elements. The results indicate that due to differences in ionic radius and doping methods, these three impurities have varying impacts on the performance of LFP. 0.

Overlapping syndrome with concomitant mGluR2-Ab and GFAP-Ab: A case report.

An 11-year-old male patient presented with acute neurological deterioration, including meningitis, encephalitis, and myelitis. Initial testing detected antibody against metabotropic glutamate receptor 2 (mGluR2-Ab); retesting identified coexisting anti-glial fibrillary acidic protein antibody (GFAP-Ab). Pathogenic examinations were negative.

Tissue-resident macrophages and renal diseases: landscapes and treatment directions.

Tissue-resident macrophage (TRM) is a specialized subset of macrophage that resides within specific tissues and organs. TRMs play crucial roles in resisting pathogen invasion, maintaining the homeostasis of the immune microenvironment, and promoting tissue repair and regeneration. The development and function of TRMs exhibit significant heterogeneity across different tissues.