Publications by authors named "Linrun Li"
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel tick-borne phlebitis virus of Bunyaviridae, newly named as Banda virus, characterized by high fever, thrombocytopenia, and leukopenia with high case fatality. Currently, no specific antiviral drugs are available to treat patients. Here, we report a natural lipid metabolite 25-Hydroxycholesterol (25HC) that inhibited SFTSV entry by activating the activity of acetyl-CoA-cholesterol acyltransferase (ACAT), a lipid metabolism enzyme, affecting the accessible cholesterol translocation between the cytoplasm and plasma membranes (PMs).
View Article and Find Full Text PDFEnterovirus 71 (EV71) infection poses a global public health challenge, especially in infants and young children, with severe cases leading to fatal consequences. EV71 infection modulates various biological processes of the host and evades host immunity through multiple mechanisms. The balance of mitochondrial dynamics is important for cellular homeostasis.
View Article and Find Full Text PDFSevere fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). SFTSV infection carries a high mortality rate and has emerged to be a public health concern. SFTSV infection could induce many classical cell death pathways.
View Article and Find Full Text PDFMicrovesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury.
Cell Commun Signal
April 2025
Enterovirus 71 (EV71) is a major etiologic pathogen for hand-foot-and-mouth disease (HFMD) in young children. Severe cases of EV71 infection could lead to neurological complications and even death, while the mechanism inducing neurological complications remains poorly understood. In this study, we firstly proved that microvesicles (MVs) could carry EV71 virions and mediate a higher efficiency in infection.
View Article and Find Full Text PDFArticle Synopsis
- Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly infectious and deadly virus characterized by immune dysfunction and aggressive viral replication.
- Research using MeRIP-seq has identified m6A modifications on SFTSV RNA, revealing that the protein YTHDF1 binds to these modifications and reduces the stability and translation of SFTSV proteins.
- The virulence factor NSs from SFTSV increases the lactylation and degradation of YTHDF1, promoting viral replication by countering the antiviral actions of the host's immune response.
MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells.
Antiviral Res
November 2024
Article Synopsis
- - Severe fever with thrombocytopenia syndrome virus (SFTSV), now known as Dabie bandavirus, has a high fatality rate and poses a significant public health risk as a newly-identified bunyavirus.
- - The study found that methyl-beta-cyclodextrin (MβCD), a drug that disrupts cholesterol in lipid rafts on cell membranes, can inhibit SFTSV infection and affect the virus's ability to enter host cells.
- - MβCD not only impacted SFTSV entry by altering lipid raft structures but also decreased the infection risk in mice, highlighting its potential as a therapeutic treatment for SFTSV.