Exploring the Predictive Value of Grading in Regions Beyond Peritumoral Edema in Gliomas Based on Radiomics.

Introduction: Accurate preoperative grading of adult-type diffuse gliomas is crucial for personalized treatment. Emerging evidence suggests tumor cell infiltration extends beyond peritumoral edema, but the predictive value of radiomics features in these regions remains underexplored.

Method: A retrospective analysis was conducted on 180 patients from the UCSF-PDGM dataset, split into training (70%) and validation (30%) cohorts.

GSH-responsive magnetic imaging for monitoring of tumor chemodynamic therapy.

Chemodynamic therapy (CDT) is a promising treatment modality that utilizes highly toxic hydroxyl radicals (˙OH) to kill tumor cells . However, real-time monitoring of drug distribution and therapeutic response remains a challenge, hindering the optimization of personalized treatment regimens. Here, we developed a glutathione (GSH)-responsive nanoreactor (FA-Mn NR), with integrated magnetic resonance imaging (MRI) functionality for self-enhanced CDT.

Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial.

Purpose: To investigate the effects of ciprofol on postoperative cognitive function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).

Patients And Methods: A total of 138 patients who underwent cardiac surgery with cardiopulmonary bypass were included in this prospective, randomized, controlled study. Patients were randomized into two groups: the Ciprofol group (Group C) and the Propofol group (Group P).

Relationship between flow-mediated dilation and urinary albumin-creatinine ratio in patients with type 2 diabetes mellitus.

Aims: To investigate the association between Flow-Mediated Dilation (FMD) and the urinary albumin-to-creatinine ratio (UACR) in individuals with type 2 diabetes mellitus (T2DM).

Methods: This cross-sectional study involved 194 individuals diagnosed with T2DM. Participants were categorized into two groups based on their UACR levels: the diabetic kidney disease group (DKD) (UACR≥30 mg/g) and the non-diabetic kidney disease group (non-DKD) (UACR <30 mg/g).

Electron Redistribution via LDH-to-DACs Coupling Enhances d-Band Regulation and Stability for Zinc-Air Battery Electrocatalysis.

The limited activity and poor long-term stability of oxygen electrocatalysts remain major obstacles to the practical deployment of zinc-air batteries (ZABs). Herein, a heterostructure catalyst, FeNi-LDH@DACs, was constructed by anchoring ultrasmall FeNi layered double hydroxide (LDH) nanodots onto polyhedral FeNi dual-atomic catalysts (DACs), forming a "sesame-ball-like" architecture. This spatial arrangement enables interfacial coupling, where electron transfer from LDH to DACs modulates the d-band center of the FeNi atomic sites and adjusts the adsorption energies of oxygen intermediates.

WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRAS-mutant lung cancer.

The clinical effect of KRAS G12C inhibitors (G12Ci) as monotherapy is poor, prompting the development of combination treatment strategies. Here, we demonstrate that the WEE1 kinase inhibitor (WEE1i), Adavosertib, can sensitize the effect of G12Ci through the MYBL2-RRM2 axis, which is associated with poor prognosis in lung cancer. Overexpressing the MYBL2-RRM2 axis or supplementing the products of the RRM2 enzyme, dNTPs/dNs, can partially reverse this synergistic inhibitory effect.

Neighboring alkenyl group participated ether-based electrolyte for wide-temperature lithium metal batteries.

The extensive dendrite formation and unstable interfacial chemical environment pose significant obstacles to operating lithium metal batteries under extreme conditions. Here, we develop an allyl ether electrolyte operated across a wide-temperature range. Leveraging the neighboring group participation effect of alkenyl groups, the designed electrolyte possesses a quasi-weak solvation structure with low desolvation energy.

Bioinspired interfacial nanofluidic layer enabling high-rate and dendrite-free lithium metal negative electrodes.

Lithium metal negative electrodes are highly promising for high-specific-energy batteries due to their low electrochemical potential and high capacity. However, dendrite growth due to limited Li transport at the interface hinder their performance and safety. Enhancing interfacial Li transport can prevent Li depletion and ensure uniform Li deposition.

Automated exo-glycosidase-based glycan sequencing on a digital microfluidic system with integrated electrochemical detection of monosaccharides.

Glycans are one of the most important biomacromolecules and are essential to nearly all known life forms. However, their structural complexity makes structural analysis more challenging than nucleic acids or proteins, significantly limiting the opportunities for investigating their structure-function relationship. Here, we proposed a novel glycan sequencing strategy in which a suite of specific non-reducing-end exoglycosidases was integrated with electrochemical detection of monosaccharides in a digital microfluidic (DMF) chip.

Effect of propofol sedation via a narrow-bore tube on hypoxemia risk during gastroscopy: a single-center, prospective, randomized controlled trial.

Background: Hypoxemia is a common adverse event during propofol sedation for gastrointestinal endoscopy. Maintaining a sufficiently slow infusion rate is known to reduce respiratory depression caused by propofol, but achieving this consistently is challenging due to variations in manual techniques. This study evaluated the use of a narrow-bore extension tube to administer propofol, which passively slows infusion, to reduce hypoxemia during gastroscopy sedation.

Engineering Anion-Diluent Matrix for Ion-Decoupled Localized High-Concentration Electrolytes toward Highly Stable Aqueous Zinc Ion Batteries.

Aqueous zinc-ion batteries suffer from electrolyte-induced degradation despite their inherent safety advantages. While localized high-concentration electrolytes (LHCEs) mitigate interfacial instability, the excessive cation-anion association elevate ionic transport barriers, resulting in sluggish migration kinetics. Herein, ion-decoupled LHCE (ID-LHCE) are proposed using amphiphilic 2,2,3,3-tetrafluoro-1-propanol (TFP) as anion-affinity diluent.

Albumin-Bilirubin and Severity as Key Factors of Recovery in Patients With PA-HSOS Undergoing Transjugular Intrahepatic Portosystemic Shunt.

Aim: To evaluate the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in the management of pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome (PA-HSOS) and to identify key factors influencing the recovery of liver imaging manifestation after TIPS procedure in PA-HSOS patients.

Methods: A retrospective review was conducted of 30 PA-HSOS patients who received TIPS at Jinhua Municipal Central Hospital between 1 January 2018, and 30 September 2021, following failure of anticoagulation-based comprehensive treatments. Baseline characteristics and follow-up data were collected, including clinical manifestations, laboratory test results, computed tomography (CT) radiological manifestations of the liver, hepatic venous pressure gradient (HVPG), survival, and complications.

Impact of Heat Stress on Gene Expression in the Hypothalamic-Pituitary-Ovarian Axis of Hu Sheep.

Heat stress (HS) is a major environmental factor negatively impacting the reproductive performance of livestock. This study investigates the molecular mechanisms of heat stress on the hypothalamic-pituitary-ovarian (HPO) axis in Hu sheep. A heat-stressed animal model was established, and high-throughput RNA sequencing (RNA-seq) was employed to analyze gene expression in the hypothalamus, pituitary, and ovarian tissues of both control and heat-stressed groups.

Self-supervised constrained super-resolution fast coded spectral imaging system.

Current coded aperture spectral imaging techniques suffer from slow imaging speeds and poor image quality at low sampling rates. To address these issues, we propose a self-supervised constrained super-resolution fast coded spectral imaging system by combining a physical process of spectral imaging with image fusion super-resolution techniques. We constructed a discrete cosine transform spectrometer (DCTS) and successfully acquired low-resolution hyperspectral images (LR-HSI) and high-resolution multispectral images (HR-MSI).

Snapshot hyperspectral imaging method based on a transformer and auxiliary learning tasks.

This paper proposes a noise-resistant coded aperture snapshot spectral imaging (CASSI) reconstruction algorithm based on a spectral awareness network (SANet). The method maps the snapshot compressed measurements to a panchromatic (PAN) image as an auxiliary learning task for reconstructing hyperspectral images. The PAN images reconstructed by the network are extracted to provide spatial detail information, which is then fed into the CASSI reconstruction network to enhance its regularization capability.

Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma.

Background: Patients with head and neck squamous cell carcinoma (HNSCC) often exhibit only partial responses to immunotherapy, resulting in poor prognosis and potential overtreatment. While pseudogenes are known to significantly impact the tumor microenvironment (TME) and tumor prognosis, their specific role in HNSCC remains unclear.

Methods: A prognostic risk profile for HNSCC patients was developed and validated using pseudogene pairs.

3D Printing via Melt Extrusion Deposition Facilitates the Use of Extended-Release Profiles in Preclinical Research and Development.

Traditional methods for developing modified-release (MR) formulations involve numerous iterations and large quantities of drug substances, which pose considerable challenges in exploration settings. Given the growing necessity for modified-release (MR) formulations in the pharmaceutical industry, particularly during the preclinical research and development phase, modified-release strategies may serve as attractive alternatives to discontinuing clinical development and could mitigate the costs and time associated with identifying new drug candidates. This study specifically explores the application of melt extrusion deposition (MED) 3D printing technology as a rapid prototyping platform for creating extended-release (ER) oral dosage forms tailored for the preclinical phase.

Real-time tracking and early diagnosis of mercury(II) exposure via a novel NIR-based fluorescent probe based on thiahemicyanine dye.

Ultrasensitive monitoring of mercury(II) (Hg) in environmental and biological systems is highly desirable due to the fact that this heavy metal ion is a ubiquitous pollutant worldwide. Despite the existence of numerous readily-available techniques for Hg-detection, optical probe-based fluorescence tracking stands out, as this powerful tool can offer the distinct advantages of real-time, noninvasive and particularly in vivo monitoring. Herein, a novel hemicyanine-based fluorescent probe (namely HDS-Hg) with an enhanced turn-on near-infrared (NIR) sensing of fluorescence response upon binding with Hg (λ/λ = 700 nm/765 nm) was constructed, which featured a rapid response, low detection limit, wide pH-tolerance, high sensitivity and selectivity as well as favorable mitochondria-targeting ability.

Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy.

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for advanced cancers, yet their efficacy remains heterogeneous among patients. Tumor mutation burden (TMB) has been extensively explored as a potential biomarker for predicting ICI response. However, its application is limited by several factors, including inconsistent predictive power across different tumor types and the lack of a clear relationship with overall survival (OS).

Molecular Design of Asymmetric Difluorinated Ether Electrolytes for Stable Operation of High-Voltage Lithium Metal Batteries.

Fluorination of electrolyte solvents is key to improving the cycling stability of high-voltage lithium metal batteries (LMBs), yet the critical role of fluorinated alkyl chain length in governing solvation and interphase chemistries remains unclear. Herein, we systematically engineered a series of methoxy ethoxy methane derivatives with tailored fluorinated alkyl groups to screen the optimal asymmetric difluorinated electrolytes for high-voltage LMBs. Spectroscopic and computational studies show that the ─CFH group in difluoroethoxy methoxy methane (DFME) facilitates balanced Li─F interactions, which are essential for ensuring efficient ion transport and maintaining oxidation stability.

Impact of cyclosporine A-related single nucleotide polymorphisms on post-transplant outcomes in pediatric hematologic malignancy patients undergoing allogeneic hematopoietic stem cell transplantation.

Background: Calcineurin inhibitors (CNIs), such as cyclosporine A (CsA), are widely used as immunosuppressants for both prophylactic and therapeutic purposes in patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). CsA-related transporters and metabolic enzymes single nucleotide polymorphisms (SNPs) are associated with the efficacy of CsA in individuals. However, few studies have explored how CsA-related SNPs correlate with post-transplant complications and prognosis.

Cu Nanocluster Size Effect Inducing the Transformation of Polysulfides to CuS/CuS for Durable Sodium Storage.

The limited conversion efficiency of polysulfides (PSs) in sodium-sulfur batteries remains a critical bottleneck to achieving optimized sulfur utilization and stable cycling. While copper-based materials present promise in anchoring PSs, the dynamic evolution of Cu nanostructures during cycling and their size-dependent interaction with PSs are poorly understood. Herein, we reveal a size-governed electrochemical mechanism in which Cu nanoclusters (<1 nm) dynamically regulate the phase transition between CuS and CuS to enable reversible sulfur redox chemistry.

Clinical features, disease burden and impact on quality of life in participants with mitochondrial encephalomyopathy.

Background: Mitochondrial encephalomyopathy (ME) is a rare genetic disorder that significantly impacts participants' quality of life and places emotional and financial burdens on caregivers. However, the dynamics between perceived financial burden, disability, and caregiver strain are not fully understood. This study aimed to explore the differences in perceived financial burden, QoL, disability levels, and caregiver burden among participants with ME.

Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes.

Background: This study aimed to examine the association between branched-chain amino acids/branched-chain α-keto acids (BCAAs/BCKAs) and adipose tissue insulin resistance (Adipo-IR) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 506 patients with T2DM were included in this cross-sectional study. Participants were categorized into two groups based on Adipo-IR levels (non-Adipo-IR: Adipo-IR<7.