Comprehensive computational modeling and interactions mechanisms of GIPR homodimerization.

G protein-coupled receptors (GPCRs) are transmembrane receptors that regulate intracellular signaling by interacting with G proteins and other effectors, influencing various physiological processes. The Glucose-dependent Insulinotropic Polypeptide Receptor (GIPR), a class B1 GPCR family member activated by GIP, regulates postprandial glycaemia by augmenting glucose-dependent insulin secretion, delaying gastric emptying, and suppressing appetite. Recent studies highlight the transmembrane domain (TMD) as the primary interface for dimerization, allowing GPCR to form homodimers or heterodimers with distinct physiological roles.

YOLOv11-AIU: a lightweight detection model for the grading detection of early blight disease in tomatoes.

Tomato early blight, caused by Alternaria solani, poses a significant threat to crop yields. Existing detection methods often struggle to accurately identify small or multi-scale lesions, particularly in early stages when symptoms exhibit low contrast and only subtle differences from healthy tissue. Blurred lesion boundaries and varying degrees of severity further complicate accurate detection.

Ethnic identity and folk-cultural adaptation: the roles of social distance and social support.

Multinational states typically face dual challenges arising from ethnic identity and folk-cultural adaptation. Balancing these elements is crucial in social science research. While previous studies have highlighted the significant impact of ethnic identity on cultural adaptation, the underlying mechanisms remain underexplored.

Phage pAEv1: A potential biocontrol agent against infections.

, a significant aquaculture pathogen, induces substantial mortality in farmed aquatic species. Given the therapeutic promise of phage-mediated bacterial lysis, we isolated from contaminated aquaculture systems and characterized its biological properties. Concurrently, the phage pAEv1 was recovered from the same aquatic environment using the pathogen as a host.

Incidence and risk factors of pneumonitis in ALK-rearranged non-small cell lung cancer patients treated with alectinib and thoracic radiotherapy.

Background: Alectinib and thoracic radiotherapy (TRT) are important modalities in the management of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), both of which can cause treatment-related pneumonitis (TRP), a serious adverse effect. We therefore aimed to assess the incidence and risk factors of TRP, when these two treatments were combined and to guide the medical decisions.

Methods: Patients with ALK-rearranged NSCLC, receiving alectinib and TRT from January 2018 to December 2023 were reviewed, and the clinical and dosimetric data were collected.

Chemically Inducible Cyclic Dinucleotides as Self-Deliverable STING Agonists with Enhanced Antitumor Immunity.

The stimulator of interferon genes (STING) has emerged as a promising therapeutic target in cancer immunotherapy. Cyclic dinucleotide (CDN)-based agonists are known to activate the STING signaling pathway; however, their clinical applications are largely hindered by challenges such as poor stability, low cell penetrability, and the lack of spatiotemporal controls that can result in off-target inflammatory responses. Here, we reported a novel design of chemically inducible CDNs (iCDNs) for efficient cellular uptake and on-demand STING activation through the installation of bio-orthogonal chemical groups onto the phosphodiester sites of CDNs.

How and when servant leadership affect public employees' innovative behavior.

Drawing on job demands-resources theory, this study explains the underlying mechanism by which servant leadership affects public employees' innovative behaviors. Building upon this foundation, the study constructs a hypothesized theoretical model positioning psychological safety as the mediator and public service motivation as the moderator. Through institutional cooperation with graduate schools at two universities in Yunnan Province, China, a survey was administered to 680 Master of Public Administration students, yielding 642 valid responses for analysis.

A Nanobiocatalyst-Driven Hybrid System for Efficient and Sustainable Hydrogen Production via Electron Flow Optimization.

Biohydrogen production offers a promising pathway for developing clean and renewable energy sources. However, its practical application has been hindered by low efficiency and sustainability issues. Here, it is introduced an energy-efficient and output-sustainable hybrid system (LPBC/CH system) for biohydrogen production by integrating self-assembling intermetallic (L1) FePt@polypyrrole nanobiocatalysts (LPBC) with Clostridium pasteurianum.

Encapsulated High-Entropy-Alloy Nanoparticles within Graphitic Shell for Improved Long-Term Prevention of Microbiologically Influenced Corrosion.

Microbiologically influenced corrosion (MIC), a trillion-dollar global issue, is driven by anaerobic biofilms that accelerate metal oxidation. Current MIC inhibition (MICI) strategies rely on antibiofilm materials and scrubbing aimed at biofilm removal but suffer from poor durability and limited mechanistic insight. Here, FeNiTiCrMnCu high-entropy alloy nanoparticles encapsulated within graphitic shells (HEA@C-NPs) are presented as an efficient and durable MICI approach.

Integrative multi-omic analysis of NLRP3 inflammasome dysregulation and subtyping for personalized treatment in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a devastating form of blood cancer characterized by uncontrolled growth and impaired maturation of myeloid precursor cells in the bone marrow. Despite advancements in treatment strategies, the prognosis for AML patients remains poor. The NLRP3 inflammasome, a multi-protein complex involved in innate immunity and inflammation, has been implicated in various diseases; however, its role in AML development and progression is not well understood.

Effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on cardiopulmonary function, body composition, and physical function in cancer survivors: a meta-analysis of randomized controlled trials.

Background: Advances in cancer treatment have led to a significant increase in the global number of cancer survivors. However, long-term health management challenges-such as reduced cardiopulmonary function, cancer-related fatigue, and metabolic dysregulation-remain formidable. The purpose of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) to comprehensively compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on Cardiopulmonary function, body composition, and physical function in cancer survivors.

Ca-Preintercalated VO as a Dual-Function Cathode Additive for Polyiodide Anchoring in Zn-I Batteries.

Aqueous zinc-iodine (Zn-I) batteries have attracted considerable attention due to their abundant resources, high safety, and environmental friendliness. However, challenges inherent to conversion-type electrodes, including severe active material shuttling and suboptimal Coulombic efficiency, continue to limit their performance. Here, we present a high-performance Zn-I battery enabled by calcium-ion-preintercalated VO (CaVO) nanobelts as a cathode additive.

Terpenoids from Aglaia edulis and their lung epithelial cells protective activity.

A significant protective effect on lung epithelial cells was observed with the terpenoids of Aglaia edulis twigs and leaves. Lung epithelial cells protective activity guided phytochemical research afforded nineteen triterpenoids (1-19), six diterpenoids (20-25) and four sesquiterpenes (26-29), including four unreported compounds (1, 16, 20 and 22), from A. edulis.

Seasonal Spatial Distribution Characteristics and Patterns of the Squid , , , and in the Southern Yellow and East China Seas: Predictions Under Different Climate Scenarios.

For successful economic management of cephalopod fisheries, short-lived squid with a 1-year life span require stock assessment over a short timescale, accompanied by both in-season and real-time stock management. However, insufficient information is available about the dynamic distribution patterns of the squid , , , and in China. Such information is vital for establishing a sustainable fisheries management system.

Proposing New Criteria for Classification of Benign Fibroepithelial Lesions Based on Clinicopathologic Evaluations of 507 Cases with Clinical Outcome.

Cellular fibroadenoma (cFA), benign phyllodes tumor (BePT), and borderline phyllodes tumor (BoPT) demonstrate overlapping clinicopathologic features. We evaluated 507 cases including 91 cFAs, 230 BePTs, and 186 BoPTs. The World Health Organization-recommended morphologic criteria were used to classify cFA and BePT.

Design and Synthesis of Ferulic Acid Derivatives with Trifluoromethyl Pyrimidine and Amide Frameworks for Combating Postharvest Kiwifruit Soft Rot Fungi.

Fungal diseases significantly affect the quality and safety of food and agricultural products. Pyrimidine ether compounds have shown effectiveness as commercial antifungal agents, but their prolonged or excessive use has led to resistance and pesticide residue issues, necessitating structural modifications. In this study, ferulic acid served as a framework for synthesizing a series of derivatives by introducing pyrimidine and amide groups.

Adebrelimab in Small Cell Lung Cancer: From Current Advances to Emerging Combination Strategy and Challenge.

Adebrelimab is a fully humanized monoclonal antibody against programmed cell death-ligand 1 (PD-L1) that has been approved in combination with chemotherapy as the first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). This approval was driven by the landmark CAPSTONE-1 trial, where adebrelimab demonstrated superior survival outcomes: median overall survival (mOS) improved from 12.8 to 15.

Hypoxic Gene Expression Signature as a Predictor of Recurrence and Mortality in Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy.

Purpose: Recurrence occurs in 20%-30% of early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). Hypoxia in the tumor microenvironment drives radiation resistance, immune evasion, and tumor progression. Biomarkers measuring hypoxia may be useful for prognostication of NSCLC treated with SBRT.

Structural characteristics of Phaeodactylum tricornutum polysaccharides and the effects on DSS-induced colitis via improving the intestinal barrier and modulating the gut microbiota.

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by bloody diarrhea and colonic inflammation. Although Phaeodactylum tricornutum polysaccharides (PTPs) possess anti-inflammatory and immunostimulatory properties, the effects on colonic inflammation remain unclear. This study investigated the molecular structure of PTPs and their potential effects in dextran sulfate sodium (DSS)-induced colitis in mice.

The relationship between clinical nurses' feelings of underqualification and work withdrawal behavior: the multiple mediating roles of self-disgust and self-efficacy.

Purpose: The purpose of this study is to analyze the influence of three variables-feelings of underqualification, self-disgust, and self-efficacy-on work withdrawal behavior, with the aim of drawing attention to the mental health of nurses.

Methods: A total of 300 nurses were recruited in Shandong Province, China for the survey. Participants completed the General Information Questionnaire, the Perceived Inadequate Qualifications Scale, the Work Withdrawal Behavior Scale, the Self-Disgust Scale, and the General Self-Efficacy Scale.

Yellow mealworm () meal in diets of grass carp (): Effects on growth performance, antioxidant capacity, immunity, intestinal morphology, and intestinal microbiota.

The impacts of substituting dietary soybean meal (SBM) with yellow mealworm meal (YMM) were investigated during a 56-day feeding trial on growth, antioxidant capacity, immunity, intestinal morphology, and intestinal microbiota of grass carp. A total of 750 grass carp were divided into 5 groups (3 replications per group and 50 fish per replication) with different levels of YMM: SBM (control group), H25, H50, H75, and H100, for 8 weeks. The results showed that dietary YMM significantly increased final body weight (FW), weight gain (WG), and protein efficiency ratio (PER) in H25 group ( < 0.

Efficacy and safety of cadonilimab combined with chemotherapy as the first-line treatment for primary advanced or recurrent endometrial cancer: a prospective single-arm open-label phase II clinical trial.

Introduction: Recently, immunotherapy has significantly transformed the treatment landscape of endometrial cancer (EC). Results from KEYNOTE-158, RUBY and AtTEnd showed programmed cell death 1 (PD-1) or programmed cell death-ligand 1 inhibitors with promising efficacy in primary advanced or recurrent EC. However, few studies focused on the role of dual immune checkpoints in primary advanced or recurrent EC.

A New Species sp. nov. (Pyralidae, Phycitinae) Revealed by Congruent Morphological and Mitogenomic Evidence.

The genus was established by Zeller [...

Changes in Seasonal Spatial Distribution Patterns of and : The Current and Predictions Under Climate Change Scenarios.

Given their small size and low value in commercial fishing and aquaculture, little is known about the seasonal spatial distribution patterns and characteristics of the bobtail squid and in seas around China. Thus, we conducted seasonal bottom-trawling surveys in the southern Yellow and East China Seas during 2018 and 2019. Our results showed that migrated from inshore areas (Yushan fishing grounds) during the summer and autumn to offshore areas (Wentai fishing grounds) during the winter.

Response patterns and community assembly processes of gut microbiota in grass carp subjected to various protein sources and their implications for growth and metabolism.

Feed nutrients are crucial in shaping the gut microbial community, especially for complex interactions. While much research focused on the impacts of dietary protein levels, exploration of protein sources remains insufficient. Accordingly, this study specifically investigated the effects of four protein sources [Clostridium autoethanolicum protein (CAP), cottonseed protein concentrate (CPC), Chlorella vulgaris meal (CVP), and Tenebrio molitor meal (TM)] replacing dietary soybean meal on microbial co-occurrence networks and key metabolic taxa.