Chemically Inducible Cyclic Dinucleotides as Self-Deliverable STING Agonists with Enhanced Antitumor Immunity.

The stimulator of interferon genes (STING) has emerged as a promising therapeutic target in cancer immunotherapy. Cyclic dinucleotide (CDN)-based agonists are known to activate the STING signaling pathway; however, their clinical applications are largely hindered by challenges such as poor stability, low cell penetrability, and the lack of spatiotemporal controls that can result in off-target inflammatory responses. Here, we reported a novel design of chemically inducible CDNs (iCDNs) for efficient cellular uptake and on-demand STING activation through the installation of bio-orthogonal chemical groups onto the phosphodiester sites of CDNs.

Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.

Metabolic dysregulation and altered metabolite concentrations are widely recognized as key characteristics of aging. Comprehensive exploration of endogenous metabolites that drive aging remains insufficient. Here, we conducted an untargeted metabolomics analysis of aging mice, revealing citrulline as a consistently down-regulated metabolite associated with aging.

NIPSNAP3A regulates cellular homeostasis by modulating mitochondrial dynamics.

Mitochondria are essential for cell metabolism and survival as they produce the majority of cellular ATP through oxidative phosphorylation as well as regulate critical processes such as cell proliferation and apoptosis. NIPSNAP family of proteins are predominantly mitochondrial matrix proteins. However, the molecular and cellular functions of the NIPSNAPs, particularly NIPSNAP3A, have remained elusive.

Trends of antimalarial marine natural products: progresses, challenges and opportunities.

Covering 1972 to 2021Malaria remains a significant public health problem in some regions of the world. The great efforts to control malaria have been severely compromised due to the widespread resistance of to nearly all frontline drugs. Pursuit of novel molecules from the sea will potentially result in new interventions against malaria, which are urgently needed to combat the increase of resistance.