Mechanism of Lipi Jiangzhuo Decoction in Improving Metabolic Dysfunction-Associated Steatohepatitis Through the PERK/PINK1/GPx4 Pathway.

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized primarily by hepatocyte lipoapoptosis and hepatic inflammation, frequently developing from overweight/obesity. To date, no specific therapeutics exist to reverse MASH. Although resmetirom has been approved in some regions, patients in many Asian countries, including China, still lack access to approved pharmacotherapy for MASH.

Fat embolism syndrome: Never give up - A case report and literature review.

Rationale: Fat embolism syndrome (FES) is a complex syndrome with high in-hospital mortality and the diagnosis and treatment of FES remain challenging. In this article, we present a case report as well as a comprehensive review of trauma-related cases to enhance the understanding of FES.

Patient Concerns: An 18-year-old young man developed a fever, tachycardia, and dyspnea about 58 hours after the trauma.

Clinical Significance of Low-Density Granulocytes in Acute Pancreatitis.

Low-density granulocytes (LDGs), a unique subset of neutrophils, have been shown in previous studies to exhibit distinct biological functions in immune-inflammatory diseases. However, their role in acute pancreatitis (AP) remains unclear. To investigate the association between peripheral blood LDGs levels and clinical severity in patients with AP.

Interaction between living conditions and plant-based dietary pattern on cognitive function: A 10-year cohort analysis of Chinese older adults.

Background: Plant-based dietary patterns have been associated with better cognitive function, whereas there has been limited research on the relationship between living conditions and cognitive function. This study aimed to examine these associations in older adults in China.

Methods: This study utilized a ten-year cohort of older adults, including 1630 participants aged 65 and older from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), all of whom had normal cognition at baseline.

Investigating the epidemiological relevance of secretory otitis media and neighboring organ diseases through an Internet search.

Background: This study examined the epidemiological correlations between secretory otitis media (SOM) and diseases of neighboring organs. We measured changes in disease incidences during the 2020 COVID-19 pandemic using Internet big data spanning from 2011 to 2021.

Methods: This study used the Baidu Index (BI) to determine the search volume for the terms "secretory otitis media (SOM)", "tonsillitis", "pharyngolaryngitis", "adenoid hypertrophy (AH)", "nasopharyngeal carcinoma (NPC)", "nasal septum deviation (NSD)", "rhinosinusitis", "allergic rhinitis (AR)", and "gastroesophageal reflux disease (GERD)" in Mandarin from January 2011 to December 2021.

The collagen matrix regulates the survival and function of pancreatic islets.

The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of cells, including pancreatic cells. Collagens are the most abundant components of the ECM. Type I, IV, V and VI collagen has been detected in pancreatic islets, and each type plays important role in the proliferation, survival, function and differentiation of pancreatic cells.

Clinical efficacy of Huanglian Wendan decoction in treating type 2 diabetes mellitus: A systematic review and meta-analysis.

Background: Huanglian Wendan decoction (HLWDD) is a traditional Chinese prescription, which has been used to treat type 2 diabetes mellitus (T2DM) in recent years. However, no studies have evaluated its underlying clinical efficacy. Therefore, we used systematic review and meta-analysis to explore the clinical efficacy of HLWDD in treating T2DM.

Probiotic Supplement for the Prevention of Gestational Diabetes: A Meta-Analysis of Randomized Controlled Trials.

Background: Probiotic supplements may have some potential in preventing gestational diabetes, and this meta-analysis aims to explore the efficacy of probiotic supplements to prevent gestational diabetes.

Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of probiotic supplements on the incidence of gestational diabetes mellitus. Meta-analysis was performed using the fixed-effect or random-effect model as appropriate.

Microstructural Characteristics and Hardness Enhancement of Super Duplex Stainless Steel by Friction Stir Processing.

In the present study, microstructural evolution and hardness of the friction stir processed (FSPed) SAF 2507 super duplex stainless steel fabricated at a rotational speed of 650 rpm and a traverse speed of 60 mm/min were investigated. A scanning electron microscope (SEM) equipped with an electron backscatter diffraction (EBSD) detector was used to study the microstructure of the stir zone. The grain sizes of austenite and ferrite in the FSPed 2507 were found to be smaller (0.

Impact of Staining Methods and Human Factors on Accuracy of Manual Reticulocyte Enumeration.

Although peripheral blood reticulocyte enumeration reflects bone marrow functional integrity, which is important for differential diagnosis of hematological diseases, the factors affecting its accuracy have not been adequately addressed. Using 100 consecutive venous blood samples being processed with four supravital staining techniques [i.e.

Wire + Arc Additive Manufacturing and Heat Treatment of Super Martensitic Stainless Steel with a Refined Microstructure and Excellent Mechanical Properties.

Due to the advantages of relatively low cost, increased energy efficiency, increased deposition rate, and the capacity to create medium to large scale components, wire + arc additive manufacturing (WAAM) has gained growing interest. Super martensitic stainless steel (SMSS) combines outstanding strength, ductility, and corrosion resistance, making it a great option for WAAM. In the present work, an SMSS component was successfully produced by WAAM.

[Analysis of first-time hearing screening tests among singlets and twin neonates in neonatal intensive care unit].

To investigate the failure in the hearing screening test among twin neonates in neonatal intensive care unit （NICU） and to further clarify the etiology of neonatal hearing impairment, thus to provide insights into prevention and early intervention. Automated auditory brainstem response（AABR）, distortion product otoacoustic emission（DPOAE） and acoustic immittance were performed on 1452 neonates（including 130 twins） admitted in NICU from January 2015 to June 2018 and the risk factors including premature birth, hyperbilirubinemia, neonatal respiratory distress syndrome, etc. were analyzed retrospectively by univariate chi-square test and multivariate logistic regression analysis.

Mental Health of Parents and Preschool-Aged Children During the COVID-19 Pandemic: The Mediating Role of Harsh Parenting and Child Sleep Disturbances.

In the context of the coronavirus disease-2019 (COVID-19) pandemic, mental health problems of parents and children have become a public issue. Herein, we explored the association between parental well-being index and child mental health problems during the pandemic and the mediating role of harsh parenting and child sleep disturbances. An online survey was conducted among 16,398 parents of children aged 3-6 years (48.

Factors Influencing the Prognosis of Patients with Intra-Abdominal Infection and Its Value in Assessing Prognosis.

Purpose: To explore the distribution of pathogenic bacteria in patients with intra-abdominal infection, to clarify the independent factors that affect the prognosis of patients with intra-abdominal infection and its evaluation value for prognosis.

Patients And Methods: The pathogens, underlying diseases, and related clinical data of patients with intra-abdominal infection from January 2012 to December 2019 in our hospital were retrospectively collected and the APACHE II score was calculated. The patients were divided into survival group and death group according to the prognosis, and the index between the two groups was compared.

Control of disinfection byproducts in drinking water treatment plants: Insight into activated carbon filter.

The removal efficiencies of disinfection byproducts formation potentials (DBPFPs) and generated DBPs under pre-chlorination condition (pre-generated DBPs) during different drinking water treatment trains in eight full-scale drinking water treatment plants (WTPs) were investigated through field and laboratory studies. Haloacetic acids (HAAs) and haloacetonitriles (HANs) were identified to be two representative DBPs based on cytotoxicity and genotoxicity assessments. The performances of advanced treatment train for HAAs and HANs were better than that of conventional treatment train.

Differential impacts of hemolysis on coagulation parameters of blood samples: A STROBE-compliant article.

This study aimed at investigating the impact of hemolysis on different coagulation parameters.A total of 216 venous blood samples without visible hemolysis were collected from adult patients at a tertiary referral center over six months. The plasma obtained was quantified for six coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, antithrombin III, and protein C.

Field studies of aluminum release and deposition in drinking water distribution systems.

Aluminum (Al) release and deposition in drinking water distribution systems (DWDS) are highly detrimental to tap water quality. In this study, five drinking water treatment plant supply areas in two cities of China were examined to understand the transportation stability of Al in the DWDS. The two cities were selected based on the wide disparity reported in pH and turbidity in the finished and tap water qualities, with higher fluctuation of pH (average 8.

Identifying the Mechanisms and Molecular Targets of Yizhiqingxin Formula on Alzheimer's Disease: Coupling Network Pharmacology with GEO Database.

Background: Yizhiqingxin formula (YZQX) is a promising formula for the treatment of Alzheimer's disease (AD) with significant clinical effects. Here, we coupled a network pharmacology approach with the Gene Expression Omnibus (GEO) database to illustrate comprehensive mechanisms and screen for molecular targets of YZQX for AD treatment.

Methods: First, active ingredients of YZQX were screened for the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database with the absorption, distribution, metabolism, and excretion (ADME) parameters.