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Background: Probiotic supplements may have some potential in preventing gestational diabetes, and this meta-analysis aims to explore the efficacy of probiotic supplements to prevent gestational diabetes.
Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of probiotic supplements on the incidence of gestational diabetes mellitus. Meta-analysis was performed using the fixed-effect or random-effect model as appropriate.
Results: Six RCTs were finally included in the meta-analysis. Overall, compared with control intervention in pregnant women, probiotic supplementation intervention showed no obvious impact on the incidence of gestational diabetes (OR=0.68; 95% CI=0.39 to 1.20; P=0.18), fasting plasma glucose (SMD=-0.05; 95% CI=-0.29 to 0.19; P=0.69), 2 h-OGTT (SMD=-0.07; 95% CI=-0.27 to 0.13; P=0.47), gestational age (SMD=0.04; 95% CI=-0.14 to 0.21; P=0.69) or preeclampsia (OR=1.22; 95% CI=0.83 to 1.78; P=0.31).
Conclusions: Probiotic supplementation was confirmed to have no benefits for the prevention of gestational diabetes.
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http://dx.doi.org/10.1055/a-1956-3927 | DOI Listing |
JAMA
September 2025
Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, the Netherlands.
Importance: Pregnant individuals with polycystic ovary syndrome (PCOS) present with a higher risk of pregnancy complications, including gestational diabetes, preeclampsia, and preterm birth. Myo-inositol supplementation may reduce these risks.
Objective: To determine whether daily supplementation with myo-inositol during pregnancy among individuals with PCOS reduces the risk of a composite outcome of gestational diabetes, preeclampsia, and preterm birth.
J Ultrasound Med
September 2025
Department of Clinical Analysis, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
Objectives: To evaluate the performance of artificial intelligence (AI)-based models in predicting elevated neonatal insulin levels through fetal hepatic echotexture analysis.
Methods: This diagnostic accuracy study analyzed ultrasound images of fetal livers from pregnancies between 37 and 42 weeks, including cases with and without gestational diabetes mellitus (GDM). Images were stored in Digital Imaging and Communications in Medicine (DICOM) format, annotated by experts, and converted to segmented masks after quality checks.
Oncoscience
September 2025
Division of Pediatric Hematology and Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Trophoblastic differentiation or beta-human chorionic gonadotropin (β-hCG) secretion in endometrial carcinoma has been associated with poorly differentiated and aggressive tumors; however, the evidence is largely inconclusive. The review aimed to explore the prognostic role of trophoblastic differentiation and β-hCG in non-trophoblastic, primary uterine corpus cancers.
Methodology: A comprehensive electronic search across databases was conducted for all cases of cancers of the uterine corpus that were either associated with elevated levels of β-hCG or showed evidence of trophoblastic differentiation upon microscopy or both.
Front Public Health
September 2025
Emergency Department, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China.
Background: Gestational diabetes mellitus (GDM) prevalence is rising in China, necessitating an understanding of knowledge, attitudes, and practices (KAP) among affected women to inform interventions.
Methods: This cross-sectional study (June 2020-June 2024) surveyed 3,426 Chinese women with GDM, aged 20-60 years, from urban and rural prenatal clinics across Qingdao city, China. A validated 25-item KAP questionnaire used a three-option response format (yes, no, maybe).
Indian J Endocrinol Metab
July 2025
Department of Endocrinology, Indraprastha Apollo Hospitals, New Delhi, India.
The significance of hypoglycaemia during oral glucose tolerance tests (OGTT) in pregnancy is uncertain. This systematic review and meta-analysis (SRM) evaluated if hypoglycaemia during OGTT predicts feto-maternal outcomes. Electronic databases were searched for studies in pregnancy where an OGTT at 24-28 weeks was done and feto-maternal outcomes were documented.
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