Brain functional alterations in type 2 diabetes with obstructive sleep apnea patients: A multicenter resting-state fMRI study.

Objective: This multicenter study aimed to investigate resting-state brain functional alterations in patients with type 2 diabetes mellitus (T2DM) comorbid with obstructive sleep apnea (OSA), and to elucidate the underlying neural mechanisms.

Methods: A total of 139 participants were enrolled from two centers, including 48 healthy controls (HCs), 46 T2DM patients, and 45 T2DM with OSA patients. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to assess brain function using degree centrality (DC), amplitude of low-frequency fluctuation (ALFF), and seed-based functional connectivity (FC).

Enhanced nitrogen removal in constructed wetlands by low-temperature tolerant heterotrophic nitrification bacteria Pseudomonas umsongensis YL-1: Pollutant removal, rhizosphere effects, and bacterial interactions.

Poor microbial and plant activities in constructed wetlands (CWs) in winter reduced nitrogen removal substantially. A novel low-temperature tolerant heterotrophic nitrification-aerobic denitrification (HN-AD) strain of Pseudomonas umsongensis YL-1, isolated from the rhizosphere of wetland plants, was periodically inoculated into CWs to improve the efficiency of winter nitrogen removal. The removal rates of NH-N and TN in CWs planted with Iris japonica and Lolium perenne L.

Robotic Care Outcomes Project (ROBOCOP) for elective cholecystectomy.

Background: Robotic cholecystectomy (RCHOLE) is being used more frequently for elective patients. We aimed to compare clinical outcomes, specifically conversion to open/subtotal cholecystectomy, for RCHOLE and laparoscopic cholecystectomy (LCHOLE).

Methods: Our study received a Non-Human Subjects Research Determination.

Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study.

Background: Thoracic muscles contribute to respiration, is a crucial indicator for assessing functional recovery following lung resection. However, there is a lack of research on the long-term prognostic value of pectoralis muscle.

Methods: Consecutive patients who underwent curative-intent resection for stage I to IIIA NSCLC between 2013 and 2018 at a cancer center were retrospectively identified.

Moderating effect of insulin resistance on the relationship between cortical surface area and cognitive function in patients with first-episode schizophrenia.

Objective: The mechanisms underlying cognitive deficits in schizophrenia remain unclear. Accumulating evidence suggests that insulin resistance (IR) is closely related to brain structure and cognitive impairment. We aimed to determine whether IR mediates or moderates the association between cortical surface area (CSA) and cognitive function in patients with first-episode schizophrenia (PFES).

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response.

Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematological malignancy with restricted effective therapy choices. Neither the recruitment of monocytes nor the functioning of the physiological mechanisms of macrophage polarization can be achieved without the involvement of the MCP-1/CCR2 axis. We investigated the feasibility of treatment targeting MCP-1-CCR2-macrophages axis in DLBCL.

Immunophenotype-guided interpretable radiomics model for predicting neoadjuvant anti-PD-1 response in stage III-IV d-MMR/MSI-H colorectal cancer.

Background: Neoadjuvant immunotherapy significantly improves the pathological complete response (pCR) rate in colorectal cancer (CRC). However, the lack of reliable tools to accurately identify responders remains a key barrier to its widespread clinical adoption. This study aimed to develop an interpretable radiomics model guided by immunophenotypes to predict response to preoperative immunotherapy in CRC, with the goal of enabling more precise and personalized treatment strategies.

Patterns of toxic side effects and prognostic factors in concurrent chemoradiotherapy for esophageal cancer.

Esophageal cancer is a leading cause of cancer-related mortality globally, characterized by poor prognosis and high recurrence rates. This study aimed to systematically evaluate the causes of death and treatment-related toxicities in esophageal cancer patients undergoing concurrent chemoradiotherapy (CCRT), to identify key prognostic factors. Clinical data from 79 patients were analyzed retrospectively, assessing survival outcomes, toxic side effects, and primary causes of death.

Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin With Concomitant Piperacillin-Tazobactam Versus Other Beta-Lactams: A Systematic Review and Meta-Analysis.

: To explore whether vancomycin (VAN) plus piperacillin-tazobactam (PTZ) was associated with an increased risk of acute kidney injury (AKI) compared with VAN plus other beta-lactams (BLs) or monotherapy in critically ill patients, where the evidence remains controversial. PubMed, Cochrane, Web of Science, and Embase were searched from inception to June 2024. Studies comparing the risk of AKI with one group receiving VAN+PTZ, and other groups receiving VAN plus other BLs, or monotherapy in critically ill.

Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score.

Objective: This study aims to investigate the prognostic value of integrating inflammatory biomarkers with the established Global Registry of Acute Coronary Events (GRACE) risk score for predicting clinical outcomes in patients with myocardial infarction (MI).

Methods: This prospective, single-center study enrolled adult MI patients admitted to the coronary care unit at Zhongshan Hospital, Fudan University. Blood samples were collected to measure inflammatory markers (IL-1β, sIL-2R, IL-6, IL-8) and myocardial biomarkers.

Challenges and strategies for cultivating young teachers in pathophysiology departments at Chinese medical colleges: a narrative review.

This narrative review examines the challenges, strategies, and future directions in the development of young teachers within the pathophysiology departments of Chinese medical colleges. A thorough review of 49 studies published between 2013 and 2024 was carried out using PubMed, Web of Science, and various Chinese databases. The primary challenges identified include teaching innovation (cited in 84.

N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock.

N4BP1 (NEDD4-binding partner 1) is a key checkpoint for proper inflammatory responses; however, its cellular localization, biologic nature, and functions in other cellular processes remain largely unknown. In this study, we demonstrate that N4BP1 is a nucleocytoplasmic shuttling protein. Treatment with leptomycin B induces nuclear accumulation of N4BP1, and the region responsible for its nuclear distribution maps to amino acids 151 to 338.

Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis.

Cognitive impairment is a core characteristic of schizophrenia. Immunosenescence has been consistently implicated in the cognitive dysfunction observed in neurodegenerative diseases, but how it may relate to cognitive deficits in schizophrenia is still unclear. We explored the associations between immunosenescence and cognitive impairment in patients with schizophrenia (SCZ, n = 65) and healthy controls (HCs, n = 39).

Optimized CDK19 PET Tracers: Spirocyclic-Driven Design and Prostate Cancer Imaging.

Cyclin-dependent kinase 19 (CDK19) has been identified as a promising target due to its high expression in prostate cancer (PCa) cells. This study focuses on optimizing the structure of CDK19-targeted imaging tracers. The linker of the lead compound was optimized based on previous structure-activity relationships and cyclization strategy.

Osthole attenuates airway inflammation in asthma by inhibiting the HMGB1-RAGE/TLR4-NF-κB signaling pathway.

Unlabelled: Osthole (OS), an active component of traditional Chinese herbal medicine, has demonstrated a wide range of pharmacological effects and potential therapeutic value. This study aimed to explore the role of OS in alleviating airway inflammation in asthma. Ovalbumin (OVA) was used to induce a C57BL/6 J mouse asthma model.

Probiotic fermentation of Polygonatum plant polysaccharides converting fructans to glucans with enhanced anti-obesity activity.

Probiotic fermentation represents a potential approach to increase the bioactivity of polysaccharides, although its mechanisms remain unclear. Polygonatum polysaccharides, an important health-promoting components of Polygonatum, may exhibit improved antiobesity effects following probiotic fermentation based on previous research findings. A bioactive polysaccharide from Polygonatum kingianum ("King Solomon's seal" (huangjing)) (PKP), consisting of →1)-β-D-Fruf-(2 → (35.

Self-perceived health control status and influencing factors in young and middle-aged peritoneal dialysis patients: a cross-sectional survey.

Self-perceived health control effectively reflects patients' self-management behaviors and predicts health outcomes, thereby making it a critical intervention point for healthcare professionals, This was a cross-sectional descriptive study that included 233 young and middle-aged (peritoneal dialysis) PD patients in China. To investigate the current state of self-perceived health control and identify influencing factors, we collected the patient data using a General Information Questionnaire, a Self-Perceived Health Control Scale, a Patient Participation Questionnaire, Coping Efficacy and Social Support Rating Scales to analyze the influencing factors. The results revealed that self-perceived health control level among young and middle-aged PD patients needs improvement and significantly influenced by outpatient follow-up frequency, complications, social support, coping efficacy, and employment status.

Facile design and synthesis of boric acid group based fluorescent probes for monitoring mitochondrial ATP fluctuation.

Adenosine 5'-triphosphate (ATP) is a high-energy phosphate compound that provides most of the energy needed for the physiological activities of organisms. The abnormal fluctuation of intracellular ATP level is closely related to a variety of physiological diseases. So, the monitoring of ATP levels is of great significance for the diagnosis and treatment of diseases.

Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder.

In this study, we aimed to integrate serum cytokine and kynurenine metabolite levels to identify key biomarkers for diagnosing and predicting treatment outcomes in bipolar disorder during manic episodes (BDM). A total of 52 patients with BDM and 49 healthy controls (HCs) were recruited. Serum levels of cytokines and kynurenine metabolites were measured at baseline.

Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.

Background: Severe Acute Pancreatitis (SAP) is a critical gastrointestinal inflammatory disease. Mesenchymal stem cells (MSCs), multipotent cells exhibiting diverse biological properties including directional migration, paracrine signaling, immunosuppression, and anti-inflammatory effects. Adipose tissue-derived mesenchymal stem cells (ADSCs) are particularly valuable in regenerative medicine and tissue engineering.

Laser capture microdissection-assisted gas chromatography-triple-quadruple mass spectrometry for spatial metabolic profiling of esophageal squamous cell carcinoma.

With the development of precision medicine and single-cell analysis, spatial metabolomics has become a hotspot in the biomedical field. However, current spatial metabolomics methods are still unable to meet the demand for the integration of spatial omics in terms of metabolite coverage, isomer differentiation, and applicability of clinical samples. Therefore, this study developed an analytical strategy based on laser capture microdissection-assisted gas chromatography-triple-quadruple mass spectrometry to characterize metabolic profile differences in clinical tissue sections.

Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes.

Background: With the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), as one of the major ionic glutamate receptors, plays a dominant role in antidepressant effects, especially in synaptic plasticity. Few studies have been conducted on changes of NMDAR-related indicators and inflammatory cytokines in major depressive disorder (MDD) patient's peripheral blood before and after effective clinical perceptual recovery.

A Tetradentate Chelator for Reducing Damage Caused by Uranium.

The rapid advancement of the nuclear industry has precipitated significant challenges in nuclear pollution, with radionuclide uranium emerging as a formidable threat to human safety due to its potent chemical toxicity and radioactivity. The development of uranium chelators represents a pivotal strategy in mitigating the internal damage caused by nuclear exposure. While the US Food and Drug Administration has approved certain drugs for this purpose, issues such as low selectivity and high toxicity remain unresolved.

Fluorescence/colorimetric intelligent sensor based on Fe-adsorbing carbon dots nanozymes for selective recognition and quantification of total antioxidant capacity in foods and cells.

Constantly escalating oxidative stress greatly increases the daily demand, and total antioxidant capacity (TAC) have become an important indicator. Therefore, the development of effective methods for TAC evaluation remains to be a research hotspot. Herein, a fluorescence/colorimetric sensor based on Fe-adsorbing carbon dots nanozymes (Fe-CDs) was constructed through a rational design.

A N^N-bidentate ligand modified with tetraphenylethylene derivative for uranium detection and decorporation in vitro and in vivo.

Uranium, once introduced into the human body, tends to accumulate in the kidneys and femurs. Its potent chemical toxicity and radioactivity can lead to severe damage, posing significant health risks. Consequently, there is an urgent need to develop low-toxicity materials capable of effectively detecting and removing uranium.