Efficacy and safety of induction immunotherapy plus chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a meta-analysis.

Background: Locally advanced nasopharyngeal carcinoma (LA-NPC) has a heterogeneous prognosis, with approximately one-fourth of patients experiencing poor outcomes. Studies have explored the application of induction chemoimmunotherapy followed by chemoradiotherapy, but its efficacy was controversial.

Methods: The protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO, CRD42024619387).

Age, Creatinine, and Ejection Fraction (ACEF) Score is Associated with the Presence of Depression and Anxiety Symptoms in PCI Patients.

Background: A significant proportion of patients after percutaneous coronary intervention (PCI) have or develop comorbid depression and/or anxiety symptoms, which are associated with adverse events. The age, creatinine, and ejection fraction (ACEF) score is a good predictor for the prognostic assessment of certain cardiac diseases. But it has never been used to predict post-PCI depression and anxiety symptoms.

Red Meat Diet Exacerbates Colitis by Promoting the Accumulation of Myeloid Cells and Disrupting Gut Microbiota.

Inflammatory bowel disease (IBD) poses a significant threat to public health, yet its exact etiology remains unclear. Epidemiological studies reveal a strong correlation between red meat consumption and the development of IBD. In this study, we aimed to determine whether intake of different red meats increased colitis sensitivity and to explore the underlying mechanisms.

Highly selective synthesis of interlocked carbazole-based cages and their applications in photothermal seawater desalination.

The design and assembly of interlocked supramolecular cages is of interest due to their exquisite topological configuration and excellent performance in a variety of applications. We introduce two carbazole-based ligands L1 and L2, they combine with four distinct half-sandwich rhodium building blocks to form three molecular-tweezer-like compounds, three interlocked cages, tetranuclear macrocycle, and hexanuclear cage. Stacking interactions between carbazole groups facilitate the formation of interlocked structures.

Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score.

Objective: This study aims to investigate the prognostic value of integrating inflammatory biomarkers with the established Global Registry of Acute Coronary Events (GRACE) risk score for predicting clinical outcomes in patients with myocardial infarction (MI).

Methods: This prospective, single-center study enrolled adult MI patients admitted to the coronary care unit at Zhongshan Hospital, Fudan University. Blood samples were collected to measure inflammatory markers (IL-1β, sIL-2R, IL-6, IL-8) and myocardial biomarkers.

Method and experimental verification of spatial attitude prediction for an advanced hydraulic support system under mining influence.

The mining roadways of fully mechanized mining faces are susceptible to complex disturbances, leading to deformation of the surrounding rock, breaking the mechanical balance of the advanced support section of the mining roadway, and potential roof safety incidents and equipment damage. Accurate prediction of the spatial attitude of the advanced hydraulic support group can provide a foundation for dynamically adjusting the spatial attitude to accommodate the deformation of the roadway's surrounding rock. The selection of training parameters in the conventional Long Short-Term Memory (LSTM) network is often random and involves a significant amount of effort, which further limits prediction accuracy and real-time performance.

Tunable synthesis of atomic one-dimensional VTe magnets within single-walled carbon nanotubes.

The unstable configurations and uncontrollable stoichiometric ratios of atomically-thick one-dimensional (1D) magnets pose challenges for practical applications. Here, we employ a spatially confined domain strategy to obtain 1D vanadium tellurides (VTe) with distinctive stoichiometry within single-walled carbon nanotubes (SWCNTs). Confined by SWCNTs with different inner diameters, three unconventional air-stable VTe can be generated: 1D 1H-VTe, VTe, and VTe.

Regulatory TCRαβ Double Negative T Cells Suppress γδ T Cells and Alleviate Colitis.

Background And Aims: Inflammatory bowel disease arises from dysregulated immune activations triggered by a myriad of factors. The maintenance of immune tolerance within the intestinal milieu and the suppression of inflammatory responses remain the most efficacious strategies for alleviating enteritis. Regulatory TCRαβ double-negative T (DNT) cells play pivotal roles in orchestrating the homeostasis of various organs; however, their specific influence on colitis has yet to be thoroughly elucidated.

Ligand-functionalized metal-organic framework-based evaporator for synchronous freshwater production and agricultural wastewater remediation.

Solar-driven interfacial evaporation has been regarded as a promising method to alleviate water shortage. However, the organic contaminants are commonly accumulated on the evaporator during the evaporation process, which not only reduces the service life of the evaporator but also causes more serious pollution. Herein, a desalination-catalysis-irrigation integrated wood-based evaporator was presented by introducing cyano groups (-CN) in a metal-organic framework (MOF) system (M-NH-CN/wood).

Protocol for measuring the Young's modulus of organoids using atomic force microscopy.

Atomic force microscopy (AFM) is extensively applied to measure cell and tissue mechanics but lacks a standardized organoid stiffness assessment. Here, we present a protocol for quantifying the Young's modulus of organoids via AFM, combining force-curve analysis with an optimized probe. We describe steps for preparing organoids, OCT embedding, slicing, AFM detection, and force-curve analysis.

CD8 T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium.

Background: The etiology and pathogenesis of inflammatory bowel disease (IBD) are generally thought to be related to immune dysfunction and intestinal microbiota dysbiosis. However, the exact mechanisms remain unclear.

Methods: We applied a DSS-induced colitis model in wild-type and perforin-deficient ( ) mice.

The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis.

Background: Sarcopenia and muscle weakness are prevalent complications of ischemic stroke (IS), with limited pharmacological options. This study identifies high-dose extracts of Chrysanthemum Flos (ECF) as a potential therapy for post-stroke muscle dysfunction by targeting PANoptosis-a pro-inflammatory programmed cell death pathway. Through its anti-inflammatory and antioxidant properties, ECF attenuates muscle atrophy and enhances functional recovery, offering novel insights into ISS treatment.

Editable Light Response in Halide Perovskites Encapsulated within Single-Walled Carbon Nanotubes.

One-dimensional (1D) perovskite heterostructures fabricated through the template method employing single-walled carbon nanotubes (SWCNTs) have garnered significant attention due to their distinctive structural properties. Nevertheless, substantial challenges remain in the device applications of 1D halide perovskite heterostructures due to the separation issue of the semiconductor SWCNTs (s-SWCNTs) after encapsulating the perovskite. Here, we report 1D perovskite heterostructures based on CsPbBr encapsulated inside s-SWCNTs (CPB@s-SWCNTs), realizing editable photoresponse.

[Spatiotemporal Evolution Patterns of Grassland Degradation and Its Driving Factors on the Loess Plateau].

The vegetation restoration strategies on the Loess Plateau are progressively orienting towards natural regeneration, utilizing grasslands for ecological recovery. However, there is a dearth of precise, in-depth quantification of the long-term spatio-temporal patterns and driving factors of grassland degradation in this area. This study, based on AVHRR and MODIS NDVI data, employs Google Earth Engine （GEE）, grassland degradation indices, and spatio-temporal analysis to examine the vegetation cover and degradation patterns of the Loess Plateau's grasslands from 1986 to 2021.

Perforin Generated by CD8 T Cells Exacerbates Inflammatory Bowel Disease-Induced Depression by Promoting CXCL9 Production in Intestinal Epithelial Cells.

Background & Aims: Approximately 25.2% of patients with inflammatory bowel disease (IBD) suffer from psychological disorders, particularly depression. Recent studies have indicated a close relationship between intestinal immunity and brain disorders.

Rationalizing high-entropy catalytic self-Fenton pollutant degradation from an effective porous piezoelectric composite film.

As an emerging catalytic strategy, heterogeneous Piezo-Self-Fenton (EPSF) has demonstrated significant potential in fields such as environmental remediation and biomedicine in recent years. However, the catalytic reactions in this process are complex and diverse, and the understanding of high-entropy catalytic systems remains limited. In this study, we constructed a series of iron-based EPSF materials by incorporating various types of iron sources into MgO@rGO/PVDF-HFP composite piezoelectric films.

Quasi-Industrial Preparation of SWCNTs-Confined High-Entropy Oxides as Self-Supported Electrodes for Continuous Electrosynthesis.

High-entropy oxides (HEOs) are emerging as highly promising materials for electrochemical applications due to their exceptional electronic properties and active sites. However, the synthesis of 1D HEO with high aspect ratios and mechanical properties has been challenging, particularly on an industrial scale. Herein, we report a spatially confined oxidation (SCO) method to synthesize 1D HEO@SWCNTs with high specific surface area and stability.

Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist.

Allergic rhinitis (AR) is a non-infectious inflammatory disease and affects nearly half of the world's population currently, thus becoming a global health problem. In our study, a series of 1,2,4-triazole enamides were designed and used to evaluate the anti-inflammatory activity of AR. We found that compound 11g could significantly reduce the increased expression of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in Raw264.

Functionalized Thorium-Based Metal-Organic Frameworks for the Photocatalytic Oxidation of 1, 5-Dihydroxynaphthalene.

It is still a challenging task to rationally design metal-organic framework (MOF) crystal catalysts with excellent light absorption and charge transfer for efficient photocatalytic reactions. In this work, the hexanuclear thorium clusters, porphyrin derivative ligands, and linear carboxylic acid ligands were assemed into Th-based metal-organic frameworks (Th-TCPP, Th-Co-TCPP, and Th-Ni-TCPP) by the mixed ligand method. The three prepared MOF crystals were applied in the photocatalytic oxidation of 1, 5-dihydroxynaphthalene (1, 5-DHN) for the synthesis of juglone.

The efficacy, safety and clinical feasibility of a percutaneous atrial septal shunt device for pulmonary arterial hypertension: a single-center cohort study.

Aim: To evaluate the safety and efficacy of FreeFlow percutaneous atrial septal shunt device (manufactured by AOLIU Medical Technology Co., Ltd, Shanghai, China) in patients with refractory pulmonary arterial hypertension (PAH) for the first time.

Methods: The study enrolled adult patients diagnosed with refractory pulmonary arterial hypertension (PAH) at the Department of Cardiology, Zhongshan Hospital, Fudan University, between Oct 2021 and Oct 2023.

Host DNA depletion assisted metagenomic sequencing of bronchoalveolar lavage fluids for diagnosis of pulmonary tuberculosis.

Metagenomic next-generation sequencing (mNGS) has greatly improved our understanding of pathogens in infectious diseases such as pulmonary tuberculosis (PTB). However, high human DNA background (> 95%) impedes the detection sensitivity of mNGS in identifying intracellular Mycobacterium tuberculosis (MTB), posing a pressing challenge for MTB diagnosis. Therefore, there is an urgent need to improve MTB diagnosis performance in PTB patients.

Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa.

Background: Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC. However, it remains unclear whether combining immunotherapy with standard induction chemotherapy enhances its efficacy. This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC.

Bioinspired Photo-Thermal Catalytic System Using Covalent Organic Framework-Based Aerogel for Synchronous Seawater Desalination and HO Production.

Efficient utilization of solar energy is widely regarded as a crucial solution to addressing the energy crisis and reducing reliance on fossil fuels. Coupling photothermal and photochemical conversion can effectively improve solar energy utilization yet remains challenging. Here, inspired by the photosynthesis system in green plants, we report herein an artificial solar energy converter (ASEC) composed of light-harvesting units as solar collector and oriented ionic hydrophilic channels as reactors and transporters.

Investigation of morphometric features of auricle in newborns and etiology of auricle deformity.

Importance: The diagnosis of congenital auricular deformity often relies on the clinical experience of clinicians, leading to a high incidence of misdiagnosis and missed diagnosis due to the lack of quantitative diagnostic criteria.

Objective: To characterize auricle morphology in newborns from southern China and explore the underlying etiology of congenital auricle deformity.

Methods: A total of 636 neonates (1272 ears) with less than seven days old were included.

Highly Selective Construction of Unique Cyclic [4]Catenanes Induced by Multiple Noncovalent Interactions.

The synthesis of high-ordered mechanically interlocked supramolecular structures is an extremely challenging topic. Only two linear [4]catenanes have been reported so far and there is no defined strategy to obtain cyclic [4]catenane. Herein, two unprecedented cyclic [4]catenanes, 1 and 2, were prepared in high yields.