CircFGFR2 induces astrocyte pyroptosis to promote ischemic stroke.

Stroke is the second leading cause of death worldwide. Organoids, as disease models that closely mimic human physiology and pathology, are highly suitable for investigating the role of neural cells in brain diseases. However, there are few reports on circRNA research based on cerebral organoid stroke models.

Exosomal circ_0093708 as a potential ferroptosis biomarker in cerebral ischemia-reperfusion injury.

Background: Ferroptosis plays a critical role in neuronal injury following cerebral infarction. However, effective therapeutic strategies targeting ferroptosis after cerebral ischemia-reperfusion injury (CI/RI) remain limited. Exosome-based therapy holds significant promise in this context.

Catestatin attenuates cerebral ischemia/reperfusion injury and suppresses endoplasmic reticulum stress.

Ischemic stroke is one of the leading causes of death worldwide. Catestatin (CST), as a pleiotropic hormone, displays an anti-apoptotic effect, in addition to its known roles in cardiovascular regulation. However, the role of CST in ischemic stroke remains unclear.

Postharvest Application of -Inositol Extends the Shelf-Life of Banana Fruit by Delaying Ethylene Biosynthesis and Improving Antioxidant Activity.

Banana fruits are harvested and then undergo rapid ripening and senescence, sharply limiting their shelf-life and marketability. -inositol (MI) is an important regulator in ethylene production and reactive oxygen species (ROS) accumulation; however, its involvement in the postharvest ripening process of banana remains to be determined. This study found that postharvest application of MI could efficiently delay the fruit ripening and extend the time in which the luster, color, and hardness were maintained in two cultivars with contrasting storage characteristics, storable 'Brazil' and unstorable 'Fenza No.

DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury.

Ferroptosis constitutes a critical pathological mechanism in cerebral ischemia-reperfusion injury (CI/RI), significantly influencing neurological outcomes. While dual specificity phosphatase 1 (DUSP1) demonstrates neuroprotective effects against CI/RI, its regulatory role in ferroptosis remains to be elucidated. This study systematically investigated the therapeutic potential of DUSP1 through ferroptosis modulation in both in vitro and in vivo models.

EEG microstate analysis in children with prolonged disorders of consciousness.

Prolonged disorders of consciousness (pDoC) in children lack objective and effective diagnostic methods to assess consciousness states, hindering targeted treatment selection and delaying recovery. It remains unclear whether EEG microstate analysis, a method capturing spatial and temporal dynamics of brain activity, can serve as a reliable tool to differentiate consciousness states in children with pDoC, warranting further investigation. Resting-state EEG data (32 channels) were collected over 10 minutes from 45 children, divided into three groups (n=15 each): Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS; 7 females, 5.

Age and body mass index are associated with type Ⅲ aortic arch in patients undergoing digital subtraction angiography.

Background And Purpose: Type Ⅲ aortic arch can increase the difficulty of interventional surgery in patients with cerebrovascular diseases. This study was performed to explore the factors associated with type Ⅲ aortic arch.

Materials And Methods: This observational, multicenter, case-control study was performed in Shaanxi Province, China and involved 841 patients who underwent cerebral angiography at 3 stroke centers from April 2019 to August 2020.

Synergistic effects of 1-MCP and H₂S co-treatment on sugar and energy metabolisms in postharvest strawberry fruit.

Introduction: 1-methylcyclopropene (1-MCP) and hydrogen sulfide (HS) play important roles in the ripening and senescence of postharvest fruits and vegetables. However, little knowledge was available for the effect of the combined treatment of 1-MCP and HS on the quality maintenance of postharvest strawberry fruit.

Methods: The synergistic effects of 1.

Complement in anti-glomerular basement membrane glomerulonephritis.

Anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that often progresses to end-stage renal disease (ESRD). Complement activation and anti-GBM GN are closely related, as evidenced by the renal pathological characteristics of patients with anti-GBM GN, which include the linear deposition of immunoglobulin G (IgG) and C3 along the GBM. Increasing evidence suggests that all three pathways of complement activation may be involved in the pathogenesis and progression of anti-GBM GN.

Management of a pediatric patient with rapidly progressive glomerulonephritis and cutaneous mucormycosis: a case report.

Mucormycosis is a highly invasive and rare opportunistic infection caused by mucor fungi, characterized by challenging diagnosis and rapid disease progression. It predominantly affects patients with compromised immune systems due to various reasons, such as kidney failure, long-term use of antibiotics or corticosteroids. We recently successfully treated a pediatric patient with rapidly progressive glomerulonephritis accompanied by severe cutaneous mucormycosis.

Exploring cortical excitability in children with cerebral palsy through lower limb robot training based on MI-BCI.

This study aims to compare brain activity differences under the motor imagery-brain-computer interface (MI-BCI), motor imagery (MI), and resting (REST) paradigms through EEG microstate and functional connectivity (FC) analysis, providing a theoretical basis for applying MI-BCI in the rehabilitation of children with cerebral palsy (CP). This study included 30 subjects aged 4-6 years with GMFCS II-III grade, diagnosed with CP and classified as spastic diplegia. They sequentially completed EEG signal acquisition under REST, MI, and MI-BCI conditions.

Crohn's disease after multiple doses of rituximab treatment in a child with refractory nephrotic syndrome and an mutation: a case report.

inflammatory bowel disease (IBD) in response to rituximab (RTX) has been documented on multiple occasions as a severe adverse effect. However, none of these reports mentioned any genetic variation associated with this complication. We describe the case of a 16-year-old patient with refractory nephrotic syndrome (NS) diagnosed at the age of 6 years, notably with a heterozygous mutation of the gene, who developed Crohn's disease (CD) following ten administrations of RTX.

Theanine enhances resistance to in postharvest strawberry fruit via modulating cell-wall and phenylpropanoid metabolisms.

Theanine (N-ethyl-γ-glutamine), as a unique non-protein amino acid, plays vital roles in abiotic stress resistance, while its roles in biotic stress resistance are still unclear. Gray mold caused by is a major disease in strawberries. Effects of theanine on the development of gray mold, cell-wall and phenylpropanoid metabolisms in strawberries were investigated in this study.

Correlation between lipoprotein(a) and recurrent ischemic events post-cerebral vascular stent implantation.

Background And Aim: The association of Lipoprotein(a) (Lp[a]) with recurrent ischemic events in stented patients remains uncertain. So, this research aimed to investigate the impact of elevated Lp(a) levels on the occurrence of ischemic events in this specific patient population.

Methods: Totally 553 patients who underwent intracranial or extracranial artery stent implantation were included.

Clinical outcomes and clinico-pathological correlations in children with MPO-ANCA-associated glomerulonephritis showing renal arteritis.

The aim of this study was to evaluate the clinical features, pathological characteristics, and prognosis in myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AAGN) with renal arteritis. The study involved 97 children from five pediatric clinical centers with MPO-AAGN who exhibited distinct clinical features. The patients were divided into AAGN-A+ and AAGN-A-, based on the presence or absence of arteritis, and the disparities in clinical, histopathological characteristics, and prognosis between the two groups was evaluated.

The development of variable system-based internet of things for the solar greenhouse and its application in lettuce.

The east-west ridge orientation has recently become an important agronomic method to improve mechanization in solar greenhouses. However, these ridge orientation changes shape differences between different ridges in crop water consumption, and there is a lack of research on the regulation and adaptation of water consumption. Therefore, this study introduces a variable irrigation decision-making method based on the Internet of Things management and control system for an east-west ridge orientation.

Anti-metabolic glutamate receptor 5 encephalitis with gangliocytoma: a case and review of the literature.

Background: There are very limited reports on anti-metabolic glutamate receptor5 (mGluR5) encephalitis, especially lacking of pediatric research. The disease was mostly accompanied by tumors, mainly Hodgkin's lymphoma. No reports of other tumors, such as gangliocytoma have been reported to associate with anti-mGluR5 encephalitis so far.

Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival.

Background: Recent developments indicated that Bowman capsule rupture (BCR) is observed in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN). We aimed to explore the relationship between BCR and clinical manifestations, pathological changes, and prognosis in children with myeloperoxidase (MPO)-AAGN.

Methods: A total of 56 children with MPO-AAGN were divided into BCR (+) and BCR (-) groups according to the status of Bowman's capsule.

Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy.

Introduction: Self-limited infantile epilepsy (SeLIE) is a benign epilepsy. Previous studies have shown that monotherapy with most antiseizure medications can effectively relieve seizures in patients with SeLIE, but the efficacy of levetiracetam has not been investigated.

Objective: This study aimed to investigate the efficacy of levetiracetam in the treatment of SeLIE patients with PRRT2 mutations.

Serum IgE levels are a risk factor with prognosis of pediatric minimal change disease.

Background: Minimal change disease (MCD) is one of the most common primary glomerular disorders with high serum IgE levels. This study was aimed to investigate the clinical features of different serum IgE levels in pediatric MCD and evaluate the prognostic significance of serum IgE levels with regard to remission and relapse in pediatric cohort.

Methods: This study enrolled 142 new-onset children diagnosed with biopsy-proven MCD from January 2010 to December 2021 at the Jinling Hospital in Nanjing, China.

Metagenomic Evidence for Cobamide Producers Driving Prokaryotic Co-occurrence Associations and Potential Function in Wastewater Treatment Plants.

Cobamides are required by most organisms but are only produced by specific prokaryotic taxa. These commonly shared cofactors play significant roles in shaping the microbial community and ecosystem function. Wastewater treatment plants (WWTPs) are the world's most common biotechnological systems; knowledge about sharing of cobamides among microorganisms is predicted to be important to decipher the complex microbial relationships in these systems.

Measuring blood glucose before or after lumbar puncture.

Background: The ratio of cerebrospinal fluid (CSF) to peripheral blood glucose at the same period is an important index for diagnosing and monitoring the efficacy of central nervous system infection, especially bacterial meningitis. Some guidelines refer that blood glucose measurement should be carried out before lumbar puncture. The main reason is to avoid possible effect of stress response induced by lumbar puncture on the level of blood glucose.

Clinical characteristics and follow-up of children with norovirus-associated benign convulsions with mild gastroenteritis.

Objective: Explore the clinical characteristics and prognosis of children with norovirus (NoV)-associated benign convulsions with mild gastroenteritis (CwG).

Methods: We retrospectively analyzed the Clinical and laboratory data of children with NoV-associated CwG admitted to the emergency department of Guangzhou Children's Hospital between January 2019 and January 2020. And patients were followed up for 23-36 months.

Pediatric myelin oligodendrocyte glycoprotein antibody-associated disease in southern China: analysis of 93 cases.

Objective: To study the clinical features of children diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in southern China.

Methods: Clinical data of children diagnosed with MOGAD from April 2014 to September 2021 were analyzed.

Results: A total of 93 children (M/F=45/48; median onset age=6.