Exosomal circ_0093708 as a potential ferroptosis biomarker in cerebral ischemia-reperfusion injury.

Background: Ferroptosis plays a critical role in neuronal injury following cerebral infarction. However, effective therapeutic strategies targeting ferroptosis after cerebral ischemia-reperfusion injury (CI/RI) remain limited. Exosome-based therapy holds significant promise in this context.

Catestatin attenuates cerebral ischemia/reperfusion injury and suppresses endoplasmic reticulum stress.

Ischemic stroke is one of the leading causes of death worldwide. Catestatin (CST), as a pleiotropic hormone, displays an anti-apoptotic effect, in addition to its known roles in cardiovascular regulation. However, the role of CST in ischemic stroke remains unclear.

Conducting Polymer Coatings for Bioelectronic Arthroscopy Probes.

This study presents conducting polymer coatings as an effective strategy to enhance the performance of electromechanical arthroscopy probes by significantly reducing electrical equilibration time (the period a surgeon must wait for the probe signal to stabilize before measurement) and improving signal stability. Microelectrodes coated with poly(3,4-ethylenedioxythiophene, PEDOT) reach electrical equilibrium in physiological medium within 10 s, compared to over 2 min for standard electroless nickel immersion gold-based (ENIG) probes and ≈20 s for electrodeposited gold, thereby eliminating impractical delays during arthroscopic procedures. PEDOT coatings also reduce impedance by two to three orders of magnitude at low frequencies (<1 kHz), minimizing sensitivity to hand motion and reducing the likelihood of repeated measurements.

DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury.

Ferroptosis constitutes a critical pathological mechanism in cerebral ischemia-reperfusion injury (CI/RI), significantly influencing neurological outcomes. While dual specificity phosphatase 1 (DUSP1) demonstrates neuroprotective effects against CI/RI, its regulatory role in ferroptosis remains to be elucidated. This study systematically investigated the therapeutic potential of DUSP1 through ferroptosis modulation in both in vitro and in vivo models.

Robust and flexible organic electrochemical transistors enabled by electropolymerized PEDOT.

Organic electrochemical transistors (OECTs) based on poly(3,4-ethylenedioxythiophene) (PEDOT) have been extensively studied, yet devices fabricated via electropolymerization remain underexplored in terms of the underlying ionic dynamics and the potential for flexible integration. In this work, we demonstrate robust OECTs based on electropolymerized PEDOT, exhibiting negligible drain current degradation after 1000 cycles of operation in aqueous NaCl. Compared to inkjet-printed devices, they offer markedly superior cycling stability, which is further enhanced by the incorporation of the small anionic dopant ClO .

Explainable machine learning-driven models for predicting Parkinson's disease and its prognosis: obesity patterns associations and models development using NHANES 1999-2018 data.

Background: Parkinson's disease (PD) is a prevalent neurodegenerative condition, the effect of obesity on PD remains controversial. We aimed to investigate the associations of obesity patterns on PD and all-cause mortality, while developing machine learning (ML)-driven predictive and prognostic models for PD.

Methods: Fifty-one thousand, three hundred ninety-four adults from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were classified into four obesity patterns via body mass index (BMI) and waist circumference (WC).

Age and body mass index are associated with type Ⅲ aortic arch in patients undergoing digital subtraction angiography.

Background And Purpose: Type Ⅲ aortic arch can increase the difficulty of interventional surgery in patients with cerebrovascular diseases. This study was performed to explore the factors associated with type Ⅲ aortic arch.

Materials And Methods: This observational, multicenter, case-control study was performed in Shaanxi Province, China and involved 841 patients who underwent cerebral angiography at 3 stroke centers from April 2019 to August 2020.

Effects of calcium-sensitive receptors on chondrogenic differentiation of rat bone marrow mesenchymal stem cells.

The purpose of this study was to investigate the role of Calcium-Sensing Receptor in the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and to provide a new target for cartilage defect repair. BMSCs were cultured in vitro, and cultured in the complete culture medium with gradient concentration of calcium sensitive receptor inhibitor and activator, and the optimum dose was selected by CCK-8 experiment. The experiment was divided into four groups.

Macrophage knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination.

Acute lung injury (ALI) caused by sepsis is a fatal disease characterized by an systemic inflammatory response to invading pathogens. Inducing macrophage macroautophagy/autophagy is a critical strategy to combat the inflammatory response in septic ALI. The E3 ubiquitin ligase TRIM21 plays important roles in autophagy.

NMB promotes the progression of colorectal cancer by regulating the NF-κB/P65 signaling pathway.

Background: Colorectal carcinoma (CRC) ranks as the fourth most prevalent malignancy globally. Neuromedin B (NMB) and its corresponding receptor have been implicated in the pathogenesis of multiple neoplastic conditions. Nevertheless, the specific involvement of NMB in CRC progression remains poorly characterized.

Recyclable Printed Liquid Metal Composite for Underwater Stretchable Electronics.

Multifunctional stretchable conductors are crucial components in fully stretchable circuits for wearable bioelectronics. Conductive composites made from liquid metal (LM) fillers and polymer matrices have garnered significant interest due to their high electrical conductivity, adjustable mechanical properties, biocompatibility, and recyclability. Herein, a printable LM composite is developed using a custom-designed block copolymer to ensure electromechanical stability in both wet and dry conditions.

Metformin exhibits inhibitory effects on ferroptosis and alleviates chondrocyte metabolic imbalance in osteoarthritis models, as well as Erastin-induced ferroptosis, through the modulation of the P53/SLC7A11 pathway.

Osteoarthritis (OA) is a prevalent degenerative disease, and metformin, the first-line treatment for type 2 diabetes, has shown potential in slowing the progression of OA, although its mechanism of action is not fully understood. This study aims to explore the role of ferroptosis in OA and evaluate the therapeutic effects and mechanisms of metformin on ferroptosis. We identified gene differences associated with OA through RNA-Seq data analysis and predicted potential targets using network pharmacology and molecular docking techniques.

Solvothermal Self-Assembly of Hollow Square-Tubular Polyimides for Aqueous Batteries.

In this study, a straightforward and environmentally benign solvothermal method for synthesizing hollow square-tubular polyimides (HST-PIs) is introduced. The process utilizes 1,4,5,8-naphthalenetetracarboxylic anhydride and urea as reactants, replacing traditional toxic organic solvents with water and ethanol. This investigation explores the effects of various reaction conditions, such as the water-to-ethanol volume ratio, reaction time, and temperature, on product morphology, resulting in distinct structures like sheets, columns, and layers.

Exploring the key technologies and applications of 6G wireless communication network.

The contemporary mobile communication has undergone a significant shift toward a novel phase characterized by the emergence of beyond 5G (B5G) and 6G technologies. These advancements underscore a focus on enhanced spectral efficiency, minimized latency, and expansive connectivity. This paper thoroughly examines 6G wireless communication networks, including their architectural framework, key technologies, application scenarios, use cases, and challenges.

Whole-Genome Analysis of G2P[4] Rotavirus Strains in China in 2022 and Comparison of Their Antigenic Epitopes with Vaccine Strains.

Group A rotavirus (RVA) is the leading cause of acute gastroenteritis in infants and young children worldwide. To elucidate the molecular epidemiology of G2P[4] rotavirus in China and the protective effects of vaccines, whole-genome analysis of 13 G2P[4] RVA strains collected from China in 2022 was performed. Twelve strains possessed the typical DS-1-like genome constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2.

The effects of coagulation factors on the risk of Alzheimer's disease: A Mendelian randomization study.

Background: Observational studies indicate a complex relationship between coagulation factors and Alzheimer's disease (AD). However, the current findings are inconsistent, and it remains uncertain whether a causal relationship exists.

Objective: This study utilizes a Mendelian randomization analysis to investigate the causal relationships between blood levels of coagulation factors and AD risk.

Calcium-sensing receptors promoted Homer1 expression and osteogenic differentiation in bone marrow mesenchymal stem cells.

Homer1 interacts with calcium-sensing receptors (CaSRs) in osteoblasts (OBs), with both CaSR and Homer1 playing essential roles in AKT phosphorylation. This study investigated the impact of CaSR on Homer1 expression during the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) at morphological, imaging, and molecular levels, both and . A post-oophorectomy osteoporosis model was established in Sprague-Dawley rats, validated through micro-computed tomography, hematoxylin-eosin staining, and biomechanical testing to assess changes in CaSR expression.

Honeycomb-like MnO/C hybrids with strong interfacial interactions for aqueous zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) have garnered significant attention for large-scale energy storage applications due to their high theoretical capacity, low cost, and inherent safety. However, the absence of cathode materials exhibiting superior electrochemical performance severely impedes their further development. In this study, we report a metal-organic framework (MOF)-derived honeycomb-like MnO/C hybrid as a high-performance cathode material for AZIBs.

Measuring mini SmartApp usability for ankylosing spondylitis from the perspective of patients and health providers.

ObjectiveTo identify beneficial experiences, areas needing improvement, and potential additional value, with a view to providing a reference for the application of mobile health management in clinical practice.MethodsThis study applied a mixed research approach to measure the mini smartApp usability among participants who were diagnosed with ankylosing spondylitis at rheumatology and immunology department of the Affiliated Hospital of Nantong University between October 2022 to March 2023 and research staff. This study lasted two weeks.

Association between life's essential 8 and Parkinson's disease: a case-control study.

Objectives: Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) is still unclear. This study aimed to elucidate the association between LE8 metrics and PD in the US adults.

Methods: Data of 26,975 participants were extracted from the last 7 National Health and Nutrition Examination Survey (NHANES) cycles (2005-2018).

Shunt Dependency Syndrome Combined with Sinus Stenosis after Cyst-peritoneal Shunting of Arachnoid Cyst: A 20-year Rare Complication.

Shunt dependence syndrome is a serious long-term complication characterized by symptoms and signs of increased intracranial pressure with normal-sized lateral ventricles after several years of arachnoid cyst-peritoneal shunting. It is easy to misdiagnose and overlook when combined with sinus stenosis, thus delaying treatment. Here, we present a 35-year-old man with an unexplained headache and binocular horizontal diplopia with high intracranial pressure.

A novel mitochondrial-targeted fluorescent probe for ratiometric imaging of nitric oxide in cells and zebrafish.

Nitric oxide (NO) is a key signaling molecule that regulates energy metabolism, apoptosis, and antioxidant balance within mitochondria. It is closely associated with the development of cardiovascular diseases, neurodegenerative diseases, and cancer. Therefore, developing fluorescent probes capable of accurately detecting NO levels in mitochondria is essential for understanding disease mechanisms and clinical diagnostics.

A novel ratiometric BenzoBODIPY-Based fluorescent probe for the detection and imaging of Cysteine in living cells and zebrafish models.

Cysteine (Cys) plays a critical role in various biological processes, including protein synthesis, cellular signaling, and antioxidant defense. However, precise detection of Cys in biological systems remains challenging due to interference from similar thiols such as homocysteine (Hcy) and glutathione (GSH). In this study, we report the synthesis and bioimaging of a novel ratio-type fluorescent probe based on the benzoBODIPY fluorophore, designed for the ratiometric detection of Cys.