Polarization and space multiplexing metasurface for high-efficiency holography.

This paper presents a fast and efficient design method for generating multiplanar, dual-linearly polarized holographic patterns in the near-field of a Huygens metasurface when illuminated by incident waves with matching polarizations. The propagation kernel of the traditional Gerchberg-Saxton (GS) algorithm is modified to utilize Green's function (DGF), and a dynamic control factor is introduced to adjust the uniformity of the pattern amplitude. This modification results in an imaging phase distribution, hereby designated as the improved weighted Gerchberg-Saxton algorithm (GS-W).

Lenvatinib Plus Paclitaxel as Second-Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study.

Second-line treatment options for advanced gastric cancer (AGC) patients remain limited. This dose escalation exploratory study is aimed to determine the maximum tolerated dose (MTD) of lenvatinib plus paclitaxel as second-line treatment in AGC and to explore molecular biomarkers using dynamic network biomarker (DNB) analysis. Eligible patients are treated with lenvatinib plus paclitaxel (135 mg m, q3w).

Mechanical behavior and energy absorption capability of trigonometric function curved rod cell-based lattice structures under compressive loading.

Traditional body-centered cubic (BCC) lattice metamaterials exhibit structural deficiencies including geometric discontinuity at cell connections and pronounced stress concentration at nodal regions, which restrict further enhancement of mechanical performance. This study proposes a novel lattice design methodology utilizing trigonometric function-modulated strut axes, yielding three novel trigonometric function curved rod cell-based lattice structures (TCRC, SCRC, and CCRC). By integrating fillet transition technology to achieve stress redistribution optimization, these configurations were systematically upgraded to TCRC-ipv, SCRC-ipv, and CCRC-ipv variants with enhanced structural performance.

Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation.

Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system. Non-toxigenic Bacteroides fragilis, a common human colon symbiote, has been shown to alleviate colitis. However, the underlying mechanisms of this alleviation remain incompletely understood.

Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miRNA-5106 suppresses NETs by restoring zinc homeostasis to alleviate colitis.

Background: Inflammatory bowel disease (IBD) is a chronic disorder marked by persistent inflammation and damage to the intestinal mucosa. Despite significant advances in treatment, there remains an unmet need for more effective and safer therapeutic strategies.

Results: In this study, we isolated and characterized extracellular vesicle-like nanoparticles (ELNs) derived from Coptis chinensis (Cc-ELNs) and evaluated their therapeutic potential in IBD.

Effects of Microalloying Elements (Mg, Ag, Al, Zn, and Sn) on Dendrite Growth and Stability in Li Metal Anodes.

In recent years, research on Li metal batteries (LMBs) has surged, with Li alloy materials garnering extensive attention due to their significant commercial prospects. Despite the progress, the precise mechanisms by which various alloying elements suppress Li dendrite growth remain inadequately understood. Herein, microalloyed LiM@Cu (M = Mg, Ag, Al, Zn, and Sn) composite anodes were successfully prepared by a melting-rolling method.

Interfacial engineered biomass-derived G/VMT-PCNCs networks as high-performance proton-conducting humidity sensors.

In this study, a novel proton-conducting film was strategically engineered by interfacial manipulation of green and sustainable biomass resources guanine and phosphorylated cellulose nanocrystals (PCNCs) within vermiculite layers. The interfacial engineering approach involved regulation of molecular interactions at the vermiculite-organic interface, whereby PCNCs were incorporated into the interlayers of guanine/vermiculite composites. This interfacial assembly process guided guanine to form tubular structures or ultrathin nanosheets architectures, enabling the fabrication of guanine/vermiculite-PCNCs (G/VMT-PCNCs) composite films with an active-site-rich and tightly interconnected network via a vacuum-assisted process.

Realizing a Robust High-Performance Ni-GDC Nanocomposite Anode for SOFCs by Self-Assembly of Reactive Cosputtered Nanolayers.

This study reports a fast and scalable route for fabricating efficient and durable SOFCs, leveraging nickel oxide-gadolinium-doped ceria (NiO-GDC) nanocomposites and thin-film electrolytes based on reactive sputtering. The Ni and GdCe targets are first cosputtered to form films with a stack-layered structure of metallic Ni and GDC, followed by sputtering YZr and GdCe targets alternatively to make multilayer electrolytes. By annealing the sputtered anode-electrolyte assembly with the LaSrCoFeO cathode in a single step at 1000 °C, full cells feature heterostructure ceramic multilayers; NiO-GDC nanocomposites with heterointerfaces are constructed, while the multilayer electrolytes are fully dense.

COVID-19 patient serum-derived extracellular vesicles deliver miR-20b-5p induces neutrophil extracellular traps.

Background: Severe cases of COVID-19 are characterized by an excessive presence of neutrophils. Neutrophil extracellular traps (NETs), released by activated neutrophils due to SARS-CoV-2 infection, contribute to lung epithelial cell death and are key drivers in COVID-19-associated immunothrombosis. However, the mechanism underlying NET formation in COVID-19 remain unclear.

Gut microbiota and potential serum metabolites biomarkers of pregnant woman for preeclampsia.

Background: The pathogenesis of preeclampsia (PE) remains unclear, but the interaction between intestinal flora and PE has been attention in recent studies. Several studies have shown that imbalanced intestinal flora plays an important role in the inducement of PE.

Purpose: The potential correlation among intestinal flora, metabolites, and fetal growth restriction was explored by integrating data and analyzing neonatal growth.

Insights into the formation of pullulan nanofilm and its feasibility as probiotic-resided oral fast dissolving carrier.

Oral fast dissolving films represent a novel dosage form for probiotics. To reduce the dependence of film preparation on synthetic materials, a polysaccharide-based oral fast dissolving nanofilm for probiotics was fabricated through pullulan (PUL) electrospinning. An electrospinnability map of PUL with varying physical properties was developed, identifying a molecular weight of 200 kDa and a concentration of 20 % as suitable conditions for achieving favorable fiber morphology.

A respiratory mucosal vaccine based on chitosan/aluminum adjuvant induces both mucosal and systemic immune responses.

The respiratory mucosa serves as a critical barrier against the invasion of pathogens. Effective mucosal vaccines are essential for enhancing local immunity. However, there is an urgent need to develop new mucosal adjuvants.

A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer.

The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy is increasing in importance. Single-omics analyses, constrained by their focus on a single biological layer, cannot fully elucidate the complexities of tumour molecular profiles and can thus overlook crucial molecular targets. In response to this limitation, we developed a multiobjective recommendation system (RJH-Metastasis 1.

Overview of PRMT1 modulators: Inhibitors and degraders.

Protein arginine methyltransferase 1 (PRMT1) is pivotal in executing normal cellular functions through its catalytic action on the methylation of arginine side chains on protein substrates. Emerging research has revealed a correlation between the dysregulation of PRMT1 expression and the initiation and progression of tumors, significantly influence on patient prognostication, attributed to the essential role played by PRMT1 in a number of biological processes, including transcriptional regulation, signal transduction or DNA repair. Therefore, PRMT1 emerged as a promising therapeutic target for anticancer drug discovery in the past decade.

MG53 binding to CAV3 facilitates activation of eNOS/NO signaling pathway to enhance the therapeutic benefits of bone marrow-derived mesenchymal stem cells in diabetic wound healing.

Impaired wound healing in diabetes results from a complex interplay of factors that disrupt epithelialization and wound closure. MG53, a tripartite motif (TRIM) family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. In this study, bone marrow-derived mesenchymal stem cells (BMSCs) were transduced with lentiviral vectors overexpressing MG53 to investigate their efficacy in diabetic wound healing.

CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib.

Background: Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been demonstrated to offer therapeutic benefits in previous studies. Circular RNAs (circRNAs) have been implicated in CRC progression and their unique structural stability serves as promising biomarkers.

Efficacy of nab‑paclitaxel vs. Gemcitabine in combination with S‑1 for advanced pancreatic cancer: A multicenter phase II randomized trial.

Patients with advanced pancreatic cancer (PC) need a cost-effective treatment regimen. The present study was designed to compare the efficacy and safety of nab-paclitaxel plus S-1 (AS) and gemcitabine plus S-1 (GS) regimens in patients with chemotherapy-naïve advanced PC. In this open-label, multicenter, randomized study named AvGmPC, eligible patients with chemotherapy-naïve advanced PC were randomly assigned (1:1) to receive AS (125 mg/m nab-paclitaxel, days 1 and 8; 80-120 mg S-1, days 1-14) or GS (1,000 mg/m gemcitabine, days 1 and 8; 80-120 mg S-1, days 1-14).

Comparing the severity of second preeclampsia with first preeclampsia: a multicenter retrospective longitudinal cohort study.

Objective: Compare the clinical severity of second preeclampsia with the first preeclampsia.

Methods: This retrospective longitudinal cohort study was conducted in three teaching hospitals in Guangzhou, where there were a total of 296 405 deliveries between 2010 and 2021. Two consecutive singleton deliveries complicated with preeclampsia were included.

AB-GRU: An attention-based bidirectional GRU model for multimodal sentiment fusion and analysis.

Multimodal sentiment analysis is an important area of artificial intelligence. It integrates multiple modalities such as text, audio, video and image into a compact multimodal representation and obtains sentiment information from them. In this paper, we improve two modules, i.

VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.

VPS35 is a key subunit of the retromer complex responsible for recognising cytosolic retrieval signals in cargo and is involved in neurodegenerative disease and tumour progression. However, the function and molecular mechanism of VPS35 in gastric cancer (GC) remains largely unknown. Here, we demonstrated that VPS35 was significantly upregulated in GC, which was associated with poor survival.

Dendrite-Free Zn Anode Endowed by Facile Al-Complex Coating for Long-Cycled Aqueous Zn-Ion Batteries.

Side reactions and dendrite growth on the zinc metal anode surface seriously damage the shelf life and calendar life of Zn-based batteries. Here, an Al-complexed artificial interfacial layer is constructed on the Zn surface (denoted as Al-complex@Zn) by a low-cost, facile, and scalable chemical method. The Al-complex interfacial layer improves the wettability of the electrolyte.