A140 plus mFOLFOX6 compared with cetuximab plus mFOLFOX6 for first-line RAS wild-type metastatic colorectal cancer: A randomized clinical trial.

Purpose: EGFR inhibition, combined with chemotherapy, forms a mainstay of treatment of first-line RAS wild-type (RASwt) metastatic CRC (mCRC). We compared the anti-EGFR antibody, A140, with cetuximab (both combined with chemotherapy) for RASwt mCRC.

Methods: In this phase 3, randomized, double-blind, multi-center equivalence trial in China, patients were randomized (1:1) to oxaliplatin, 5-fluorouracil, and leucovorin (modified [m] FOLFOX6), plus either A140 or cetuximab for ≤ 16 weeks until disease progression or unacceptable toxicity.

Unraveling the dual nature of FLASH radiotherapy: From normal tissue sparing to tumor control.

FLASH radiotherapy (FLASH-RT), characterized by the delivery of ultra-high dose rate irradiation within microseconds to milliseconds, has rapidly emerged as a paradigm-shifting approach in radiation oncology. Preclinical studies have consistently demonstrated its remarkable ability to spare normal tissues while maintaining effective tumor control, challenging long-standing paradigms of radiobiology. This review comprehensively synthesizes current experimental findings from diverse in vitro and in vivo models, including zebrafish embryos, mice, Drosophila melanogaster, and Caenorhabditis elegans, emphasizing the distinct protective effects of FLASH-RT across various tissue types.

The effects of indole-2,3-dione on radiosensitivity of U251 cells and zebrafish embryos.

Radiotherapy is an effective treatment for gliomas, which are among the most malignant tumors in the central nervous system (CNS). A significant challenge in glioma radiotherapy is improving tumor control while minimizing damage to normal nervous tissue. In this study, we investigated the dual role of indole-2,3-dione (Isatin, ISA), a compound with diverse biological and pharmacological activities, including anticancer, antioxidant, and anti-inflammatory properties, in modulating radiosensitivity.

gen. nov. (Hymenochaetales, Basidiomycota) Segregated from Based on Morphological, Phylogenetic, and Ecological Evidence.

Taxonomic and phylogenetic studies of (Hymenochaetales, Basidiomycota) were performed. A phylogenetic estimate based on six genetic markers revealed that in the current sense includes species belonging to three distantly related clades in the Hymenochaetales. Based on morphology, phylogeny, and ecological habitat, the name s.

A Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of A140 Injection and Cetuximab (Erbitux) in Healthy Chinese Male Subjects.

Introduction: This study aimed to compare the pharmacokinetic (PK) profiles, safety, and immunogenicity of the proposed A140 with those of cetuximab (Erbitux) in healthy Chinese male subjects.

Methods: We conducted a randomized, single-dose, double-blind, parallel-controlled phase I study in which 82 healthy subjects were randomized equally into the A140 group and the cetuximab group. Both the test and comparator drug were administered as a single intravenous (IV) dose of 250 mg/m.

Pharmacokinetics, pharmacodynamics and safety profile of SKB336, a selective inhibitor of coagulation factor XI/XIa in healthy subjects.

Aims: Coagulation factor XI (FXI) plays a crucial role in the intrinsic coagulation pathway, and inhibitors targeting it may mitigate the risk of haemorrhage compared to anticoagulants currently on the market. SKB336, a novel selective inhibitor of FXI/FXIa, has been shown to prolong the activated partial thromboplastin time (APTT) in both in vitro and in vivo studies. This study aimed to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of SKB336 in healthy subjects.

Assembly and comparative analysis of the complete mitochondrial genome of (Polyporaceae, Basidiomycota), contributing to understanding fungal evolution and ecological functions.

is a crucial wood-decaying fungus with significant lignocellulose-degrading ability, which plays a vital role in the material cycle and energy flow of forest ecosystems. However, the mitochondrial genome of has not yet been revealed. In the present study, the complete mitochondrial genome of was assembled and compared with related species.

Carbon ion irradiation conquers the radioresistance by inducing complex DNA damage and apoptosis in U251 human glioblastomas cells.

Glioblastoma multiforme (GBM) is the most malignant brain tumor, with radiotherapy frequently employed following surgical resection. However, conventional radiation therapies often yield suboptimal results. This study investigated the effects of X-ray and carbon ion irradiation on the glioblastoma cell line U251 to assess the distinctive advantages of carbon ion treatment and explore mechanisms for overcoming radiation resistance.

Alternating inverse modulation of xylem K/NO loading by HY5 and PIF facilitates diurnal regulation of root-to-shoot water and nutrient transport.

Diurnal light-dark cycles regulate nutrient uptake and transport; however, the underlying molecular mechanisms remain largely unknown. Transcription factor MYB59 and ion transporter NPF7.3 participate in root-to-shoot K/NO translocation in Arabidopsis.

ZmNPF7.10 confers potassium and nitrogen distribution from node to leaf in maize.

In graminaceous plants, nodes play vital roles in nutrient allocation, especially for preferential nutrient distribution to developing leaves and reproductive organs. However, the molecular mechanisms underlying this distribution remain poorly understood. In this study, we identified a transporter named ZmNPF7.

Degradation of High Concentrations of Anthracene Using White-Rot Wood-Inhabiting Fungi and Investigation of Enzyme Activities.

Owing to the production of lignin-modifying enzymes (LMEs), white-rot fungi (WRF) such as polypores are potent organisms in the biodegradation of xenobiotic pollutants. The nonspecific function of LMEs including laccase and manganese peroxidase (MnP), has enabled the use of WRF in biotechnological applications, particularly in bioremediation. In this study, 12 strains from nine white-rot basidiomycete genera viz.

The role of lncRNA NEAT1 in human cancer chemoresistance.

Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become an urgent problem to be solved in the field of cancer chemotherapy. Therefore, it is very important to deeply study and analyze the mechanism of cancer chemotherapy resistance and its regulatory factors.

Laccase immobilization and its degradation of emerging pollutants: A comprehensive review.

The chronic lack of effective disposal of pollutants has resulted in the detection of a wide variety of EPs in the environment, with concentrations high enough to affect ecological health. Laccase, as a versatile oxidase capable of catalyzing a wide range of substrates and without producing toxic by-products, is a potential candidate for the biodegradation of pollutants. Immobilization can provide favorable protection for free laccase, improve the stability of laccase in complex environments, and greatly enhance the reusability of laccase, which is significant in reducing the cost of industrial applications.

The role of lncRNA HCG18 in human diseases.

A substantial number of long noncoding RNAs (lncRNAs) have been identified as potent regulators of human disease. Human leukocyte antigen complex group 18 (HCG18) is a new type of lncRNA that has recently been proven to play an important role in the occurrence and development of various diseases. Studies have found that abnormal expression of HCG18 is closely related to the clinicopathological characteristics of many diseases.

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells.

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to redirect isoform expression of apoptosis-related genes could lead to promising anti-cancer phenotypes. Glioblastoma (GBM) is the most common type of malignant brain tumor in adults.

Whole genome sequencing and annotation of , a wood-decaying fungus significantly degrading lignocellulose.

is a fungus that grows on wood and secretes a series of enzymes to degrade cellulose, hemicellulose, and lignin and cause wood rot decay. Wood-decaying fungi have ecological, economic, edible, and medicinal functions. Furthermore, the use of microorganisms to biodegrade lignocellulose has high application value.

N-nitrosodimethylamine exposure to zebrafish embryos/larvae causes cardiac and spinal developmental toxicity.

N-nitrosodimethylamine (NDMA), one of the new nitrogen-containing disinfection by-products, is potentially cytotoxic, genotoxic, and carcinogenic. Its potential toxicological effects have attracted a wide range of attention, but the mechanism is still not sufficiently understood. To better understand the toxicological mechanisms of NDMA, zebrafish embryos were exposed to NDMA from 3 h post-fertilization (hpf) to 120hpf.

Taxonomic and phylogenetic contributions to (Hymenochaetales, Basidiomycota): two new species from Hawaii with a key to North American species.

is a cosmopolitan, poroid, wood-decaying genus, belonging to the Hymenochaetales. During a study of wood-inhabiting fungi in the USA, four unknown specimens were collected from Hawaii. Both morphological criteria and molecular genetic analyses based on the ITS+nLSU+EF1-α datasets and the nLSU dataset confirmed that these four specimens represent two new species of , and they are described as and is characterized by pileate basidiocarps, the absence of cystidioles, hooked hymenial setae, broadly ellipsoid to subglobose basidiospores measuring 4-6 × 3.

Phylogeny and diversity of (, ), including three new species from Asia.

Phylogenetic and morphological analyses on were carried out. The genus (, ), typified by (Fr.) Overeem.

Enlargement of the knowledge of section (Agaricales, Basidiomycota): introducing three new species from China.

is a globally distributed agaricoid genus that has been well studied in Europe and America with over 1,000 described species. However, as part of an ongoing effort to investigate the diversity of section in China, the resource investigation and classification research are still limited, and the species diversity has not been clarified by far. During the re-examination of the Chinese specimens, , , and , belonging to the sect.

Carbon ions trigger DNA damage response to overcome radioresistance by regulating β-catenin signaling in quiescent HeLa cells.

Quiescent cancer cells are major impediments to effective radiotherapy (RT) and exhibit limited sensitivity to traditional photon therapy. Herein, the functional role and underlying mechanism of carbon ions in overcoming the radioresistance of quiescent cervical cancer HeLa cells were determined. Briefly, serum withdrawal was used to induce synchronized quiescence in HeLa cells.

A contribution to the genus (Steccherinaceae, Polyporales): Introducing two new species and two new combinations of the genus.

Two new wood-inhabiting fungi from China, and , in the family Steccherinaceae are described and illustrated based on morphological and molecular analyses. The species was found growing on the rotten wood of in Qinghai Province, China, while was collected on rotten angiosperm wood in Yunnan Province, China. The characteristics of include annual, resupinate basidiomata with a buff yellow fresh pore surface that becomes apricot orange when bruised, angular pores of 3-6 per mm, subicular generative hyphae sometimes covered with crystals, the presence of encrusted skeletocystidia in tube trama only, fusiform to slim clavate cystidioles, and ellipsoid basidiospores measuring as 3-4 × 2-3 μm.

Evaluation of the immunization effectiveness of bOPV booster immunization and IPV revaccination.

To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV) at 48 months of age after different primary polio immunization schedules. At 48 months of age, one dose of bOPV was administered, and their poliovirus types 1-3 (PV1, PV2, and PV3, respectively)-specific neutralizing antibody levels were determined. Participants found to be negative for any type of PV-specific neutralizing antibody at 24, 36, or 48 months of age were re-vaccinated with inactivated polio vaccine (IPV).