Potential of AI Chatbots in Online Hair Transplantation Consultations: A Multi-metric Assessment of Three Models.

Background: The use of artificial intelligence (AI) chatbots has demonstrated considerable promise in assisting medical consultations. However, their potential for application in online hair transplantation consultations remains largely unexplored.

Objectives: This study aims to assess the effectiveness of AI chatbots in responding to patient inquiries during online hair transplantation consultations.

Comprehensive Prevention for Edema after Hair Transplantation: A Multicenter Study of 1167 Patients.

Background: Postoperative edema is the most common complication of hair transplantation. Although triamcinolone tumescent solution (TTS) has been shown to effectively reduce edema, a minority of patients may still experience severe edema. This study aims to explore optimized procedures and conduct a systematic analysis comparing TTS with our comprehensive prevention (CP) for preventing postoperative edema.

Enhancing Graft Survival Rates in Follicular Unit Excision: A Chinese Expert Consensus on Perioperative Procedures.

Background: The survival rate of grafts, a critical metric for evaluating the postoperative outcomes of follicular unit excision (FUE), can be significantly improved through standardized perioperative procedures. This expert consensus aims to provide evidence-based recommendations to healthcare professionals in the field of hair transplantation to enhance graft survival rates.

Methods: A systematic review was conducted on all clinical issues related to the graft survival of FUE.

Temperature-dependent local and global dynamics of atactic polystyrene: A coarse-grained molecular dynamics simulation study.

A systematic coarse-grained (CG) model, as a promising and helpful tool to access the accurate knowledge of the local and global polymer dynamics of real polymers, is required to preserve structural, thermodynamic, and dynamic properties of the underlying atomistic model over a wide temperature range. In the present work, to explore the temperature-dependent local and global dynamic properties of atactic polystyrene (PS) as well as the dynamic consistency of a PS CG model constructed via a structure- and thermodynamics-based CG approach with the united-atom (UA) counterpart, we have investigated and compared the translational and rotational dynamics of the two models in the scale from a single monomer to a global chain in a broad temperature range. The CG model accurately reproduces the time-dependent translational diffusion scaling and the shift from a multistep relaxation to a single-step long-time decay process with increasing span of bond vectors as the UA model.

Development of an Evaluation System to Classify Beard Donor Area for Hair Transplantation.

Background: Beards are important donor sources for hair transplantation in male patients. However, standardized assessment criteria for beard grafts' suitability and application are unavailable.

Objective: To develop an evaluation system for classifying beard suitability and defining its specific applications in hair transplantation.

Premade Incisions vs. Stick and Place: A Multicenter Retrospective Comparison of Hair Transplantation Outcomes in China.

Background: Based on the differences in the procedures of recipient site creation and graft placement, hair transplantation implantation techniques can be classified into premade incisions (PI) and stick and place (S&P). However, limited studies have systematically compared their clinical outcomes.

Methods: A retrospective analysis was conducted on 191 Chinese patients (95 in the PI group and 96 in the S&P group) from four hospitals, undergoing follicular unit excision between August 2022 and August 2024.

Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from : A Review.

Blume is a well-known medicinal and edible plant in China, celebrated for its extensive history in traditional medicine and functional food applications. Among its key bioactive components, polysaccharides have drawn significant attention from researchers in the fields of health food and medicine due to their potential health benefits. Recent studies have revealed various biological activities associated with polysaccharides, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, anti-aging, immune regulation, and neuroprotective properties.

Utidelone combined with anti‑angiogenic therapy for the treatment of anthracycline/taxane‑treated and endocrine‑resistant HRHER2 refractory breast cancer with brain metastases: A case report.

For patients with hormone receptor-positive (HR) and human epidermal growth factor receptor 2-negative (HER2) metastatic breast cancer (mBC), the treatment choices become more complex after progression on first-line CDK4/6 inhibitors combined with endocrine therapy. Currently, there are no guidelines that provide a unified standard protocol for this situation. Almost half of patients with mBC develop brain metastases (BMs), and once BMs occur, the survival of the patient is often significantly reduced.

Follicular Unit Excision Hair Removal of Unwanted Facial Terminal Hair in Five Facial Areas: A Retrospective Multicenter Cohort Study.

Background: Conventional epilation methods commonly encounter challenges in achieving permanent removal of unwanted facial terminal hair (uFTH), particularly when it is interspersed among normal hairs.

Objective: To assess the safety and effectiveness of follicular unit excision (FUE) for permanent removal of uFTH.

Methods: The retrospective analysis included 231 patients who underwent FUE hair removal at three medical centers.

Hyperandrogenism Decreases Seizure Threshold in a Rat Model of Polycystic Ovary Syndrome.

Introduction: In women of childbearing age with epilepsy, 30% experience the comorbidity of polycystic ovary syndrome (PCOS), which is marked by a higher prevalence of hyperandrogenism. Our recent clinical observations indicate the potential contribution of hyperandrogenism-induced PCOS to epilepsy susceptibility, and this study aimed to unravel the underlying factors that increase the susceptibility of females to epilepsy.

Methods: A letrozole-induced PCOS rat model was employed to simulate endogenous hyperandrogenism.

Research and application of the wavelet high-frequency coefficient direct mapping algorithm in the micro-defect target detection system of an infrared objective lens.

Various lens detection techniques for military sighting telescopes have been the focus of military production. However, most of the micro-defect detection of lenses is detected manually, which cannot guarantee the measurement precision and quality. In order to solve these problems, the wavelet high-frequency coefficients direct mapping algorithm is applied to the automatic detection system of a micro-defect target in an infrared objective lens, thus obtaining a new method of detection.

Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia.

Background: Depletion or permanent quiescence of the hair follicle stem cell (HFSC) pool underlies pathogenesis in androgenetic alopecia (AGA). Reactivation of quiescent HFSCs is considered an efficient treatment strategy for hair loss. The retinoic acid (RA) is critical to ensure stem cell homeostasis and function.

Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin.

Background: No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure and chronic obstructive pulmonary disease (COPD) risk. This study aims to explore this relationship.

Methods: This study enrolled 4541 individuals who had available data on PFAS, COPD, and covariates from NHANES 2007-2018.

Integrating serum pharmacochemistry and network pharmacology to reveal the mechanism of chickpea in improving insulin resistance.

Although chickpea have great potential in the treatment of obesity and diabetes, the bioactive components and therapeutic targets of chickpea to prevent insulin resistance (IR) are still unclear. The purpose of this study was to investigate the chemical and pharmacological characteristics of chickpea on IR through serum pharmacochemistry and network pharmacology. The results revealed that compared with other polar fractions, the ethyl acetate extract of chickpea (CE) had the definitive performance on enhancing the capacities of glucose consumption and glycogen synthesis.

Hair follicle extraction combined with an expanded scalp flap for facial organ reconstruction.

Background: Use of scalp skin for facial organ reconstruction represents a mainstream procedure for organ reconstruction. In most cases, adequate amounts of skin can be obtained by using tissue expanders, but harvesting sufficient scalp tissue in patients with low hairlines is challenging. Hair follicular unit extraction (FUE) is one approach to resolve this problem.

Characterization and Risk Factors of Folliculitis after Hair Transplantation: A Multicenter Retrospective Study.

Background: Postoperative folliculitis is a common complication of hair transplantation (HT) requiring effective preventive interventions. This study characterized postoperative folliculitis and determined risk factors in patients undergoing HT.

Methods: The authors retrospectively reviewed 1317 patients who underwent HT and completed 9-month follow-up between January of 2018 and June of 2021 at 4 medical centers.

A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle.

Background: Androgenic alopecia (AGA) is characterized by progressive hair follicle miniaturization. Novel treatments are needed to intervene in the miniaturization process. The authors aimed to evaluate the efficacy, safety, effectiveness, and effective population of autologous hair follicle mesenchymal stem cell therapy for the treatment of advanced AGA in Chinese individuals.

Pharmacological modulation of autophagy for epilepsy therapy: Opportunities and obstacles.

Epilepsy (EP) is a long-term neurological disorder characterized by neuroinflammatory responses, neuronal apoptosis, imbalance between excitatory and inhibitory neurotransmitters, and oxidative stress in the brain. Autophagy is a process of cellular self-regulation to maintain normal physiological functions. Emerging evidence suggests that dysfunctional autophagy pathways in neurons are a potential mechanism underlying EP pathogenesis.

Evaluation of a Novel Graft-Holding Solution in Hair Transplantation: A Randomized Controlled Clinical Study.

Background: Hair transplantation has become a popular choice for alopecia treatment; however, postsurgical hair shedding still annoys both patients and surgeons.

Objective: To explore the impact of graft-holding solution on postsurgical hair shedding and testify the protective efficacy of histidine-tryptophan-ketoglutarate solution with adenosine triphosphate and deferoxamine (HTK-AD).

Methods: There were 240 patients enrolled in the study, and the follicles were placed into either HTK-AD or Ringer solution (RS).

Live alleviates ulcerative colitis the SCFAs/mitophagy/NLRP3 inflammasome axis.

As a disease caused by an impaired intestinal epithelial barrier, imbalanced flora, immune imbalance and genetic susceptibility, ulcerative colitis (UC) is becoming a health threat for all ages. (), an attracting probiotic, has already been confirmed to improve immune dysfunction, stabilize intestinal microflora, and combat gut disorders. However, no studies have focused on the effects of different forms of on UC, and its mechanism involved in the mitophagy/NLRP3 inflammasome pathway has not been reported.