Mutation of homologous genes confers ideal plant architecture in .

Unlabelled: Varieties with a semi-dwarf compact plant architecture may increase yield per unit area in rapeseed () by allowing high-density cultivation and mechanical harvesting while conferring lodging resistance. Mutation of (), which encodes a receptor-like protein kinase, generates a compact and upright plant architecture in ; however, there have been no reports on the roles of the ER family (ERf) in . In this study, we used the CRISPR/Cas9 system to generate mutants in each of the two homoeologs of members and (), and in the single gene, resulting in the homozygous mutants , /, and .

Influence of helicobacter pylori infection on Chinese adult males' body muscle mass: a cross-sectional and cohort analysis.

Aim: Helicobacter pylori (HP) infection may cause many disorders outside the digestive system, although research on the association between HP infection and muscular atrophy among males is limited. This study aimed to examine the influence of HP infection on adult Chinese males' body muscle mass using a cross-sectional and cohort analysis.

Methods: A total of 8110 Chinese adult males were enrolled in the study.

Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis.

Background: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulation. In non-small cell lung cancer (NSCLC), ferroptosis offers promising strategies to overcome drug resistance and enhance the efficacy of existing therapies. While the literature on ferroptosis in NSCLC has expanded rapidly over the past decade, a comprehensive understanding of its research trends, global collaboration patterns, and emerging hotspots remains lacking.

Microscopic investigation of chemical and physical alteration behaviors in sandstone minerals induced by CO-HO-rock interactions during CO saline aquifer storage.

CO saline aquifer storage represents a promising strategy for mitigating the environmental impact of greenhouse gas emissions. However, the long-term effects of CO dissolved in formation water on rock minerals remain insufficiently understood. This study utilizes cast thin section analysis, scanning electron microscopy, and energy dispersive spectrometry techniques to perform a comprehensive microscopic investigation on this issue.

Continuous measurement of the dynamics of residential indoor and outdoor NO and the contributions to human exposure.

In residential environment, NO is an important air pollutant. Yet, the dynamics of indoor NO and source contributions to human exposure are not well understood. Here, we conducted a continuous NO measurement in and out of eight households in Guangzhou, China.

Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults.

Aims: Previous evidence suggests that serum lung cancer biomarkers are associated with inflammatory conditions; however, their relationship with peripheral arterial stiffness remains unclear. Therefore, the present study investigated the relationship between serum lung cancer biomarkers and peripheral arterial stiffness in middle-aged Chinese adults.

Methods: In total, 3878 middle-aged Chinese adults were enrolled in this study.

The abundance and pathogenicity of microbes in automobile air conditioning filters across the typical cities of China and Europe.

Bioaerosols are widely distributed in urban air and can be transmitted across the atmosphere, biosphere, and anthroposphere, resulting in infectious diseases. Automobile air conditioning (AAC) filters can trap airborne microbes. In this study, AAC filters were used to investigate the abundance and pathogenicity of airborne microorganisms in typical Chinese and European cities.

Mutating via CRISPR-Cas9 increases the seed size and weight in .

Unlabelled: Seed weight, which is highly correlated to seed size, is a critical agronomic trait that determines the yield of However, there have been limited researches on the genes involved in regulating seed size. In , (), an E3 ubiquitin ligase gene, has been identified as a significant negative regulator in controlling organ size, but the function of its homologs in rapeseed remains unknown. Only two homologous of , , have been found in and were mutated using the CRISPR-Cas9 system.

Treatment for Triple-Negative Breast Cancer: An Umbrella Review of Meta-Analyses.

Purpose: In recent years, many meta-analyses of triple-negative breast cancer (TNBC) treatment have been published; however, these studies still lack systematic summary. Therefore, the aim of this study is to summarize and evaluate the evidence level and efficacy of treatment for TNBC.

Materials And Methods: Retrospective and prospective studies on treatment of TNBC were searched in the PubMed, Embase, and Cochrane Library databases.

Use of Computed Tomography-Guided Percutaneous Biopsy of Invasive Non-Mucinous Lung Adenocarcinoma to Predict the Degree of Histological Differentiation.

Background: The International Association for the Study of Lung Cancer (IASLC) published a grading system for invasive pulmonary adenocarcinoma that is closely associated with prognosis. This study aimed to investigate the accuracy of computed tomography (CT)-guided biopsy specimen grading and surgery-guided grading systems for detecting invasive non-mucinous lung adenocarcinoma and to determine whether CT-guided biopsy can predict the degree of histological differentiation.

Methods: In total, 130 patients with invasive non-mucinous lung adenocarcinoma who underwent CT-guided biopsy before surgical excision were retrospectively studied.

The emission and dynamics of droplets from human expiratory activities and COVID-19 transmission in public transport system: A review.

The public transport system, containing a large number of passengers in enclosed and confined spaces, provides suitable conditions for the spread of respiratory diseases. Understanding how diseases are transmitted in public transport environment is of vital importance to public health. However, this is a highly multidisciplinary matter and the related physical processes including the emissions of respiratory droplets, the droplet dynamics and transport pathways, and subsequently, the infection risk in public transport, are poorly understood.

The association of chemical composition particularly the heavy metals with the oxidative potential of ambient PM in a megacity (Guangzhou) of southern China.

Atmospheric fine particulate matters (PM) can cause adverse health effects through the generation of reactive oxygen species (ROS), which is normally characterized by the oxidative potential (OP). However, the particulate components that are mainly responsible for the ROS-induced OP remain controversial and warrant further investigation, especially in megacities where high exposure exists and particulate composition is complex. In this study, we measured the OP of PM using the dithiothreitol (DTT) assay with and without chelation of metals in a megacity in southern China, Guangzhou, in January and April.

Metagenomic Assessment of the Pathogenic Risk of Microorganisms in Sputum of Postoperative Patients With Pulmonary Infection.

Respiratory infections are complicated biological processes associated with an unbalanced microbial community and a wide range of pathogens. To date, robust approaches are still required for distinguishing the pathogenic microorganisms from the colonizing ones in the clinical specimens with complex infection. In this study, we retrospectively analyzed the data of conventional culture testing and metagenomic next-generation sequencing (mNGS) of the sputum samples collected from 50 pulmonary infected patients after cardiac surgery from December 2020 and June 2021 in Ruijin Hospital.

Platelet-Derived Growth Factor-Functionalized Scaffolds for the Recruitment of Synovial Mesenchymal Stem Cells for Osteochondral Repair.

Cartilage regeneration is still a challenge for clinicians because of avascularity, denervation, load-bearing, synovial movement, and the paucity of endogenous repair cells. We constructed a multilayered osteochondral bionic scaffold and examined its repair capacity using a rabbit osteochondral defect model. The cartilage phase and interface layer of the scaffold were prepared by freeze-drying, whereas the bone phase of the scaffold was prepared by high-temperature sintering.

The underappreciated role of monocarbonyl-dicarbonyl interconversion in secondary organic aerosol formation during photochemical oxidation of m-xylene.

Photochemical oxidation (including photolysis and OH-initiated reactions) of aromatic hydrocarbon produces carbonyls, which are involved in the formation of secondary organic aerosols (SOA). However, the mechanism of this process remains incompletely understood. Herein, the monocarbonyl-dicarbonyl interconversion and its role in SOA production were investigated via a series of photochemical oxidation experiments for m-xylene and representative carbonyls.

Low emission zones reduced PM but not NO concentrations in Berlin and Munich, Germany.

Low emission zones (LEZs) aiming at improving the air quality in urban areas have been implemented in many European cities. However, studies are limited in evaluating the effects of LEZ, and most of which used simple methods. In this study, a general additive mixed model was utilized to account for confounders in the atmosphere and validate the effects of LEZ on PM and NO concentrations in two German cities.

Measurement and evaluation of gaseous and particulate emissions from burning scented and unscented candles.

It has been known for a long time that incomplete combustion processes produce by-products that are harmful to human health. Particularly high concentrations of such by-products can arise in indoor environments when operating open flames without venting. The emission behavior of many combustion sources, including candles, has already been examined in detail.

Clinical utility of [Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography for primary staging and recurrence detection in nasopharyngeal carcinoma.

Purpose: This study aimed to explore the clinical utility of [Ga]Ga-labeled fibroblast activation protein inhibitor ([Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) relative to [F]-fluorodeoxyglucose ([F]FDG) PET/CT and magnetic resonance imaging (MRI) for primary staging and recurrence detection in nasopharyngeal carcinoma (NPC).

Methods: This retrospective analysis utilized a sub-cohort of patients from a previously acquired database. Patients with NPC who underwent [F]FDG and [Ga]Ga-FAPI PET/CT between October 2019 and November 2020 were included.

Characteristics of chemical profile, sources and PAH toxicity of PM in beijing in autumn-winter transit season with regard to domestic heating, pollution control measures and meteorology.

Several air pollution episodes occurred in Beijing before and after the 2014 Asia-Pacific Economic Cooperation (APEC) summit, during which air-pollution control measures were implemented. Within this autumn-winter transit season, domestic heating started. Such interesting period merits comprehensive chemical characterization, particularly the organic species, to look into the influence of additional heating sources and the control measures on air pollution.

Relation of infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus.

Purpose: This study was conducted to investigate the relation of HP infection to peripheral arterial stiffness and 10-year cardiovascular risk in diabetes mellitus (DM).

Methods: DM subjects who underwent the C13-breath test were enrolled and divided into DMHP+ and DMHP- groups. Peripheral arterial stiffness was measured using brachial to ankle pulse wave velocity (baPWV).

[Effect of catgut implantation at "Yingxiang"(LI20) on lower airway remodeling in allergic rhinitis rats].

Objective: To observe the effect of catgut implantation at "Yingxiang"(LI20) on lower airway remodeling and levels of osteopon-tin (OPN) protein in allergic rhinitis (AR) rats, so as to reveal its mechanisms underlying improvement of AR.

Methods: Male SD rats were randomly divided into control, model and catgut implantation groups, with 10 rats in each group. The AR model was established by intraperitoneal injection and nasal drip of ovalbumin.

68Ga-FAPI PET/CT in Assessment of Liver Nodules in a Cirrhotic Patient.

Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by F-FDG PET/CT. Increased Ga-FAPI liver uptake was observed in this cirrhotic patient. However, the nodules had no pathological Ga-FAPI uptake and were clearly visualized due to the low activity compared with surrounding liver parenchyma.

Clinical Study on Prelaryngeal Lymph Node Metastasis in Papillary Thyroid Carcinoma.

Objective: This study aims to investigate the risk factors of prelaryngeal lymph node metastasis in papillary thyroid carcinoma and its clinical application value.

Methods: The clinical pathological features and metastatic risks were statistically analyzed by reviewing 254 patients with papillary thyroid carcinoma, who received their first operation and prelaryngeal lymph node dissection in our department.

Results: The detection of prelaryngeal lymph nodes, tumor size and any paratracheal lymph node metastasis were correlated with the number of paratracheal lymph node metastasis (<0.

Relationship between plasma levels of 25-hydroxyvitamin D and arterial stiffness in elderly Chinese with non-dipper hypertension: An observational study.

Elderly individuals with non-dipper hypertension are at high risk of cardiovascular disease because of increased stiffness of peripheral arteries. Since, vitamin D deficiency is prevalent in elderly Chinese. We examined whether reduced plasma levels of 25-hydroxyvitamin D [25(OH)D] may help promote this stiffness.