Rainfall, seasonal variation, and stream type governing the multi-media fate and ecological risks of tire additives and their transformation products in mega-urban streams.

Tire additives and their transformation products (TATPs) are increasingly recognized for their toxicity and widespread environmental presence. However, the interplay of rainfall, seasonal variation, and stream type in governing their multi-media partitioning and risks remains largely unexplored. This study investigated the spatiotemporal distribution, environmental drivers, and ecological risks of 21 TATPs in three distinct urban streams (general road, expressway, and rural road-adjacent).

Suspect and Nontarget Screening of Sulfonamides and Novel Transformation Products in Pharmaceutical Wastewater-Contaminated Areas: Distribution, Migration, and Environmental Risks.

High-concentration wastewater from antibiotic manufacturing plants generates significant pollutants in the receiving environment. However, the fate of antibiotics and their transformation products (TPs) in multimedia environments, as well as their environmental risks, remains limited. By utilizing comprehensive target, suspect, and nontarget screening strategies, we identified 22 sulfonamides (SAs) and 29 TPs in surface water, sediment, groundwater, and soil column samples contaminated with sulfonamide pharmaceutical wastewater.

High-risk plasmid-borne resistance genes from swine farm environments infiltrate deep soil and interact with the human gut microbiome via horizontal transfer.

Swine farms serve as critical reservoirs of antibiotic resistance genes (ARGs), yet the frequency of horizontal gene transfer (HGT) remains poorly understood. In this study, we explored the gene exchange within the "swine farm-human-pig" network and assessed its risks. We identified 16,612 plasmid contigs from 107 field samples, revealing a significant presence of previously uncharacterized plasmid types.

Spatiotemporal distribution of neonicotinoids in urban rivers: implications for rainfall-driven pollution in Guangzhou, China.

Neonicotinoids (NEOs), insecticides prevalent in urban river environment, contribute to dynamic pollution through their persistence and rainfall-driven dispersion into aquatic systems. However, the fluctuations in NEO concentrations during transient rainfall events and across rainy seasons remain poorly understood. This study examines the spatiotemporal distribution of five NEOs-imidacloprid, acetamiprid, clothianidin, thiamethoxam, and thiacloprid-under rainfall-driven dispersal in urban rivers of Guangzhou, China.

Hybrid Physical Mechanism and Artificial Intelligence-Based Model for Evaluating Nonpoint Source Pesticide Pollution at a Megacity Scale.

Large-scale nonpoint source (NPS) pesticide pollution is a growing concern in urban areas; however, modeling of such pollution is constrained by challenges in acquiring urban pipeline data and the scarcity of pollutant monitoring data. This study presents a hybrid model comprising a rainfall runoff module based on a modified gated recurrent unit and a pesticide concentration module grounded in physical process equations to assess NPS pesticide pollution in large urban areas, adopting Guangzhou City as a case study. The model parameters were calibrated and validated using monitored runoff volumes and pesticide concentrations, employing a stochastic gradient descent algorithm.

Association of changes in overall and specific leisure activities with long-term all-cause mortality in older adults: a nationwide cohort study.

Background: Leisure activities (LAs) are vital for healthy ageing and are linked to lower mortality risk in older adults. However, most previous longitudinal studies have assessed LAs at only one time point. We aimed to explore the impact of dynamic changes in LAs on subsequent all-cause mortality among older adults.

A comprehensive reconnaissance and risk assessment of rubber additives and their transformation products (RATPs) in groundwater: 1,3-Diphenylguanidine (DPG) as a pressing ecological concern.

The widespread detection of rubber additives and their transformation products (RATPs) in surface water environments is well-documented, but their pollution characteristics in groundwater remain unclear. This study comprehensively revealed the occurrence and distribution of 27 RATPs in groundwater across southern China (n = 212). RATPs were detected in groundwater at total levels of 1.

Deciphering key traits and dissemination of antibiotic resistance genes and degradation genes in pharmaceutical wastewater receiving environments.

Discharge of pharmaceutical wastewater significantly affects the receiving environments. However, the development of antibiotic resistance and microbial enzymatic degradation in wastewater-receiving soils and rivers remains unclear. This study investigated a sulfonamide-producing factory to explore the distribution of antibiotic resistance genes (ARGs) in the receiving river and soil environments (0-100 cm depth), and the potential hosts of sadABC genes (sulfonamide-degrading genes) as well as their phylogenetic characterization.

Unveiling spatiotemporal distribution, partitioning, and transport mechanisms of tire additives and their transformation products in a highly urbanized estuarine region.

Numerous tire additives are high-production volume chemicals that are used extensively worldwide. However, their presence and partitioning behavior remain largely unknown, particularly in marine environments. This study is the first to reveal the spatiotemporal distribution, multimedia partitioning, and transport processing of 22 tire additives and their transformation products (TATPs) in a highly urbanized estuary (n = 166).

Aerobic granular sludge for swine wastewater treatment: Implications for antibiotic and antibiotic resistance gene elimination.

Swine wastewater (SW) contains high levels of traditional pollutants, antibiotics, and antibiotic resistance genes (ARGs), necessitating effective elimination. Two parallel aerobic granular sludge (AGS) reactors, R and R, were constructed and optimized for treating SW from two pig farms, identified as SW and SW. R showed higher antibiotic removal efficiency, particularly in the removal of sulfonamides, while fluoroquinolones tended to adsorb onto the sludge.

Precipitation contributes to alleviating pollution of rubber-derived chemicals in receiving watersheds: Combining confluent stormwater runoff from different functional areas.

The release of rubber-derived chemicals (RDCs) in road surface runoff has received significant attention. Urban surface runoff is often the confluence of stormwater runoff from specific areas. However, the impact of precipitation on RDCs contamination in confluent stormwater runoff and receiving watersheds remains poorly understood.

Characterising polycyclic aromatic hydrocarbons in road dusts and stormwater in urban environments.

The presence of polycyclic aromatic hydrocarbons (PAHs) pollution on urban road surfaces is one of the major environmental concerns. However, knowledge on the distribution variability of PAHs in road dusts (RDS) and stormwater is limited, which would restrict the further risk evaluation and mitigation implementation of PAHs in road stormwater runoff. This study collected RDS samples and stormwater samples on fourteen urban roads in Shenzhen, China.

Carbon emissions from road transportation in China: from past to the future.

Road transportation is an important contributor to carbon emissions. China's car ownership is rapidly increasing, ranking first worldwide; however, there are limited data about carbon emission inventories. This study assesses carbon emissions from road transportation from the past to the future across China, using market survey, COPERT (Computer Programme to Calculate Emissions from Road Transport) model, and a combination method of principal component analysis and backpropagation neural network.

Discovering transformation products of pharmaceuticals in domestic wastewaters and receiving rivers by using non-target screening and machine learning approaches.

Wastewater treatment plants (WWTPs) are an important source of pharmaceuticals in surface water, but information about their transformation products (TPs) is very limited. Here, we investigated occurrence and transformation of pharmaceuticals and TPs in WWTPs and receiving rivers by using suspect and non-target analysis as well as target analysis. Results showed identification of 113 pharmaceuticals and 399 TPs, including mammalian metabolites (n = 100), environmental microbial degradation products (n = 250), photodegradation products (n = 44) and hydrolysis products (n = 5).

Non-target discovery and risk prediction of per- and polyfluoroalkyl substances (PFAS) and transformation products in wastewater treatment systems.

Wastewater treatment plants (WWTPs) serve as the main destination of many wastes containing per- and polyfluoroalkyl substances (PFAS). Here, we investigated the occurrence and transformation of PFAS and their transformation products (TPs) in wastewater treatment systems using high-resolution mass spectrometry-based target, suspect, and non-target screening approaches. The results revealed the presence of 896 PFAS and TPs in aqueous and sludge phases, of which 687 were assigned confidence levels 1-3 (46 PFAS and 641 TPs).

Metagenomic investigation of antibiotic resistance genes and resistant bacteria contamination in pharmaceutical plant sites in China.

Pharmaceutical plant sites play a significant role in the dissemination of antibiotic resistance genes (ARGs) into the environment. It is imperative to comprehensively monitor of ARGs across various environmental media at these sites. This study focused on three pharmaceutical plants, two located in North China and one in South China.

Small-Intensity Rainfall Triggers Greater Contamination of Rubber-Derived Chemicals in Road Stormwater Runoff from Various Functional Areas in Megalopolis Cities.

Rubber-derived chemicals (RDCs) originating from tire and road wear particles are transported into road stormwater runoff, potentially threatening organisms in receiving watersheds. However, there is a lack of knowledge on time variation of novel RDCs in runoff, limiting initial rainwater treatment and subsequent rainwater resource utilization. In this study, we investigated the levels and time-concentration profiles of 35 target RDCs in road stormwater runoff from eight functional areas in the Greater Bay Area, South China.

Airborne antibiotic resistome and microbiome in pharmaceutical factories.

Antimicrobial resistance is considered to be one of the biggest public health problems, and airborne transmission is an important but under-appreciated pathway for the spread of antibiotic resistance genes (ARGs) in the environment. Previous research has shown pharmaceutical factories to be a major source of ARGs and antibiotic resistant bacteria (ARB) in the surrounding receiving water and soil environments. Pharmaceutical factories are hotspots of antibiotic resistance, but the atmospheric transmission and its environmental risk remain more concerns.

First Evidence of the Bioaccumulation and Trophic Transfer of Tire Additives and Their Transformation Products in an Estuarine Food Web.

The discovery of the significant lethal impacts of the tire additive transformation product -(1,3-dimethylbutyl)-'-phenyl--phenylenediamine quinone (6PPD-Q) on coho salmon has garnered global attention. However, the bioaccumulation and trophic transfer of tire additives and their transformation products (TATPs) within food webs remain obscure. This study first characterized the levels and compositions of 15 TATPs in the Pearl River Estuary, estimated their bioaccumulation and trophic transfer potential in 21 estuarine species, and identified priority contaminants.

Uptake, tissue distribution, and biotransformation pattern of triclosan in tilapia exposed to environmentally-relevant concentrations.

Although triclosan has been ubiquitously detected in aquatic environment and is known to have various adverse effects to fish, details on its uptake, bioconcentration, and elimination in fish tissues are still limited. This study investigated the uptake and elimination toxicokinetics, bioconcentration, and biotransformation potential of triclosan in Nile tilapia (Oreochromis niloticus) exposed to environmentally-relevant concentrations under semi-static regimes for 7 days. For toxicokinetics, triclosan reached a plateau concentration within 5-days of exposure, and decreased to stable concentration within 5 days of elimination.

In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q) is an ozonation product of the rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD). 6PPD-Q has recently been detected in various environmental media, which may enter the human body via inhalation and skin contact pathways. However, the human metabolism of 6PPD-Q has remained unknown.

Integrating global microbiome data into antibiotic resistance assessment in large rivers.

Rivers are important in spreading antimicrobial resistance (AMR). Assessing AMR risk in large rivers is challenged by large spatial scale and numerous contamination sources. Integrating river resistome data into a global framework may help addressing this difficulty.

Comprehensive discovery and migration evaluation of antimicrobial drugs and their transformation products in a swine farm by target, suspect, and nontarget screening.

Swine farms contaminated the surrounding environment through manure application and biogas slurry irrigation, hence causing the wide residual of multiple antimicrobial drugs (ADs) and their transformation products (TPs). This study performed target, suspect, and nontarget screening methods to comprehensively investigate the pollution profiles of ADs in a typical swine farm, and characterize the potential transformed pathway of TPs and distinguish specific reactions of different catalog of ADs. Samples of fresh feces, compost, biogas slurry, topsoil, column soil, groundwater and plants were analyzed using the database containing 98 target analytes, 679 suspected parent ADs, and ∼ 10 TPs.