Salt-Induced Gel Formation by Zwitterionic Polymer for Synergistic Methane Hydrate Inhibition.

In deepwater drilling operations, inhibiting methane hydrate (MH) formation is critical for wellbore flow assurance. This study synthesized a zwitterionic polymer NDAD and evaluated its hydrate inhibition performance through high-pressure reactor tests, magnetic resonance imaging (MRI), and molecular simulations. Results demonstrate that NDAD at concentrations of 1.

Assessment of the public health risk of novel reassortant H3N3 avian influenza viruses that emerged in chickens.

Influenza A (H3N2) viruses are historically responsible for the 1968 Hong Kong flu pandemic. Since then, H3N2 has continued to circulate as a seasonal influenza virus in humans. Public health concerns were raised in 2022 when human infections with novel reassortant H3N8 influenza viruses originating from chickens were first reported in China.

SnO Nanosheet Transistor with Remarkably High Hole Effective Mobility and More than Six Orders of Magnitude On-Current/Off-Current.

Using novel SiO surface passivation and ultraviolet (UV) light anneal, a 12 nm thick SnO p-type FET (pFET) shows hole effective mobilities (µ) of more than 100 cm/V·s and 31.1 cm/V·s at hole densities (Q) of 1 × 10 and 5 × 10 cm, respectively. To further improve the on-current/off-current (I/I), an ultra-thin 7 nm thick SnO nanosheet pFET shows a record-breaking I/I of 6.

Impact of UV annealing on the hole effective mobility in SnO pFET.

Using ultraviolet (UV) annealing through wide energy bandgap HfO/SiO gate dielectric, nanosheet SnO pFET achieved hole effective mobility (µ) from 55 cm/V-s at low hole density (Q) to 13.38 cm/V-s at 5 × 10 cm Q, compared to that of 9.03 cm/V-s at 5 × 10 cm Q for SnO device without UV annealing.

The miR-34b/MEK/ERK pathway is regulated by NR5A1 and promotes differentiation in primary bovine Sertoli cells.

Sertoli cells play a key role in testicular development and spermatogenesis. It has been suggested that Sertoli cells differentiate after their proliferation ceases. Our previous study showed that miR-34b inhibits proliferation by targeting MAP2K1 mediated MEK/ERK signaling pathway in bovine immature Sertoli cells.

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway.

Background: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) does not respond well to current treatment options like sorafenib, and there is an urgent need for developing therapeutical strategies for HBV + HCC. Brassicasterol has previously shown anti-cancer and anti-viral activities, however, its value against HBV + HCC remains to be explored.

Methods: The inhibitory effect of brassicasterol and sorafenib was evaluated on HBV + HCC cell lines and xenograft mouse model.

p21CIP/WAF1 saRNA inhibits proliferative vitreoretinopathy in a rabbit model.

Purpose: Proliferative vitreoretinopathy (PVR) is a disease process resulting from proliferation of retinal pigment epithelial (RPE) cells in the vitreous and periretinal area, leading to periretinal membrane formation and traction and eventually to postoperative failure after vitreo-retinal surgery for primary rhegmatogenous retinal detachment (RRD). The present study was designed to test the therapeutic potential of a p21CIP/WAF1 (p21) inducing saRNA for PVR.

Methods: A chemically modified p21 saRNA (RAG1-40-53) was tested in cultured human RPE cells for p21 induction and for the inhibition of cell proliferation, migration and cell cycle progression.

Improving the spatial and temporal estimation of ecosystem respiration using multi-source data and machine learning methods in a rainfed winter wheat cropland.

The investigation of ecosystem respiration (RE) and its vital influential factors along with the timely and accurate detection of spatiotemporal variations in RE are essential for guiding agricultural production planning. RE observation in the plot region is primarily based on the laborious chamber method. However, upscaling the spatial-temporal estimates of RE at the canopy scale is still challenging.

Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice.

Methcathinone (MCAT) belongs to the designer drugs called synthetic cathinones, which are abused worldwide for recreational purposes. It has strong stimulant effects, including enhanced euphoria, sensation, alertness, and empathy. However, little is known about how MCAT modulates neuronal activity in vivo.

The beneficial effects of square dance on musculoskeletal system in early postmenopausal Chinese women: a cross-sectional study.

Background: This study was set to investigate the correlation between square dance and musculoskeletal system of early postmenopausal Chinese women.

Methods: Chinese postmenopausal women, who had been without menstruation for 1-10 years from the onset of menopause were recruited from community centers for this study. A standardized structured face-to-face interview was performed to collect demographic information, life styles, personal medical history, diet and menstrual status.

Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells.

The loss of inner ear hair cells leads to irreversible acoustic injury in mammals, and regeneration of inner ear hair cells to restore hearing loss is challenging. is a key gene in the development and regeneration of hair cells. Small activating RNAs (saRNAs) can target a gene to specifically upregulate its expression.

Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.

Peripheral nerve injury triggers sequential phenotype alterations in Schwann cells, which are critical for axonal regeneration. Long noncoding RNAs (lncRNAs) are long transcripts without obvious coding potential. It has been reported that lncRNAs participate in diverse biological processes and diseases.

Clinical outcomes of Ti-Ni shape-memory patella concentrator combined with cannulated compression screws in the treatment of C2 and C3 patella fracture: a retrospective study of 54 cases.

Background: Ti-Ni shape-memory patella concentrator (TNSMPC) has been designed as an alternative approach for fixation of patella fracture, which has some advantages like higher hardness, higher tenacity, better wearing resistance, excellent corrosion resistance and desired histocompatibility. The present study was to investigate the efficiency of TNSMPC combined with cannulated compression screws in the treatment of comminuted patella fractures.

Methods: Between January 2014 and December 2017, 54 patients of C2 and C3 patella fractures underwent open reduction and internal fixation with TNSMPC combined with cannulated compression screws.

Dose preservation of ligament flavum really help prevent postoperative epidural fibrosis and improve outcome in microdiscectomy?

Objective: A prospective, randomized, controlled clinical study was conducted with surgery performed by the same surgeon. The aim was to present a new technique for preserving the ligament flavum during lumbar microdiscectomy, and to evaluate whether this helps prevent postoperative fibrosis and improve outcome.

Methods: From January to December 2017, 251 patients with indication for microdiscectomy were randomly divided into test group using ligament flavum preservation technique and control group using conventional procedures.

Turning solid into gel for high-efficient persistent luminescence-sensitized photodynamic therapy.

Bioavailable persistent luminescence material is an ideal internal light source for long-term photodynamic therapy, but inevitably suffers from low utilization efficiency and weak persistent luminescence due to corrosion and screening processes. Herein, we show a facile and smart "turning solid into gel" strategy to fabricate persistent luminescence hydrogel for high-efficient persistent luminescence-sensitized photodynamic therapy. The homogeneous persistent luminescence hydrogel was synthesized via dispersing high-temperature calcined persistent luminescence material without corrosion and screening into a biocompatible alginate-Ca hydrogel.

Transcription factor networks involved in cell death in the dorsal root ganglia following peripheral nerve injury.

The peripheral nervous system has the potential to regenerate after nerve injury owing to the intrinsic regrowth ability of neurons and the permissive microenvironment. The regenerative process involves numerous gene expression changes, in which transcription factors play a critical role. Previously, we profiled dysregulated genes in dorsal root ganglion neurons at different time points (0, 3 and 9 hours, and 1, 4 and 7 days) after sciatic nerve injury in rats by RNA sequencing.

Global analysis of transcriptome in dorsal root ganglia following peripheral nerve injury in rats.

Peripheral nervous system has intrinsic regeneration ability after injury, accompanied with the coordination of numerous cells, molecules and signaling pathways. These post-injury biological changes are complex with insufficient understanding. Thus, to obtain a global perspective of changes following nerve injury and to elucidate the mechanisms underlying nerve regeneration are of great importance.

Deep Sequencing and Bioinformatic Analysis of Lesioned Sciatic Nerves after Crush Injury.

The peripheral nerve system has an intrinsic regenerative capacity in response to traumatic injury. To better understand the molecular events occurring after peripheral nerve injury, in the current study, a rat model of sciatic nerve crush injury was used. Injured nerves harvested at 0, 1, 4, 7, and 14 days post injury were subjected to deep RNA sequencing for examining global gene expression changes.

Air-cathode preparation with activated carbon as catalyst, PTFE as binder and nickel foam as current collector for microbial fuel cells.

A cathode is a critical factor that limits the practical application of microbial fuel cells (MFCs) in terms of cost and power generation. To develop a cost-effective cathode, we investigate a cathode preparation technique using nickel foam as a current collector, activated carbon as a catalyst and PTFE as a binder. The effects of the type and loading of conductive carbon, the type and loading of activated carbon, and PTFE loading on cathode performance are systematically studied by linear sweep voltammetry (LSV).

Investigation on the application of titania nanorod arrays to the determination of chemical oxygen demand.

In the present paper, the TiO2 nanorod arrays electrode was developed as a sensor for the determination of chemical oxygen demand (COD) based on a photoelectrochemical degradation principle. Effects of common parameters, such as applied potential, light intensity and pH on its analytical performance were investigated. Under the optimized conditions, the nanorod arrays electrode was successfully applied in the COD determination for both synthetic and real samples.

[Clinical study of treatment with continuous renal replacement therapy on severe hepatitis with hepatic encephalopathy].

Objective: To evaluate clinical significance and the therapeutic mechanisms of the treatment with continuous renal replacement therapy on severe hepatitis with hepatic encephalopathy.

Methods: Forty-seven cases were randomly divided into three groups: continuous renal replacement therapy (CRRT) group, plasma exchange (PE)+CRRT group and basic treatment group. The former two groups were respectively operated by CRRT and PE+CRRT with basic treatment.