Development and validation of a Nomogram to predict postoperative flap necrosis risk in breast cancer patients undergoing modified radical mastectomy.

Background: Flap necrosis is a critical complication following modified radical mastectomy (MRM) for breast cancer (BC). It not only impairs wound healing but also delays postoperative treatment, adversely affecting patient survival rate and the overall quality of life. Thus, developing an accurate prediction model is crucial for early intervention and improving patient prognosis.

Short-Term Relationship Between Air Pollution and Mortality from Respiratory and Cardiovascular Diseases in China, 2008-2020.

Most existing epidemiological studies on the impact of air pollution on noncommunicable diseases have focused on urban areas, rather than nationwide studies that include rural areas. This study utilized a time-stratified case-crossover study that included deaths registered in the National Mortality Surveillance System from 2008 to 2020. Atmospheric particulate matter (PM and PM), nitrogen dioxide (NO), sulfur dioxide (SO), and carbon monoxide (CO) were evaluated via the National Nested Air Quality Prediction Modeling System.

Mortality risk of short-term air pollution exposure in urban and rural Chinese populations: A nationwide time-stratified case-crossover study, 2008-2020.

Background: Epidemiologic evidence underpinning current World Health Organization Air Quality Guidelines (WHO AQGs) is primarily derived from urban populations, which remains challenging for implementing the guidelines in low- and middle-income countries (LMICs) where most people reside in rural or less developed areas. Here, we aimed to characterize the associations between ambient air pollution and mortality in Chinese populations living in both urban and rural areas, where rural populations have not been studied previously at national level.

Methods: In this nationwide time-stratified case-crossover study, we extracted non-accidental death cases of all ages in both urban and rural areas during 2008-2020 from National Mortality Surveillance System, which covered 40,300 representative township-level administration units from 29 provinces, representing nearly 24 % of Chinese population.

Greenness, nighttime light, and couple fecundability: A national cohort study between 2014 and 2020.

Background: Reduced greenness and increased nighttime light (NTL) have been associated with adverse health outcomes; however, the impacts of greenness and NTL on human fecundability remain uncertain.

Methods: Data was collected from 14,239,365 couples across 31 provinces in China. Greenness exposure was estimated using the Normalized Difference Vegetation Index (NDVI) within 1000-m buffer zones, while NTL data was derived from the Visible and Infrared Imaging Suite Day Night Band aboard satellites, both based on individual residential addresses.

Rpl12 is a conserved ribophagy receptor.

Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, functions as a conserved ribophagy receptor in multiple organisms.

Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis.

Parkinson's disease (PD) is a common neurodegenerative disease and is difficult to treat due to its elusive mechanisms. Recent studies have identified a striking association between oligodendrocytes and PD progression, yet how oligodendrocytes regulate the pathogenesis of PD is still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) is upregulated in oligodendrocytes of the substantia nigra and that prosaposin (PSAP) secretion is increased in parkinsonian mice.

Operation strategy and capacity configuration of digital renewable energy power station with energy storage.

As the utilization of renewable energy sources continues to expand, energy storage systems assume a crucial role in enabling the effective integration and utilization of renewable energy. This underscores their fundamental significance in mitigating the inherent intermittency and variability associated with renewable energy sources. This study focuses on the involvement of photovoltaic (PV) plants in medium and long-term transactions.

Percutaneous endoscopic lumbar discectomy in lumbar disc herniation with posterior ring apophysis fracture: A case report in a 15-year-old child.

Rationale: Lumbar disc herniation (LDH) with posterior ring apophysis fracture (PRAF) is rather rare in children, and in all age-stratified LDH patients, the incidence of RAF was 5.3% to 7.5%.

Association between short-term air pollution exposure and perturbation in thyrotropin levels in 1.38 million Chinese women: A national longitudinal analysis, 2014-2019.

Prevalence of subclinical hypothyroidism substantially increased during the last decade in China, which has been commonly/clinically diagnosed as elevation in thyrotropin (thyroid-stimulating hormone [TSH]). Tobacco smoke containing toxic substances has been linked to thyroid dysfunction; however, data on perturbation of TSH following air pollution exposure in human has not been assessed at nationwide population level. We investigated the longitudinal impact of daily ambient air pollution estimated at residential level on serum TSH in 1.

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21.

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C. elegans. How the EN acquires senescence, however, is unknown.

A Mendelian randomization-based approach to explore the relationship between leukocyte counts and breast cancer risk in European ethnic groups.

Exploring the potential association between peripheral blood leukocyte counts and breast cancer risk by Mendelian randomization (MR) analysis methods. Genetic data related to peripheral blood sorting counts of leukocytes were collected from a genome-wide association study by Blood Cell Consortium (BCX). Single nucleotide polymorphic loci predicting peripheral blood sorting counts of these leukocytes were selected as instrumental variables according to the correlation assumption, independence assumption and exclusivity assumption of MR.

Scoliosis in osteogenesis imperfecta: identifying the genetic and non-genetic factors affecting severity and progression from longitudinal data of 290 patients.

Background: Scoliosis is widely prevalent among osteogenesis imperfecta (OI) patients, and is progressive with age. However, factors affecting scoliosis in OI are not well known.

Methods: We retrospectively retrieved longitudinal radiographic and clinical records of consecutive OI patients seeking treatments at our hospital from 2014 to 2022, graded their pre-operative spinal conditions into four outcome groups, estimated their progression rates, and descriptively and inferentially analyzed the genetic and non-genetic factors that may affect the outcomes and progression rates.

The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery.

Background: The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, the present study was performed to evaluate the effect of sarcopenia on the outcome of patients with left-sided colon and rectal cancer.

Methods: Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery between January 2008 and December 2014 were retrospectively reviewed.

Effectiveness of post-mastectomy adjuvant chemotherapy for the treatment of patients with prognostic stage IB breast cancer: A SEER-based study.

Background: Adjuvant chemotherapy (AC) is an important, effective treatment for breast cancer. This study evaluates the effectiveness of post-mastectomy AC in treating patients with prognostic stage IB breast cancer.

Method: We conducted a retrospective cohort-based study using Surveillance, Epidemiology, and End-Results database.

Driving forces and recovery potential of the macrophyte decline in East Taihu Lake.

Macrophytes are of key importance to the structure and ecological services of shallow lakes and are sensitive to anthropogenic and natural perturbations. Ongoing eutrophication and hydrological regime change affect macrophytes through changes in water transparency and water level, which lead to a dramatic decrease in bottom light availability. Here an integrated dataset (2005-2021) of multiple environmental factors is used to demonstrate the driving forces and recovery potential of the macrophyte decline in East Taihu Lake by using a critical indicator, which is the ratio of the Secchi disk depth to the water depth (SD/WD).

Distribution, driving forces, and risk assessment of 2-MIB and its producer in a drinking water source-oriented shallow lake.

Freshwater blooms of harmful cyanobacteria in drinking water source-oriented shallow lakes affect public health and ecosystem services worldwide. Therefore, identifying 2-methylisoborneol (2-MIB)-producing cyanobacteria and predicting the risks of 2-MIB are critical for managing 2-MIB-infected water sources. Previous studies on the potential producers and risks of 2-MIB have focused on reservoirs or have been limited by the ecosystems of phytoplankton-dominated areas.

Intergenerational Integration in Community Building to Improve the Mental Health of Residents-A Case Study of Public Space.

This study defined intergenerational integration in communities at a theoretical level and verified whether a series of measures could facilitate negotiation and communication between community residents and other stakeholders to generate a positive and healthy community environment and gradually improve intergroup relations. Specifically, we applied community psychology and used Hongqiao New Village in Shanghai, China, as a research site to explore intergenerational conflict in public community spaces. The research was divided into two stages: an input stage and an output stage.

Blockchain based energy efficient multi-tasking optimistic scenario for mobile edge computing.

Mobile edge computational power faces the difficulty of balancing the energy consumption of many devices and workloads as science and technology advance. Most related research focuses on exploiting edge server computing performance to reduce mobile device energy consumption and task execution time during task processing. Existing research, however, shows that there is no adequate answer to the energy consumption balances between multi-device and multitasking.

Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease.

Background: Although both environmental and genetic factors were linked to coronary artery disease (CAD), the extent to which the association of air pollution exposure with CAD can be influenced by genetic risk was not well understood.

Methods: A total of 41,149 participants recruited from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) were included. Genetic risk scores of CAD were constructed based on 540 genetic variants.

Incorporating the Co-Creation Method into Social Innovation Design to Promote Intergenerational Integration: A Case Study of a Public Square.

With the COVID-19 pandemic sweeping the world, there is an increased focus on intergenerational relationships, community mental health issues, and well-being in community contexts. This paper assesses the effectiveness of a co-creation approach for intergenerational integration at the theoretical level. The study used a collaborative co-creation design method in the community design process to explore whether the participation of community residents of all ages in addressing community issues promoted communication and alleviated stereotyping between the various generations.

Li-doped calcium phosphate cement for accelerated bone regeneration of osteoporotic bone defect.

Osteoporotic fractures seriously endanger the elderly quality of life, especially postmenopausal women. Currently, calcium phosphate cement (CPC) is one of the materials used for the treatment of osteoporotic fractures. This study intends to investigate the biological effects of lithium (Li)-doped CPC.

Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis.

Tryptophan, an essential amino acid, has been reported that it has the potential to regulate depression-like behavior. Meanwhile, Chronic stress-induced depression also has a close relationship with gut microbiota structure and composition. In the current research, we demonstrated that a tryptophan-rich diet (0.

Deciphering the Effects and Mechanisms of Yi-Fei-San-Jie-pill on Non-Small Cell Lung Cancer With Integrating Network Target Analysis and Experimental Validation.

Non-small cell lung cancer (NSCLC), which accounts for 85% of lung cancer cases, calls for better therapy. Yi-Fei-San-Jie-pill (YFSJ), a well-applicated traditional Chinese medicine formula, was reported to be effective in the treatment of NSCLC. However, its anti-tumor mechanism still needs to be fully elucidated.

Identification of CD4 Conventional T Cells-Related lncRNA Signature to Improve the Prediction of Prognosis and Immunotherapy Response in Breast Cancer.

Background: Breast cancer (BC) is one of the most common malignancies in women, and long non-coding RNAs (lncRNAs) are key regulators of its development. T cells can recognize and kill cancer cells, and CD4 T conventional (Tconv) cells are the main orchestrators of cancer immune function. However, research on CD4 Tconv-related lncRNAs (CD4TLAs) prognostic signature in patients with BC is still lacking.