AZU1 as a DNA Methylation-Driven Gene: Promoting Oxidative Stress in High-Altitude Pulmonary Edema.

High-altitude pulmonary edema (HAPE) is a severe condition associated with high-altitude environments, and its molecular mechanism has not been fully elucidated. This study systematically analyzed the DNA methylation status of HAPE patients and healthy controls using reduced-representation bisulfite sequencing (RRBS) and 850K DNA methylation chips, identifying key differentially methylated regions (DMRs). Targeted bisulfite sequencing (TBS) revealed significant abnormalities in DMRs of five genes, azurocidin 1 (AZU1), growth factor receptor bound protein 7 (GRB7), mannose receptor C-type 2 (MRC2), RUNX family transcription factor 3 (RUNX3), and septin 9 (SEPT9).

Prognostic ability of the haemoglobin-to-red blood cell distribution width ratio in predicting in-hospital mortality: a retrospective, longitudinal, observational study among elderly patients with acute ischaemic stroke.

Objective: To evaluate the prognostic ability of the haemoglobin-to-red blood cell distribution width ratio in predicting in-hospital mortality among elderly patients diagnosed with acute ischaemic stroke.

Design: Retrospective, longitudinal, observational study using a hospital-based database.

Setting: Claims data from 1 January 2014 until 31 January 2020 were extracted from the database of two hospitals affiliated with Nanjing University.

Epidemiological association and machine learning-based prediction of lung cancer risk linked to long-term lagged satellite-derived PM in China.

Objectives: This study investigated association between long-term PM exposure and lung cancer incidence, focusing on Jiangsu Province, China. We aimed to explore the effects of historical PM with time lags and build a prediction model using machine learning methods.

Study Design: An ecological epidemiology study.

Causal associations between gut microbiota and rheumatoid arthritis: A two-sample Mendelian randomization study.

The gut microbiota has been implicated in the development of rheumatoid arthritis (RA), but whether these associations reflect causal relationships remains unclear. We conducted a two-sample Mendelian randomization analysis to investigate the potential causal effects of gut microbial taxa on RA risk. Summary-level data from the MiBioGen consortium (n = 13,266) and a large RA genome-wide association study (n = 97,173) were used.

Floating-leaved and submerged macrophytes suppress filamentous cyanobacteria blooms and 2-MIB episodes in eutrophic shallow lakes.

Although macrophytes can control filamentous cyanobacteria that produce 2-methylisoborneol (2-MIB) in lakes, there is a lack of evidence regarding the inhibitory effects of different macrophyte growth forms on 2-MIB producers, as well as the underlying mechanisms. To address this knowledge gap, this study compared the impact of floating-leaved and submerged macrophytes on Pseudanabaena growth and 2-MIB release, combing a field investigation and culture experiments. The field survey showed that both the Pseudanabaena cell density and 2-MIB concentrations were significantly lower in areas dominated by floating-leaved or submerged macrophytes than in phytoplankton-dominated areas.

Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance.

Widespread environmental contamination with benzyl butyl phthalate (BBP) has raised concerns due to its high potential for bioaccumulation and male reproductive toxicity. However, the mechanisms underlying BBP-induced male reproductive damage remain unclear. As the adjacent Sertoli cell-formed blood-testis barrier (BTB) creates a privileged niche for spermatogenesis and may serve as the first target of reproductive toxicants, we mainly focused on the detrimental effect of BBP on Sertoli cells and the BTB in this study.

Health effects of mixed metal exposure on accelerating aging among the elderly population.

Background: Human exposure to heavy metals occurs through multiple pathways in daily life. However, the effects of mixed heavy metal exposure on accelerated aging in the elderly U.S.

Clinical characteristics and a diagnostic model for high-altitude pulmonary edema in habitual low altitude dwellers.

Background: The fatal risk of high-altitude pulmonary edema (HAPE) is attributed to the inaccurate diagnosis and delayed treatment. This study aimed to identify the clinical characteristics and to establish an effective diagnostic nomogram for HAPE in habitual low altitude dwellers.

Methods: A total of 1,255 individuals of Han Chinese were included in the study on the Qinghai-Tibet Plateau at altitudes exceeding 3,000 m.

Identification and Validation of STC1 Act as a Biomarker for High-Altitude Diseases and Its Pan-Cancer Analysis.

High-altitude diseases, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE), are closely related to an individual's ability to adapt to hypoxic environments. However, specific research in this field is relatively limited, and further biomarker research and clinical trials are needed to clarify the exact role and potential therapeutic applications of key genes in high-altitude diseases. This study focuses on the role of the STC1 gene in high-altitude diseases and explores its expression patterns in different types of cancer.

ERH Impacts Patient Prognosis and Tumor Immune Microenvironment: A Pan-Cancer Analysis.

Background: The enhancer of rudimentary homolog (ERH) has been shown to play significant roles in tumorigenesis and progression. However, few systematic pan-cancer analyses about ERH have been described.

Methods: From the tumor immune estimation resource web server2.

Association Between Urinary Glyphosate Exposure and Cognitive Impairment in Older Adults from NHANES 2013-2014.

Background: Glyphosate is the most commonly used herbicide with potential neurotoxicity. However, limited epidemical evidence is found in the relationship between glyphosate and cognitive impairment, especially in the cognitive-disrupting sensitive elderly populations.

Objective: This study aimed to examine the association of urinary glyphosate exposure with cognitive impairment in the United State (US) older adults.

Association between Dietary Intake of Live Microbes and Chronic Constipation in Adults.

Background: Chronic constipation (CC) is a common gut health problem, and the role of live dietary microbes in CC is unclear.

Objective: This study aimed to investigate the relationship between dietary live microbes consumption and CC.

Methods: Using the National Health and Nutrition Examination Survey data (2005-2010), 11,170 adults who completed the 24-h face-to-face dietary recall and bowel health questionnaire were identified.

Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety.

Background: Depression and anxiety are common comorbid diseases of constipation. Fecal microbiota transplantation (FMT) significantly relieves gastrointestinal-related symptoms, but its impact on psychiatric symptoms remains uncharted.

Methods: We collected fecal and serum samples before and after FMT from 4 functional constipation patients with psychiatric symptoms and corresponding donor stool samples.

Lifting the veils on transmembrane proteins: Potential anticancer targets.

Cancer, as a prevalent cause of mortality, poses a substantial global health burden and hinders efforts to enhance life expectancy. Nevertheless, the prognosis of patients with malignant tumors remains discouraging, owing to the lack of specific diagnostic and therapeutic targets. Therefore, the development of early diagnostic indicators and novel therapeutic drugs for the prevention and treatment of cancer is essential.

Comparative Study on the Resistance of Beta-Cypermethrin Nanoemulsion and Conventional Emulsion in .

Objective: This study aimed to compare the resistance rates of to beta-cypermethrin nanoemulsion and conventional emulsion and establish reference values via biochemical detection for conventional emulsion.

Methods: We conducted experiments using subcultured and applied the micro-drop method for treatment. Subsequently, the activity of metabolic enzymes was measured using spectrophotometry.

TMEM200A is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer.

Background: Gastric cancer (GC) is one of the most common malignant tumors in the digestive system. Several transmembrane (TMEM) proteins are defined as tumor suppressors or oncogenes. However, the role and underlying mechanism of TMEM200A in GC remain unclear.

Characterization of gut microbiota in adults with coronary atherosclerosis.

Background: Cardiovascular disease, which is mainly caused by coronary atherosclerosis, is one of the leading causes of death and disability worldwide. Gut microbiota likely play an important role in coronary atherosclerosis. This study aims to investigate the microbiota profile of adults with coronary atherosclerosis to provide a theoretical basis for future research.

Driving forces and recovery potential of the macrophyte decline in East Taihu Lake.

Macrophytes are of key importance to the structure and ecological services of shallow lakes and are sensitive to anthropogenic and natural perturbations. Ongoing eutrophication and hydrological regime change affect macrophytes through changes in water transparency and water level, which lead to a dramatic decrease in bottom light availability. Here an integrated dataset (2005-2021) of multiple environmental factors is used to demonstrate the driving forces and recovery potential of the macrophyte decline in East Taihu Lake by using a critical indicator, which is the ratio of the Secchi disk depth to the water depth (SD/WD).

Distribution, driving forces, and risk assessment of 2-MIB and its producer in a drinking water source-oriented shallow lake.

Freshwater blooms of harmful cyanobacteria in drinking water source-oriented shallow lakes affect public health and ecosystem services worldwide. Therefore, identifying 2-methylisoborneol (2-MIB)-producing cyanobacteria and predicting the risks of 2-MIB are critical for managing 2-MIB-infected water sources. Previous studies on the potential producers and risks of 2-MIB have focused on reservoirs or have been limited by the ecosystems of phytoplankton-dominated areas.

Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization meta-analysis and integrated bioinformatics analysis.

For individuals acutely exposed to high-altitude regions, environmental hypobaric hypoxia induces several physiological or pathological responses, especially immune dysfunction. Therefore, hypoxia is a potentially life-threatening factor, which has closely related to high-altitude acclimatization. However, its specific molecular mechanism is still unclear.