Genomic and transcriptomic profiling of peripheral T cell lymphoma reveals distinct molecular and microenvironment subtypes.

Peripheral T cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin's lymphomas varying in clinical, phenotypic, and genetic features. The molecular pathogenesis and the role of the tumor microenvironment in PTCL are poorly understood, with limited biomarkers available for genetic subtyping and targeted therapies. Through an integrated genomic and transcriptomic study of 221 PTCL patients, we delineate the genetic landscape of PTCL, enabling molecular and microenvironment classification.

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion.

Ethnopharmacological Relevance: Salidroside (SAL), a phenolic natural product present in Rhodiola rosea, are commonly used in the treatment of various ischemic-hypoxic diseases, including intestinal ischemia-reperfusion (IR) injury. However, their efficacy and potential mechanisms in the treatment of intestinal IR injury have not been investigated.

Objective: The objective of the present study is to investigate the pharmacological mechanism of action of SAL on intestinal IR injury using a network pharmacology approach combined with experimental validation.

The crucial roles of long noncoding RNA SNHGs in lung cancer.

Lung cancer is one of the most common malignant tumors with growing morbidity and mortality worldwide. Several treatments are used to manage lung cancer, including surgery, radiotherapy and chemotherapy, as well as molecular-targeted therapy. However, the current measures are still far from satisfactory.

[Therapeutic observation on 's acupuncture for cervical spondylosis of vertebral artery type based on method].

Objective: To verify the superiority of 's acupuncture for cervical spondylosis of vertebral artery type (CSA) based on 's method.

Methods: A total of 150 patients with CSA were randomly divided into a Tongtuo Fu's acupuncture group, a Tongtuo acupuncture group and a conventional Fu's acupuncture group, 50 cases in each group. Under the guidance of the theory of method, the Tongtuo Fu's acupuncture group was treated with 's acupuncture, the distal method was performed at the distal myofascial trigger point (MTrP) of the dorsal forearm, and then the method was performed at the proximal MTrP of the cervical muscle group.

[The Effect of Immunized Platelet Transfusion Refractoriness on Allo-HSCT Patients with Malignant Hematological Diseases].

Objective: To investigate the characteristics of platelet antibody in patients with hematological diseases, so as to research the effect of immunized platelet transfusion refractoriness (PTR) on the prognosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recepients with malignant hematological diseases patients.

Methods: The clinical data of platelet antibody positive patients tested by Capture-P in the First Affiliated Hospital of Soochow University from July 1, 2014 to July 1, 2019 were retrospectively analyzed, including sex, age, disease, platelet transfusion assessments, CD34 cells, transplant prognosis, and so on.

Results: In 5 years, 913 (7.

Functionalized Silicon Electrodes Toward Electrostatic Catalysis.

Oriented external electric fields are now emerging as "smart effectors" of chemical changes. The key challenges in experimentally studying electrostatic catalysis are (i) controlling the orientation of fields along the reaction axis and (ii) finely adjusting the magnitudes of electrostatic stimuli. Surface models provide a versatile platform for addressing the direction of electric fields with respect to reactants and balancing the trade-off between the solubility of charged species and the intensity of electric fields.

Bone marrow infiltrated natural killer cells predicted the anti-leukemia activity of MCL1 or BCL2 inhibitors in acute myeloid leukemia.

Acute myeloid leukemia (AML) is still incurable due to its heterogeneity and complexity of tumor microenvironment. It is imperative therefore to understand the molecular pathogenesis of AML and identify leukemia-associated biomarkers to formulate effective treatment strategies. Here, we systematically analyzed the clinical characters and natural killer (NK) cells portion in seventy newly-diagnosis (ND) AML patients.

[Clinical observation of the therapeutic effect on posterior circulation ischemic vertigo treated with "" acupuncture].

Objective: To observe the short-term and long-term clinical effect on posterior circulation ischemic vertigo treated with "" acupuncture (minor regaining consciousness and opening orifice) and explore its effect mechanism.

Methods: Ninety patients with posterior circulation ischemic vertigo were randomly divided into a treatment group and a control group, 45 cases in each group. The patients of the two groups were all treated on the base of neurological medicine.

The role of medical gas in stroke: an updated review.

Medical gas is a large class of bioactive gases used in clinical medicine and basic scientific research. At present, the role of medical gas in neuroprotection has received growing attention. Stroke is a leading cause of death and disability in adults worldwide, but current treatment is still very limited.

SSH3 facilitates colorectal cancer cell invasion and metastasis by affecting signaling cascades involving LIMK1/Rac1.

Slingshot phosphatase 3 (SSH3) is a member of the SSH phosphatase family that regulates actin filament dynamics. However, its role in cancer metastasis is relatively unclear compared to that of SSH1. Here, we showed that SSH3 was upregulated in colorectal cancer (CRC).

KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression.

Clear cell renal cell carcinoma (ccRCC) is one of the most common types of kidney cancer and is accompanied by a poor prognosis due to a high potential for metastasis and recurrence. The mechanism of ccRCC metastasis is not well known. N-lysine methyltransferase KMT5A serves a crucial role in the progression of human cancer; however, the function of KMT5A in the development of ccRCCs has not yet been investigated, which has triggered an interest in investigating the potential association between KMT5A and ccRCC.

Incidence of human rabies and characterization of rabies virus nucleoprotein gene in dogs in Fujian Province, Southeast China, 2002-2012.

Background: Rabies is a global fatal infectious viral disease that is characterized by a high mortality after onset of clinical symptoms. Recently, there has been an increase in the incidence of rabies in China. The aim of this study was to investigate the incidence of human rabies and characterize the rabies virus nucleoprotein gene in dogs sampled from Fujian Province, Southeast China from 2002 to 2012.

Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.

The progression of CRC is a multistep process involving several genetic changes or epigenetic modifications. NDN is a member of the MAGE family, encoding a protein that generally suppresses cell proliferation and acting as a transcriptional repressor. Immunohistochemical staining revealed that the expression of NDN was significantly down-regulated in CRC tissues compared with normal tissues and the down-regulation of NDN in CRC could reflect the hypermethylation of the NDN promoter.

Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.

Signal transducer and activator of transcription 3 (STAT3) is known to activate targets associated with invasion, proliferation, and angiogenesis in a wide variety of cancers. The adaptor protein NCK1 is involved in cytoskeletal movement and was identified as a STAT3-associated target in human tumors. However, the underlying molecular mechanism associated with colorectal cancer (CRC) metastasis is not yet completely understood.

[Quantitatively Determination of Available Phosphorus and Available Potassium in Soil by Near Infrared Spectroscopy Combining with Recursive Partial Least Squares].

Soil available phosphorus (P) and available potassium (K) don't possess direct spectral response in the near infrared (NIR) region. They are predictable because of their correlation with spectrally active constituents (organic matter, carbonates, clays, water, etc.).

[Visible and near infrared spectroscopy combined with recursive variable selection to quantitatively determine soil total nitrogen and organic matter].

In the present work, recursive variable selection methods (updating both the model coefficients and effective variables during the prediction process) were applied to maintain the predictive abilities of calibration models. This work compared the performances of partial least squares (PLS), recursive PLS (RPLS) and three recursive variable selection methods, namely vari- able importance in the projection combined with RPLS (VIP-RPLS), VIP-PLS, and uninformative variable elimination combined with PLS (UVE-PLS) for the measurement of soil total nitrogen (TN) and organic matter (OM) using Vis-NIR spectroscopy. The dataset consisted of 195 soil samples collected from eight towns in Wencheng County, Zhejiang Province, China.

Neutralizing antibodies respond to a bivalent dengue DNA vaccine or/and a recombinant bivalent antigen.

There is currently no effective vaccine to prevent dengue infection, despite the existence of multiple studies on potential methods of immunization. The aim of the present study was to explore the effect of DNA and/or recombinant protein on levels of neutralizing antibodies. For this purpose, envelope domain IIIs of dengue serotypes 1 and 2 (DEN-1/2)were spliced by a linker (Gly‑Gly‑Ser‑Gly‑Ser)3 and cloned into the prokaryotic expression plasmid pET30a (+) and eukaryotic vector pcDNA3.

[Application of functional magnetic resonance imaging in acupoint functional significance of encephalic region].

Literatures of study on acupoint functional effect of encephalic region with functional magnetic resonance imaging (fMRI) are collected from the database of China National Knowledge Information (CNKI) and Wan fang database. Analysis and comments are made respectively from the status quo of studies on combination of single acupoint, two acupoints and multiple acupoints under both physiological and pathological conditions. The results show that the corresponding encephalic regions can be specifically activated by acupuncture.

Mechanical stimulus inhibits the growth of a bone tissue model cultured in vitro △.

Objectives: To construct the cancellous bone explant model and a method of culturing these bone tissues in vitro, and to investigate the effect of mechanical load on growth of cancellous bone tissue in vitro.

Methods: Cancellous bone were extracted from rabbit femoral head and cut into 1-mm-thick and 8-mm-diameter slices under sterile conditions. HE staining and scanning electron microscopy were employed to identify the histomorphology of the model after being cultured with a new dynamic load and circulating perfusion bioreactor system for 0, 3, 5, and 7 days, respectively.

[Thyroid lymphography:a new clinical approach for protecting parathyroid in surgery].

Objective: To research the role of lymph tracers to protect parathyroid in surgery for papillary thyroid carcinoma.

Methods: Patients with papillary thyroid carcinoma who met selected criteria were enrolled in this study. Patients were divided into carbon nanoparticle group, methylene blue group, and conventional surgery group.

[A prospective randomized and controlled study on no drainage after surgery for benign thyroid disorders].

Objective: To evaluate the necessity of drainage after thyroidectomy for benign thyroid disorders.

Methods: A total of 272 patients who underwent thyroidectomy for benign thyroid disorders were randomly divided into drainage group or non-drainage group. Operating time, postoperative stay time in hospital, comfort of neck assessed by visual analogue scale (VAS) on postoperative day (POD) 0 and POD1 were and the incidence of complications, including post-thyroidectomy bleeding, hematoma, seroma, wound infection, hoarseness, and hypoparathyroidism, were assessed and compared between two groups.

Population pharmacokinetics of lamotrigine in Chinese children with epilepsy.

Aim: To establish a population pharmacokinetics (PPK) model for lamotrigine (LTG) in Chinese children with epilepsy in order to formulate an individualized dosage guideline.

Methods: LTG steady-state plasma concentration data from therapeutic drug monitoring (TDM) were collected retrospectively from 284 patients, with a total of 404 plasma drug concentrations. LTG concentrations were determined using a HPLC method.

[Research on the spectral characteristics of grassland in arid regions based on hyperspectral image].

The grassland spectrum was got from Hyperion images of Shiyang River Basin using PPI, after FLAASH atmosphere correction, to understand the spectral characteristics quantitatively. The results show that red edge moves left, slope reduced, blue and yellow edge feature is abated, reflectance is higher in visible bands, and lower near-infrared bands when grassland is at decline stage relative to the spectrum characteristics of grassland at well growth. The red edge, green peaks, absorption valley location of blue and red light keep consistent for different coverage grassland, and spectrum absorption characteristics (band depth, width, area, symmetry) in visual bands change regularly as coverage increases, so it can be a basis for extraction or judgment of vegetation coverage.