Remediation of arsenic-cationic metals from smelter contaminated soil by washings of NaEDTA and phosphoric acid: removal efficiencies and mineral transformation.

Sequential and combined soil washing tests of NaEDTA and phosphoric acids were conducted to remediation soil contaminated with arsenic and cationic metals (cadmium, copper, and lead) at a former metal smelter. The aim of the testing was to improve the heavy metals removal efficiency and investigate the mechanism of the influence of soil minerals on washing efficiency, including the influence on soil mineral, metal oxides, and functional groups of soil surface. The results indicated that the combined washing of NaEDTA and phosphoric acid was effective in removing both arsenic and cationic metals from contaminated soil and had synergy effect for most target metals.

Effects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: A meta-analysis.

Objective: Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk of PDD and to identify the relationship between GBA genotype and PDD.

Methods: A computer-based search was performed to retrieve publications from PubMed, Cochrane library, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Wanfang databases using the search terms "glucocerebrosidase", "Parkinson's disease", and "dementia".

The effects of tamoxifen on mouse behavior.

The CreER recombinase system is an advanced method to temporally control site-specific mutagenesis in adult rodents. In this process, tamoxifen is injected to induce Cre recombinase expression, and then, Cre recombinase can excise LoxP-flanked DNA. However, tamoxifen is a nonselective estrogen receptor antagonist that may influence behavioral alterations.

Level the Conversion/Alloying Voltage Gap by Grafting the Endogenetic SbTe Building Block into Layered GeTe to Build GeSbTe for Li-Ion Batteries.

Many research efforts for advanced Li-ion batteries have been made to design new material with large capacity and long cycle life, but little attention has been paid to regulate the voltage platform until now. Although quite attractive for the binary Ge-based chalcogenides, challenge is that a large potential gap as well as incongruous reaction kinetics is typically found between their conversion step (>1.6 V) and alloying region (<0.

LncRNA SNHG3 is activated by E2F1 and promotes proliferation and migration of non-small-cell lung cancer cells through activating TGF-β pathway and IL-6/JAK2/STAT3 pathway.

Recently, long noncoding RNAs (lncRNAs) have been widely reported to play pivotal roles in the regulation of human cancers. Although the oncogenic property of lncRNA small nucleolar RNA host gene 3 (SNHG3) has been revealed in a variety of cancers, functions and regulatory mechanism of SNHG3 in non-small-cell lung cancer (NSCLC) remain to be investigated. In this study, we detected the upregulated expression of SNHG3 in NSCLC tissues as well as cells through quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis.

Enhanced Electrochemical Performance of the Lithium-Manganese-Rich Cathode for Li-Ion Batteries with Na and F CoDoping.

The lithium-manganese-rich layered oxide cathode (LMR-NMC), LiMnO·(1 - )LiMO (M = Co, Ni, and Mn), is on demand because of its high specific capacity of over 250 mA h g between the voltage range 2.0-4.8 V (vs Li/Li).

RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells.

Regulatory factors function by modulating a variety of cascade mechanisms in cells. RBM4 is a multifunctional RNA-binding protein in post-transcriptional gene regulation. Cytoplasmic RBM4 interacts with Ago2 to regulate inflammatory responses by affecting mRNA decay and cap-dependent translation.

Hereditary spastic paraplegia associated with a rare mutation: a case report and literature review.

Here, the pathogenesis of an gene mutation is discussed through the analysis of a sporadic case of hereditary spastic paraplegia. Next-generation sequencing was performed for the patient and his family members to detect mutations at the locus. The patient and his father were found to carry the same heterozygous missense mutation (c.

Recovery of EDTA from soil-washing wastewater with calcium-hydroxide-enhanced sulfide precipitation.

It is cost effective and thermodynamically feasible to recover EDTA and remove potential toxic elements (PTEs) with sulfide precipitation from soil-washing wastewater produced from EDTA washing PTEs-contaminated soil. However, poor solid-liquid separation and EDTA recovery restrict its application due to a large number of fine particles formed during the precipitation process. This study investigated the effect of single factor on PTEs (Cu, Pb, Cd, and Zn) removal and solid-liquid separation from wastewater.

Risk factors associated with the progression of overactive bladder among patients with type 2 diabetes.

Aim: To investigate the risk factors specific to diabetes mellitus that influence the progression of overactive bladder in Chinese population.

Methods: A total of 457 patients who were diagnosed with overactive bladder and diabetes mellitus at the Department of Endocrinology and Urinary Surgery Center of Zhejiang University Jinhua Hospital were enrolled from July 2015 to July 2018. Patients were assessed using a questionnaire and then divided into two groups according to the severity score: mild overactive bladder group and the moderate-severe overactive bladder group.

Inhibitory effects of plasmid small interfering RNA targeting signal transducer and activator of transcription‑3 in C6 glioma cells.

The current study investigated the effect of plasmid small interfering RNA (psiRNA)‑mediated silencing of signal transducer and activator of transcription‑3 (STAT3) on the invasion, apoptosis, and expression levels of cyclin D1, caspase‑3 and B‑cell lymphoma‑2 (Bcl‑2) in C6 glioma cells. Cell invasion was determined using a Transwell assay, while the apoptosis rate and cell cycle distribution of cells were assessed using Annexin V‑FITC/PI double staining. The expression levels of cyclin D1, caspase‑3 and Bcl‑2 proteins were measured by western blotting.

Identification of a novel mutation in the CACNA1C gene in a Chinese family with autosomal dominant cerebellar ataxia.

Background: Hereditary ataxia is a group of neurodegenerative diseases with progressive cerebellar ataxia of the gait and limbs as the main symptoms. The genetic patterns of the disease are diverse but it is mainly divided into autosomal dominant cerebellar ataxia (ADCA) and autosomal recessive cerebellar ataxia (ARCA), and about 45 pathogenic loci have been found in ADCA. The purpose of this study was to explore the genetic defect in a Chinese family with ADCA.

BiSbS@N-doped carbon core-shell nanorods as efficient anode materials for sodium-ion batteries.

BiSbS3@N-doped carbon (NC) core-shell nanorods were prepared through a simple preparation process. As anode materials for sodium-ion batteries (SIBs), BiSbS3@NC core-shell nanorods present excellent electrochemical performance with higher specific capacity and better rate capability compared with the unmodified pristine BiSbS3 nanorods. The BiSbS3@NC electrode delivers high sodium storage capacity (771.

Diagnosis of hereditary diffuse leukoencephalopathy with neuroaxonal spheroids based on next-generation sequencing in a family: Case report and literature review.

Rationale: Hereditary diffuse leukoencephalopathy with neuroaxonal spheroids (HDLS) is a rare disease with white matter lesions of the central nervous system, and it usually has autosomal dominant inheritance. Its pathogenesis and causes are complex, and it has obvious clinical and genetic heterogeneities; also, it is classed as a neurodegenerative disease.

Patient Concerns: In preliminary clinical work, we identified a family with rapid progressive dementia.

WiFi-controlled portable atomic force microscope.

This article proposes to develop a WiFi-controlled portable atomic force microscope (AFM). The AFM consists of a horizontal probe, controlling circuits, digital to analog (D/A) and analog to digital (A/D) interfaces, a microcomputer (Raspberry Pi, RPi), and a laptop. The proposed AFM uses a pocket-size power supply to drive the controlling circuits, the D/A and A/D interfaces, as well as the RPi that constructs network hotspots and generates scanning signals.

A Randomized Controlled Trial of Surgical Rib Fixation in Polytrauma Patients With Flail Chest.

Background: Flail chest (FC) is known to account for high mortality and morbidity and is typically treated with conservative care. Operative fixation of FC has been advocated as an alternative treatment choice. This prospective randomized controlled trial aims to compare surgical and nonsurgical management of FC in patients with severe polytrauma.

A Novel Variant in Non-coding Region of Is Associated With X-Linked Charcot-Marie-Tooth Disease Type 1 and Transient CNS Symptoms.

X-linked Charcot-Marie-Tooth disease type 1 (CMTX1) is a dominantly inherited peripheral neuropathy and is caused by mutations in gap junction beta 1 gene (). Here, a novel variant of c.-170T>G in was identified in a large Chinese CMTX1 pedigree.

Performance of microbial fuel cells based on the operational parameters of biocathode during simultaneous Congo red decolorization and electricity generation.

A biocathode microbial fuel cell was constructed to investigate Congo red decolorization and power generation under different cathode operational parameters. The results showed that the suspended sludge in the cathode could improve the performance of the microbial fuel cell for electricity generation but had a negligible effect on the Congo red decolorization. The maximum voltage increased as the aeration rate was increased up to 100 mL/min.

Synthesis of Wafer-Scale Monolayer WS Crystals toward the Application in Integrated Electronic Devices.

Two-dimensional transition-metal dichalcogenides (TMDCs) possess unique electronic and optical properties, which open up a new opportunity for atomically thin optoelectronic devices. Synthesizing large-scale monolayer TMDCs on the SiO/Si substrate is crucial for practical applications, however, it remains a big challenge. In this work, a method which combines chemical vapor deposition (CVD) and thermal evaporation was employed to grow monolayer tungsten disulfide (WS) crystals.

Self-Assembling 2D Arrays with de Novo Protein Building Blocks.

Modular self-assembly of biomolecules in two dimensions (2D) is straightforward with DNA but has been difficult to realize with proteins, due to the lack of modular specificity similar to Watson-Crick base pairing. Here we describe a general approach to design 2D arrays using de novo designed pseudosymmetric protein building blocks. A homodimeric helical bundle was reconnected into a monomeric building block, and the surface was redesigned in Rosetta to enable self-assembly into a 2D array in the C12 layer symmetry group.

Polarization-Controllable Plasmonic Enhancement on the Optical Response of Two-Dimensional GaSe Layers.

Resonant plasmonic coupling has been considered as a promising strategy to enhance the optical response and manipulate the polarization of two-dimensional (2D) layer materials toward the practical applications. Here, a hybrid structure with periodic Ag nanoprism arrays was designed and fabricated on 2D GaSe layers to enhance these optical properties. By using the optimized hybrid structure with well-matched resonance, significant enhanced Raman scattering and band edge emission were successfully realized, and it is also interestingly found that the higher enhancement would be achieved while decreasing the thickness of GaSe layers.

Dechelation of Cd-EDTA complex and recovery of EDTA from simulated soil-washing solution with sodium sulfide.

Washing water containing poorly degradable heavy metal-EDTA complexes is produced by ethylenediaminetetraacetic acid (EDTA) washing of heavy metal-contaminated soil. A series of batch experiments were performed to explore the dechelation of heavy metal-EDTA complexes and the recovery of EDTA from simulated soil-washing solution using sulfide precipitation with NaS. The results showed that the effect of NaS dosage on the dechelation of Cd-EDTA solution was greater than that of other factors (reaction temperature, time, and pH) and excess EDTA suppressed cadmium removal.

Transcriptome sequencing in a 6-hydroxydopamine rat model of Parkinson's disease.

The neurotoxin 6-hydroxydopamine (6-OHDA) has been widely exploited as a tool for modeling Parkinson's disease (PD) in the rat. This study aimed to provide a comprehensive profile of the mRNAs and long noncoding RNAs (lncRNAs) in rats treated with 6-OHDA as a model of PD. Female SPF Wistar rats were randomly divided into two groups: a PD model group and a control group.

Building two-dimensional materials one row at a time: Avoiding the nucleation barrier.

Assembly of two-dimensional (2D) molecular arrays on surfaces produces a wide range of architectural motifs exhibiting unique properties, but little attention has been given to the mechanism by which they nucleate. Using peptides selected for their binding affinity to molybdenum disulfide, we investigated nucleation of 2D arrays by molecularly resolved in situ atomic force microscopy and compared our results to molecular dynamics simulations. The arrays assembled one row at a time, and the nuclei were ordered from the earliest stages and formed without a free energy barrier or a critical size.

Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study.

Background: Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC).

Methods: Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC.