Ceramic-in-Polymer Composite Solid Electrolyte Enabled by Metal-Sulfur Interactions with Enhanced Li-Ion Conductivity.

Ceramic-in-polymer composite solid electrolytes (SEs) show great potential for meeting the high-performance requirements of all-solid-state batteries (ASSBs) due to the combined benefits of easy processability, tunable Li-ion conductivity, wide electrochemical window, and facile interfacial contact with the Li-metal anode. However, their Li-ion conductivity remains lower than that of the pure ceramic phase, which can be attributed to the highly resistive ceramic/polymer interphase. In this paper, we introduced sulfur-containing functional groups through a less-explored metal/sulfur interaction strategy, enabling simultaneous modification of the polyethylene glycol diacrylate (PEGDA) polymer scaffold and the LiLaZrTaO (LLZO) ceramic surface.

Unconventional High-Entropy Oxide with Inner Metallic Coordination and Surface Medium-Entropy Metal-OH for Durable PEM Water Electrolysis at 2 A cm.

The multicomponent synergistic effect has become increasingly important for electrocatalysis; however, there remain large unexplored compositional and structural spaces. Here, an unconventional high-entropy oxide (HEO) with inner metallic coordination interactions and surface medium-entropy metal-OH for durable proton exchange membrane water electrolyzers (PEMWEs) is presented. The metallic clusters inside the HEO particles generate the inner metallic coordination interactions that reserve electrons, with a multicomponent effect, to inhibit Ru/Ir overoxidation and switch reaction mechanisms toward an exclusive adsorbate evolution mechanism for acidic oxygen evolution reaction (OER).

Emodin Alleviates Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting Serum Exosomal miRNA-21-3p-Induced M1 Alveolar Macrophage Polarisation.

Severe acute pancreatitis (SAP) is a common abdominal emergency in clinical practice. Approximately 20%-40% of patients with SAP will be associated with acute lung injury (SAP-ALI), which is a major cause of death. Emodin (EMO) is a naturally occurring anthraquinone derivative with various pharmacological properties.

Understanding rate-dependent textured growth in zinc electrodeposition via high-throughput in situ x-ray diffraction.

Zn-ion batteries with aqueous electrolytes are promising for large-scale energy storage as they are low-cost, environment-friendly and safe. The commercialization of Zn-ion batteries is hindered by several challenges such as the formation of detrimental Zn dendrites. High current density is previously thought to stimulate the dendritic growth of metals such as Li in electrodeposition.

Nonmetal-Metal Strategy to Reduce Ru-O Covalency while Promoting Local Reactive Water Concentration for Efficient Acidic Oxygen Evolution.

Affordable, active, and durable oxygen evolution reaction (OER) catalysts are crucial for proton exchange membrane water electrolysis (PEMWE). The low-cost RuO, relative to IrO, is attractive for acidic OER while suffering from durability. To resolve this activity-stability dilemma of RuO, we propose a universal nonmetal-metal strategy to reduce Ru-O covalency while promoting local reactive water concentration for efficient acidic OER.

Access to -aryl-2,2'-diindole via Fluoroarene-induced One-Pot Bicyclization Strategy with BuOK.

We present a systematic and concise one-pot protocol for synthesizing diversely substituted -aryl-2,2'-biindoles with BuOK. The fluoroarene-facilitated dual cycloisomerization of 1,3-diynylaniline enables efficient construction of target compounds under mild conditions. Substrate scope investigation revealed that fluoroarenes bearing electron-deficient substituents exhibited exceptional reactivity, achieving yields up to 99%.

Automatic and complete optical 3D digitization strategy with adaptive global view planning.

This paper presents a practical automatic 3D scanning pipeline aimed at achieving comprehensive 3D digitization of complex unknown objects in real-world settings. Addressing the challenge of selecting minimal yet effective viewpoints for complete surface coverage while reducing redundancy, we introduce an adaptive global viewpoint planning algorithm that models a viewpoint energy field based on spatial and placement constraints, and applies a field-guided optimization strategy to maximize coverage efficiency. We built an autonomous scanning system that integrates multi-resolution optical sensors with a robot and motor to support efficient and high-fidelity 3D reconstruction.

UBD-mediated glycolytic reprogramming promotes M2 macrophage polarization in ovarian cancer immune evasion.

Ovarian cancer (OC) is one of the most common malignant tumors in women, with immunotherapy resistance (ITR) being a major challenge. Glycolytic metabolic reprogramming has been shown to play a crucial role in the tumor immune microenvironment and immune evasion, yet the underlying mechanisms remain unclear. This study aims to investigate the role of Ubiquitin D (UBD) in OC immunotherapy, particularly its regulation of macrophage polarization through glycolytic metabolism.

Severe Acute Pancreatitis-Associated Lung Injury: A Comprehensive Quadruple Analysis of Animal Models.

Background: Severe acute pancreatitis (SAP) is a common clinical acute abdominal disorder. One of the critical complications of SAP is acute lung injury (ALI), which is the leading cause of high mortality in SAP patients. Establishing an animal model is pivotal in understanding of SAP pathogenesis and treatment.

Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review.

Epidemiological evidence suggests that there is a direct relationship between the degree of obesity and acute pancreatitis severity. Intake of different fatty acids leads to different types of hyperlipidemias. Adipose degradation by pancreatic lipase generates different free fatty acids, which can exacerbate pancreatitis.

Access to Sondheimer-Wong Diyne-Embedded Diaza[7]helicene with High Dissymmetry Factor Via Spontaneous Valence Isomerization.

The synthesis of Sondheimer-Wong diyne-fused diaza[7]helicene was achieved through spontaneous valence isomerization, which was a key step. Crystallographic analysis resolved the diaza[7]helicene's absolute configuration. The , and ,enantiomers were separated by chiral HPLC and further characterized by CD and CPL spectroscopy.

Lenvatinib versus bevacizumab when combined with PD-1/L1 inhibitor and hepatic arterial infusion chemotherapy in unresectable hepatocellular carcinoma.

Introduction: The combination of anti-angiogenic agents, PD-1/L1 inhibitors, and hepatic arterial infusion chemotherapy (HAIC) has emerged as an important strategy for unresectable hepatocellular carcinoma (uHCC), yet comparative data on efficacy and safety between different anti-angiogenic agents (lenvatinib [LenHAP] or bevacizumab [BevHAP]) remain lacking, especially in patients with potential resectable features (PotenR).

Methods: This retrospective study included patients from 3 hospitals. Included patients received LenHAP or BevHAP as the first-line treatment.

Macroscale optimal size of ICM vesicles regulated by quantum design principle in LH2 structure.

The photosynthetic bacterial light-harvesting antenna complex 2 (LH2), consisting of ring-like bacteriochlorophylls aggregates, constitutes an optimal excitonic structure for efficient energy transfer. Any distortion from this structure would cause efficiency losses. When adapted to low-light growing conditions, LH2-embedded membranes form vesicles to enhance light capture, albeit at the expense of curvature-induced LH2 deformation.

TAGLN2 Exacerbates Acute Pancreatitis-Induced Liver Injury by Increasing Hepatocyte Pyroptosis via Kupffer Cells-Mediated Inflammatory Response.

Pyroptosis, a programmed form of inflammatory cell death, has been demonstrated to participate in both Acute pancreatitis (AP) and its complication liver injury. Transgelin-2 (TAGLN2), an actin-binding protein involved in inflammatory response, has been reported to be highly expressed in AP. However, the role of TAGLN2 in AP-induced liver injury remains unclear.

The glycocalyx: a key target for treatment of severe acute pancreatitis-associated multiple organ dysfunction syndrome.

The endothelial glycocalyx is a dynamic brush-like layer composed of proteoglycans and glycosaminoglycans, including heparan sulfate (HS) and hyaluronic acid (HA), and is an important regulator of vascular homeostasis. Its structure (thickness ranges from 20 to 6450 nm in different species) not only provides a charge-selective barrier but also serves to anchor mechanosensors such as the glypican-1 (GPC-1)/caveolin-1 (CAV-1) complex and buffers shear stress. In severe acute pancreatitis (SAP), inflammatory factors promote the expression of matrix metalloproteinases (MMPs) and heparinases, which degrade syndecan-1 (SDC-1) and HS, while oxidative stress disrupts HA-CD44 binding, leading to increased capillary leakage and neutrophil adhesion.

Enhancing O Production with Biomimetic Pt Catalysts through Electronic Structure Modification.

Singlet oxygen (O) is an excellent reactive oxygen species in the biomedical disinfection field; however, efficient and selective generation of O remains challenging. Herein, we design bioinspired Pt@UiO-66-X catalysts (X = -NH, -H, -Br), with Pt nanoparticles as active centers and metal-organic framework (MOF) nanocavities as biomimetic binding pockets, to form a tailored electronic microenvironment for enhancing O generation. The results demonstrate that the electron-withdrawing functionalized Pt@UiO-66-Br can significantly improve the production efficiency of O, which is 1.

Quantum phase synchronization revealing few-hundred femtosecond coherence in cryptophyte phycoerythrin 545 antenna from exciton-vibrational coupling.

Quantum beats lasting a few hundred femtoseconds have been regarded as signatures of quantum energy transfer in photosynthetic antennae. The fragile coherence at room temperature casts doubt on its long-lived feature arising from the electronic coherence. Recently, the long-lived exciton-vibrational coherences of several hundred femtoseconds via quantum phase synchronization of the resonant higher frequency collective vibrational modes have been observed in core antenna allophycocyanin from algae.

Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM).

Objective: This study analyzes data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES) to explore the relationship between the Aggregate Index of Systemic Inflammation (AISI), also referred to as the pan-immune-inflammation value (PIV), and Type 2 Diabetes Mellitus (T2DM) among adults in the United States. Furthermore, it evaluates the mediating effect of obesity indicators on this association.

Methods: This study included 9,947 individuals from NHANES and applied appropriate weighting techniques.

Influence of Aging and Salt-Alkali Coupling on the Fatigue and Self-Healing Behavior of Graphene Oxide-Modified Asphalt.

The harsh environments in saline-alkaline areas and high-altitude regions with intense ultraviolet radiation pose great challenges to the durability of asphalt pavements. The fatigue performance of asphalt binder significantly determines the actual service life of asphalt pavements. Existing studies have predominantly focused on the impact of individual environmental factors (e.

Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons.

The gut microbiota and its metabolites are bi-directionally associated with various human illnesses, which has received extensive attention. Trimethylamine N-oxide (TMAO) is a gut microbiota metabolite produced in the liver, which may serve the role of an "axis" connecting the gut and host organs. TMAO levels are significantly higher in the blood of individuals with cardiovascular, renal, neurological, and metabolic diseases.

Costunolide: Targeting endothelial cell PANoptosis to mitigate lung injury in acute pancreatitis mice.

Background: Acute pancreatitis (AP) presents several critical risks, among which acute lung injury (ALI) is one of the most severe complications. Previous research has highlighted the anti-inflammatory properties of costunolide (COS); however, its potential to prevent AP-associated ALI remains unexplored. Here, we hypothesize that COS can mitigate AP-induced lung injury by reducing endothelial cell PANoptosis-a form of programmed cell death.

Predictive factors associated with the onset of Kummell's disease.

Background Context: Kummell's disease (KD) is a long-term complication of vertebral compression fractures, resulting in vertebral collapse and kyphosis. Despite its clinical significance, the underlying mechanisms remain poorly understood.

Purpose: To identify the predictive factors for the onset of KD and provide clinical insights for early screening and intervention in KD patients.

Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury.

Emodin (EMO), an anthraquinone derivative from roots and leaves of various plants, has been widely used in many inflammatory diseases. Alveolar macrophages (AMs) play a critical role in maintaining alveolar homeostasis in the lung. However, the comprehensive mechanisms of EMO therapy on AMs during acute pancreatitis-associated lung injury (AP-ALI) have not been reported.