Event-triggered dynamic landing control of cooperative USV-UAV plant with the compensation mechanism for rolling kinematics.

In this paper, an event-triggered fuzzy control algorithm is proposed for the unmanned surface vessel (USV) and unmanned aerial vehicle (UAV) cooperative plant to achieve the high-precision landing mission. In the guidance module, an L virtual ship-L virtual aerial vehicle (LVS-LVA) guidance principle is developed to generate the reasonable reference signals for the USV-UAV plant under the landing mission. The proposed guidance principle incorporates a rolling kinematic compensation mechanism based on the 4-degree-of-freedom model of USV, specifically designed to counteract wave-induced rolling disturbances during UAV landing operations on unstable marine platforms.

Quantitative Characterization of Microtubule Ultrastructure Based on Single-Molecule Localization Microscopy.

Single-molecule localization microscopy (SMLM) enables visualization of cytoskeletal architecture at nanoscale, uncovering ultrastructural details obscured in conventional imaging. In this study, we present a quantitative framework for characterizing microtubule continuity and integrity based on SMLM super-resolution imaging. We first applied this approach to evaluate the effects of various chemical fixation protocols on microtubule structural preservation.

Fuzheng Jiedu granules for high-risk adults with COVID-19: A randomized, double-blind, placebo-controlled, multi-centre trial.

Background: Fuzheng Jiedu granules (FZJD) is widely used for COVID-19 in China, with early studies indicating reduced mortality in severe cases. However, with emerging variants and shifted treatment focus on preventing severity and relieving symptoms, high-level clinical evidence, especially for high-risk patients, remains lacking.

Methods: A randomized controlled trial (ChiCTR2200058181 ) was performed to assess FZJD's efficacy and safety in high-risk adults with non-severe COVID-19.

EPB41L3 as a prognostic biomarker suppressing cellular malignancy and correlating with the immune microenvironment in glioma.

Background: Glioma, the most common primary tumour of the nervous system. The prognosis of glioma often depends on WHO grade. EPB41L3 (4.

Decoding inflammatory mediators in the Correa's cascade: From chronic gastritis to carcinogenesis and targeted therapies.

Gastric cancer (GC) stands as one of the most prevalent malignant tumors worldwide, with its pathogenesis remaining incompletely elucidated. Correa's cascade delineates a sequential progression from normal gastric mucosa through chronic gastritis, atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia, ultimately culminating in adenocarcinoma. Inflammation serves as the initiating phase of this cascade, predominantly triggered by Helicobacter pylori (H.

Unveiling the multifaceted role of the FLNC gene: implications for cancer diagnosis and prognosis.

Background: The Filamin C (FLNC) gene, pivotal for cellular structure and function, holds significance in cancer biology.

Methods: We conducted a comprehensive study using various analytical approaches, including survival analysis, immune response assessment, methylation profiling, and single-cell analysis.

Results: Our findings indicate that abnormal FLNC expression correlates with unfavorable prognosis across multiple cancer types, suggesting its potential as a prognostic biomarker.

Effect of super-fast freezing before rigor mortis on quality of bovine M. longissimus lumborum.

In order to explore the effects of super-fast freezing (SFF) on beef quality, conventional chilling (CC, 0 ± 2 °C) and very fast chilling (VFC, hot-boned beef loins chilled at -30 °C and then stored at 0 ± 2 °C to bring the temperature down to 0 °C within 5 h post-mortem) were used as controls to investigate the effects of three SFF treatments (-30 °C until the core temperature decreased to -3 °C (SFF-I), -7 °C (SFF-II) and -10 °C (SFF-III), and then stored at 0 ± 2 °C until 24 h post-mortem) on beef tenderness, meat color, water holding capacity, and other related indicators. The results showed that both SFF and VFC improved the tenderness of beef at the early stage of storage compared with CC, and of these SFF-II and SFF-III were the most effective. The SFF has the potential to reduce the cooking loss but increases the purge loss of beef.

Prescribed Performance Path-Following Control for Rotor-Assisted Vehicles via an Improved Reinforcement Learning Mechanism.

This article investigates an adaptive prescribed performance path-following control algorithm for rotor-assisted vehicles, incorporating reinforcement learning (RL) to execute energy-saving cruising missions. For obtaining a high-performance path-following controller, a concise prescribed performance control (PPC) algorithm is designed to tightly constrain the output errors within the defined boundaries, while a shifting function is introduced to solve the problem of initial condition restrictions. Furthermore, through integrating the Backstepping method and the optimal control technique, an improved RL with the form of actor-critic neural networks (AC-NNs) is proposed to offer an innovative approach to the challenges of the model uncertainties and external disturbances.

Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization.

Background: Pancreatic ductal adenocarcinoma (PDAC) is challenging to treat due to its immunosuppressive tumor microenvironment (TME) and resistance to immune checkpoint inhibitors. This study aims to discover new therapeutic targets and predictive biomarkers for PDAC.

Methods: Using Mendelian randomization, we studied causal relationships between PDAC and an array of immune cell traits, bacterial traits, inflammatory factors, and blood metabolites.

Game-Based Event-Triggered Control for Unmanned Surface Vehicle: Algorithm Design and Harbor Experiment.

To improve the trajectory tracking performance of unmanned surface vehicle (USV), this article investigates the USV optimal control problem with the consideration of actuator wear. In the proposed algorithm, the USV control system is divide into kinematic subsystem and kinetic subsystem. In particular, corresponding performance indexes that looking forward to be optimized are defined for each subsystem.

Increased diagnostic accuracy and better morphology characterization of unruptured intracranial aneurysm by ultra-high-resolution photon-counting detector CT angiography.

Background: Accurate detection and morphology evaluation of unruptured intracranial aneurysms (UIAs) are essential for patient management. This study aimed to assess the efficacy of ultra-high-resolution (UHR) photon-counting detector-CT angiography (PCD-CTA) in detecting UIAs and characterizing their morphological features.

Methods: This prospective study recruited consecutive participants suspected of cerebral vascular diseases who underwent PCD-CTA and subsequent digital subtraction angiography (DSA) within 1 month from September 2023 to May 2024.

Vinculin: A new target for the diagnosis and treatment of disease.

Vinculin, a crucial adhesion plaque protein, plays a significant role in cell morphology and tissue development. Dysregulation of focal adhesion proteins has been linked to numerous diseases, including cardiovascular conditions, gastrointestinal disorders, and cancer. Recent studies increasingly highlight vinculin's involvement in the progression of these diseases; however, a comprehensive review remains lacking.

Genetic Associations between Obesity and Brain Cortical Thickness: Combined Genetic Correlation, Multi-Trait Meta-Analysis, and Mendelian Randomization.

Introduction: Obesity may lead to cognitive impairment and neuropsychiatric disorders, which are associated with changes in the brain cortical structure, particularly in cortical thickness. However, the exact genetic association between obesity and brain cortical thickness remains inconclusive. We aimed to identify the relationship between obesity-related traits (body mass index [BMI], waist-hip ratio [WHR], and waist-hip ratio adjusted for BMI [WHRadjBMI]) and brain cortical thickness.

Basophils may as a risk factor for upper gastrointestinal cancer: a Mendelian randomization (MR) study.

Objective: Upper gastrointestinal (UGI) cancers, including esophageal (EC) and gastric (GC) cancers, pose a significant global health challenge. Previous studies have indicated a fundamental correlation between basophil count and the risk of UGI cancer. However, confirming a causal relationship demands further investigation.

The causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomization (MR).

Objective: Hepatocellular carcinoma (HCC) is a complex and multifaceted disease that is increasingly prevalent globally. The involvement of immune cells in the tumour microenvironment has been linked to the progression of HCC, but the exact cause-and-effect relationship is not yet clear. In this study, we utilise Mendelian randomization (MR) to investigate the potential causal links between immune factors and the development of HCC.

Knockdown of LAMA3 enhances the sensitivity of colon cancer to oxaliplatin by regulating the Hippo-YAP pathway.

Background: Oxaliplatin is the first-line chemotherapy for patients with colon cancer (CC). However, its resistance limits its therapeutic efficacy.

Methods: Oxaliplatin resistance-associated differentially expressed genes (DEGs) in the GSE42387 and GSE227315 datasets were identified through bioinformatics methods.

The role of miR-155 in cardiovascular diseases: Potential diagnostic and therapeutic targets.

Cardiovascular diseases (CVDs), such as atherosclerotic cardiovascular diseases, heart failure (HF), and acute coronary syndrome, represent a significant threat to global health and impose considerable socioeconomic burdens. The intricate pathogenesis of CVD involves various regulatory mechanisms, among which microRNAs (miRNAs) have emerged as critical posttranscriptional regulators. In particular, miR-155 has demonstrated differential expression patterns across a spectrum of CVD and is implicated in the etiology and progression of arterial disorders.

Liushen Wan alleviates the virulence and inflammation of Staphylococcus aureus via NLRP3 inflammasome and TLR2-NF-κB/p38 MAPK signaling pathways.

Infectious diseases have been a major threat to health worldwide, with bacterial infections being particularly prominent. Staphylococcus aureus (S. aureus) infections are associated with the most deaths.

Formability and Failure Mechanisms of Continuous Glass Fiber-Reinforced Polypropylene Composite Laminates in Thermoforming Below the Melting Temperature.

In this study, the thermoforming formability of continuous glass fiber-reinforced polypropylene (CGFRPP) laminates below the melting temperature were investigated. The forming limits of CGFRPP laminates were explored using flexural tests, Erichsen tests and deep drawing tests. The failure mechanism of CGFRPP in thermoforming was investigated by observing typical failure specimens using a microscope.

Phosphate-to-alanine ratio and bilirubin-to-androsterone glucuronide ratio are the hub metabolites in upper gastrointestinal cancers: a Mendelian randomisation (MR) study.

Objective: Upper gastrointestinal (UGI) cancers, particularly esophageal cancer (EC) and gastric cancer (GC) represent a significant health burden with complex etiologies. Metabolic alterations are known to play a crucial role in cancer development and progression. Identifying key metabolic biomarkers may offer insights into the pathophysiology of UGI cancers and potential therapeutic targets.

Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study.

Purpose: To investigate the feasibility and accuracy of iodine quantification using PCD-CT in standard-pitch and high-pitch scanning at different scan parameters in a phantom model.

Materials And Methods: Four inserts with known iodine concentrations (2, 5, 10, and 15 mg/mL) were placed in the removable CT phantom and scanned using high-pitch (3.2) and standard-pitch (0.

Ultrahigh-Resolution Photon-Counting Detector CTA of the Head and Neck: Image Quality Assessment and Vascular Kernel Optimization.

Head and neck CTA requires fine-detail evaluation, including characterization of potentially very small vessels and intrastent lumina. Blooming artifacts also hinder evaluation. The purpose of this study was to evaluate image quality of ultrahigh-resolution (UHR) photon-counting detector (PCD) CTA of the head and neck and to explore variation of image quality across body vascular (Bv) reconstruction kernels.

Causal association between metabolites and upper gastrointestinal tumors: A Mendelian randomization study.

Upper gastrointestinal (UGI) tumors, notably gastric cancer (GC) and esophageal cancer (EC), are significant global health concerns due to their high morbidity and mortality rates. However, only a limited number of metabolites have been identified as biomarkers for these cancers. To explore the association between metabolites and UGI tumors, the present study conducted a comprehensive two‑sample Mendelian randomization (MR) analysis using publicly available genetic data.