Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI.

Mitochondria coordinate with lysosomes to maintain cellular homeomstasis. However, in mitochondrial defect condition, how they communicate is less clear. Here, utilizing dMterf4 RNAi fly model, we find that expression of lysosomal alpha-mannosidase VI (LManVI) is significantly downregulated.

Association between hydrometeorological conditions and hemorrhagic fever with renal syndrome in Shandong Province, China, from 2005 to 2019.

Background: Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease with a case fatality rate ranging from 1% to 15%. Long-term evidence regarding its association with local hydrometeorological conditions remain limited. This study aimed to assess the non-linear and lagged effects of extreme hydrometeorological conditions on HFRS risk and examine the modifying effects of regional characteristics in Shandong Province, China.

Plasma kynurenine pathway metabolites in association with diabetes: A cross-sectional study.

Background: Abnormalities of the kynurenine pathway of tryptophan catabolism have been linked with an increased risk of cardiovascular disease. However, the association between kynurenine pathway metabolism and diabetes remains unclear.

Methods: We conducted a secondary analysis of the baseline data of 796 adults from the Prospective Follow-up Study on Cardiovascular Morbidity and Mortality in China (PFS-CMMC).

Association of sleep duration in pregnancy with preterm birth in China: a cross-sectional survey.

Introduction: Only a few studies have reported the relationship between the sleep duration of pregnant women and preterm birth (PTB), and the findings are inconsistent. This study aimed to examine the association of maternal sleep duration in pregnancy with PTB in China.

Methods: A cross-sectional survey.

Analysis of the Relationship Between Cervical Cancer Progression and the Microbiome.

Background: Cervical cancer remains a leading malignancy among women worldwide. Emerging evidence suggests that alterations in the cervical microbiota may influence its development and progression.

Objective: To compare the cervical microbiota composition and diversity between cervical cancer patients and healthy women using 16S rRNA gene sequencing.

Parkin mediates the mitochondrial dysfunction through mRpL18.

Loss of function of parkin leads to mitochondrial dysfunction, which is closely related to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma is that impaired Parkin causes dysfunction of mitophagy mediated by Pink1-Parkin axis.

Trends in Prevalent Cases and Disability-Adjusted Life-Years of Depressive Disorders Worldwide: Findings From the Global Burden of Disease Study From 1990 to 2021.

Depression is a primary public health challenge that affects individuals of all ages. This study aims to reveal information on spatial and temporal changes in depression by describing temporal trend differences, regional differences, and gender differences. Utilizing data from the Global Burden of Disease Study 2021 (GBD2021) from 1990 to 2021, we outlined the prevalence and burden of depression among 204 countries in 21 regions, including age and sex disparities, and explored the correlation between depressive burden and the sociodemographic index (SDI).

Genomic characterization of extended-spectrum β-lactamase-producing spread among chickens and healthy residents in Lombok, Indonesia.

Extended-spectrum β-lactamase-producing (ESBL-Ec) poses a substantial public health challenge, particularly in developing countries where antimicrobial resistance is a growing concern. Although extensive research has documented the prevalence and impact of ESBL-Ec in clinical settings and farm animals, the intricate relationship between poultry farming practices and human health remains unclear. To elucidate the genomic relationships between isolates from chickens and humans, we conducted a whole-genome sequencing analysis of 200 isolates derived from chickens, chicken farmers, and non-farmer volunteers in Lombok, Indonesia.

Associations between short-term exposure to fine particulate matter with ischemic stroke mortality and the role of green space: a time-series study in Zibo, China.

Background: Previous studies on associations between short-term exposure to fine particulate matter (PM) and ischemic stroke (IS) mortality reported inconclusive results. Additionally, whether and how PM and green space interact to precipitate IS deaths remains unclear. We aimed to examine the impacts of short-term exposure to PM on IS mortality and the role of green space in the association.

Extreme thermophilic microbial inoculation for reducing NH and NO emissions in hyperthermophilic aerobic composting of refinery waste activated sludge.

Ammonia (NH) and nitrous oxide (NO) release are the main causes of nitrogen loss during aerobic composting. In this study, hyperthermophilic aerobic composting of refinery waste activated sludge (RWAS) was performed by adding extreme thermophilic bacteria, and the effects of inoculation on NH and NO emissions were systematically studied. The results revealed that inoculation achieved hyperthermophilic aerobic composting (T group), increased maturity, and reduced NH and NO emissions by 32.

Effects and interaction of humidex and air pollution on influenza: A national analysis of 319 cities in mainland China.

Influenza imposes a significant global health burden. This study investigates the effects of humidex and air pollution on influenza and their interactions, using multi-city surveillance data in China. Daily data on reported influenza cases, meteorological factors and air pollution from 319 cities in mainland China over the study period of 2014-2019 were collected.

Meteorological factors and normalized difference vegetation index drivers of scrub typhus incidence in Shandong Province based on a 16-year time-frequency analysis.

Objective: Scrub typhus, a natural epidemic disease that seriously impacts the health of the population, has imposed a substantial disease burden in Shandong Province. This study aimed to determine the periodicity of the scrub typhus incidence and identify the environmental risk factors affecting scrub typhus to help prevent and control its occurrence in Shandong Province.

Methods: Monthly cases of scrub typhus, mean air temperature, relative humidity, cumulative precipitation, and Normalized Difference Vegetation Index (NDVI) data in Shandong Province from 2006 to 2021 were collected.

Associations of lamplight exposure during sleep and sleep duration with attention-deficit/hyperactivity disorder among preschool children in China.

Introduction: This study aimed to examine the associations of exposure to light while sleeping at night and different sleep durations with attention-deficit/hyperactivity disorder (ADHD) among preschool children in China.

Methods: A cross-sectional study including 4197 preschool children (2190 boys and 2007 girls) was conducted in 2021. Lamplight exposure during sleep and sleep duration were collected via a validated questionnaire.

Effect modification of the association between vitamin B2 intake and diabetes mellitus by sex: findings from the National Health and Nutrition Examination Survey 2013-2020.

Background And Objectives: The relationship between vitamin intake and diabetes mellitus (DM) has attracted growing attention. Only few studies have linked vitamin B2 (VB2) and development of DM. In this study, we aimed to assess the association between VB2 intake and DM among U.

Associations of baseline and longitudinal changes in basic activity of daily living with risk of cardiovascular disease among older adults in China.

Background And Aims: The purpose of this study was to examine the associations of basic activities of daily living (BADL) and its longitudinal changes with cardiovascular disease (CVD) risk among older population.

Methods And Results: We conducted a prospective analysis of the Chinese Longitudinal Healthy Longevity Survey between 2008 and 2018 in 7051 participants aged 65 years or over. Cox proportional hazards models were performed to evaluate the associations of baseline and longitudinal changes in BADL with the incidence of CVD.

Parental/guardians' satisfaction with vaccination service and its associated factors: a cross-sectional study from Eastern China.

Background: Vaccination is a simple and effective preventative measure against infections and diseases among populations, especially children. This study aimed to evaluate parental/guardians' satisfaction with vaccination services and examine its associated factors in China.

Methods: This study used mixed methods of quantitative and qualitative research methods.

Association between maternal exercise during pregnancy and attention-deficit/hyperactivity disorder among preschool children in Southwest China.

Objective: Maternal moderate-intensity exercise during pregnancy has important health benefits for the offspring, however, less is known about its association with offspring attention-deficit/hyperactivity disorder (ADHD). This study aimed to explore the association between maternal exercise during pregnancy and ADHD among preschool children in Southwest China.

Methods: A web-based cross-sectional study was performed in 2021, and the revised Conners Parental Symptom Questionnaire and maternal exercise during pregnancy were obtained through a self-reported structured questionnaire.

Changes in the Phylogenetic Structure of Alpine Grassland Plant Communities on the Qinghai-Tibetan Plateau with Long-Term Nitrogen Deposition.

Nitrogen (N) deposition rates have notably increased around the world, especially in high-altitude regions like the Qinghai-Tibetan Plateau (QTP). We conducted a six-year comprehensive experiment to simulate nitrogen deposition in an alpine grassland area near Qinghai Lake. Four levels of nitrogen depositions, i.

Performance evaluation and microbial community succession analysis of co-composting treatment of refinery waste activated sludge.

Refinery waste activated sludge (RWAS) is riched in organic matter with energy recovery value, while unique petroleum components in RWAS may pose challenges to the recycling process. Aerobic composting technology is an effective means of organic solid waste resource treatment, which can convert organic solid waste into fertilizer for agriculture. This study explores the effect of petroleum components on the performance of RWAS composting by co-composting it with chicken manure.

Ethnic differences in the effects of lifestyle interventions on adverse pregnancy outcomes among women with gestational diabetes mellitus: A systematic review and meta-analysis.

Aims: Lifestyle interventions are widely used among women with gestational diabetes mellitus (GDM). This study aimed to assess the ethnic disparities in the effectiveness of lifestyle interventions on reducing adverse pregnancy outcomes, particularly macrosomia and neonatal hypoglycemia among women with GDM.

Methods: We systematically searched the PubMed/MEDLINE, Web of Science, and Cochrane Library databases from January 1, 2000, up to March 31, 2024, to identify randomized controlled trials (RCTs) examining the effects of lifestyle interventions in GDM patients.

An Efficient Boron Source Activation Strategy for the Low-Temperature Synthesis of Boron Nitride Nanotubes.

Lowering the synthesis temperature of boron nitride nanotubes (BNNTs) is crucial for their development. The primary reason for adopting a high temperature is to enable the effective activation of high-melting-point solid boron. In this study, we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO-B system.

Associations of plasma arginine, homoarginine, and ADMA/SDMA levels with risk of ischemic stroke: A nested case-control study.

Background And Aims: Previous studies have linked aberrant nitric oxide (NO) metabolism with vascular diseases. Although arginine, homoarginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) are involved in NO metabolic pathways, their associations with ischemic stroke (IS) remain unclear.

Methods And Results: We conducted a case-control study nested within the Prospective Follow-up Study on Cardiovascular Morbidity and Mortality in China (PFS-CMMC) (2013-2018, n = 16,457; median follow-up time: 5.

Different responses of individuals, functional groups and plant communities in CSR strategies to nitrogen deposition in high-altitude grasslands.

The Competitor, Stress Tolerator, and Ruderal (CSR) theory delineates the ecological strategies of plant species. Nevertheless, how these ecological strategies shift at the levels of individuals, functional groups and plant communities to cope with increasing nitrogen deposition remains unclear. In this study, simulated nitrogen deposition experiments were performed in high-altitude grasslands of alpine meadows and alpine steppe on the Qinghai-Tibetan Plateau (QTP) by employing the strategy and functional type framework (StrateFy) methodology to evaluate plant CSR strategies.