PKD-YOLOv8: A Collaborative Pruning and Knowledge Distillation Framework for Lightweight Rapeseed Pest Detection.

As an important oil and vegetable crop, rapeseed is widely planted and has important economic value worldwide. Rapeseed is often threatened by various pests during its growth. In order to effectively deal with rapeseed pests, this paper proposes a lightweight method based on collaborative compression learning.

Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility.

Purpose: This study explores whether certain trace elements are genetically linked to male infertility by using large-scale genetic data and a method called Mendelian randomization (MR), which helps infer causal relationships.

Materials And Methods: We obtained genetic data related to trace minerals and iron metabolism from three databases: the IEU Open GWAS, UK Biobank, and FinnGen Biobank. We used standard MR analysis tools to evaluate the relationship between genetic variants associated with trace elements and the risk of male infertility.

Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer.

Background: Collagen, within the tumor microenvironment (TME), assumes a crucial function in the development of cancer. However, the expression of collagen genes in bladder cancer (BCa) remains inadequately comprehended. The aim of this study is to examine the collagen genes expression in the BCa TME, and construct a nomogram to predict the overall survival for patients diagnosed with BCa.

Smoking and bladder cancer: insights into pathogenesis and public health implications from a bibliometric analysis (1999-2023).

Background: Cigarette smoking is a major contributor to the global burden of bladder cancer. Its carcinogenic effects result from the harmful substances in tobacco smoke, which induce genetic mutations and disrupt cellular processes. Understanding how smoking contributes to bladder cancer is essential for developing effective prevention and treatment strategies.

Machine learning-driven construction and validation of an intra-tumoral heterogeneity-associated prognostic model for bladder urothelial carcinoma.

Intra-tumoral heterogeneity (ITH) plays a crucial role in tumor progression and prognosis. This study aimed to construct a prognostic model for bladder urothelial carcinoma (BLCA) based on ITH-related genes. Transcriptomic and clinical data from multiple public cohorts were collected and processed.

Global burden of chronic kidney disease due to diabetes mellitus, 1990-2021, and projections to 2050.

Introduction: Chronic kidney disease (CKD) is a serious complication of diabetes, and the global burden of the disease is gradually increasing.

Methods: This study systematically analyzed the trends and future projections of the worldwide burden of chronic kidney disease caused by type 1 and type 2 diabetes mellitus based on the Global Burden of Disease Study (GBD) using data from 1990 to 2021. Number of deaths, Age-standardized mortality rates, disability-adjusted life years (DALYs), and age-standardized DALYs rate were used to estimate the disease burden.

Prediction model for spontaneous combustion temperature of coal based on PSO-XGBoost algorithm.

The construction of a predictive model that accurately reflects the spontaneous combustion temperature of coal in goaf is fundamental to monitoring and early warning systems for thermodynamic disasters, including coal spontaneous combustion and gas explosions. In this paper, on the basis of programming temperature experiment and industrial analysis, 381 data sets of 9 coal types are established, and feature selection was executed through the utilization of the Pearson correlation coefficient, ultimately identifying O, CO, CO, CH, CH, CH/CH, CH/CH, CH/CH, CO/CO, and CO/O as input indicators for the prediction model. The chosen indicator data were divided into training and testing sets in a 4:1 ratio, the Particle Swarm Optimization (PSO) methodology was applied to optimize the parameters of the XGBoost regressor, and a universal PSO-XGBoost prediction model is proposed.

Investigation of electromagnetic wave propagation characteristics across various frequencies in porous media of goaf.

The reliable long-distance transmission of electromagnetic wave signals within goaf is fundamental for the implementation of wireless monitoring and early warning systems for goaf-related disasters. This paper establishes an experimental platform for electromagnetic wave signal transmission within goaf and develops a propagation model for electromagnetic waves in the porous media of goaf. The transmission characteristics of electromagnetic waves at various frequencies within the porous media environment of goaf are investigated through experimental and numerical simulation approaches.

TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease.

Obstructive sleep apnea syndrome (OSAS) is associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Tripartite motif containing 24 (TRIM24) deficiency causes hepatic lipid accumulation and hepatitis. However, the expression, function, and mechanism of TRIM24 in OSAS and MASLD remain unclear.

Systematic review and meta-analysis of percutaneous nephrolithotomy in flank versus prone position.

Background: This systematic review and meta-analysis aimed to evaluate the efficiency and safety of percutaneous nephrolithotomy (PCNL) between flank position and prone position for the treatment of renal stones.

Methods: PubMed, Embase, OVID, and Cochrane Library were comprehensively searched from their inception to Jul 2024. Randomized and nonrandomized trials evaluating renal calculi patients who underwent PCNL via flank position or prone position were included.

Mechanism study of ubiquitination in T cell development and autoimmune disease.

T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg with the help of TEC and DC, serving for immune tolerance.

PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling.

Previous study showed that higher expression of prolactin (PRL) was found in CRPC samples compared with hormone-naive prostate cancer (HNPC) and benign prostatic hyperplasia (BPH) samples. We further investigate the function of PRL in prostate cancer (PCa) and explored its downstream effects. We found heterogeneous expression of the PRLR in clinical prostate samples.

Prevalence and Risk Factors of Hyperuricemia Among Young and Middle-Aged Tibetan Men Living at Ultrahigh Altitudes: A Cross-Sectional Study.

He, Ben, Jiayue Feng, Yan Shu, Lichun Yang, Zepin He, Kanxiu Liao, Hui Zhuo, and Hui Li. Prevalence and risk factors of hyperuricemia among young and middle-aged Tibetan men living at ultrahigh altitudes: a cross-sectional study. .

Quantitative calculation of gases generation during low-temperature oxidation of coal.

The gases evolution during the low-temperature oxidation of coal is an essential parameter used to assess the state of coal oxidation and to estimate the gaseous pollutants. However, the current semi-quantitative method, which employs gas concentration as the measurement standard, is flawed. This paper presents a quantitative calculation method for gas products during coal oxidation.

Identification of a cancer-associated fibroblast signature for predicting prognosis and immunotherapeutic responses in bladder urothelial carcinoma.

Background: Cancer-associated fibroblasts (CAFs) are the most important cellular components in bladder urothelial carcinoma (BLCA) and are involved in the development and immunosuppression of BLCA. Therefore, we aimed to construct a CAF-associated signature for predicting the prognosis and immunotherapy response in patients with BLCA.

Methods: CAF infiltration and stromal score were quantified using two algorithms.

A meta-fusion RCNN network for endoscopic visual bladder lesions intelligent detection.

This study investigates a visual object detection technology in order to help doctors diagnose bladder lesions with endoscopy. A new object detection approach based on deep learning is presented, which derived from the cascade R-CNN and extended the ability of network for adapting insufficient endoscopic lesions samples when training a deep neural network. We propose a feature adaptive fusion model to increase the network's mobility and reduce the possibility of overfitting problems, and use task adaptation meta-learning approach to train the feature fusion process of the entire model and the target network update process in order to complete the task-adaptive classification and detection.

High Fat Diet Induces Kidney Injury Stimulating Wnt/β-Catenin Signaling.

High fat diet could cause kidney injury, and the underlying mechanism remains incompletely understood. In this study, we investigated the role of Wnt signaling in this process. Mice were fed with high-fat diet , and podocytes were stimulated with palmitate .

Body Composition Parameters May Be Prognostic Factors in Upper Urinary Tract Urothelial Carcinoma Treated by Radical Nephroureterectomy.

Objective: This study assessed the association between body composition and prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) patients treated by radical nephroureterectomy.

Methods: We retrospectively collected baseline data on age, sex, body mass index (BMI), hypertension, diabetes, and tumor-related factors. Computed tomography (CT) scans were performed to measure body composition parameters such as muscle attenuation (MA), total abdominal muscle area (TAMA), visceral fat area (VFA), intermuscular fat area (IMF), and lateral/posterior perirenal fat thickness (L/P PNF), visceral fat density (VD), and subcutaneous fat density (SD).

Intravenous insulin injection supplemented with subsequent milk consumption is a safer formulation for cardiac viability F-FDG imaging.

Background: The safety and efficacy of intravenous insulin injection coupled with subsequent milk consumption was evaluated for high-quality cardiac viability F-18-fluorodeoxyglucose (F-FDG) images.

Methods And Results: A total of 328 patients with known/suspected coronary artery disease received intravenous insulin injection with or without subsequent milk consumption for cardiac F-FDG imaging. When blood glucose levels had decreased by ≥ 20%, F-FDG was injected.

Application of the hospital-family holistic care model in caregivers of patients with permanent enterostomy: A randomized controlled trial.

Aims: To evaluate the effectiveness of the hospital-family holistic care model based on the theory of 'Timing It Right' in caregivers of patients with permanent enterostomy.

Design: A prospective randomized controlled trial.

Methods: One hundred and twenty-five caregivers of patients with permanent enterostomy were recruited from 1 May 2017-31 August 2019.

Tspan8 Is Highly Expressed in Clear Cell Renal Cell Carcinoma and Indicates Poor Prognosis.

Objective: Tspan8 (tetraspanin 8) plays critical roles in cell adhesion and motility. Recently, Tspan8 overexpression has been found in various tumors. However, its expression status and prognostic significance in clear cell renal cell carcinoma (ccRCC) remains unknown.

Intravenous regular insulin is an efficient and safe procedure for obtaining high-quality cardiac F-FDG PET images: an open-label, single-center, randomized controlled prospective trial.

Background: An open-label, single-center, randomized controlled prospective trial was performed to assess the efficiency and safety of an insulin loading procedure to obtain high-quality cardiac F-FDG PET/CT images for patients with coronary artery disease (CAD).

Methods: Between November 22, 2018 and August 15, 2019, 60 patients with CAD scheduled for cardiac F-FDG PET/CT imaging in our department were randomly allocated in a 1:1 ratio to receive an insulin or standardized glucose loading procedure for cardiac F-FDG imaging. The primary outcome was the ratio of interpretable images (high-quality images defined as myocardium-to-liver ratios ≥ 1).

LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3.

Diabetic nephropathy (DN), characterized by the chronic loss of kidney function during diabetes, is a long-term kidney disease that affects millions of populations. However, the etiology of DN remains unclear. DN cell model was established by treating HK-2 cells with high glucose (HG) in vitro.