Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk.

Background: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant liver cancer subtype with limited effective treatment options. Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment (TME). However, causal relationships between specific inflammatory factors and ICC risk remain unclear.

Unlocking the bioremediation potential of adapted Desulfovibrio desulfuricans in acidic low-temperature U-contaminated groundwater.

Addressing the global challenge of uranium (U)-contaminated groundwater requires innovative bioremediation strategies. This study investigates Desulfovibrio desulfuricans, a neutrophilic and mesophilic sulfate-reducing bacteria (SRB) strain optimized for low-temperature (15 °C) and acidic (initial pH 4) conditions, to validate its bioaugmentation potential for uranium decontamination in groundwater. Our research aimed to assess its efficacy in treating U-contaminated groundwater and elucidate the optimal growth conditions for this strain in acidic and sulfate-enriched environments.

Modified Code Index Modulation Scheme Based on Multi-Carrier M-ary DCSK System.

In this paper, a modified code index modulation scheme based on the multi-carrier M-ary DCSK system, referred to as a MC-MCIM-MDCSK system, is proposed. In the proposed MC-MCIM-MDCSK system, a modified code index modulation scheme is carried out, which selects two orthogonal Walsh codes for realizing the M-ary DCSK encoder. The theoretical BER expression of the proposed system is obtained over additive white Gaussian noise (AWGN) and the multipath Rayleigh fading channels.

Behavior and Mechanisms of Antimony Precipitation from Wastewater by Sulfate-Reducing Bacteria .

The development of the non-ferrous metal industry is generating increasingly large quantities of wastewater containing heavy metals (e.g., Sb).

Efficacy and Safety of Aerosol Inhalation of Colistin Sulfate for the Treatment of Carbapenem-Resistant Infection in the Peri-Operative Period of Liver Transplantation: A Single-Center Retrospective Study.

This study intended to evaluate the clinical efficacy and safety of colistin sulfate aerosol inhalation in combination with ceftazidime-avibactam for the treatment of pulmonary carbapenem-resistant (CRKP) infection during the peri-operative period of liver transplantation. A retrospective analysis was designed to investigate 52 patients who developed pulmonary CRKP infection after liver transplantation between December 1, 2019, and November 30, 2022. On the basis of whether they received colistin sulfate aerosol inhalation, the patients were divided into the treatment group ( = 29) and the control group ( = 23).

Ecological features of microbial community linked to stochastic and deterministic assembly processes in acid mine drainage.

Unlabelled: Ecological processes greatly shape microbial community assembly, but the driving factors remain unclear. Here, we compiled a metagenomic data set of microbial communities from global acid mine drainage (AMD) and explored the ecological features of microbial community linked to stochastic and deterministic processes from the perspective of species niche position, interaction patterns, gene functions, and viral infection. Our results showed that dispersal limitation (DL) (48.

Design, dynamic modeling and testing of a novel MR damper for cable-stayed climbing robots under wind loads.

To increase the adaptability of bridge construction equipment in high-altitude settings, this study examines a magnetorheological (MR) damper designed for cable-stayed climbing robots. Initially, a novel damper incorporating a spring-MR fluid combination and three magnetic circuit units is developed. A robot-cable-wind coupling dynamic model is subsequently formulated via Hamilton's principle, based on force analysis.

Model-free distributed state estimation with local measurements.

In this paper, the state estimation problem of physical plants with unknown system dynamic is revisited from the perspective of limited output information measurement, which corresponds to those with characteristics of high-dimensional, wide-area coverage and scatter. Given this fact, a network of sensors are used to carry out the measurement with each one accessing only partial outputs of the targeted systems and a novel model-free state estimation approach, named distributed stochastic variational inference state estimation, is proposed. The key idea of this method is to compensate for the impacts of local output measurements by adding nearest-neighbor rule-based information interaction among estimators to complete the state estimation.

Eradication rate and safety of vonoprazan-amoxicillin dual therapy for helicobacter pylori eradication: a randomized controlled trial.

Background: Helicobacter pylori (), prevalent in developing regions, is a key factor in gastrointestinal diseases. Despite the common use of bismuth-based quadruple therapy, its drawbacks have prompted the search for alternatives. Recently, vonoprazan, a novel acid suppressant, has shown promise in combination with antibiotics as a dual therapy for eradication.

Impact of metabolic disorders on gallstone disease and perioperative recovery after laparoscopic cholecystectomy.

Background: Gallstone disease (GSD), nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and metabolic syndrome (MetS) are common medical disorders worldwide. This study aimed to ascertain how NAFLD, MAFLD, MetS, and other factors affect the development of GSD, and how the GSD-associated factors influence patient recovery after laparoscopic cholecystectomy (LC).

Methods: We included 200 patients who were diagnosed with GSD and underwent LC between January 2017 and February 2022.

Response of bacterial ecological and functional properties to anthropogenic interventions during maturation of mine sand soil.

Soil formation is a complex process that starts from the biological development. The ecological principles and biological function in soil are of great importance, whereas their response to anthropogenic intervention has been poorly understood. In this study, a 150-day microcosmic experiment was conducted with the addition of sludge and/or fermented wood chips (FWC) to promote the soil maturation.

Case Report: Perianal infection in children caused by ingested jujube pits: a report of two cases.

Background: The ingestion of jujube pits by children is a rare cause of perianal infection.This article aimed to report two cases of perianal infection in children resulting from the ingestion of jujube pits.

Methods: We reviewed the clinical records of perianal infection caused by jujube pits at our hospital.

A data-driven epidemic model with human mobility and vaccination protection for COVID-19 prediction.

Epidemiological models allow for quantifying the dynamic characteristics of large-scale outbreaks. However, capturing detailed and accurate epidemiological information often requires consideration of multiple kinetic mechanisms and parameters. Due to the uncertainty of pandemic evolution, such as pathogen variation, host immune response and changes in mitigation strategies, the parameter evaluation and state prediction of complex epidemiological models are challenging.

Phase I study of a non-S2P SARS-CoV-2 mRNA vaccine LVRNA009 in Chinese adults.

Background: COVID-19 caused by SARS-CoV-2 is a great threat to public health. We present the safety and immunogenicity data from a phase I trial in China of an mRNA vaccine (LVRNA009).

Methods: In the single-centre, double-blind, placebo-controlled and dose-escalation study, 72 healthy unvaccinated adults aged 18-59 years were randomized (3:1) to receive LVRNA009 with one of three vaccine dosage (25, 50 and 100 μg) or placebo, to evaluate for the safety, tolerability and immunogenicity of LVRNA009.

Kinematic modelling and experimental testing of a particle-jamming soft robot based on a DEM-FEM coupling method.

Particle-jamming soft robots are characterised by high flexibility in motion and high stiffness when executing a task. Regarding particle jamming of soft robots, the discrete element method (DEM)-finite element method (FEM) coupling was used for modelling and control. At first, a real-time particle-jamming soft actuator was proposed by integrating advantages of the driving Pneu-Net and the driven particle-jamming mechanism.

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most lethal malignant cancers across the world. It has a poor prognosis and lacks effective therapies, especially for patients with advanced-stage cancer, indicating an urgent need for new therapies and novel therapeutic targets. Here, by screening the U.

[Expression level and clinical significance of CD44 and CD33 in 77 patients with benign lymphoadenosis of oral mucosa].

Purpose: To investigate the expression and clinical significance of CD44 and CD33 in benign lymphoadenosis of oral mucosa(BLOM).

Methods: From January 2017 to March 2020, seventy-seven BLOM wax blocks from the Department of Pathology of Qingdao Traditional Chinese Medicine Hospital were selected as the experimental group, and 63 cases of normal oral mucosal tissue wax blocks during the same period were selected as the control group. Immunohistochemical method was used to detect the positive expression of CD44 and CD33 in the two groups.

Reactive-diffusion epidemic model on human mobility networks: Analysis and applications to COVID-19 in China.

The complex dynamics of human mobility, combined with sporadic cases of local outbreaks, make assessing the impact of large-scale social distancing on COVID-19 propagation in China a challenge. In this paper, with the travel big dataset supported by Baidu migration platform, we develop a reactive-diffusion epidemic model on human mobility networks to characterize the spatio-temporal propagation of COVID-19, and a novel time-dependent function is incorporated into the model to describe the effects of human intervention. By applying the system control theory, we discuss both constant and time-varying threshold behavior of proposed model.

Probability Distribution Characteristics of Horizontal and Vertical Mechanical Properties of Rubber Bearings.

Rubber bearings are widely used to protect civil structures from destructive earthquakes. The mechanical properties of the bearings are the key technical parameters that determine the seismic isolation performance of isolated structures. To estimate the probability distribution of the mechanical properties related to rubber bearings (including horizontal stiffness, vertical stiffness, post-yield stiffness and yield force) under seismic events.

Primary Hepatoid Adenocarcinoma of the Lung: A Systematic Literature Review.

Background: Hepatoid adenocarcinoma (HAC) of the lung (HAL) is a rare and aggressive extrahepatic adenocarcinoma with an unknown etiology and unfavorable prognosis, which is similar to the pathophysiological characteristics of hepatocellular carcinoma (HCC).

Methods: We first presented a 67-year-old patient diagnosed with HAC in the right middle lobe of the lung. Then, a systematic literature search was performed for HAL cases recorded between 1990 and 2020 based on three databases.

Analysis of Esophageal Motility and Reflux Characteristics in Patients with Gastroesophageal Reflux Disease With or Without Extraesophageal Symptoms.

Background: The pathogenesis of extraesophageal symptoms of gastroesophageal reflux disease is complex, and esophageal motility and reflux may be involved in it. In this study, we aimed to compare esophageal motility and reflux characteristics in gastroesopha- geal reflux disease patients with and without extraesophageal symptoms by high-resolution manometry and multichannel intraluminal impedance-pH monitoring.

Methods: We retrospectively studied gastroesophageal reflux disease patients between January 2014 and December 2018.

Sulfated polysaccharides from pacific abalone attenuated DSS-induced acute and chronic ulcerative colitis in mice regulating intestinal micro-ecology and the NF-κB pathway.

Due to potential side effects of current drugs in colitis treatment, polysaccharides with anti-inflammatory activities can be considered as alternative molecules for colitis treatment. Sulfated polysaccharide from pacific abalone (AGSP) reduced the level of lipopolysaccharides (LPS) and increased the production of short chain fatty acids in the colon of mice, and it reduced the levels of interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α and increased the IL-10 level in cell models, suggesting that it can be used as a probiotic agent to inhibit intestinal inflammation. Furthermore, AGSP reduced the disease activity index and intestinal damage, improved the mucosal immune response, and inhibited oxidative damage in mice with DSS-induced acute and chronic colitis, which can be associated with modulation of the NF-κB signaling pathway and gut microbiota.